Sh3gl2 (SH3 domain containing GRB2 like 2, endophilin A1)

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Gene: Sh3gl2 (SH3 domain containing GRB2 like 2, endophilin A1) Rattus norvegicus

Analyze

Symbol:

Sh3gl2

Name:

SH3 domain containing GRB2 like 2, endophilin A1

RGD ID:

620276

Description:

Enables several functions, including identical protein binding activity; protein kinase binding activity; and transmembrane transporter binding activity. Involved in several processes, including membrane bending; positive regulation of membrane tubulation; and vesicle scission. Located in several cellular components, including basal dendrite; neuronal cell body; and perinuclear region of cytoplasm. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and synaptic vesicle membrane. Biomarker of visual epilepsy. Orthologous to human SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; endocytosis pathway; INTERACTS WITH 17beta-estradiol; ammonium chloride; amphetamine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

endophilin-1; endophilin-A1; SH3 domain protein 2A; SH3 domain-containing GRB2-like 2; SH3 domain-containing GRB2-like protein 2; SH3-domain GRB2-like 2; Sh3d2a; Sh3p4

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	99,653,189 - 99,827,500 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	99,653,152 - 100,113,843 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	102,036,367 - 102,216,379 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	5	103,824,073 - 103,998,825 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	5	103,847,211 - 104,027,230 (+)	NCBI	Rnor_WKY
Rnor_6.0	5	103,479,767 - 103,654,507 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	103,479,767 - 103,654,247 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	107,479,270 - 107,653,523 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	104,129,280 - 104,308,317 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	104,300,491 - 104,313,320 (+)	NCBI
Celera	5	98,159,729 - 98,334,521 (+)	NCBI		Celera
Cytogenetic Map	5	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

visual epilepsy (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4-hydroxyphenyl retinamide (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Brodifacoum (EXP)

cadmium dichloride (EXP)

captan (ISO)

CGP 52608 (ISO)

choline (ISO)

copper atom (EXP)

copper(0) (EXP)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

flavonoids (EXP)

folic acid (ISO)

folpet (ISO)

fonofos (ISO)

gentamycin (EXP)

hydroquinone O-beta-D-glucopyranoside (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead(0) (ISO)

lead(2+) (ISO)

lipopolysaccharide (ISO)

methamphetamine (EXP,ISO)

methylmercury chloride (ISO)

O-methyleugenol (ISO)

paracetamol (EXP)

paraquat (ISO)

parathion (ISO)

PCB138 (EXP)

phenylmercury acetate (ISO)

potassium dichromate (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

Soman (EXP)

terbufos (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to brain-derived neurotrophic factor stimulus (ISO,ISS)

dendrite extension (ISO,ISS)

lipid tube assembly (IDA)

membrane bending (IMP)

membrane tubulation (IDA,IMP)

negative regulation of blood-brain barrier permeability (ISO)

negative regulation of gene expression (ISO)

negative regulation of protein phosphorylation (ISO)

neuron projection development (ISO,ISS)

positive regulation of membrane tubulation (IMP)

postsynaptic actin cytoskeleton organization (ISO)

regulation of clathrin-dependent endocytosis (IMP)

regulation of receptor internalization (ISO)

synaptic vesicle endocytosis (IDA,IMP,ISO)

synaptic vesicle uncoating (IBA,ISO)

vesicle scission (IDA)

Cellular Component

basal dendrite (IDA)

cytoplasm (IEA)

cytosol (IDA)

early endosome (ISO,ISS)

glutamatergic synapse (IBA,IDA,ISO)

hippocampal mossy fiber to CA3 synapse (IDA)

membrane (IEA)

neuronal cell body (IDA)

perinuclear region of cytoplasm (IDA,ISO)

photoreceptor ribbon synapse (ISO)

plasma membrane (TAS)

postsynapse (ISO)

presynapse (IBA,IDA)

presynaptic cytosol (ISO)

Schaffer collateral - CA1 synapse (IDA)

synapse (IDA)

synapse (IDA,IEA)

synaptic vesicle membrane (IDA)

