HSPA8 (heat shock protein family A (Hsp70) member 8) - Rat Genome Database

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Gene: HSPA8 (heat shock protein family A (Hsp70) member 8) Homo sapiens
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Symbol: HSPA8
Name: heat shock protein family A (Hsp70) member 8
RGD ID: 736219
HGNC Page HGNC:5241
Description: Enables several functions, including ATP binding activity; ATP-dependent protein disaggregase activity; and C3HC4-type RING finger domain binding activity. Involved in several processes, including negative regulation of cellular component organization; protein refolding; and protein targeting to lysosome involved in chaperone-mediated autophagy. Located in cytosol; extracellular exosome; and spliceosomal complex. Part of Prp19 complex; protein folding chaperone complex; and ribonucleoprotein complex. Is active in lysosomal membrane. Implicated in Parkinson's disease and renal hypertension. Biomarker of several diseases, including cervical cancer; colorectal cancer; hypertension; multiple sclerosis (multiple); and pancreatic ductal adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: constitutive heat shock protein 70; epididymis luminal protein 33; epididymis secretory sperm binding protein Li 72p; heat shock 70kd protein 10; heat shock 70kD protein 8; heat shock 70kDa protein 8; heat shock cognate 71 kDa protein; heat shock cognate protein 54; heat shock cognate protein, 71-kDa; heat shock protein 8; HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; LAP-1; LAP1; lipopolysaccharide-associated protein 1; LPS-associated protein 1; MGC131511; MGC29929; N-myristoyltransferase inhibitor protein 71; NIP71
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: HSPA8P1   HSPA8P10   HSPA8P11   HSPA8P12   HSPA8P13   HSPA8P14   HSPA8P15   HSPA8P16   HSPA8P17   HSPA8P18   HSPA8P19   HSPA8P2   HSPA8P20   HSPA8P3   HSPA8P4   HSPA8P5   HSPA8P6   HSPA8P7   HSPA8P8   HSPA8P9   LOC343165  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811123,057,489 - 123,062,462 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11123,057,489 - 123,063,230 (-)EnsemblGRCh38hg38GRCh38
GRCh3711122,928,197 - 122,932,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611122,433,410 - 122,438,054 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411122,433,410 - 122,438,054NCBI
Celera11120,087,529 - 120,092,173 (-)NCBICelera
Cytogenetic Map11q24.1NCBI
HuRef11118,870,278 - 118,875,122 (-)NCBIHuRef
CHM1_111122,814,192 - 122,819,035 (-)NCBICHM1_1
T2T-CHM13v2.011123,086,071 - 123,093,285 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-alpha-phellandrene  (EXP)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(R)-adrenaline  (ISO)
(S)-amphetamine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methylcholine  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
7H-xanthine  (ISO)
8-Br-cAMP  (EXP)
9H-xanthine  (ISO)
acrolein  (EXP)
acrylamide  (EXP,ISO)
afimoxifene  (EXP)
albendazole  (EXP)
aldrin  (ISO)
all-trans-retinoic acid  (EXP)
alpha-naphthoflavone  (ISO)
alpha-phellandrene  (EXP)
alpha-pinene  (EXP)
AM-251  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (EXP)
amphotericin B  (EXP)
antimonite  (EXP)
apigenin  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
astemizole  (ISO)
atrazine  (EXP)
azoxystrobin  (EXP)
bathocuproine disulfonic acid  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (ISO)
bifenthrin  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bromobenzene  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
cannabidiol  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
casticin  (ISO)
ceruletide  (ISO)
CGP 52608  (EXP)
chlordecone  (ISO)
chloromethylisothiazolinone  (EXP)
chloropicrin  (EXP)
chloroprene  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
coumarin  (EXP)
crocidolite asbestos  (EXP)
CU-O LINKAGE  (EXP)
Cuprizon  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
deguelin  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (EXP)
diethyl maleate  (ISO)
dihydroartemisinin  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
disodium selenite  (EXP)
disulfiram  (EXP)
diuron  (EXP,ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
enzyme inhibitor  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (EXP)
fenofibrate  (ISO)
fenvalerate  (ISO)
ferric oxide  (ISO)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
formetanate  (EXP)
FR900359  (EXP)
fulvestrant  (EXP)
furan  (ISO)
gallic acid  (EXP)
gamma-poly(L-glutamic acid) macromolecule  (ISO)
gentamycin  (ISO)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hyaluronic acid  (ISO)
hydralazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxyurea  (EXP)
ibuprofen  (EXP)
imipramine  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (EXP,ISO)
iodide salt  (ISO)
ionomycin  (EXP)
iron atom  (ISO)
iron dichloride  (EXP)
iron(0)  (ISO)
isobutanol  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
Licochalcone B  (EXP)
lipopolysaccharide  (EXP)
lovastatin  (ISO)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
mercury dichloride  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methomyl  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (EXP)
methylarsonic acid  (ISO)
microcystin-LR  (ISO)
mitomycin C  (EXP)
monocrotaline  (ISO)
morphine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methylformamide  (ISO)
N-nitrosomorpholine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrofurantoin  (ISO)
ochratoxin A  (ISO)
oxidopamine  (EXP,ISO)
ozone  (EXP,ISO)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorododecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phorone  (ISO)
pirimicarb  (EXP)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
Propiverine  (ISO)
prostaglandin A1  (ISO)
pyrimidifen  (EXP)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
