Map4k3 (mitogen-activated protein kinase kinase kinase kinase 3) - Rat Genome Database

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Gene: Map4k3 (mitogen-activated protein kinase kinase kinase kinase 3) Rattus norvegicus
Analyze
Symbol: Map4k3
Name: mitogen-activated protein kinase kinase kinase kinase 3
RGD ID: 621280
Description: Enables SH3 domain binding activity. Predicted to be involved in several processes, including protein phosphorylation; response to UV; and response to tumor necrosis factor. Predicted to be active in cytoplasm. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2614,276,623 - 14,446,321 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl614,277,121 - 14,446,334 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx614,582,521 - 14,745,689 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0614,897,736 - 15,066,918 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0614,393,979 - 14,563,171 (+)NCBIRnor_WKY
Rnor_6.063,276,732 - 3,444,519 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl63,276,738 - 3,444,519 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.063,247,181 - 3,414,716 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.463,473,694 - 3,642,461 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.163,475,028 - 3,642,293 (-)NCBI
Celera613,956,412 - 14,123,546 (+)NCBICelera
Cytogenetic Map6q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase. Ramjaun AR, etal., J Biol Chem 2001 Aug 3;276(31):28913-9.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Enhancement of chondrocyte autophagy is an early response in the degenerative cartilage of the temporomandibular joint to biomechanical dental stimulation. Zhang M, etal., Apoptosis. 2013 Apr;18(4):423-34. doi: 10.1007/s10495-013-0811-0.
Additional References at PubMed
PMID:8889548   PMID:9275185   PMID:28731988  


Genomics

Comparative Map Data
Map4k3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2614,276,623 - 14,446,321 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl614,277,121 - 14,446,334 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx614,582,521 - 14,745,689 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0614,897,736 - 15,066,918 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0614,393,979 - 14,563,171 (+)NCBIRnor_WKY
Rnor_6.063,276,732 - 3,444,519 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl63,276,738 - 3,444,519 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.063,247,181 - 3,414,716 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.463,473,694 - 3,642,461 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.163,475,028 - 3,642,293 (-)NCBI
Celera613,956,412 - 14,123,546 (+)NCBICelera
Cytogenetic Map6q11NCBI
MAP4K3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38239,249,266 - 39,437,285 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl239,249,266 - 39,437,301 (-)EnsemblGRCh38hg38GRCh38
GRCh37239,476,407 - 39,664,426 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36239,329,926 - 39,517,723 (-)NCBINCBI36Build 36hg18NCBI36
Build 34239,388,073 - 39,575,870NCBI
Celera239,317,367 - 39,505,201 (-)NCBICelera
Cytogenetic Map2p22.1NCBI
HuRef239,215,530 - 39,403,591 (-)NCBIHuRef
CHM1_1239,406,810 - 39,594,778 (-)NCBICHM1_1
T2T-CHM13v2.0239,258,084 - 39,446,168 (-)NCBIT2T-CHM13v2.0
Map4k3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391780,887,942 - 81,039,118 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1780,887,941 - 81,035,914 (-)EnsemblGRCm39 Ensembl
GRCm381780,580,513 - 80,728,806 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1780,580,512 - 80,728,485 (-)EnsemblGRCm38mm10GRCm38
MGSCv371780,979,852 - 81,127,433 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361780,488,838 - 80,636,419 (-)NCBIMGSCv36mm8
MGSCv361779,860,491 - 80,008,566 (-)NCBIMGSCv36mm8
Celera1784,897,744 - 85,059,626 (-)NCBICelera
Cytogenetic Map17E3NCBI
Map4k3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554416,846,719 - 6,956,418 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554416,843,066 - 6,956,443 (-)NCBIChiLan1.0ChiLan1.0
MAP4K3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A40,040,492 - 40,228,109 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A40,040,497 - 40,228,109 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A39,286,787 - 39,474,780 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MAP4K3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11731,253,632 - 31,439,148 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1731,254,941 - 31,439,118 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1731,006,278 - 31,200,097 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01731,910,677 - 32,098,182 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1731,910,926 - 32,098,323 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11731,131,531 - 31,319,037 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01731,201,764 - 31,389,216 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01731,415,443 - 31,602,890 (-)NCBIUU_Cfam_GSD_1.0