Molecular Function

identical protein binding (IPI,ISO)

lipid binding (IDA)

protein binding (IPI,ISO)

protein kinase binding (IPI)

transmembrane transporter binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

clathrin-dependent synaptic vesicle endocytosis (ISO)

endocytosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation.	Ambroso MR, etal., Proc Natl Acad Sci U S A. 2014 May 13;111(19):6982-7. doi: 10.1073/pnas.1402233111. Epub 2014 Apr 28.
2.	Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis.	Anggono V and Robinson PJ, J Neurochem. 2007 Aug;102(3):931-43. Epub 2007 Apr 16.
3.	Intradimer/Intermolecular interactions suggest autoinhibition mechanism in endophilin A1.	Chen Z, etal., J Am Chem Soc. 2014 Mar 26;136(12):4557-64. doi: 10.1021/ja411607b. Epub 2014 Mar 13.
4.	Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking.	Chowdhury S, etal., Neuron. 2006 Nov 9;52(3):445-59.
5.	Identification of endophilins 1 and 3 as selective binding partners for VGLUT1 and their co-localization in neocortical glutamatergic synapses: implications for vesicular glutamate transporter trafficking and excitatory vesicle formation.	De Gois S, etal., Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):679-93. doi: 10.1007/s10571-006-9054-8. Epub 2006 May 19.
6.	Identification of the major synaptojanin-binding proteins in brain.	de Heuvel E, etal., J Biol Chem. 1997 Mar 28;272(13):8710-6.
7.	Generation of high curvature membranes mediated by direct endophilin bilayer interactions.	Farsad K, etal., J Cell Biol. 2001 Oct 15;155(2):193-200. doi: 10.1083/jcb.200107075. Epub 2001 Oct 15.
8.	Mechanism of endophilin N-BAR domain-mediated membrane curvature.	Gallop JL, etal., EMBO J. 2006 Jun 21;25(12):2898-910. doi: 10.1038/sj.emboj.7601174. Epub 2006 Jun 8.
9.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
11.	Early increase of apoptosis-linked gene-2 interacting protein X in areas of kainate-induced neurodegeneration.	Hemming FJ, etal., Neuroscience. 2004;123(4):887-95.
12.	Interaction of SPIN90 with dynamin I and its participation in synaptic vesicle endocytosis.	Kim Y, etal., J Neurosci. 2005 Oct 12;25(41):9515-23.
13.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
14.	Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission.	Milosevic I, etal., Neuron. 2011 Nov 17;72(4):587-601. doi: 10.1016/j.neuron.2011.08.029.
15.	Multiple modes of endophilin-mediated conversion of lipid vesicles into coated tubes: implications for synaptic endocytosis.	Mizuno N, etal., J Biol Chem. 2010 Jul 23;285(30):23351-8. doi: 10.1074/jbc.M110.143776. Epub 2010 May 18.
16.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
17.	Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals.	Nemoto Y, etal., J Biol Chem 2001 Nov 2;276(44):41133-42.
18.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
19.	Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase.	Ramjaun AR, etal., J Biol Chem 2001 Aug 3;276(31):28913-9.
20.	GOA pipeline	RGD automated data pipeline
21.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
23.	Differential expression of endophilin 1 and 2 dimers at central nervous system synapses.	Ringstad N, etal., J Biol Chem. 2001 Nov 2;276(44):40424-30. doi: 10.1074/jbc.M106338200. Epub 2001 Aug 22.
24.	The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain.	Ringstad N, etal., Proc Natl Acad Sci U S A 1997 Aug 5;94(16):8569-74.
25.	Synaptic vesicle endocytosis.	Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
26.	Inhibitory role of endophilin 3 in receptor-mediated endocytosis.	Sugiura H, etal., J Biol Chem. 2004 May 28;279(22):23343-8. doi: 10.1074/jbc.M312607200. Epub 2004 Apr 5.
27.	Endophilin isoforms have distinct characteristics in interactions with N-type Ca2+ channels and dynamin I.	Tian Q, etal., Neurosci Bull. 2012 Oct;28(5):483-92. doi: 10.1007/s12264-012-1257-z. Epub 2012 Jul 13.
28.	Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling.	Voglmaier SM, etal., Neuron. 2006 Jul 6;51(1):71-84. doi: 10.1016/j.neuron.2006.05.027.
29.	A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains.	Wuertenberger S and Groemping Y, FEBS Lett. 2015 Apr 28;589(10):1156-63. doi: 10.1016/j.febslet.2015.03.014. Epub 2015 Mar 24.

