Slc17a7 (solute carrier family 17 member 7) - Rat Genome Database

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Gene: Slc17a7 (solute carrier family 17 member 7) Rattus norvegicus
Analyze
Symbol: Slc17a7
Name: solute carrier family 17 member 7
RGD ID: 620101
Description: Enables chloride channel activity and secondary active transmembrane transporter activity. Involved in several processes, including neurotransmitter loading into synaptic vesicle; regulation of synaptic vesicle endocytosis; and sodium-dependent phosphate transport. Located in excitatory synapse and presynaptic active zone. Is active in synaptic vesicle membrane. Biomarker of sciatic neuropathy and transient cerebral ischemia. Orthologous to human SLC17A7 (solute carrier family 17 member 7); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BNPI; brain-specific Na(+)-dependent inorganic phosphate cotransporter; brain-specific Na-dependent inorganic phosphate cotransporter; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7; solute carrier family 17 (vesicular glutamate transporter), member 7; vesicular glutamate transporter 1; Vglut1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,786,172 - 104,798,049 (+)NCBIGRCr8
mRatBN7.2195,649,709 - 95,661,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,649,745 - 95,661,588 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,035,136 - 101,046,992 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,507,805 - 109,519,655 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,798,210 - 102,810,056 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,161,265 - 101,172,292 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,161,252 - 101,173,174 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,226,212 - 102,237,165 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,640,743 - 95,651,938 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,718,860 - 95,730,049 (+)NCBI
Celera189,908,033 - 89,919,082 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-amphetamine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
atrazine  (EXP)
bafilomycin A1  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
Butylparaben  (EXP)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
Citreoviridin  (ISO)
clothianidin  (ISO)
clozapine  (ISO)
cocaine  (EXP)
Cuprizon  (EXP)
desipramine  (ISO)
dexamethasone  (EXP)
Diacetoxyscirpenol  (ISO)
diethylstilbestrol  (EXP)
diiodine  (ISO)
enzacamene  (EXP)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
fenvalerate  (EXP)
fluoxetine  (EXP,ISO)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydrogen sulfide  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
morphine  (ISO)
niclosamide  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
PCB138  (EXP)
PhIP  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
Riluzole  (EXP)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium atom  (ISO)
sotorasib  (ISO)
sterigmatocystin  (EXP)
Tetrachlorobisphenol A  (ISO)
trametinib  (ISO)
triazines  (ISO)
trichloroethene  (EXP)
trichostatin A  (EXP)
triptonide  (ISO)
urethane  (ISO)
valinomycin  (EXP)
valproic acid  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. Bellocchio EE, etal., Science. 2000 Aug 11;289(5481):957-60.
2. Vesicular glutamate and GABA transporters sort to distinct sets of vesicles in a population of presynaptic terminals. Boulland JL, etal., Cereb Cortex. 2009 Jan;19(1):241-8. doi: 10.1093/cercor/bhn077. Epub 2008 May 22.
3. Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters. Boulland JL, etal., J Comp Neurol. 2004 Dec 13;480(3):264-80.
4. Vesicular Glutamate Transporters (SLCA17 A6, 7, 8) Control Synaptic Phosphate Levels. Cheret C, etal., Cell Rep. 2021 Jan 12;34(2):108623. doi: 10.1016/j.celrep.2020.108623.
5. Control of excitatory and inhibitory synapse formation by neuroligins. Chih B, etal., Science. 2005 Feb 25;307(5713):1324-8. Epub 2005 Jan 27.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. Ko J, etal., EMBO J. 2009 Oct 21;28(20):3244-55. doi: 10.1038/emboj.2009.249. Epub 2009 Sep 3.
9. Postsynaptic scaffolding molecules modulate the localization of neuroligins. Levinson JN, etal., Neuroscience. 2010 Feb 3;165(3):782-93. doi: 10.1016/j.neuroscience.2009.11.016. Epub 2009 Nov 13.
10. Age and meloxicam modify the response of the glutamate vesicular transporters (VGLUTs) after transient global cerebral ischemia in the rat brain. Llorente IL, etal., Brain Res Bull. 2013 May;94:90-7. doi: 10.1016/j.brainresbull.2013.02.006. Epub 2013 Feb 28.