Map4k3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629240,456,473 - 40,633,948 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650811,884,684 - 12,064,066 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493650811,885,066 - 12,062,560 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP4K3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3100,887,143 - 101,084,677 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13100,887,148 - 101,084,667 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAP4K3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11467,931,906 - 68,121,640 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1467,931,940 - 68,122,556 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604543,860,848 - 43,989,643 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map4k3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473820,715,296 - 20,875,393 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473820,716,430 - 20,874,930 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map4k3
631 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:193
Count of miRNA genes:141
Interacting mature miRNAs:168
Transcripts:ENSRNOT00000010366
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6507449719988050Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat

Markers in Region
D6Rat56  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,404,162 - 14,404,306 (-)MAPPERmRatBN7.2
Rnor_6.063,318,804 - 3,318,947NCBIRnor6.0
Rnor_5.063,289,093 - 3,289,236UniSTSRnor5.0
RGSC_v3.463,515,636 - 3,515,780RGDRGSC3.4
RGSC_v3.463,515,637 - 3,515,780UniSTSRGSC3.4
RGSC_v3.163,515,636 - 3,515,780RGD
Celera614,081,473 - 14,081,616UniSTS
RH 2.0 Map6147.8RGD
FHH x ACI Map613.73RGD
Cytogenetic Map6q11UniSTS
RH127652  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,445,723 - 14,445,903 (-)MAPPERmRatBN7.2
Rnor_6.063,277,156 - 3,277,335NCBIRnor6.0
Rnor_5.063,247,605 - 3,247,784UniSTSRnor5.0
RGSC_v3.463,474,112 - 3,474,291UniSTSRGSC3.4
Celera614,122,949 - 14,123,128UniSTS
Cytogenetic Map6q11UniSTS
RH131821  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,403,508 - 14,403,704 (-)MAPPERmRatBN7.2
Rnor_6.063,319,406 - 3,319,601NCBIRnor6.0
Rnor_5.063,289,695 - 3,289,890UniSTSRnor5.0
RGSC_v3.463,516,239 - 3,516,434UniSTSRGSC3.4
Celera614,080,818 - 14,081,013UniSTS
Cytogenetic Map6q11UniSTS
AU047952  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,371,915 - 14,372,207 (-)MAPPERmRatBN7.2
Rnor_6.063,350,603 - 3,350,894NCBIRnor6.0
Rnor_5.063,320,253 - 3,320,544UniSTSRnor5.0
RGSC_v3.463,547,922 - 3,548,213UniSTSRGSC3.4
Celera614,049,980 - 14,050,271UniSTS
Cytogenetic Map6q11UniSTS
AU046365  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,417,735 - 14,417,963 (-)MAPPERmRatBN7.2
Rnor_6.063,305,147 - 3,305,372NCBIRnor6.0
Rnor_5.063,275,631 - 3,275,856UniSTSRnor5.0
RGSC_v3.463,502,254 - 3,502,479UniSTSRGSC3.4
Celera614,094,967 - 14,095,192UniSTS
Cytogenetic Map6q11UniSTS
PMC16375P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,297,928 - 14,298,396 (-)MAPPERmRatBN7.2
Rnor_6.063,423,247 - 3,423,714NCBIRnor6.0
Rnor_5.063,393,444 - 3,393,911UniSTSRnor5.0
RGSC_v3.463,621,189 - 3,621,656UniSTSRGSC3.4
Cytogenetic Map6q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 33 43 27 19 27 8 8 74 35 41 11 8
Low 10 14 14 14 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA819812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF312224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI502900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK474868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV716943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000010366   ⟹   ENSRNOP00000010366
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl614,277,121 - 14,446,321 (+)Ensembl
Rnor_6.0 Ensembl63,276,738 - 3,444,519 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078044   ⟹   ENSRNOP00000070735
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl614,325,888 - 14,446,321 (+)Ensembl
Rnor_6.0 Ensembl63,276,756 - 3,395,954 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084602   ⟹   ENSRNOP00000069683
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl614,277,121 - 14,446,321 (+)Ensembl
Rnor_6.0 Ensembl63,278,073 - 3,355,339 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110847   ⟹   ENSRNOP00000090754
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl614,277,121 - 14,446,334 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113666   ⟹   ENSRNOP00000081073
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl614,325,888 - 14,446,321 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118971   ⟹   ENSRNOP00000097492
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl614,277,121 - 14,446,321 (+)Ensembl
RefSeq Acc Id: NM_133407   ⟹   NP_596898
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2614,277,121 - 14,446,321 (+)NCBI
Rnor_6.063,276,738 - 3,444,519 (-)NCBI
Rnor_5.063,247,181 - 3,414,716 (-)NCBI
RGSC_v3.463,473,694 - 3,642,461 (-)RGD
Celera613,956,412 - 14,123,546 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239656   ⟹   XP_006239718
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2614,276,632 - 14,446,321 (+)NCBI
Rnor_6.063,276,732 - 3,444,514 (-)NCBI
