SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1) - Rat Genome Database

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Gene: SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1) Canis lupus familiaris
Analyze
Symbol: SH3GL2
Name: SH3 domain containing GRB2 like 2, endophilin A1
RGD ID: 12276841
Description: ENCODES a protein that exhibits identical protein binding (ortholog); lipid binding (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to brain-derived neurotrophic factor stimulus (ortholog); dendrite extension (ortholog); lipid tube assembly (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ASSOCIATED WITH genetic disease (ortholog); visual epilepsy (ortholog); FOUND IN basal dendrite (ortholog); early endosome (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: endophilin-A1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11137,720,793 - 37,769,027 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1137,577,053 - 37,767,572 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1136,210,473 - 36,429,450 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01138,479,939 - 38,699,050 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1138,479,865 - 38,844,393 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11137,183,251 - 37,402,158 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01136,975,724 - 37,194,721 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01137,613,946 - 37,832,890 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SH3GL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11137,720,793 - 37,769,027 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1137,577,053 - 37,767,572 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1136,210,473 - 36,429,450 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01138,479,939 - 38,699,050 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1138,479,865 - 38,844,393 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11137,183,251 - 37,402,158 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01136,975,724 - 37,194,721 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01137,613,946 - 37,832,890 (+)NCBIUU_Cfam_GSD_1.0
SH3GL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38917,579,066 - 17,797,124 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl917,579,066 - 17,797,124 (+)EnsemblGRCh38hg38GRCh38
GRCh37917,579,064 - 17,797,122 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36917,569,194 - 17,787,122 (+)NCBINCBI36Build 36hg18NCBI36
Build 34917,569,193 - 17,787,120NCBI
Celera917,507,463 - 17,725,658 (+)NCBICelera
Cytogenetic Map9p22.2NCBI
HuRef917,541,205 - 17,759,965 (+)NCBIHuRef
CHM1_1917,579,359 - 17,797,531 (+)NCBICHM1_1
T2T-CHM13v2.0917,591,797 - 17,809,924 (+)NCBIT2T-CHM13v2.0
Sh3gl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39485,123,663 - 85,307,617 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl485,123,363 - 85,557,432 (+)EnsemblGRCm39 Ensembl
GRCm38485,205,456 - 85,389,380 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl485,205,126 - 85,639,195 (+)EnsemblGRCm38mm10GRCm38
MGSCv37484,851,360 - 85,035,284 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36484,676,687 - 84,860,611 (+)NCBIMGSCv36mm8
Celera483,721,182 - 83,903,108 (+)NCBICelera
Cytogenetic Map4C4NCBI
cM Map440.23NCBI
Sh3gl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85104,699,270 - 104,874,724 (+)NCBIGRCr8
mRatBN7.2599,653,189 - 99,827,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl599,653,152 - 100,113,843 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5102,036,367 - 102,216,379 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05103,824,073 - 103,998,825 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05103,847,211 - 104,027,230 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05103,479,767 - 103,654,507 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5103,479,767 - 103,654,247 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05107,479,270 - 107,653,523 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45104,129,280 - 104,308,317 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15104,300,491 - 104,313,320 (+)NCBI
Celera598,159,729 - 98,334,521 (+)NCBICelera
Cytogenetic Map5q31NCBI
Sh3gl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543420,331,779 - 20,381,376 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543420,332,727 - 20,381,320 (+)NCBIChiLan1.0ChiLan1.0
SH3GL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211106,761,688 - 106,981,117 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19106,767,634 - 106,987,062 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0917,386,298 - 17,605,722 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1917,878,860 - 18,097,579 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl918,045,198 - 18,097,579 (+)Ensemblpanpan1.1panPan2
SH3GL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1205,081,231 - 205,285,364 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11205,081,227 - 205,285,359 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21228,802,236 - 229,005,151 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SH3GL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11261,862,997 - 62,085,254 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1261,862,943 - 61,917,315 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603850,001,458 - 50,229,863 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh3gl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473621,554,969 - 21,716,877 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473621,554,950 - 21,715,522 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SH3GL2
326 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 5 11 12 8 6 5
Low 4 6 1 6 1 6 4 1
