Pde4b (phosphodiesterase 4B) - Rat Genome Database

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Gene: Pde4b (phosphodiesterase 4B) Rattus norvegicus
Analyze
Symbol: Pde4b
Name: phosphodiesterase 4B
RGD ID: 3280
Description: Enables 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in several processes, including cellular response to epinephrine stimulus; positive regulation of cytokine production; and regulation of muscle system process. Predicted to act upstream of or within several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and neutrophil homeostasis. Located in perinuclear region of cytoplasm. Orthologous to human PDE4B (phosphodiesterase 4B); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3',5'-cyclic AMP phosphodiesterase; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; DPDE4; MGC93193; PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4; Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4; Phosphodiesterase 4B cAMP-specific (dunce; Phosphodiesterase 4B cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4); phosphodiesterase 4B, cAMP specific; Phosphodiesterase 4B, cAMP-specific (dunce; phosphodiesterase 4B, variant 1; phosphodiesterase 4B, variant 2; phosphodiesterase 4B, variant 3; phosphodiesterase 4B, variant 4; phosphodiesterase type 4B5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Pde4bem1Sage  
Genetic Models: SD-Pde4bem1Sage
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25116,799,827 - 117,367,707 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5116,799,971 - 117,367,696 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5119,427,039 - 120,003,548 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05121,152,375 - 121,728,874 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05121,203,684 - 121,780,134 (+)NCBIRnor_WKY
Rnor_6.05121,759,236 - 122,136,814 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5121,952,977 - 122,136,814 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05125,623,815 - 126,001,128 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45123,158,156 - 123,533,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15123,163,381 - 123,539,103 (+)NCBI
Celera5115,579,422 - 115,946,626 (+)NCBICelera
Cytogenetic Map5q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
albuterol  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (ISO)
cisplatin  (ISO)
clozapine  (EXP)
colforsin daropate hydrochloride  (ISO)
coumarin  (EXP)
crocidolite asbestos  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cytarabine  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
Genipin  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
histamine  (ISO)
hydroquinone  (ISO)
irinotecan  (EXP,ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium chloride  (ISO)
lithium hydride  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N(6)-dimethylallyladenine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
oxycodone  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
roflumilast  (ISO)
rolipram  (EXP,ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topiramate  (EXP)
torcetrapib  (ISO)
trichloroethene  (EXP,ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. Acin-Perez R, etal., J Biol Chem. 2011 Sep 2;286(35):30423-32. doi: 10.1074/jbc.M111.266379. Epub 2011 Jul 1.
2. Phosphodiesterase 4B (PDE4B) and cAMP-level regulation within different tissue fractions of rat hippocampal slices during long-term potentiation in vitro. Ahmed T and Frey JU, Brain Res. 2005 Apr 18;1041(2):212-22.
3. Phosphodiesterase 4B knockout prevents skeletal muscle atrophy in rats with burn injury. Balasubramaniam A, etal., Am J Physiol Regul Integr Comp Physiol. 2018 Aug 1;315(2):R429-R433. doi: 10.1152/ajpregu.00042.2018. Epub 2018 Apr 25.
4. Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases. Bolger GB, etal., Gene 1994 Nov 18;149(2):237-44.
5. Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase. Colicelli J, etal., Proc Natl Acad Sci U S A 1989 May;86(10):3599-603.
6. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3. Huston E, etal., Biochem J 1997 Dec 1;328 ( Pt 2):549-58.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Structure of two rat genes coding for closely related rolipram-sensitive cAMP phosphodiesterases. Multiple mRNA variants originate from alternative splicing and multiple start sites. Monaco L, etal., J Biol Chem 1994 Jan 7;269(1):347-57.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform. Shepherd M, etal., Biochem J 2003 Mar 1;370(Pt 2):429-38.
18. Properties and hormonal regulation of two structurally related cAMP phosphodiesterases from the rat Sertoli cell. Swinnen JV, etal., J Biol Chem 1991 Sep 25;266(27):18370-7.
19. Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes. Swinnen JV, etal., Proc Natl Acad Sci U S A 1989 Jul;86(14):5325-9.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Activation and induction of cyclic AMP phosphodiesterase (PDE4) in rat pulmonary microvascular endothelial cells. Zhu B, etal., Biochem Pharmacol. 2004 Aug 1;68(3):479-91.
Additional References at PubMed
PMID:8413254   PMID:11267656   PMID:12477932   PMID:12617967   PMID:14519662   PMID:15026126   PMID:15585880   PMID:15993984   PMID:16641100   PMID:17204557   PMID:17404263   PMID:17917586  
PMID:18227403   PMID:18455876   PMID:18571642   PMID:18923023   PMID:18983980   PMID:21670503   PMID:22384243   PMID:22865690   PMID:23008439   PMID:23080174   PMID:23887098   PMID:24413164  
PMID:25931508   PMID:30053369   PMID:30628641   PMID:32212953   PMID:32699940   PMID:36495666  


Genomics

Comparative Map Data
Pde4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25116,799,827 - 117,367,707 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5116,799,971 - 117,367,696 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5119,427,039 - 120,003,548 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05121,152,375 - 121,728,874 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05121,203,684 - 121,780,134 (+)NCBIRnor_WKY
Rnor_6.05121,759,236 - 122,136,814 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5121,952,977 - 122,136,814 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05125,623,815 - 126,001,128 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45123,158,156 - 123,533,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15123,163,381 - 123,539,103 (+)NCBI
Celera5115,579,422 - 115,946,626 (+)NCBICelera
Cytogenetic Map5q33NCBI
PDE4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38165,792,510 - 66,374,579 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl165,792,514 - 66,374,579 (+)EnsemblGRCh38hg38GRCh38
GRCh37166,258,193 - 66,840,262 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36166,030,781 - 66,612,850 (+)NCBINCBI36Build 36hg18NCBI36
Build 34165,970,884 - 66,551,208NCBI
Celera164,548,796 - 65,130,612 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef164,366,982 - 64,949,229 (+)NCBIHuRef
CHM1_1166,374,133 - 66,955,827 (+)NCBICHM1_1
T2T-CHM13v2.0165,669,985 - 66,252,011 (+)NCBIT2T-CHM13v2.0
Pde4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394101,944,529 - 102,464,459 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4101,944,740 - 102,464,456 (+)EnsemblGRCm39 Ensembl
GRCm384102,087,332 - 102,607,275 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4102,087,543 - 102,607,259 (+)EnsemblGRCm38mm10GRCm38
MGSCv374101,927,347 - 102,279,867 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364101,752,935 - 102,103,771 (+)NCBIMGSCv36mm8
Celera4100,608,595 - 100,971,313 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map446.99NCBI
Pde4b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542324,463,953 - 24,906,394 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542324,464,503 - 24,906,409 (-)NCBIChiLan1.0ChiLan1.0
PDE4B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11159,649,043 - 160,231,740 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0165,038,120 - 65,620,764 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1166,924,478 - 67,506,291 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl167,045,911 - 67,506,291 (+)Ensemblpanpan1.1panPan2
PDE4B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1544,063,145 - 44,606,070 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl544,065,106 - 44,500,999 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha544,186,161 - 44,663,652 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0544,251,621 - 44,793,357 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl544,251,983 - 44,793,329 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1544,216,433 - 44,758,769 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0544,161,847 - 44,703,948 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0544,405,153 - 44,947,628 (-)NCBIUU_Cfam_GSD_1.0