Rnor_5.063,247,181 - 3,414,716 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594019   ⟹   XP_017449508
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2614,276,625 - 14,446,321 (+)NCBI
Rnor_6.063,276,732 - 3,444,514 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594020   ⟹   XP_017449509
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2614,276,628 - 14,446,321 (+)NCBI
Rnor_6.063,276,732 - 3,444,514 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594021   ⟹   XP_017449510
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2614,276,625 - 14,446,321 (+)NCBI
Rnor_6.063,276,732 - 3,444,514 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111726   ⟹   XP_038967654
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2614,276,623 - 14,446,321 (+)NCBI
RefSeq Acc Id: XM_039111727   ⟹   XP_038967655
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2614,276,626 - 14,446,321 (+)NCBI
RefSeq Acc Id: XM_039111728   ⟹   XP_038967656
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2614,276,624 - 14,446,321 (+)NCBI
RefSeq Acc Id: XM_039111729   ⟹   XP_038967657
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2614,276,627 - 14,446,321 (+)NCBI
RefSeq Acc Id: XM_039111730   ⟹   XP_038967658
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2614,276,630 - 14,446,321 (+)NCBI
RefSeq Acc Id: XM_039111731   ⟹   XP_038967659
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2614,294,252 - 14,446,321 (+)NCBI
RefSeq Acc Id: XM_039111732   ⟹   XP_038967660
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2614,350,313 - 14,446,321 (+)NCBI
RefSeq Acc Id: XM_039111733   ⟹   XP_038967661
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2614,379,424 - 14,446,321 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_596898   ⟸   NM_133407
- UniProtKB: Q924I2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006239718   ⟸   XM_006239656
- Peptide Label: isoform X8
- UniProtKB: A0A0G2JVZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449510   ⟸   XM_017594021
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_017449509   ⟸   XM_017594020
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017449508   ⟸   XM_017594019
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000069683   ⟸   ENSRNOT00000084602
RefSeq Acc Id: ENSRNOP00000070735   ⟸   ENSRNOT00000078044
RefSeq Acc Id: ENSRNOP00000010366   ⟸   ENSRNOT00000010366
RefSeq Acc Id: XP_038967654   ⟸   XM_039111726
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038967656   ⟸   XM_039111728
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038967655   ⟸   XM_039111727
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038967657   ⟸   XM_039111729
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038967658   ⟸   XM_039111730
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038967659   ⟸   XM_039111731
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038967660   ⟸   XM_039111732
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038967661   ⟸   XM_039111733
- Peptide Label: isoform X12
RefSeq Acc Id: ENSRNOP00000081073   ⟸   ENSRNOT00000113666
RefSeq Acc Id: ENSRNOP00000090754   ⟸   ENSRNOT00000110847
RefSeq Acc Id: ENSRNOP00000097492   ⟸   ENSRNOT00000118971
Protein Domains
CNH   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q924I2-F1-model_v2 AlphaFold Q924I2 1-873 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621280 AgrOrtholog
BIND 130461
BioCyc Gene G2FUF-38531 BioCyc
Ensembl Genes ENSRNOG00000007172 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010366 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000069683 ENTREZGENE
  ENSRNOP00000069683.2 UniProtKB/TrEMBL
  ENSRNOP00000070735.2 UniProtKB/TrEMBL
  ENSRNOP00000081073.1 UniProtKB/TrEMBL
  ENSRNOP00000090754 ENTREZGENE
  ENSRNOP00000090754.1 UniProtKB/TrEMBL
  ENSRNOP00000097492.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010366 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000078044.2 UniProtKB/TrEMBL
  ENSRNOT00000084602 ENTREZGENE
  ENSRNOT00000084602.2 UniProtKB/TrEMBL
  ENSRNOT00000110847 ENTREZGENE
  ENSRNOT00000110847.1 UniProtKB/TrEMBL
  ENSRNOT00000113666.1 UniProtKB/TrEMBL
  ENSRNOT00000118971.1 UniProtKB/TrEMBL
InterPro Citron UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPKKKK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170920 UniProtKB/Swiss-Prot
NCBI Gene 170920 ENTREZGENE
Pfam CNH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Map4k3 PhenoGen
PIRSF MAPKKKK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CNH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JVZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JYP2_RAT UniProtKB/TrEMBL
  A0A8I5ZRP2_RAT UniProtKB/TrEMBL
  A0A8I6AAR5_RAT UniProtKB/TrEMBL
  A0A8I6AV17_RAT UniProtKB/TrEMBL
  M4K3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  R9PXT4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Map4k3  mitogen-activated protein kinase kinase kinase kinase 3      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Map4k3  mitogen-activated protein kinase kinase kinase kinase 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds to endophilin I 727317
gene_regulation may be activated by endophilin I binding 727317