11. Analysis of a vesicular glutamate transporter (VGLUT2) supports a cell-leakage mode in addition to vesicular packaging. Mackenzie B, etal., Neurochem Res. 2008 Feb;33(2):238-47. doi: 10.1007/s11064-007-9546-z. Epub 2007 Dec 13.
12. Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra. Martin-Ibanez R, etal., Eur J Neurosci. 2006 Feb;23(4):1063-70.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Cloning and expression of a cDNA encoding a brain-specific Na(+)-dependent inorganic phosphate cotransporter. Ni B, etal., Proc Natl Acad Sci U S A 1994 Jun 7;91(12):5607-11.
16. The components required for amino acid neurotransmitter signaling are present in adipose tissues. Nicolaysen A, etal., J Lipid Res. 2007 Oct;48(10):2123-32. Epub 2007 Jun 28.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. Dual and Direction-Selective Mechanisms of Phosphate Transport by the Vesicular Glutamate Transporter. Preobraschenski J, etal., Cell Rep. 2018 Apr 10;23(2):535-545. doi: 10.1016/j.celrep.2018.03.055.
19. Vesicular glutamate transporters use flexible anion and cation binding sites for efficient accumulation of neurotransmitter. Preobraschenski J, etal., Neuron. 2014 Dec 17;84(6):1287-301. doi: 10.1016/j.neuron.2014.11.008. Epub 2014 Nov 26.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. A chloride conductance in VGLUT1 underlies maximal glutamate loading into synaptic vesicles. Schenck S, etal., Nat Neurosci. 2009 Feb;12(2):156-62. doi: 10.1038/nn.2248. Epub 2009 Jan 25.
24. Comparison of the ontogeny of the vesicular glutamate transporter 3 (VGLUT3) with VGLUT1 and VGLUT2 in the rat retina. Stella SL Jr, etal., Brain Res. 2008 Jun 18;1215:20-9. doi: 10.1016/j.brainres.2008.03.038. Epub 2008 Apr 1.
25. Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens. Tukey DS, etal., Mol Brain. 2013 Jul 9;6:32. doi: 10.1186/1756-6606-6-32.
26. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Um JW, etal., Cell Rep. 2014 Mar 27;6(6):1096-109. doi: 10.1016/j.celrep.2014.02.010. Epub 2014 Mar 6.
27. Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Voglmaier SM, etal., Neuron. 2006 Jul 6;51(1):71-84. doi: 10.1016/j.neuron.2006.05.027.
Additional References at PubMed
PMID:10820226   PMID:12915319   PMID:15028755   PMID:15103023   PMID:15118123   PMID:15157812   PMID:15224985   PMID:15379996   PMID:15579147   PMID:15632090   PMID:15714284   PMID:15845085  
PMID:15860731   PMID:15983996   PMID:15987952   PMID:16079394   PMID:16084661   PMID:16231188   PMID:16306404   PMID:16606361   PMID:16710756   PMID:16786558   PMID:16814779   PMID:16856164  
PMID:16980967   PMID:16987242   PMID:17134699   PMID:17241289   PMID:17299752   PMID:17503488   PMID:17611277   PMID:17612597   PMID:17823315   PMID:17825268   PMID:17826944   PMID:17965879  
PMID:18291592   PMID:18436385   PMID:18986540   PMID:19058187   PMID:19103593   PMID:19191347   PMID:19264112   PMID:19626270   PMID:19627441   PMID:19747495   PMID:19778580   PMID:19952853  
PMID:20025917   PMID:20450947   PMID:20519538   PMID:20533365   PMID:20534840   PMID:20593358   PMID:20632124   PMID:20849834   PMID:21079182   PMID:21172319   PMID:21356198   PMID:21375596  
PMID:21378974   PMID:21609737   PMID:21832035   PMID:21957077   PMID:22009457   PMID:22871113   PMID:23226425   PMID:23326507   PMID:23380804   PMID:23791195   PMID:23804088   PMID:23897509  
PMID:24599449   PMID:24639017   PMID:25749864   PMID:26224632   PMID:26769360   PMID:27210824   PMID:28188742   PMID:28238468   PMID:28938481   PMID:29462701   PMID:29476059   PMID:29650024  
PMID:30500398   PMID:32562720   PMID:34321562  


Genomics

Comparative Map Data
Slc17a7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,786,172 - 104,798,049 (+)NCBIGRCr8
mRatBN7.2195,649,709 - 95,661,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,649,745 - 95,661,588 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,035,136 - 101,046,992 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,507,805 - 109,519,655 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,798,210 - 102,810,056 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,161,265 - 101,172,292 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,161,252 - 101,173,174 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,226,212 - 102,237,165 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,640,743 - 95,651,938 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,718,860 - 95,730,049 (+)NCBI
