RGD Reference Report - Synaptic vesicle endocytosis. - Rat Genome Database

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Synaptic vesicle endocytosis.

Authors: Saheki, Yasunori  De Camilli, Pietro 
Citation: Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
RGD ID: 10450547
Pubmed: PMID:22763746   (View Abstract at PubMed)
PMCID: PMC3428771   (View Article at PubMed Central)
DOI: DOI:10.1101/cshperspect.a005645   (Journal Full-text)

Neurons can sustain high rates of synaptic transmission without exhausting their supply of synaptic vesicles. This property relies on a highly efficient local endocytic recycling of synaptic vesicle membranes, which can be reused for hundreds, possibly thousands, of exo-endocytic cycles. Morphological, physiological, molecular, and genetic studies over the last four decades have provided insight into the membrane traffic reactions that govern this recycling and its regulation. These studies have shown that synaptic vesicle endocytosis capitalizes on fundamental and general endocytic mechanisms but also involves neuron-specific adaptations of such mechanisms. Thus, investigations of these processes have advanced not only the field of synaptic transmission but also, more generally, the field of endocytosis. This article summarizes current information on synaptic vesicle endocytosis with an emphasis on the underlying molecular mechanisms and with a special focus on clathrin-mediated endocytosis, the predominant pathway of synaptic vesicle protein internalization.



RGD Manual Annotations

1 to 20 of 66 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
AP2A1Humanclathrin-dependent synaptic vesicle endocytosis  TAS  RGD 
AP2A2Humanclathrin-dependent synaptic vesicle endocytosis  TAS  RGD 
AP2B1Humanclathrin-dependent synaptic vesicle endocytosis  TAS  RGD 
AP2M1Humanclathrin-dependent synaptic vesicle endocytosis  TAS  RGD 
AP2S1Humanclathrin-dependent synaptic vesicle endocytosis  TAS  RGD 
Ap2a1Ratclathrin-dependent synaptic vesicle endocytosis  ISOAP2A1 (Homo sapiens) RGD 
Ap2a1Mouseclathrin-dependent synaptic vesicle endocytosis  ISOAP2A1 (Homo sapiens) RGD 
Ap2a2Ratclathrin-dependent synaptic vesicle endocytosis  ISOAP2A2 (Homo sapiens) RGD 
Ap2a2Mouseclathrin-dependent synaptic vesicle endocytosis  ISOAP2A2 (Homo sapiens) RGD 
Ap2b1Ratclathrin-dependent synaptic vesicle endocytosis  ISOAP2B1 (Homo sapiens) RGD 
Ap2b1Mouseclathrin-dependent synaptic vesicle endocytosis  ISOAP2B1 (Homo sapiens) RGD 
Ap2m1Ratclathrin-dependent synaptic vesicle endocytosis  ISOAP2M1 (Homo sapiens) RGD 
Ap2m1Mouseclathrin-dependent synaptic vesicle endocytosis  ISOAP2M1 (Homo sapiens) RGD 
Ap2s1Ratclathrin-dependent synaptic vesicle endocytosis  ISOAP2S1 (Homo sapiens) RGD 
Ap2s1Mouseclathrin-dependent synaptic vesicle endocytosis  ISOAP2S1 (Homo sapiens) RGD 
CLTAHumanclathrin-dependent synaptic vesicle endocytosis  TAS  RGD 
CLTBHumanclathrin-dependent synaptic vesicle endocytosis  TAS  RGD 
CLTCHumanclathrin-dependent synaptic vesicle endocytosis  TAS  RGD 
CltaRatclathrin-dependent synaptic vesicle endocytosis  ISOCLTA (Homo sapiens) RGD 
CltaMouseclathrin-dependent synaptic vesicle endocytosis  ISOCLTA (Homo sapiens) RGD 
1 to 20 of 66 rows