Additional References at PubMed

PMID:9341169	PMID:10908605	PMID:14704270	PMID:15821731	PMID:16115810	PMID:16164598	PMID:18391417	PMID:18940612	PMID:19481455	PMID:20404169	PMID:20418375	PMID:21849472
PMID:22768939	PMID:23376485	PMID:23442862	PMID:23482561	PMID:23785143	PMID:24854121	PMID:25517094	PMID:26854628	PMID:28235806	PMID:28933693	PMID:29476059	PMID:31059028

Genomics

Comparative Map Data

Sh3gl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	99,653,189 - 99,827,500 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	99,653,152 - 100,113,843 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	102,036,367 - 102,216,379 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	5	103,824,073 - 103,998,825 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	5	103,847,211 - 104,027,230 (+)	NCBI	Rnor_WKY
Rnor_6.0	5	103,479,767 - 103,654,507 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	103,479,767 - 103,654,247 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	107,479,270 - 107,653,523 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	104,129,280 - 104,308,317 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	104,300,491 - 104,313,320 (+)	NCBI
Celera	5	98,159,729 - 98,334,521 (+)	NCBI		Celera
Cytogenetic Map	5	q31	NCBI

SH3GL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	17,579,066 - 17,797,124 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	9	17,579,066 - 17,797,124 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	17,579,064 - 17,797,122 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	17,569,194 - 17,787,122 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	17,569,193 - 17,787,120	NCBI
Celera	9	17,507,463 - 17,725,658 (+)	NCBI		Celera
Cytogenetic Map	9	p22.2	NCBI
HuRef	9	17,541,205 - 17,759,965 (+)	NCBI		HuRef
CHM1_1	9	17,579,359 - 17,797,531 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	17,591,797 - 17,809,924 (+)	NCBI		T2T-CHM13v2.0

Sh3gl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	85,123,340 - 85,307,617 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	85,123,363 - 85,557,432 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	85,205,456 - 85,389,380 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	85,205,126 - 85,639,195 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	84,851,360 - 85,035,284 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	84,676,687 - 84,860,611 (+)	NCBI		MGSCv36	mm8
Celera	4	83,721,182 - 83,903,108 (+)	NCBI		Celera
Cytogenetic Map	4	C4	NCBI
cM Map	4	40.23	NCBI

Sh3gl2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955434	20,331,779 - 20,381,376 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955434	20,332,727 - 20,381,320 (+)	NCBI	ChiLan1.0	ChiLan1.0

SH3GL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	9	17,878,860 - 18,097,579 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	18,045,198 - 18,097,579 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	9	17,386,298 - 17,605,722 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

SH3GL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	37,720,793 - 37,769,027 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	37,577,053 - 37,767,572 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	36,210,473 - 36,429,450 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	38,479,939 - 38,699,050 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	38,479,865 - 38,844,393 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	37,183,251 - 37,402,158 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	36,975,724 - 37,194,721 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	37,613,946 - 37,832,890 (+)	NCBI		UU_Cfam_GSD_1.0