quercitrin  (EXP)
quinolin-8-ol  (EXP)
quizartinib  (EXP)
rac-lactic acid  (EXP)
raloxifene  (EXP)
rifampicin  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sarin  (ISO)
SB 431542  (EXP)
sertraline  (EXP,ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (EXP)
thifluzamide  (EXP)
thioacetamide  (ISO)
thiostrepton  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
titanium dioxide  (ISO)
triadimefon  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
triphenylstannane  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)
vorinostat  (EXP)
warfarin  (ISO)
Yessotoxin  (EXP)
zinc pyrithione  (EXP)
zinc sulfate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (IDA)
autophagy  (IEA)
axo-dendritic transport  (IEA,ISO)
cellular response to cadmium ion  (IEA,ISO)
cellular response to heat  (IEA,ISO)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to starvation  (TAS)
cellular response to steroid hormone stimulus  (TAS)
cerebellum development  (IEA,ISO)
chaperone cofactor-dependent protein refolding  (IBA,IEA,ISO)
chaperone-mediated autophagy  (IEA,ISO,ISS,TAS)
chaperone-mediated autophagy translocation complex disassembly  (IEA,ISS)
chaperone-mediated protein folding  (IEA,ISO)
clathrin coat disassembly  (IBA,IDA,IEA,ISO)
estrous cycle  (IEA,ISO)
forebrain development  (IEA,ISO)
G1/S transition of mitotic cell cycle  (IEA,ISO)
kidney development  (IEA,ISO)
late endosomal microautophagy  (IEA)
maintenance of postsynaptic specialization structure  (IEA)
membrane organization  (TAS)
modulation by host of viral process  (IEA)
mRNA processing  (IEA)
mRNA splicing, via spliceosome  (NAS)
negative regulation of cardiac muscle cell apoptotic process  (IEA,ISO)
negative regulation of DNA-templated transcription  (IDA)
negative regulation of NLRP3 inflammasome complex assembly  (IDA)
negative regulation of supramolecular fiber organization  (IDA)
positive regulation by host of viral genome replication  (IEA)
positive regulation of catalytic activity  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of lysosomal membrane permeability  (IEA,ISO)
positive regulation of mRNA splicing, via spliceosome  (IEA,ISO)
positive regulation of phagocytosis  (IEA,ISO)
positive regulation of protein refolding  (IEA,ISO)
positive regulation of proteolysis  (IEA,ISO)
positive regulation of T cell mediated cytotoxicity  (IEA,ISO)
protein autophosphorylation  (ISO)
protein folding  (IEA,ISO,NAS)
protein import into nucleus  (IEA,ISO)
protein refolding  (IBA,IDA)
protein targeting to lysosome involved in chaperone-mediated autophagy  (IDA,IEA,IMP,TAS)
protein transmembrane import into intracellular organelle  (IEA,ISO)
protein-containing complex disassembly  (IEA,ISO)
regulation of cell cycle  (IEA,ISO)
regulation of postsynapse organization  (IEA)
regulation of protein complex stability  (IEA,ISS)
regulation of protein import  (TAS)
regulation of protein stability  (IMP)
regulation of protein-containing complex assembly  (TAS)
response to activity  (IEA,ISO)
response to estradiol  (IEA,ISO)
response to ethanol  (IEA,ISO)
response to nickel cation  (IEA,ISO)
response to odorant  (IEA,ISO)
response to progesterone  (IEA,ISO)
response to starvation  (IEA,ISO)
response to unfolded protein  (NAS)
response to xenobiotic stimulus  (IEA,ISO)
RNA splicing  (IEA)
skeletal muscle tissue development  (IEA,ISO)
slow axonal transport  (IEA,ISO)
synaptic vesicle uncoating  (IEA)

Cellular Component
asymmetric synapse  (IEA,ISO)
autophagosome  (IEA,ISO)
axon  (IEA,ISO)
blood microparticle  (HDA)
cell surface  (IEA,ISO)
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane  (TAS)
cytoplasm  (IBA,IEA)
cytosol  (IBA,IDA,IEA,TAS)
dendrite  (IEA,ISO)
dendritic shaft  (IEA,ISO)
dendritic spine  (IEA,ISO)
extracellular exosome  (HDA,IDA,IEA)
extracellular region  (TAS)
extracellular space  (HDA)
ficolin-1-rich granule lumen  (TAS)
focal adhesion  (HDA)
glutamatergic synapse  (IEA,ISO)
glycinergic synapse  (IEA,ISO)
intermediate filament  (IEA,ISO)
late endosome  (IEA)
lumenal side of lysosomal membrane  (TAS)
lysosomal lumen  (TAS)
lysosomal matrix  (IEA,ISO)
lysosomal membrane  (IDA,IEA,ISO,ISS)
lysosome  (IEA)
melanosome  (IEA)
membrane  (HDA)
microtubule  (IEA,ISO)
neuron spine  (IEA)
neuronal cell body  (IEA,ISO)
nucleolus  (IEA)
nucleoplasm  (TAS)
nucleus  (IBA,IDA,IEA)
perikaryon  (IEA,ISO)
perinuclear region of cytoplasm  (IEA,ISO)
photoreceptor inner segment  (IEA,ISO)
photoreceptor ribbon synapse  (IEA,ISO)
plasma membrane  (IBA,IEA,TAS)
postsynapse  (IEA,ISO)
postsynaptic cytosol  (IEA)
postsynaptic density  (IEA,ISO)
postsynaptic specialization membrane  (IEA,ISO)
presynapse  (IEA,ISO)
presynaptic cytosol  (IEA)
protein folding chaperone complex  (IPI)
protein-containing complex  (IEA,ISO)
Prp19 complex  (IDA,IPI)
ribonucleoprotein complex  (IDA)
secretory granule lumen  (TAS)
spliceosomal complex  (IEA,IPI)
synaptic vesicle  (IEA,ISO)
terminal bouton  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Chaperone-mediated autophagy markers in Parkinson disease brains. Alvarez-Erviti L, etal., Arch Neurol. 2010 Dec;67(12):1464-72. Epub 2010 Aug 9.
2. In vivo induction of heat shock proteins in the substantia nigra following L-DOPA administration is associated with increased activity of mitochondrial complex I and nitrosative stress in rats: regulation by glutathione redox state. Calabrese V, etal., J Neurochem. 2007 May;101(3):709-17. Epub 2007 Jan 4.
3. Splicing and beyond: the many faces of the Prp19 complex. Chanarat S and Strasser K, Biochim Biophys Acta. 2013 Oct;1833(10):2126-34. doi: 10.1016/j.bbamcr.2013.05.023. Epub 2013 Jun 3.
4. Autoantibodies against HSP70 family proteins were detected in the cerebrospinal fluid from patients with multiple sclerosis. Chiba S, etal., J Neurol Sci. 2006 Feb 15;241(1-2):39-43. Epub 2005 Nov 21.