Celera189,908,033 - 89,919,082 (+)NCBICelera
Cytogenetic Map1q22NCBI
SLC17A7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,429,401 - 49,441,527 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,429,401 - 49,442,360 (-)EnsemblGRCh38hg38GRCh38
GRCh371949,932,658 - 49,944,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,624,470 - 54,636,596 (-)NCBINCBI36Build 36hg18NCBI36
Build 341954,624,469 - 54,636,596NCBI
Celera1946,800,275 - 46,812,426 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1946,309,356 - 46,321,531 (-)NCBIHuRef
CHM1_11949,934,593 - 49,946,744 (-)NCBICHM1_1
T2T-CHM13v2.01952,426,980 - 52,439,104 (-)NCBIT2T-CHM13v2.0
Slc17a7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,813,345 - 44,825,563 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,813,373 - 44,825,566 (+)EnsemblGRCm39 Ensembl
GRCm38745,163,921 - 45,176,139 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,163,949 - 45,176,142 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,419,291 - 52,431,509 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,037,600 - 45,044,181 (+)NCBIMGSCv36mm8
Celera740,619,812 - 40,632,032 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.16NCBI
Slc17a7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,399,182 - 1,409,134 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,399,182 - 1,409,074 (+)NCBIChiLan1.0ChiLan1.0
SLC17A7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,546,137 - 55,558,265 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,466,481 - 57,478,608 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,443,076 - 46,455,195 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,365,811 - 55,377,438 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,365,811 - 55,377,438 (-)Ensemblpanpan1.1panPan2
SLC17A7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,054,242 - 107,064,444 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,054,410 - 107,063,550 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,637,561 - 106,647,714 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,574,355 - 107,584,513 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,574,336 - 107,584,513 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,247,363 - 107,257,512 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,889,697 - 106,900,075 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01107,730,574 - 107,740,729 (+)NCBIUU_Cfam_GSD_1.0
Slc17a7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,689,372 - 21,700,795 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366643,306,931 - 3,318,279 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366643,307,562 - 3,318,184 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC17A7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,511,124 - 54,521,611 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,511,121 - 54,521,616 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,240,102 - 50,250,578 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC17A7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,609,766 - 42,622,004 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,609,706 - 42,621,925 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607322,537,441 - 22,549,736 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc17a7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,765,212 - 4,775,515 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248324,765,233 - 4,775,515 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc17a7
21 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir327rno-miR-327Mirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Mir8rno-miR-7a-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:314
Count of miRNA genes:111
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000028064, ENSRNOT00000064184
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat

Markers in Region
HSCZSA032  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,661,343 - 95,661,555 (+)MAPPERmRatBN7.2
Rnor_6.01101,172,923 - 101,173,134NCBIRnor6.0
Rnor_5.01102,237,796 - 102,238,007UniSTSRnor5.0
RGSC_v3.4195,652,569 - 95,652,780UniSTSRGSC3.4
Celera189,919,713 - 89,919,924UniSTS
Cytogenetic Map1q22UniSTS
RH143588  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,654,670 - 95,654,834 (+)MAPPERmRatBN7.2