SH3GL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	205,081,231 - 205,285,364 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	205,081,227 - 205,285,359 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	228,802,236 - 229,005,151 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SH3GL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	61,862,997 - 62,085,254 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	61,862,943 - 61,917,315 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	50,001,458 - 50,229,863 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sh3gl2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	21,554,969 - 21,716,877 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624736	21,554,950 - 21,715,522 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sh3gl2
1761 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	205
Count of miRNA genes:	152
Interacting mature miRNAs:	175
Transcripts:	ENSRNOT00000008999
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	9823266	99753708	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	34730116	104251008	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	34944474	113558310	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	43726656	129132602	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	55715622	100715622	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55805606	132207589	Rat
1358895	Bp254	Blood pressure QTL 254	3.6	0.0003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	58829236	128034027	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	59793399	143070159	Rat
2316957	Pur21	Proteinuria QTL 21	6.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	5	59793528	113558156	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
2290005	Mcs24	Mammary carcinoma susceptibility QTL 24			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	64719390	109719390	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	66174080	124160948	Rat
2312671	Scl64	Serum cholesterol level QTL 64		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	68984307	104251008	Rat
61380	Edpm5	Estrogen-dependent pituitary mass QTL 5	4.5	0.92	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	5	68984307	104251008	Rat
1357396	Bw44	Body weight QTL 44	4.19		body mass (VT:0001259)	body weight (CMO:0000012)	5	68984307	104251008	Rat
1357402	Bw46	Body weight QTL 46	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	68984307	104251008	Rat
2302381	Bw84	Body weight QTL 84	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	68984307	104251008	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat
1298070	Scl18	Serum cholesterol level QTL 18	3.7		blood LDL cholesterol amount (VT:0000181)	calculated plasma low density lipoprotein cholesterol level (CMO:0001245)	5	79584860	124584860	Rat
1598846	Bp293	Blood pressure QTL 293	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	79584860	124584860	Rat
1598859	Cm66	Cardiac mass QTL 66	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	79584860	124584860	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1298086	Bp156	Blood pressure QTL 156			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	84132602	129132602	Rat
7411601	Foco12	Food consumption QTL 12	19.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	87468046	132468046	Rat
7411564	Bw135	Body weight QTL 135		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	87468046	132468046	Rat
7411582	Foco3	Food consumption QTL 3	7.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	87468046	132468046	Rat
6903316	Bw113	Body weight QTL 113	2	0.0103	body mass (VT:0001259)	body weight (CMO:0000012)	5	87765973	132765973	Rat
1358889	Bp261	Blood pressure QTL 261	2.86		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	90067849	128034027	Rat
1358909	Kidm25	Kidney mass QTL 25	1.87		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	90067849	128034027	Rat
631527	Tls1	T-lymphoma susceptibility QTL 1	0	0.001	thymus integrity trait (VT:0010555)	post-insult time to onset of T-cell lymphoma (CMO:0001907)	5	90450144	135450144	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	94858972	143070159	Rat
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	97059760	147465714	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	97570330	136479578	Rat
1582212	Livw2	Liver weight QTL 2	3.5	0.0004	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	5	99016066	119085810	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	99216724	148607142	Rat
1600362	Mcs19	Mammary carcinoma susceptibility QTL 19	2.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	99485997	103690167	Rat
7394708	Emca11	Estrogen-induced mammary cancer QTL 11			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	99753548	113061097	Rat

Markers in Region

D5Rat151

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	99,753,548 - 99,753,708 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	103,580,245 - 103,580,403	NCBI	Rnor6.0
Rnor_5.0	5	107,580,081 - 107,580,201	NCBI	Rnor5.0
Rnor_5.0	5	107,580,080 - 107,580,201	NCBI	Rnor5.0
RGSC_v3.4	5	104,231,741 - 104,231,900	RGD	RGSC3.4
RGSC_v3.4	5	104,231,742 - 104,231,900	UniSTS	RGSC3.4
RGSC_v3.1	5	104,236,968 - 104,237,126	RGD
Celera	5	98,259,651 - 98,259,809	UniSTS
RH 3.4 Map	5	742.7	UniSTS
RH 3.4 Map	5	742.7	RGD
RH 2.0 Map	5	653.0	RGD
Cytogenetic Map	5	q31	UniSTS

AU047584

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	99,800,893 - 99,801,089 (+)	MAPPER	mRatBN7.2
mRatBN7.2	5	99,800,932 - 99,801,089 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	103,628,140 - 103,628,296	NCBI	Rnor6.0
Rnor_6.0	5	103,628,101 - 103,628,296	NCBI	Rnor6.0
Rnor_5.0	5	107,627,416 - 107,627,572	UniSTS	Rnor5.0
Rnor_5.0	5	107,627,377 - 107,627,572	UniSTS	Rnor5.0
RGSC_v3.4	5	104,281,296 - 104,281,452	UniSTS	RGSC3.4
RGSC_v3.4	5	104,281,257 - 104,281,452	UniSTS	RGSC3.4
Celera	5	98,308,162 - 98,308,355	UniSTS
Celera	5	98,308,201 - 98,308,355	UniSTS
Cytogenetic Map	5	q31	UniSTS