5. Chaperone-mediated autophagy: roles in disease and aging. Cuervo AM and Wong E, Cell Res. 2014 Jan;24(1):92-104. doi: 10.1038/cr.2013.153. Epub 2013 Nov 26.
6. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
7. Expression of 70-kDa heat-shock protein during acute graft-versus-host disease. Goral J, etal., Clin Immunol Immunopathol. 1998 Mar;86(3):252-8.
8. Assembly of proteins to postsynaptic densities after transient cerebral ischemia. Hu BR, etal., J Neurosci. 1998 Jan 15;18(2):625-33.
9. Serum level of soluble 70-kD heat shock protein is associated with high mortality in patients with colorectal cancer without distant metastasis. Kocsis J, etal., Cell Stress Chaperones. 2010 Mar;15(2):143-51. Epub 2009 Jul 4.
10. Constitutive upregulation of chaperone-mediated autophagy in Huntington's disease. Koga H, etal., J Neurosci. 2011 Dec 14;31(50):18492-505.
11. Intracellular localization of HSP73 and HSP90 in rat kidneys with acute lysosomal thesaurismosis. Komatsuda A, etal., Pathol Int. 1999 Jun;49(6):513-8.
12. Association of neovascular age-related macular degeneration with specific gene expression patterns in peripheral white blood cells. Lederman M, etal., Invest Ophthalmol Vis Sci. 2010 Jan;51(1):53-8. Epub 2009 Aug 13.
13. Induction of molecular chaperones in carbon tetrachloride-treated rat liver: implications in protection against liver damage. Lee KJ, etal., Cell Stress Chaperones. 2004 Mar;9(1):58-68.
14. Hereditary sensory neuropathy is caused by a mutation in the delta subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct4 ) gene. Lee MJ, etal., Hum Mol Genet 2003 Aug 1;12(15):1917-25.
15. Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. Lo Bianco C, etal., J Clin Invest. 2008 Sep;118(9):3087-97.
16. Diagnostic protein marker patterns in squamous cervical cancer. Lomnytska MI, etal., Proteomics Clin Appl. 2010 Jan;4(1):17-31. doi: 10.1002/prca.200900086. Epub 2009 Nov 11.
17. Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism. Mashukova A, etal., Mol Cell Biol. 2011 Feb;31(4):756-65. Epub 2010 Dec 6.
18. 73-kDa molecular chaperone HSP73 is a direct target of antibiotic gentamicin. Miyazaki T, etal., J Biol Chem. 2004 Apr 23;279(17):17295-300. Epub 2004 Feb 13.
19. Induction of heat-shock proteins HSP73 and HSP90 in rat kidneys after ischemia. Morita K, etal., Ren Fail. 1995 Jul;17(4):405-19.
20. Association of polymorphisms of THBS2 and HSPA8 with hypertension in Japanese individuals with chronic kidney disease. Oguri M, etal., Mol Med Rep. 2009 Mar-Apr;2(2):205-11. doi: 10.3892/mmr_00000085.
21. Cancer-associated retinopathy induced by both anti-recoverin and anti-hsc70 antibodies in vivo. Ohguro H, etal., Invest Ophthalmol Vis Sci. 1999 Dec;40(13):3160-7.
22. Redox regulation of cellular stress response in multiple sclerosis. Pennisi G, etal., Biochem Pharmacol. 2011 Nov 15;82(10):1490-9. Epub 2011 Jul 30.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. Molecular chaperones throughout the life cycle of the androgen receptor. Prescott J and Coetzee GA, Cancer Lett. 2006 Jan 8;231(1):12-9.
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
27. PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression. Sahni S, etal., Biochim Biophys Acta Gen Subj. 2020 Nov;1864(11):129682. doi: 10.1016/j.bbagen.2020.129682. Epub 2020 Jul 12.
28. Altered chaperone and protein turnover regulators expression in cultured skin fibroblasts from type 1 diabetes mellitus with nephropathy. Tessari P, etal., J Proteome Res. 2007 Mar;6(3):976-86.
29. Altered gene expression pattern in peripheral blood leukocytes from patients with arterial hypertension. Timofeeva AV, etal., Ann N Y Acad Sci. 2006 Dec;1091:319-35.
30. Chaperone mediated autophagy to the rescue: A new-fangled target for the treatment of neurodegenerative diseases. Xilouri M and Stefanis L, Mol Cell Neurosci. 2015 May;66(Pt A):29-36. doi: 10.1016/j.mcn.2015.01.003. Epub 2015 Feb 25.
31. Immunohistochemical studies on the expression pattern of molecular chaperones HSC70 and HSP25 and cell cycle-related proteins cyclin D1 and PCNA in rat liver after thioacetamide intoxication. Zborek A, etal., Histochem Cell Biol. 2002 Oct;118(4):311-9. Epub 2002 Sep 5.
32. Irreversible aggregation of protein synthesis machinery after focal brain ischemia. Zhang F, etal., J Neurochem. 2006 Jul;98(1):102-12.
33. Critical role of extracellular heat shock cognate protein 70 in the myocardial inflammatory response and cardiac dysfunction after global ischemia-reperfusion. Zou N, etal., Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2805-13. Epub 2008 Apr 25.