Pde4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505878,822,844 - 79,336,912 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365915,152,441 - 5,573,129 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365915,152,491 - 5,666,728 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE4B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6146,166,688 - 146,719,682 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16146,167,262 - 146,720,105 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26134,870,996 - 134,913,607 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE4B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12066,729,561 - 67,297,729 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2066,728,664 - 66,771,691 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603350,280,843 - 50,864,221 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde4b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474228,557,283 - 29,016,844 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474228,557,159 - 29,113,269 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pde4b
2258 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:344
Count of miRNA genes:170
Interacting mature miRNAs:193
Transcripts:ENSRNOT00000007738, ENSRNOT00000008278, ENSRNOT00000068158
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)599016066119085810Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat

Markers in Region
Pde4b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25116,993,488 - 116,993,688 (+)MAPPERmRatBN7.2
Rnor_6.05121,759,289 - 121,759,488NCBIRnor6.0
Rnor_5.05125,623,868 - 125,624,067UniSTSRnor5.0
RGSC_v3.45123,158,209 - 123,158,408UniSTSRGSC3.4
Celera5115,579,475 - 115,579,674UniSTS
Cytogenetic Map5q32UniSTS
D5Got246  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,177,749 - 117,177,900 (+)MAPPERmRatBN7.2
Rnor_6.05121,944,611 - 121,944,761NCBIRnor6.0
Rnor_5.05125,809,190 - 125,809,340UniSTSRnor5.0
RGSC_v3.45123,343,387 - 123,343,537UniSTSRGSC3.4
Celera5115,756,656 - 115,756,806UniSTS
Cytogenetic Map5q32UniSTS
PMC25763P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,367,073 - 117,367,228 (+)MAPPERmRatBN7.2
Rnor_6.05122,136,205 - 122,136,359NCBIRnor6.0
Rnor_5.05126,000,519 - 126,000,673UniSTSRnor5.0
RGSC_v3.45123,533,268 - 123,533,422UniSTSRGSC3.4
Celera5115,946,017 - 115,946,171UniSTS
Cytogenetic Map5q32UniSTS
22.MMHAP70FRH7.seq  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,266,911 - 117,267,059 (+)MAPPERmRatBN7.2
Rnor_6.05122,036,069 - 122,036,216NCBIRnor6.0
Rnor_5.05125,900,383 - 125,900,530UniSTSRnor5.0
RGSC_v3.45123,433,113 - 123,433,260UniSTSRGSC3.4
Celera5115,845,753 - 115,845,900UniSTS
Cytogenetic Map5q32UniSTS
BE120216  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,158,884 - 117,159,036 (+)MAPPERmRatBN7.2
Rnor_6.05121,925,748 - 121,925,899NCBIRnor6.0
Rnor_5.05125,790,327 - 125,790,478UniSTSRnor5.0
RGSC_v3.45123,324,524 - 123,324,675UniSTSRGSC3.4
Celera5115,737,826 - 115,737,977UniSTS
RH 3.4 Map5787.2UniSTS
Cytogenetic Map5q32UniSTS
AI535520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25116,993,789 - 116,994,039 (+)MAPPERmRatBN7.2
Rnor_6.05121,759,590 - 121,759,839NCBIRnor6.0
Rnor_5.05125,624,169 - 125,624,418UniSTSRnor5.0
RGSC_v3.45123,158,510 - 123,158,759UniSTSRGSC3.4
Celera5115,579,776 - 115,580,025UniSTS
Cytogenetic Map5q32UniSTS
RH138005  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,153,278 - 117,153,442 (+)MAPPERmRatBN7.2
Rnor_6.05121,920,142 - 121,920,305NCBIRnor6.0
Rnor_5.05125,784,721 - 125,784,884UniSTSRnor5.0
RGSC_v3.45123,318,918 - 123,319,081UniSTSRGSC3.4
Celera5115,732,220 - 115,732,383UniSTS