G47071

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	99,819,473 - 99,819,695 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	103,646,221 - 103,646,442	NCBI	Rnor6.0
Rnor_5.0	5	107,645,497 - 107,645,718	UniSTS	Rnor5.0
RGSC_v3.4	5	104,300,068 - 104,300,289	UniSTS	RGSC3.4
Celera	5	98,326,495 - 98,326,716	UniSTS
Cytogenetic Map	5	q31	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2								64	25	18	2
Low	1	32	15		18		4	6	10	10	23	9	4
Below cutoff		11	35	34	1	34	4	5					4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006238359	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593124	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF009603	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000008999 ⟹ ENSRNOP00000008999

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	99,787,847 - 99,827,500 (+)	Ensembl
Rnor_6.0 Ensembl	5	103,479,767 - 103,654,247 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000100135 ⟹ ENSRNOP00000081211

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	99,653,189 - 99,825,720 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000110787 ⟹ ENSRNOP00000087931

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	99,653,152 - 99,827,500 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111420 ⟹ ENSRNOP00000088763

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	99,653,189 - 100,113,843 (+)	Ensembl

RefSeq Acc Id:

NM_053935 ⟹ NP_446387

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	99,653,189 - 99,827,500 (+)	NCBI
Rnor_6.0	5	103,479,767 - 103,654,247 (+)	NCBI
Rnor_5.0	5	107,479,270 - 107,653,523 (+)	NCBI
Celera	5	98,159,729 - 98,334,521 (+)	NCBI

Sequence:

show sequence

CGGCCGCACGACCAGCGGCGGCCAGGCGACCCCCGCCGCCTCTCCGCATCCGCAGCTACCAGCC
GCGCGGCCTCTCGCATCCCATCATGTCGGTGGCAGGGCTGAAGAAGCAGTTCCACAAAGCCACT
CAGAAAGTGAGTGAGAAGGTGGGAGGAGCCGAAGGCACCAAGCTCGATGATGACTTCAAAGAGA
TGGAGAGGAAAGTGGATGTTACCAGCAGGGCCGTGATGGAGATAATGACGAAAACAATTGAATA
CCTCCAACCCAATCCAGCTTCCAGGGCTAAACTCAGTATGATCAACACCATGTCGAAAATCCGT
GGCCAAGAGAAGGGGCCAGGCTATCCTCAGGCAGAAGCACTGCTGGCAGAGGCTATGCTCAAGT
TCGGCAGGGAGCTCGGCGATGATTGCAACTTTGGTCCGGCTCTTGGTGAGGTAGGAGAAGCCAT
GAGGGAGCTCTCGGAGGTCAAGGACTCTTTGGACATGGAAGTGAAGCAGAACTTCATCGACCCC
CTTCAGAATCTTCATGACAAAGATCTGAGGGAGATTCAGCATCACCTGAAAAAGCTGGAAGGCC
GACGCTTAGACTTTGATTATAAGAAGAAGCGACAAGGAAAGATTCCAGACGAAGAACTCCGCCA
AGCTCTGGAGAAATTTGATGAGTCTAAAGAAATCGCTGAGTCGAGCATGTTCAACCTCTTGGAG
ATGGATATTGAACAGGTGAGCCAGCTCTCTGCACTTGTTCAGGCTCAGCTGGAGTACCACAAAC
AGGCTGTGCAGATCCTGCAACAGGTCACTGTCAGGCTGGAAGAGAGAATAAGACAAGCTTCATC
TCAACCAAGAAGGGAATATCAGCCCAAACCACGAATGAGCCTAGAGTTTGCCACTGGAGACGGT
ACGCAGCCCAACGGGGGTCTCTCCCACACAGGCACACCCAAACCTGCAGGTGTCCAAATGGATC
AGCCTTGCTGCCGAGCCCTGTATGACTTTGAACCTGAAAATGAAGGGGAGTTGGGTTTTAAAGA
GGGTGATATCATCACGCTCACTAATCAGATTGATGAGAACTGGTATGAGGGGATGCTTCATGGC
CAGTCCGGCTTTTTCCCCATCAACTATGTAGAAATTCTGGTTGCTCTGCCCCATTAGGGTCCTG
TGCTGGCTGGCTCACCTCCTTCTGACCCAGATAGTTAAGTTTAACCACTGCTTTGGTAATGCCG
CTTCCAATACATCACGAATGCAGGCCGCAGTGGATGATTCATCAAGCCCACACGTGCCCTGGGT
TGGCCTGTGTGCTCCTACAGGAGACACGGTGATAGATGGTATCTTCCAAGGCCACTGGGCCTGG
CACATGCTTTAAAACACCATCTGAGACTAGCCCGTGGTCACAGAACTGGCTATGCCGTTCTCAG
GAGGCTGTGGTTCCTGATGACCCACACCACAGAAAACCTCTCCTCACTGAAGATATTGTCTCTC
ACCCAAGGGCCATCTCAAG