Below cutoff 5 5 5 6

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022425468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038490375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038490376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038552480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038552481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038616341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038616342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038660569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038660570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038681823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038681824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000002459   ⟹   ENSCAFP00000002279
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1137,577,053 - 37,767,572 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845024695   ⟹   ENSCAFP00845019439
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1138,479,865 - 38,844,393 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845024744   ⟹   ENSCAFP00845019469
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1138,479,906 - 38,694,763 (+)Ensembl
RefSeq Acc Id: XM_038490375   ⟹   XP_038346303
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11137,183,253 - 37,397,885 (+)NCBI
RefSeq Acc Id: XM_038490376   ⟹   XP_038346304
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11137,183,251 - 37,402,158 (+)NCBI
RefSeq Acc Id: XM_038552480   ⟹   XP_038408408
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01137,613,948 - 37,828,609 (+)NCBI
RefSeq Acc Id: XM_038552481   ⟹   XP_038408409
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01137,613,946 - 37,832,890 (+)NCBI
RefSeq Acc Id: XM_038616341   ⟹   XP_038472269
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01136,975,726 - 37,190,441 (+)NCBI
RefSeq Acc Id: XM_038616342   ⟹   XP_038472270
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01136,975,724 - 37,194,721 (+)NCBI
RefSeq Acc Id: XM_038660569   ⟹   XP_038516497
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1136,210,475 - 36,425,169 (+)NCBI
RefSeq Acc Id: XM_038660570   ⟹   XP_038516498
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1136,210,473 - 36,429,450 (+)NCBI
RefSeq Acc Id: XM_038681823   ⟹   XP_038537751
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01138,479,941 - 38,694,769 (+)NCBI
RefSeq Acc Id: XM_038681824   ⟹   XP_038537752
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01138,479,939 - 38,699,050 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000002279   ⟸   ENSCAFT00000002459
RefSeq Acc Id: XP_038346304   ⟸   XM_038490376
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038346303   ⟸   XM_038490375
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038472270   ⟸   XM_038616342
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038472269   ⟸   XM_038616341
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038537752   ⟸   XM_038681824
- Peptide Label: isoform X2
- UniProtKB: A0A8C0MJ39 (UniProtKB/TrEMBL),   A0A8I3NNH5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038537751   ⟸   XM_038681823
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NRM5 (UniProtKB/TrEMBL),   A0A8C0KIL3 (UniProtKB/TrEMBL),   A0A8C0T1L3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038516498   ⟸   XM_038660570
- Peptide Label: isoform X2
- UniProtKB: A0A8C0MJ39 (UniProtKB/TrEMBL),   A0A8I3NNH5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038516497   ⟸   XM_038660569
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NRM5 (UniProtKB/TrEMBL),   A0A8C0KIL3 (UniProtKB/TrEMBL),   A0A8C0T1L3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038408409   ⟸   XM_038552481
- Peptide Label: isoform X2
- UniProtKB: A0A8C0MJ39 (UniProtKB/TrEMBL),   A0A8I3NNH5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038408408   ⟸   XM_038552480
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KIL3 (UniProtKB/TrEMBL),   A0A8C0T1L3 (UniProtKB/TrEMBL),   A0A8I3NRM5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845019469   ⟸   ENSCAFT00845024744
RefSeq Acc Id: ENSCAFP00845019439   ⟸   ENSCAFT00845024695
Protein Domains
BAR   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001567 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006628 UniProtKB/TrEMBL
  ENSCAFG00040018262 UniProtKB/TrEMBL
  ENSCAFG00845013834 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000002459.5 UniProtKB/TrEMBL
  ENSCAFT00000102248.1 UniProtKB/TrEMBL
  ENSCAFT00000110105.1 UniProtKB/TrEMBL
  ENSCAFT00030012194.1 UniProtKB/TrEMBL
  ENSCAFT00030012243.1 UniProtKB/TrEMBL
  ENSCAFT00030012289.1 UniProtKB/TrEMBL
  ENSCAFT00040033725.1 UniProtKB/TrEMBL
  ENSCAFT00845024695.1 UniProtKB/TrEMBL
  ENSCAFT00845024744 ENTREZGENE
  ENSCAFT00845024744.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/TrEMBL
  BAR_dom UniProtKB/TrEMBL
  Endophilin_A_SH3 UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene SH3GL2 ENTREZGENE
PANTHER ENDOPHILIN-A1 UniProtKB/TrEMBL
  SH3 DOMAIN-CONTAINING UniProtKB/TrEMBL
Pfam BAR UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS SH3DOMAIN UniProtKB/TrEMBL
  SPECTRNALPHA UniProtKB/TrEMBL
PROSITE BAR UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART BAR UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A8C0KIL3 ENTREZGENE
  A0A8C0MJ39 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0MKG2_CANLF UniProtKB/TrEMBL
  A0A8C0T1L3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NNH5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NRM5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N4Q5_CANLF UniProtKB/TrEMBL
  A0A8P0PGU3_CANLF UniProtKB/TrEMBL
  A0A8P0TMG7_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:46125 ENTREZGENE