RGD Reference Report - Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase. - Rat Genome Database

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Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase.

Authors: Ramjaun, AR  Angers, A  Legendre-Guillemin, V  Tong, XK  McPherson, PS 
Citation: Ramjaun AR, etal., J Biol Chem 2001 Aug 3;276(31):28913-9.
RGD ID: 727317
Pubmed: PMID:11384986   (View Abstract at PubMed)
DOI: DOI:10.1074/jbc.M103198200   (Journal Full-text)

The endophilin family of proteins function in clathrin-mediated endocytosis. Here, we have identified and cloned the rat germinal center kinase-like kinase (rGLK), a member of the GCK (germinal center kinase) family of c-Jun N-terminal kinase (JNK) activating enzymes, as a novel endophilin I-binding partner. The interaction occurs both in vitro and in cells and is mediated by the Src homology 3 domain of endophilin I and a region of rGLK containing the endophilin consensus-binding sequence PPRPPPPR. Overlay analysis of rat brain extracts demonstrates that endophilin I is a major Src homology 3 domain-binding partner for rGLK. Overexpression of full-length endophilin I activates rGLK-mediated JNK activation, whereas N- and C-terminal fragments of endophilin I block JNK activation. Thus, endophilin I appears to have a novel function in JNK activation.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Sh3gl2Ratprotein kinase binding  IPIMap4k3 (Rattus norvegicus) RGD 
Map4k3RatSH3 domain binding  IPISh3gl2 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Map4k3  (mitogen-activated protein kinase kinase kinase kinase 3)
Sh3gl2  (SH3 domain containing GRB2 like 2, endophilin A1)

Objects referenced in this article
Gene Dnm1 dynamin 1 Rattus norvegicus

Additional Information