hide sequence

RefSeq Acc Id:

XM_006238359 ⟹ XP_006238421

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	99,770,011 - 99,827,154 (+)	NCBI
Rnor_6.0	5	103,595,629 - 103,654,507 (+)	NCBI
Rnor_5.0	5	107,479,270 - 107,653,523 (+)	NCBI

Sequence:

show sequence

CAGGCATGGCATAATTATGAAAACCCCAGCCGTAAAACCTGTTTCTCATTGGCATGTTCATGAA
ACCAAACCCGTGTGATTTATACCTAGGCACAGACACAGATATGTGATACTACTCAGCAGAGAGC
AAGGCCCTGGATATTAGTCTATTTCCAGTACTGTGTTTTGTGTCCTAATAGGTAATGGGCCATC
CATGCATTTATCCATGGTGCTTAAAGGACTGCCAGGCAGCATCATTAAGAGATTACAAATGAGA
CTAACATGTGAATGCGAAGAATGATGTAAGGGAAAGGGATATTAATATGGATATAAATTCGTGT
ATGTGTATAGAGACCGGTCCCTGGTGTTAGTCAGACTGGCTCCATTTTTTGGATCTTCTCAAAC
CAAAGGGCATGCTAGGGAGAGCTTCTCACCTCATGGTATCTGAAAAACAGAGAGAAGCCAAAGG
CAAGAAGTGCCCTTCAAAGGCACAACCCTCTGGGATCTACTTCTTCGAATTAGGCTGCCCTTGT
ACAAGTTTCCATTATTTTCTAGTGATGTCATCAAGTTACGAGTCTACCAATAGATTTATGAACT
GACCAAGTCAGAATCATTCATGGTTAAATTTTCAATGGGTGGATCCATGAACTGGAGGCCAGGT
CTTCAATGTTCTTTTCCAGGGACATTTTATAAACTGTAACAAACTATATGTGTGCACATGCACA
CATAGACATATATACATGAGGATAAAATTTTTATTTTTTTAAACATCTGAACTGTTATTCATTA
ATTTAACAAATAGGCATTGAGTTTCTAGTATATTCTAGGTACTGTGGAAGGACACTGTGGATGC
AAAAGAAGTAAGACTATGTGTCTTGTTTCAAGTGACTTACCGACTCAGGAGGGAGATTGAAGTA
CAAAGCGTTGACATAAGAACAAGGGCATTGCTAAGTGTATTGTGTGAATGGAGTACTTTGGGAC
CTCAGAGGAAGGATCAAAGTTCTGACACTTAAAAAAGTGGAGGATGGCAGATCAATTAAAAAAA
AAAAAAAAAGAACCATACAGCTTACGTGGCTAAGTCTCCAAGTCTCTGCACAAAACCTTTTCAA
TATACTTCTCCACTTCAATGAAAATGTTTTCTGTTTCAGACTCTTTTGCATGAAGTTACAAACT
TCGTTCTTATATTAGCTGAAGTCAGTTCCCTCCTAATCTCCATCCAGATTTCTCCAGTGCAGTC
ATGGGAGGAGTCTAACTTCTACTCAACCACAGCCCTACTCAGTTCTGAGAGCATGTTGTTTCCT
TCCTTCCCAAGTCACCTCTCCAGATCTCTGTGATCATCTGTTGCCTCCTTTCTAGCTTGTGACA
CTTAGTAGAAGTCTATCTTCCTTCTCTGAGGAGCCGGATACACACCATACGCTAAGGATTCATG
TCTCTTCTGGAAACTGCCAGGATGTGGAAGGGAGATAACAACATGGAGAGAAACATTCAGTGAT
TTCTGGATGCTCCCAATTTCTAAGAAGAAAGTGAGTGAGAAGGTGGGAGGAGCCGAAGGCACCA
AGCTCGATGATGACTTCAAAGAGATGGAGAGGAAAGTGGATGTTACCAGCAGGGCCGTGATGGA