RH 3.4 Map5786.4UniSTS
Cytogenetic Map5q32UniSTS
RH138148  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,080,708 - 117,080,897 (+)MAPPERmRatBN7.2
Rnor_6.05121,846,522 - 121,846,710NCBIRnor6.0
Rnor_5.05125,711,101 - 125,711,289UniSTSRnor5.0
RGSC_v3.45123,246,482 - 123,246,670UniSTSRGSC3.4
Celera5115,666,495 - 115,666,683UniSTS
RH 3.4 Map5786.8UniSTS
Cytogenetic Map5q32UniSTS
RH138697  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,271,304 - 117,271,535 (+)MAPPERmRatBN7.2
Rnor_6.05122,040,462 - 122,040,692NCBIRnor6.0
Rnor_5.05125,904,776 - 125,905,006UniSTSRnor5.0
RGSC_v3.45123,437,506 - 123,437,736UniSTSRGSC3.4
Celera5115,850,146 - 115,850,376UniSTS
RH 3.4 Map5786.8UniSTS
Cytogenetic Map5q32UniSTS
BF390420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,327,502 - 117,327,652 (+)MAPPERmRatBN7.2
Rnor_6.05122,096,658 - 122,096,807NCBIRnor6.0
Rnor_5.05125,960,972 - 125,961,121UniSTSRnor5.0
RGSC_v3.45123,493,703 - 123,493,852UniSTSRGSC3.4
Celera5115,906,356 - 115,906,505UniSTS
Cytogenetic Map5q32UniSTS


Genetic Models
This gene Pde4b is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 8 19 3 3 62 5 8 11 3
Low 1 17 49 41 41 5 8 12 30 33 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001398935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF202732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF202733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH000840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ288997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L27058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M28413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U95748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000007738   ⟹   ENSRNOP00000007738
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5117,351,429 - 117,367,696 (+)Ensembl
Rnor_6.0 Ensembl5122,100,099 - 122,136,769 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000008278   ⟹   ENSRNOP00000008278
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5117,186,058 - 117,367,418 (+)Ensembl
Rnor_6.0 Ensembl5121,952,977 - 122,136,554 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000068158   ⟹   ENSRNOP00000059858
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5117,249,580 - 117,367,696 (+)Ensembl
Rnor_6.0 Ensembl5122,019,301 - 122,136,814 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098470   ⟹   ENSRNOP00000096704
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5116,993,132 - 117,367,696 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099065   ⟹   ENSRNOP00000084515
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5116,799,971 - 117,367,696 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108780   ⟹   ENSRNOP00000083508
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5116,993,132 - 117,315,418 (+)Ensembl
RefSeq Acc Id: NM_017031   ⟹   NP_058727
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25116,993,436 - 117,367,683 (+)NCBI
Rnor_6.05121,759,236 - 122,136,814 (+)NCBI
Rnor_5.05125,623,815 - 126,001,128 (+)NCBI
RGSC_v3.45123,158,156 - 123,533,877 (+)RGD
Celera5115,579,422 - 115,946,626 (+)RGD
Sequence:
RefSeq Acc Id: XM_039109271   ⟹   XP_038965199
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25116,799,827 - 117,367,707 (+)NCBI
RefSeq Acc Id: XM_039109272   ⟹   XP_038965200
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25117,182,584 - 117,367,707 (+)NCBI
RefSeq Acc Id: XM_039109273   ⟹   XP_038965201
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25117,329,920 - 117,367,707 (+)NCBI
RefSeq Acc Id: XM_039109274   ⟹   XP_038965202
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25117,347,420 - 117,367,707 (+)NCBI
RefSeq Acc Id: XM_039109275   ⟹   XP_038965203
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25116,799,937 - 117,363,494 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058727   ⟸   NM_017031