Additional References at PubMed
PMID:1286667   PMID:1586970   PMID:1975516   PMID:2155506   PMID:2799391   PMID:2966179   PMID:3037489   PMID:7545947   PMID:7559589   PMID:7578144   PMID:7639722   PMID:7673249  
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PMID:20675402   PMID:20729196   PMID:20804732   PMID:20806039   PMID:20850016   PMID:20884878   PMID:20890123   PMID:20930503   PMID:20953179   PMID:20972266   PMID:21050049   PMID:21103899  
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PMID:21987572   PMID:21988832   PMID:22039833   PMID:22053931   PMID:22074182   PMID:22079093   PMID:22085931   PMID:22090113   PMID:22170045   PMID:22178446   PMID:22234250   PMID:22268729  
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Genomics

Comparative Map Data
HSPA8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811123,057,489 - 123,062,462 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11123,057,489 - 123,063,230 (-)EnsemblGRCh38hg38GRCh38
GRCh3711122,928,197 - 122,932,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611122,433,410 - 122,438,054 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411122,433,410 - 122,438,054NCBI
Celera11120,087,529 - 120,092,173 (-)NCBICelera
Cytogenetic Map11q24.1NCBI
HuRef11118,870,278 - 118,875,122 (-)NCBIHuRef
CHM1_111122,814,192 - 122,819,035 (-)NCBICHM1_1
T2T-CHM13v2.011123,086,071 - 123,093,285 (-)NCBIT2T-CHM13v2.0
Hspa8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39940,712,572 - 40,716,498 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl940,712,280 - 40,721,383 (+)EnsemblGRCm39 Ensembl
GRCm38940,801,276 - 40,805,202 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl940,800,984 - 40,810,087 (+)EnsemblGRCm38mm10GRCm38
MGSCv37940,609,356 - 40,613,282 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3658,102,053 - 8,104,168 (+)NCBIMGSCv36mm8
MGSCv36940,552,355 - 40,556,269 (+)NCBIMGSCv36mm8
Celera938,034,609 - 38,038,251 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map921.55NCBI
Hspa8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8850,080,514 - 50,084,376 (+)NCBIGRCr8
mRatBN7.2841,183,397 - 41,187,260 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl841,183,264 - 41,187,259 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx846,682,619 - 46,686,480 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0844,961,220 - 44,965,081 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0842,828,805 - 42,832,666 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0844,989,401 - 44,993,261 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl844,990,014 - 44,993,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0846,005,304 - 46,006,864 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0843,478,238 - 43,480,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4843,784,035 - 43,787,760 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1843,792,829 - 43,796,525 (+)NCBI
Celera840,782,916 - 40,786,778 (+)NCBICelera
Cytogenetic Map8q22NCBI
Hspa8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541223,862,590 - 23,867,984 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541223,863,513 - 23,867,984 (-)NCBIChiLan1.0ChiLan1.0
HSPA8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29123,758,689 - 123,764,231 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111124,863,401 - 124,868,370 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011117,890,545 - 117,895,262 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111121,809,800 - 121,814,628 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11121,809,800 - 121,815,773 (-)Ensemblpanpan1.1panPan2
HSPA8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1511,292,219 - 11,296,851 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl511,292,262 - 11,296,797 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha511,348,073 - 11,352,702 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0511,243,037 - 11,247,671 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl511,242,826 - 11,307,583 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1511,346,458 - 11,351,078 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0511,279,270 - 11,283,884 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0511,323,539 - 11,328,166 (+)NCBIUU_Cfam_GSD_1.0
Hspa8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947104,655,786 - 104,660,238 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365427,577,149 - 7,581,923 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365427,577,192 - 7,581,598 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl949,982,284 - 49,990,508 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1949,982,278 - 49,986,760 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2955,405,395 - 55,409,839 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSPA8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11114,447,348 - 114,452,693 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1114,446,544 - 114,451,562 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604311,677,166 - 11,681,993 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspa8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248802,070,523 - 2,079,421 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248802,070,410 - 2,075,069 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HSPA8
10 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q23.3-25(chr11:116851395-134998513)x3 copy number gain See cases [RCV000050331] Chr11:116851395..134998513 [GRCh38]
Chr11:116722111..134868407 [GRCh37]