GATAATGACGAAAACAATTGAATACCTCCAACCCAATCCAGCTTCCAGGGCTAAACTCAGTATG
ATCAACACCATGTCGAAAATCCGTGGCCAAGAGAAGGGGCCAGGCTATCCTCAGGCAGAAGCAC
TGCTGGCAGAGGCTATGCTCAAGTTCGGCAGGGAGCTCGGCGATGATTGCAACTTTGGTCCGGC
TCTTGGTGAGGTAGGAGAAGCCATGAGGGAGCTCTCGGAGGTCAAGGACTCTTTGGACATGGAA
GTGAAGCAGAACTTCATCGACCCCCTTCAGAATCTTCATGACAAAGATCTGAGGGAGATTCAGC
ATCACCTGAAAAAGCTGGAAGGCCGACGCTTAGACTTTGATTATAAGAAGAAGCGACAAGGAAA
GATTCCAGACGAAGAACTCCGCCAAGCTCTGGAGAAATTTGATGAGTCTAAAGAAATCGCTGAG
TCGAGCATGTTCAACCTCTTGGAGATGGATATTGAACAGGTGAGCCAGCTCTCTGCACTTGTTC
AGGCTCAGCTGGAGTACCACAAACAGGCTGTGCAGATCCTGCAACAGGTCACTGTCAGGCTGGA
AGAGAGAATAAGACAAGCTTCATCTCAACCAAGAAGGGAATATCAGCCCAAACCACGAATGAGC
CTAGAGTTTGCCACTGGAGACGGTACGCAGCCCAACGGGGGTCTCTCCCACACAGGCACACCCA
AACCTGCAGGTGTCCAAATGGATCAGCCTTGCTGCCGAGCCCTGTATGACTTTGAACCTGAAAA
TGAAGGGGAGTTGGGTTTTAAAGAGGGTGATATCATCACGCTCACTAATCAGATTGATGAGAAC
TGGTATGAGGGGATGCTTCATGGCCAGTCCGGCTTTTTCCCCATCAACTATGTAGAAATTCTGG
TTGCTCTGCCCCATTAGGGTCCTGTGCTGGCTGGCTCACCTCCTTCTGACCCAGATAGTTAAGT
TTAACCACTGCTTTGGTAATGCCGCTTCCAATACATCACGAATGCAGGCCGCAGTGGATGATTC
ATCAAGCCCACACGTGCCCTGGGTTGGCCTGTGTGCTCCTACAGGAGACACGGTGATAGATGGT
ATCTTCCAAGGCCACTGGGCCTGGCACATGCTTTAAAACACCATCTGAGACTAGCCCGTGGTCA
CAGAACTGGCTATGCCGTTCTCAGGAGGCTGTGGTTCCTGATGACCCACACCACAGAAAACCTC
TCCTCACTGAAGATATTGTCTCTCACCCAAGGGCCATCTCAAGGTCTCCAGCTCTCCATTTACA
GAGGAGAAAGTCCTTTTGTTGCACTTTCCCTTCCTAAATATGTGAGTCACAGAATTGTTGGTAA
AAACATCCCCTTACCAGCAAGTTGTCTGCTGGTCTAAGCAACTTAGTCTCTTGATGCCATCAGC
AGAAGTATTAATTGTCCAAAGCACCTTTGTTCACCAACTTCTTTCTTTCTATCCTCTCTCTCTC
TCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCACTCTCTCTCTCT

hide sequence

Protein Sequences


Protein RefSeqs	NP_446387	(Get FASTA)	NCBI Sequence Viewer
	XP_006238421	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC14883	(Get FASTA)	NCBI Sequence Viewer
	EDM10450	(Get FASTA)	NCBI Sequence Viewer
	O35179	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_446387 ⟸ NM_053935