Genes (Rattus norvegicus)
Ap2a1  (adaptor related protein complex 2 subunit alpha 1) Ap2a2  (adaptor related protein complex 2 subunit alpha 2) Ap2b1  (adaptor related protein complex 2 subunit beta 1)
Ap2m1  (adaptor related protein complex 2 subunit mu 1) Ap2s1  (adaptor related protein complex 2 subunit sigma 1) Clta  (clathrin, light chain A)
Cltb  (clathrin, light chain B) Cltc  (clathrin heavy chain) Dnajc6  (DnaJ heat shock protein family (Hsp40) member C6)
Dnm1  (dynamin 1) Dnm3  (dynamin 3) Dnmbp  (dynamin binding protein)
Epn1  (Epsin 1) Eps15  (epidermal growth factor receptor pathway substrate 15) Hspa8  (heat shock protein family A (Hsp70) member 8)
Itsn1  (intersectin 1) Pip5k1c  (phosphatidylinositol-4-phosphate 5-kinase type 1 gamma) Sh3gl1  (SH3 domain containing GRB2 like 1, endophilin A2)
Sh3gl2  (SH3 domain containing GRB2 like 2, endophilin A1) Sh3gl3  (SH3 domain containing GRB2 like 3, endophilin A3) Snap91  (synaptosome associated protein 91)
Synj1  (synaptojanin 1)

Genes (Mus musculus)
Ap2a1  (adaptor-related protein complex 2, alpha 1 subunit) Ap2a2  (adaptor-related protein complex 2, alpha 2 subunit) Ap2b1  (adaptor-related protein complex 2, beta 1 subunit)
Ap2m1  (adaptor-related protein complex 2, mu 1 subunit) Ap2s1  (adaptor-related protein complex 2, sigma 1 subunit) Clta  (clathrin light chain A)
Cltb  (clathrin light chain B) Cltc  (clathrin heavy chain) Dnajc6  (DnaJ heat shock protein family (Hsp40) member C6)
Dnm1  (dynamin 1) Dnm3  (dynamin 3) Dnmbp  (dynamin binding protein)
Epn1  (epsin 1) Eps15  (epidermal growth factor receptor pathway substrate 15) Hspa8  (heat shock protein 8)
Itsn1  (intersectin 1 (SH3 domain protein 1A)) Pip5k1c  (phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma) Sh3gl1  (SH3-domain GRB2-like 1)
Sh3gl2  (SH3-domain GRB2-like 2) Sh3gl3  (SH3-domain GRB2-like 3) Snap91  (synaptosomal-associated protein 91)
Synj1  (synaptojanin 1)

Genes (Homo sapiens)
AP2A1  (adaptor related protein complex 2 subunit alpha 1) AP2A2  (adaptor related protein complex 2 subunit alpha 2) AP2B1  (adaptor related protein complex 2 subunit beta 1)
AP2M1  (adaptor related protein complex 2 subunit mu 1) AP2S1  (adaptor related protein complex 2 subunit sigma 1) CLTA  (clathrin light chain A)
CLTB  (clathrin light chain B) CLTC  (clathrin heavy chain) DNAJC6  (DnaJ heat shock protein family (Hsp40) member C6)
DNM1  (dynamin 1) DNM3  (dynamin 3) DNMBP  (dynamin binding protein)
EPN1  (epsin 1) EPS15  (epidermal growth factor receptor pathway substrate 15) HSPA8  (heat shock protein family A (Hsp70) member 8)
ITSN1  (intersectin 1) PIP5K1C  (phosphatidylinositol-4-phosphate 5-kinase type 1 gamma) SH3GL1  (SH3 domain containing GRB2 like 1, endophilin A2)
SH3GL2  (SH3 domain containing GRB2 like 2, endophilin A1) SH3GL3  (SH3 domain containing GRB2 like 3, endophilin A3) SNAP91  (synaptosome associated protein 91)
SYNJ1  (synaptojanin 1)