Chr11:116227321..134373617 [NCBI36]
Chr11:11q23.3-25		 pathogenic
GRCh38/hg38 11q23.3-25(chr11:119433909-134998513)x1 copy number loss See cases [RCV000050905] Chr11:119433909..134998513 [GRCh38]
Chr11:119304619..134868407 [GRCh37]
Chr11:118809829..134373617 [NCBI36]
Chr11:11q23.3-25		 pathogenic
GRCh38/hg38 11q23.3-25(chr11:118789765-134998513)x3 copy number gain See cases [RCV000051213] Chr11:118789765..134998513 [GRCh38]
Chr11:118660474..134868407 [GRCh37]
Chr11:118165684..134373617 [NCBI36]
Chr11:11q23.3-25		 pathogenic
GRCh38/hg38 11q23.3-25(chr11:119215032-134998654)x1 copy number loss See cases [RCV000052715] Chr11:119215032..134998654 [GRCh38]
Chr11:119085742..134868548 [GRCh37]
Chr11:118590952..134373758 [NCBI36]
Chr11:11q23.3-25		 pathogenic
GRCh38/hg38 11q23.3-25(chr11:120507265-134576266)x1 copy number loss See cases [RCV000052716] Chr11:120507265..134576266 [GRCh38]
Chr11:120377974..134446160 [GRCh37]
Chr11:119883184..133951370 [NCBI36]
Chr11:11q23.3-25		 pathogenic
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25		 pathogenic
GRCh38/hg38 11q23.3-25(chr11:120236432-135040246)x3 copy number gain See cases [RCV000053643] Chr11:120236432..135040246 [GRCh38]
Chr11:120107141..134910140 [GRCh37]
Chr11:119612351..134415350 [NCBI36]
Chr11:11q23.3-25		 pathogenic
GRCh38/hg38 11q23.3-24.2(chr11:120426093-124771213)x1 copy number loss See cases [RCV000134405] Chr11:120426093..124771213 [GRCh38]
Chr11:120296802..124641109 [GRCh37]
Chr11:119802012..124146319 [NCBI36]
Chr11:11q23.3-24.2		 pathogenic
GRCh38/hg38 11q23.3-25(chr11:116851372-134998526)x3 copy number gain See cases [RCV000134064] Chr11:116851372..134998526 [GRCh38]
Chr11:116722088..134868420 [GRCh37]
Chr11:116227298..134373630 [NCBI36]
Chr11:11q23.3-25		 pathogenic
GRCh38/hg38 11q24.1-24.2(chr11:122182443-125957977)x1 copy number loss See cases [RCV000136594] Chr11:122182443..125957977 [GRCh38]
Chr11:122053151..125827872 [GRCh37]
Chr11:121558361..125333082 [NCBI36]
Chr11:11q24.1-24.2		 pathogenic
GRCh38/hg38 11q23.2-25(chr11:112864326-131189315)x3 copy number gain See cases [RCV000137582] Chr11:112864326..131189315 [GRCh38]
Chr11:112832130..131059210 [GRCh37]
Chr11:112240259..130564420 [NCBI36]
Chr11:11q23.2-25		 pathogenic
GRCh38/hg38 11q23.3-25(chr11:116868935-135075271)x3 copy number gain See cases [RCV000137453] Chr11:116868935..135075271 [GRCh38]
Chr11:116739651..134945165 [GRCh37]
Chr11:116244861..134450377 [NCBI36]
Chr11:11q23.3-25		 pathogenic|conflicting data from submitters
GRCh38/hg38 11q24.1-25(chr11:121780459-135075271)x1 copy number loss See cases [RCV000138014] Chr11:121780459..135075271 [GRCh38]
Chr11:121651167..134945165 [GRCh37]
Chr11:121156377..134450377 [NCBI36]
Chr11:11q24.1-25		 pathogenic
GRCh38/hg38 11q23.3-25(chr11:120515759-135075271)x1 copy number loss See cases [RCV000138373] Chr11:120515759..135075271 [GRCh38]
Chr11:120386468..134945165 [GRCh37]
Chr11:119891678..134450377 [NCBI36]
Chr11:11q23.3-25		 pathogenic
GRCh38/hg38 11q23.3-25(chr11:116806268-135075271)x3 copy number gain See cases [RCV000138307] Chr11:116806268..135075271 [GRCh38]
Chr11:116676984..134945165 [GRCh37]
Chr11:116182194..134450377 [NCBI36]
Chr11:11q23.3-25		 pathogenic
GRCh38/hg38 11q23.3-24.2(chr11:117333952-127709156)x3 copy number gain See cases [RCV000139362] Chr11:117333952..127709156 [GRCh38]
Chr11:117204668..127579051 [GRCh37]
Chr11:116709878..127084261 [NCBI36]
Chr11:11q23.3-24.2		 pathogenic
GRCh38/hg38 11q23.3-25(chr11:119424297-135075271)x1 copy number loss See cases [RCV000138947] Chr11:119424297..135075271 [GRCh38]
Chr11:119295007..134945165 [GRCh37]
Chr11:118800217..134450377 [NCBI36]
Chr11:11q23.3-25		 pathogenic|likely benign
GRCh38/hg38 11q23.3-24.2(chr11:120080142-125829106)x1 copy number loss See cases [RCV000140070] Chr11:120080142..125829106 [GRCh38]
Chr11:119950851..125699001 [GRCh37]
Chr11:119456061..125204211 [NCBI36]
Chr11:11q23.3-24.2		 pathogenic
GRCh38/hg38 11q24.1-25(chr11:121689052-135075271)x1 copy number loss See cases [RCV000139622] Chr11:121689052..135075271 [GRCh38]
Chr11:121559760..134945165 [GRCh37]
Chr11:121064970..134450377 [NCBI36]
Chr11:11q24.1-25		 pathogenic|likely benign
GRCh38/hg38 11q24.1-25(chr11:121806547-135068576)x1 copy number loss See cases [RCV000142210] Chr11:121806547..135068576 [GRCh38]
Chr11:121677255..134938470 [GRCh37]
Chr11:121182465..134443680 [NCBI36]
Chr11:11q24.1-25		 pathogenic
GRCh38/hg38 11q24.1-25(chr11:121611476-135068576)x1 copy number loss See cases [RCV000142185] Chr11:121611476..135068576 [GRCh38]
Chr11:121482185..134938470 [GRCh37]
Chr11:120987395..134443680 [NCBI36]
Chr11:11q24.1-25		 pathogenic
GRCh38/hg38 11q23.3-25(chr11:116851395-134998513)x3 copy number gain See cases [RCV000148276] Chr11:116851395..134998513 [GRCh38]
Chr11:116722111..134868407 [GRCh37]
Chr11:116227321..134373617 [NCBI36]
Chr11:11q23.3-25		 pathogenic
GRCh37/hg19 11q23.3-25(chr11:119807473-134868407)x1 copy number loss See cases [RCV000240237] Chr11:119807473..134868407 [GRCh37]
Chr11:11q23.3-25		 pathogenic
GRCh37/hg19 11q23.3-25(chr11:120615374-134868407)x1 copy number loss See cases [RCV000239781] Chr11:120615374..134868407 [GRCh37]
Chr11:11q23.3-25		 pathogenic
GRCh37/hg19 11q24.1-25(chr11:121416261-134938470)x1 copy number loss See cases [RCV000511335] Chr11:121416261..134938470 [GRCh37]
Chr11:11q24.1-25		 pathogenic
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
GRCh37/hg19 11q23.3-25(chr11:116691675-134889485) copy number gain not provided [RCV000767667] Chr11:116691675..134889485 [GRCh37]
Chr11:11q23.3-25		 pathogenic
GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3 copy number gain See cases [RCV000449449] Chr11:116681007..134938470 [GRCh37]
Chr11:11q23.3-25		 pathogenic
GRCh37/hg19 11q23.3-25(chr11:119513909-134938470)x1 copy number loss See cases [RCV000447077] Chr11:119513909..134938470 [GRCh37]
Chr11:11q23.3-25		 pathogenic
GRCh37/hg19 11q24.1-25(chr11:121501072-134868348)x1 copy number loss See cases [RCV000445814] Chr11:121501072..134868348 [GRCh37]
Chr11:11q24.1-25		 pathogenic
GRCh37/hg19 11q23.3-25(chr11:116684163-134938470)x3 copy number gain See cases [RCV000447848] Chr11:116684163..134938470 [GRCh37]
Chr11:11q23.3-25		 pathogenic
GRCh37/hg19 11q24.1-25(chr11:121559102-134938470)x1 copy number loss See cases [RCV000449003] Chr11:121559102..134938470 [GRCh37]
Chr11:11q24.1-25		 pathogenic
GRCh37/hg19 11q24.1-25(chr11:122403610-134938470)x1 copy number loss See cases [RCV000448215] Chr11:122403610..134938470 [GRCh37]
Chr11:11q24.1-25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q24.1-25(chr11:122884694-134938470)x3 copy number gain See cases [RCV000511146] Chr11:122884694..134938470 [GRCh37]
Chr11:11q24.1-25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q23.3-25(chr11:120527021-134938470)x1 copy number loss See cases [RCV000511283] Chr11:120527021..134938470 [GRCh37]
Chr11:11q23.3-25		 pathogenic
GRCh37/hg19 11q23.3-25(chr11:121136603-134938470)x1 copy number loss See cases [RCV000510856] Chr11:121136603..134938470 [GRCh37]
Chr11:11q23.3-25		 pathogenic
GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3 copy number gain See cases [RCV000512291] Chr11:116681007..134938470 [GRCh37]
Chr11:11q23.3-25		 pathogenic
GRCh37/hg19 11q23.3-25(chr11:119538664-134938470)x1 copy number loss not provided [RCV000683371] Chr11:119538664..134938470 [GRCh37]
Chr11:11q23.3-25		 pathogenic
GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3 copy number gain not provided [RCV000683373] Chr11:116681007..134938470 [GRCh37]
Chr11:11q23.3-25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
Single allele duplication Schizophrenia [RCV000754124] Chr11:118989374..135076622 [GRCh38]
Chr11:11q23.3-25		 likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q23.3-25(chr11:116697066-134934063)x3 copy number gain not provided [RCV000737686] Chr11:116697066..134934063 [GRCh37]
Chr11:11q23.3-25		 pathogenic
NM_006597.6(HSPA8):c.375A>G (p.Thr125=) single nucleotide variant not provided [RCV000965857] Chr11:123060629 [GRCh38]
Chr11:122931337 [GRCh37]
Chr11:11q24.1		 benign
NM_006597.6(HSPA8):c.333C>G (p.Thr111=) single nucleotide variant not provided [RCV000905420] Chr11:123060671 [GRCh38]
Chr11:122931379 [GRCh37]
Chr11:11q24.1		 benign
NM_006597.6(HSPA8):c.1074A>G (p.Glu358=) single nucleotide variant not provided [RCV000968241] Chr11:123059519 [GRCh38]
Chr11:122930227 [GRCh37]
Chr11:11q24.1		 benign
GRCh37/hg19 11q23.3-25(chr11:116700253-134904063) copy number gain not provided [RCV000767816] Chr11:116700253..134904063 [GRCh37]
Chr11:11q23.3-25		 pathogenic
GRCh37/hg19 11q23.3-25(chr11:117830263-134938470)x3 copy number gain not provided [RCV000848151] Chr11:117830263..134938470 [GRCh37]
Chr11:11q23.3-25		 pathogenic
GRCh37/hg19 11q23.3-25(chr11:120576984-134934063)x1 copy number loss See cases [RCV000790567] Chr11:120576984..134934063 [GRCh37]
Chr11:11q23.3-25		 pathogenic
GRCh37/hg19 11q23.3-25(chr11:120742540-134938470)x1 copy number loss not provided [RCV001006452] Chr11:120742540..134938470 [GRCh37]
Chr11:11q23.3-25		 pathogenic
NM_006597.6(HSPA8):c.1005C>T (p.Val335=) single nucleotide variant not provided [RCV000974107] Chr11:123059588 [GRCh38]
Chr11:122930296 [GRCh37]
Chr11:11q24.1		 benign
GRCh37/hg19 11q23.3-25(chr11:120531028-134257553) copy number loss 11q partial monosomy syndrome [RCV003236728] Chr11:120531028..134257553 [GRCh37]
Chr11:11q23.3-25		 pathogenic
Single allele deletion Short stature [RCV001003892] Chr11:114433313..131230466 [GRCh37]
Chr11:11q23.2-25		 likely pathogenic
NC_000011.9:g.104288964_134937416dup duplication Distal trisomy 11q [RCV001250234] Chr11:104288964..134937416 [GRCh37]
Chr11:11q22.3-25		 pathogenic
GRCh37/hg19 11q23.1-24.3(chr11:112375478-128785742)x3 copy number gain not provided [RCV001829187] Chr11:112375478..128785742 [GRCh37]
Chr11:11q23.1-24.3		 pathogenic
Single allele duplication not provided [RCV002227754] Chr11:122413116..123669322 [GRCh38]
Chr11:11q24.1		 uncertain significance
NM_006597.6(HSPA8):c.842G>A (p.Ser281Asn) single nucleotide variant Inborn genetic diseases [RCV002773307] Chr11:123059751 [GRCh38]
Chr11:122930459 [GRCh37]
Chr11:11q24.1		 uncertain significance
NM_006597.6(HSPA8):c.787C>T (p.Leu263Phe) single nucleotide variant Inborn genetic diseases [RCV002773617] Chr11:123059806 [GRCh38]
Chr11:122930514 [GRCh37]
Chr11:11q24.1		 uncertain significance
NM_006597.6(HSPA8):c.1384A>G (p.Thr462Ala) single nucleotide variant Inborn genetic diseases [RCV002983999] Chr11:123058770 [GRCh38]
Chr11:122929478 [GRCh37]
Chr11:11q24.1		 uncertain significance
NM_006597.6(HSPA8):c.422A>G (p.Asn141Ser) single nucleotide variant Inborn genetic diseases [RCV002814168] Chr11:123060258 [GRCh38]
Chr11:122930966 [GRCh37]
Chr11:11q24.1		 uncertain significance
NM_006597.6(HSPA8):c.1874T>A (p.Phe625Tyr) single nucleotide variant Inborn genetic diseases [RCV003204249] Chr11:123057801 [GRCh38]
Chr11:122928509 [GRCh37]
Chr11:11q24.1		 uncertain significance
Single allele duplication not provided [RCV003448710] Chr11:102134973..134945611 [GRCh37]
Chr11:11q22.2-25		 pathogenic
GRCh37/hg19 11q23.3-24.2(chr11:121183636-127620828)x1 copy number loss not specified [RCV003986915] Chr11:121183636..127620828 [GRCh37]