- UniProtKB:

O35179 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPAS
RAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVK
DSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDE
SKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQ
PKPRMSLEFATGDGTQPNGGLSHTGTPKPAGVQMDQPCCRALYDFEPENEGELGFKEGDIITLT
NQIDENWYEGMLHGQSGFFPINYVEILVALPH

hide sequence

RefSeq Acc Id:	XP_006238421 ⟸ XM_006238359
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GFM2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLPISKKKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMIN TMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVK QNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESS MFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLE FATGDGTQPNGGLSHTGTPKPAGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWY EGMLHGQSGFFPINYVEILVALPH hide sequence

RefSeq Acc Id:

ENSRNOP00000008999 ⟸ ENSRNOT00000008999

RefSeq Acc Id:

ENSRNOP00000087931 ⟸ ENSRNOT00000110787

RefSeq Acc Id:

ENSRNOP00000088763 ⟸ ENSRNOT00000111420

RefSeq Acc Id:

ENSRNOP00000081211 ⟸ ENSRNOT00000100135

Protein Domains

BAR SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35179-F1-model_v2	AlphaFold	O35179	1-352	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693821

Promoter ID:

EPDNEW_R4346

Type:

initiation region

Name:

Sh3gl2_1

Description:

SH3 domain containing GRB2 like 2, endophilin A1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	103,479,726 - 103,479,786	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620276	AgrOrtholog
BIND	130461
	130589
	134434
BioCyc Gene	G2FUF-40854	BioCyc
Ensembl Genes	ENSRNOG00000006761	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000008999	ENTREZGENE
	ENSRNOP00000008999.6	UniProtKB/TrEMBL
	ENSRNOP00000081211.1	UniProtKB/TrEMBL
	ENSRNOP00000087931	ENTREZGENE
	ENSRNOP00000087931.1	UniProtKB/TrEMBL
	ENSRNOP00000088763.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000008999	ENTREZGENE
	ENSRNOT00000008999.7	UniProtKB/TrEMBL
	ENSRNOT00000100135.1	UniProtKB/TrEMBL
	ENSRNOT00000110787	ENTREZGENE
	ENSRNOT00000110787.1	UniProtKB/TrEMBL
	ENSRNOT00000111420.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1270.60	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	AH/BAR_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BAR_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Endophilin_A_SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:116743	UniProtKB/Swiss-Prot
NCBI Gene	116743	ENTREZGENE
PANTHER	ENDOPHILIN-A1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3 DOMAIN-CONTAINING	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	BAR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Sh3gl2	PhenoGen
PRINTS	SH3DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SPECTRNALPHA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	BAR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	BAR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF103657	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF50044	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZRH7_RAT	UniProtKB/TrEMBL
	A0A8I6ABD8_RAT	UniProtKB/TrEMBL
	A0A8I6GFM2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2Q412_RAT	UniProtKB/TrEMBL
	O35179	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-06-19	Sh3gl2	SH3 domain containing GRB2 like 2, endophilin A1	Sh3gl2	SH3 domain-containing GRB2-like 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-05-04	Sh3gl2	SH3 domain-containing GRB2-like 2	Sh3gl2	SH3-domain GRB2-like 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Sh3gl2	SH3-domain GRB2-like 2		SH3 domain protein 2A	Name updated	1299863	APPROVED
2004-09-10	Sh3gl2	SH3 domain protein 2A	Sh3d2a		Symbol and Name updated	1299863	APPROVED
2002-08-07	Sh3d2a	SH3 domain protein 2A			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed only in brain	633918

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)