Rnor_6.01101,166,251 - 101,166,414NCBIRnor6.0
Rnor_5.01102,231,124 - 102,231,287UniSTSRnor5.0
RGSC_v3.4195,645,897 - 95,646,060UniSTSRGSC3.4
Celera189,913,041 - 89,913,204UniSTS
RH 3.4 Map1908.8UniSTS
Cytogenetic Map1q22UniSTS
SLC17A7_839.2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,660,454 - 95,661,204 (+)MAPPERmRatBN7.2
Rnor_6.01101,172,035 - 101,172,783NCBIRnor6.0
Rnor_5.01102,236,908 - 102,237,656UniSTSRnor5.0
RGSC_v3.4195,651,681 - 95,652,429UniSTSRGSC3.4
Celera189,918,825 - 89,919,573UniSTS
Cytogenetic Map1q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 49
Low 43 3 1 1 1 4 4 23 20 7 4
Below cutoff 37 23 15 23 4 7 2 20 19 1 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028064   ⟹   ENSRNOP00000028064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,649,745 - 95,661,588 (+)Ensembl
Rnor_6.0 Ensembl1101,161,252 - 101,173,174 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000064184   ⟹   ENSRNOP00000063604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,649,868 - 95,660,551 (+)Ensembl
Rnor_6.0 Ensembl1101,161,375 - 101,172,131 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1101,166,948 - 101,173,174 (+)Ensembl
RefSeq Acc Id: NM_053859   ⟹   NP_446311
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,786,205 - 104,798,049 (+)NCBI
mRatBN7.2195,649,745 - 95,661,591 (+)NCBI
Rnor_6.01101,161,265 - 101,172,292 (+)NCBI
Rnor_5.01102,226,212 - 102,237,165 (+)NCBI
RGSC_v3.4195,640,743 - 95,651,938 (+)RGD
Celera189,908,033 - 89,919,082 (+)RGD
Sequence:
RefSeq Acc Id: XM_039110953   ⟹   XP_038966881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,786,172 - 104,798,049 (+)NCBI
mRatBN7.2195,649,709 - 95,661,591 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_446311   ⟸   NM_053859
- UniProtKB: A9LRT0 (UniProtKB/Swiss-Prot),   Q62634 (UniProtKB/Swiss-Prot),   A6JAZ0 (UniProtKB/TrEMBL),   A6JAY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028064   ⟸   ENSRNOT00000028064
RefSeq Acc Id: ENSRNOP00000063604   ⟸   ENSRNOT00000064184
RefSeq Acc Id: XP_038966881   ⟸   XM_039110953
- Peptide Label: isoform X1
- UniProtKB: A6JAY9 (UniProtKB/TrEMBL)
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62634-F1-model_v2 AlphaFold Q62634 1-560 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690029
Promoter ID:EPDNEW_R554
Type:initiation region
Name:Slc17a7_1
Description:solute carrier family 17 member 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,161,252 - 101,161,312EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620101 AgrOrtholog
BioCyc Gene G2FUF-59707 BioCyc
Ensembl Genes ENSRNOG00000020650 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055005694 UniProtKB/Swiss-Prot
  ENSRNOG00060008397 UniProtKB/Swiss-Prot
  ENSRNOG00065028761 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028064 ENTREZGENE
  ENSRNOT00000028064.6 UniProtKB/Swiss-Prot
  ENSRNOT00000064184.5 UniProtKB/Swiss-Prot
  ENSRNOT00055009185 UniProtKB/Swiss-Prot
  ENSRNOT00060014013 UniProtKB/Swiss-Prot
  ENSRNOT00065049662 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.540 UniProtKB/TrEMBL
  1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_channel_N UniProtKB/TrEMBL
KEGG Report rno:116638 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 116638 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VESICULAR GLUTAMATE TRANSPORTER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc17a7 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020650 RatGTEx
  ENSRNOG00055005694 RatGTEx
  ENSRNOG00060008397 RatGTEx
  ENSRNOG00065028761 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JAY9 ENTREZGENE, UniProtKB/TrEMBL
  A6JAZ0 ENTREZGENE, UniProtKB/TrEMBL
  A9LRS8_RAT UniProtKB/TrEMBL
  A9LRT0 ENTREZGENE
  Q62634 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A9LRT0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc17a7  solute carrier family 17 member 7  Slc17a7  solute carrier family 17 (vesicular glutamate transporter), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc17a7  solute carrier family 17 (vesicular glutamate transporter), member 7  Slc17a7  solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Slc17a7  solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Slc17a7  solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains 6-8 putative transmembrane-spanning segments 633922
gene_expression expressed mainly in brain 633922