Chr11:11q23.3-24.2		 pathogenic
GRCh37/hg19 11q24.1-25(chr11:121423232-134938470)x1 copy number loss not specified [RCV003986923] Chr11:121423232..134938470 [GRCh37]
Chr11:11q24.1-25		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3228
Count of miRNA genes:963
Interacting mature miRNAs:1177
Transcripts:ENST00000227378, ENST00000453788, ENST00000524552, ENST00000524590, ENST00000525463, ENST00000525624, ENST00000526110, ENST00000526686, ENST00000526862, ENST00000527387, ENST00000527983, ENST00000528292, ENST00000530391, ENST00000531063, ENST00000532091, ENST00000532167, ENST00000532182, ENST00000532636, ENST00000532780, ENST00000533238, ENST00000533540, ENST00000534319, ENST00000534567, ENST00000534624
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
HSPA8  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711122,927,754 - 122,928,382UniSTSGRCh37
Build 3611122,432,964 - 122,433,592RGDNCBI36
Celera11120,087,083 - 120,087,711RGD
Cytogenetic Map11q24.1UniSTS
HuRef5124,668,546 - 124,668,765UniSTS
HuRef11118,869,832 - 118,870,460UniSTS
GeneMap99-GB4 RH Map11373.28UniSTS
RH27394  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711122,928,271 - 122,928,441UniSTSGRCh37
Build 3611122,433,481 - 122,433,651RGDNCBI36
Celera11120,087,600 - 120,087,770RGD
Cytogenetic Map11q24.1UniSTS
Cytogenetic Map11q23.3-q25UniSTS
HuRef11118,870,349 - 118,870,519UniSTS
RH104170  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711122,933,797 - 122,933,916UniSTSGRCh37
Build 3611122,439,007 - 122,439,126RGDNCBI36
Celera11120,093,126 - 120,093,245RGD
Cytogenetic Map11q24.1UniSTS
HuRef11118,875,876 - 118,875,995UniSTS
GeneMap99-GB4 RH Map11410.2UniSTS
WI-12733  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711122,928,778 - 122,928,927UniSTSGRCh37
Build 3611122,433,988 - 122,434,137RGDNCBI36
Celera11120,088,107 - 120,088,256RGD
Cytogenetic Map11q24.1UniSTS
Cytogenetic Map11q23.3-q25UniSTS
HuRef11118,870,856 - 118,871,005UniSTS
GeneMap99-GB4 RH Map11410.2UniSTS
Whitehead-RH Map11573.8UniSTS
NCBI RH Map111052.1UniSTS
SHGC-8077  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q24.1UniSTS
SHGC-8020  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q24.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 139 71 92 30 538 31 272 103 219 68 185 275 8 28 45 2
Medium 2293 2912 1631 592 1410 433 4084 2090 3490 348 1263 1333 163 1176 2743 2
Low 7 8 3 2 2 1 4 25 3 12 5 4 1 2 2
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_153201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011542798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054368614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB034951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB073886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF217511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF352832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK000571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC312904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC395565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU668349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ224294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S72464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000227378   ⟹   ENSP00000227378
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,057,497 - 123,061,332 (-)Ensembl
RefSeq Acc Id: ENST00000453788   ⟹   ENSP00000404372
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,057,489 - 123,062,335 (-)Ensembl
RefSeq Acc Id: ENST00000524552   ⟹   ENSP00000435908
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,057,779 - 123,059,448 (-)Ensembl
RefSeq Acc Id: ENST00000524590   ⟹   ENSP00000434565
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,060,593 - 123,062,032 (-)Ensembl
RefSeq Acc Id: ENST00000525463   ⟹   ENSP00000436762
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,059,965 - 123,062,136 (-)Ensembl
RefSeq Acc Id: ENST00000525624   ⟹   ENSP00000435154
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,060,118 - 123,063,230 (-)Ensembl
RefSeq Acc Id: ENST00000526110   ⟹   ENSP00000433584
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,057,701 - 123,061,331 (-)Ensembl
RefSeq Acc Id: ENST00000526686   ⟹   ENSP00000435019
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,057,879 - 123,059,097 (-)Ensembl
RefSeq Acc Id: ENST00000526862
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,059,156 - 123,060,223 (-)Ensembl
RefSeq Acc Id: ENST00000527387   ⟹   ENSP00000436183
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,060,146 - 123,062,352 (-)Ensembl
RefSeq Acc Id: ENST00000527983
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,059,233 - 123,062,207 (-)Ensembl
RefSeq Acc Id: ENST00000528292   ⟹   ENSP00000432884
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,059,476 - 123,062,124 (-)Ensembl
RefSeq Acc Id: ENST00000530391   ⟹   ENSP00000434851
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,060,607 - 123,061,833 (-)Ensembl
RefSeq Acc Id: ENST00000531063
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,060,825 - 123,062,136 (-)Ensembl
RefSeq Acc Id: ENST00000532091
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,057,496 - 123,060,426 (-)Ensembl
RefSeq Acc Id: ENST00000532167
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,059,982 - 123,062,136 (-)Ensembl
RefSeq Acc Id: ENST00000532182   ⟹   ENSP00000434415
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,060,165 - 123,062,022 (-)Ensembl