- UniProtKB: A0A8I6AT13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008278   ⟸   ENSRNOT00000008278
RefSeq Acc Id: ENSRNOP00000007738   ⟸   ENSRNOT00000007738
RefSeq Acc Id: ENSRNOP00000059858   ⟸   ENSRNOT00000068158
RefSeq Acc Id: XP_038965199   ⟸   XM_039109271
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038965203   ⟸   XM_039109275
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038965200   ⟸   XM_039109272
- Peptide Label: isoform X2
- UniProtKB: D3ZLB2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965201   ⟸   XM_039109273
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038965202   ⟸   XM_039109274
- Peptide Label: isoform X4
- UniProtKB: A0A8L2Q3F0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000096704   ⟸   ENSRNOT00000098470
RefSeq Acc Id: ENSRNOP00000083508   ⟸   ENSRNOT00000108780
RefSeq Acc Id: ENSRNOP00000084515   ⟸   ENSRNOT00000099065
Protein Domains
PDEase   Phosphodiesterase 4 upstream conserved regions

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14646-F1-model_v2 AlphaFold P14646 1-736 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693863
Promoter ID:EPDNEW_R4388
Type:initiation region
Name:Pde4b_1
Description:phosphodiesterase 4B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05122,100,631 - 122,100,691EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3280 AgrOrtholog
BioCyc Gene G2FUF-40525 BioCyc
Ensembl Genes ENSRNOG00000005905 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007738 ENTREZGENE
  ENSRNOP00000007738.5 UniProtKB/TrEMBL
  ENSRNOP00000008278 ENTREZGENE
  ENSRNOP00000008278.5 UniProtKB/TrEMBL
  ENSRNOP00000059858.3 UniProtKB/TrEMBL
  ENSRNOP00000083508.1 UniProtKB/TrEMBL
  ENSRNOP00000084515 ENTREZGENE
  ENSRNOP00000084515.1 UniProtKB/TrEMBL
  ENSRNOP00000096704 ENTREZGENE
  ENSRNOP00000096704.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007738 ENTREZGENE
  ENSRNOT00000007738.7 UniProtKB/TrEMBL
  ENSRNOT00000008278 ENTREZGENE
  ENSRNOT00000008278.7 UniProtKB/TrEMBL
  ENSRNOT00000068158.4 UniProtKB/TrEMBL
  ENSRNOT00000098470 ENTREZGENE
  ENSRNOT00000098470.1 UniProtKB/TrEMBL
  ENSRNOT00000099065 ENTREZGENE
  ENSRNOT00000099065.1 UniProtKB/TrEMBL
  ENSRNOT00000108780.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7189628 IMAGE-MGC_LOAD
InterPro HD/PDEase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDE4_UCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24626 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93193 IMAGE-MGC_LOAD
NCBI Gene 24626 ENTREZGENE
PANTHER 3',5'-CYCLIC-AMP PHOSPHODIESTERASE UniProtKB/TrEMBL
  3',5'-CYCLIC-AMP PHOSPHODIESTERASE-RELATED UniProtKB/TrEMBL
  CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11347:SF108 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PDE4_UCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pde4b PhenoGen
PRINTS PDIESTERASE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC206247
  TC206248
UniProt A0A8I5ZX49_RAT UniProtKB/TrEMBL
  A0A8I5ZY41 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AT13 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q3F0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZLB2 ENTREZGENE, UniProtKB/TrEMBL
  F1M1T9_RAT UniProtKB/TrEMBL
  P14646 ENTREZGENE, UniProtKB/Swiss-Prot
  Q8VD81
  Q8VD82
UniProt Secondary Q5RKL0 UniProtKB/Swiss-Prot
  Q8VD81 UniProtKB/Swiss-Prot
  Q8VD82 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-22 Pde4b  phosphodiesterase 4B  Pde4b_v4  phosphodiesterase 4B, variant 4  Data Merged 737654 PROVISIONAL
2015-11-30 Pde4b  phosphodiesterase 4B  Pde4b  phosphodiesterase 4B, cAMP specific  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Pde4b  phosphodiesterase 4B, cAMP specific      Name updated 1299863 APPROVED
2002-06-10 Pde4b  Phosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation activation by increased cAMP levels is associated with Pde4B4 Ser56 phosphorylation 633623