RefSeq Acc Id: ENST00000532636   ⟹   ENSP00000437125
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,057,489 - 123,061,789 (-)Ensembl
RefSeq Acc Id: ENST00000532780
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,059,814 - 123,062,669 (-)Ensembl
RefSeq Acc Id: ENST00000533238
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,058,791 - 123,062,139 (-)Ensembl
RefSeq Acc Id: ENST00000533540   ⟹   ENSP00000437189
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,057,489 - 123,062,136 (-)Ensembl
RefSeq Acc Id: ENST00000534319   ⟹   ENSP00000433316
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,057,498 - 123,060,386 (-)Ensembl
RefSeq Acc Id: ENST00000534567   ⟹   ENSP00000431641
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,060,129 - 123,061,483 (-)Ensembl
RefSeq Acc Id: ENST00000534624   ⟹   ENSP00000432083
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11123,057,489 - 123,062,136 (-)Ensembl
RefSeq Acc Id: NM_006597   ⟹   NP_006588
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811123,057,489 - 123,062,136 (-)NCBI
GRCh3711122,928,200 - 122,933,074 (-)NCBI
Build 3611122,433,410 - 122,438,054 (-)NCBI Archive
HuRef11118,870,278 - 118,875,122 (-)NCBI
CHM1_111122,814,192 - 122,819,035 (-)NCBI
T2T-CHM13v2.011123,086,071 - 123,090,720 (-)NCBI
Sequence:
RefSeq Acc Id: NM_153201   ⟹   NP_694881
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811123,057,489 - 123,062,136 (-)NCBI
GRCh3711122,928,200 - 122,933,074 (-)NCBI
Build 3611122,433,410 - 122,438,054 (-)NCBI Archive
HuRef11118,870,278 - 118,875,122 (-)NCBI
CHM1_111122,814,192 - 122,819,035 (-)NCBI
T2T-CHM13v2.011123,086,071 - 123,090,720 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011542798   ⟹   XP_011541100
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811123,057,489 - 123,062,462 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054368614   ⟹   XP_054224589
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.011123,086,071 - 123,093,285 (-)NCBI
Protein Sequences
Protein RefSeqs NP_006588 (Get FASTA)   NCBI Sequence Viewer  
  NP_694881 (Get FASTA)   NCBI Sequence Viewer  
  XP_011541100 (Get FASTA)   NCBI Sequence Viewer  
  XP_054224589 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF67622 (Get FASTA)   NCBI Sequence Viewer  
  AAH07276 (Get FASTA)   NCBI Sequence Viewer  
  AAH08907 (Get FASTA)   NCBI Sequence Viewer  
  AAH15699 (Get FASTA)   NCBI Sequence Viewer  
  AAH16179 (Get FASTA)   NCBI Sequence Viewer  
  AAH16660 (Get FASTA)   NCBI Sequence Viewer  
  AAH19816 (Get FASTA)   NCBI Sequence Viewer  
  AAK17898 (Get FASTA)   NCBI Sequence Viewer  
  ACF94502 (Get FASTA)   NCBI Sequence Viewer  
  ACI45986 (Get FASTA)   NCBI Sequence Viewer  
  ADO22186 (Get FASTA)   NCBI Sequence Viewer  
  ADO22260 (Get FASTA)   NCBI Sequence Viewer  
  BAA91262 (Get FASTA)   NCBI Sequence Viewer  
  BAB18615 (Get FASTA)   NCBI Sequence Viewer  
  BAD96348 (Get FASTA)   NCBI Sequence Viewer  
  BAD96505 (Get FASTA)   NCBI Sequence Viewer  
  BAF84756 (Get FASTA)   NCBI Sequence Viewer  
  BAG53212 (Get FASTA)   NCBI Sequence Viewer  
  BAG62134 (Get FASTA)   NCBI Sequence Viewer  
  BAG64863 (Get FASTA)   NCBI Sequence Viewer  
  CAA68445 (Get FASTA)   NCBI Sequence Viewer  
  EAW67539 (Get FASTA)   NCBI Sequence Viewer  
  EAW67540 (Get FASTA)   NCBI Sequence Viewer  
  EAW67541 (Get FASTA)   NCBI Sequence Viewer  
  EAW67542 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000227378.3
  ENSP00000404372
  ENSP00000404372.2
  ENSP00000431641.1
  ENSP00000432083
  ENSP00000432083.1
  ENSP00000432884.1
  ENSP00000433316.1
  ENSP00000433584.1
  ENSP00000434415.1
  ENSP00000434565.1
  ENSP00000434851.1
  ENSP00000435019.1
  ENSP00000435154.1
  ENSP00000435908.1
  ENSP00000436183.1
  ENSP00000436762.1
  ENSP00000437125.1
  ENSP00000437189.1
GenBank Protein P11142 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_694881   ⟸   NM_153201
- Peptide Label: isoform 2
- UniProtKB: Q53HF2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_006588   ⟸   NM_006597
- Peptide Label: isoform 1
- UniProtKB: Q9H3R6 (UniProtKB/Swiss-Prot),   P11142 (UniProtKB/Swiss-Prot),   V9HW22 (UniProtKB/TrEMBL),   Q53GZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011541100   ⟸   XM_011542798
- Peptide Label: isoform X1
- UniProtKB: Q9H3R6 (UniProtKB/Swiss-Prot),   P11142 (UniProtKB/Swiss-Prot),   V9HW22 (UniProtKB/TrEMBL),   Q53GZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000227378   ⟸   ENST00000227378
RefSeq Acc Id: ENSP00000434851   ⟸   ENST00000530391
RefSeq Acc Id: ENSP00000404372   ⟸   ENST00000453788
RefSeq Acc Id: ENSP00000434415   ⟸   ENST00000532182
RefSeq Acc Id: ENSP00000437125   ⟸   ENST00000532636
RefSeq Acc Id: ENSP00000437189   ⟸   ENST00000533540
RefSeq Acc Id: ENSP00000432083   ⟸   ENST00000534624
RefSeq Acc Id: ENSP00000431641   ⟸   ENST00000534567
RefSeq Acc Id: ENSP00000433316   ⟸   ENST00000534319
RefSeq Acc Id: ENSP00000434565   ⟸   ENST00000524590
RefSeq Acc Id: ENSP00000435908   ⟸   ENST00000524552
RefSeq Acc Id: ENSP00000435154   ⟸   ENST00000525624
RefSeq Acc Id: ENSP00000436762   ⟸   ENST00000525463
RefSeq Acc Id: ENSP00000433584   ⟸   ENST00000526110
RefSeq Acc Id: ENSP00000435019   ⟸   ENST00000526686
RefSeq Acc Id: ENSP00000436183   ⟸   ENST00000527387
RefSeq Acc Id: ENSP00000432884   ⟸   ENST00000528292
RefSeq Acc Id: XP_054224589   ⟸   XM_054368614
- Peptide Label: isoform X1
- UniProtKB: Q9H3R6 (UniProtKB/Swiss-Prot),   P11142 (UniProtKB/Swiss-Prot),   V9HW22 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11142-F1-model_v2 AlphaFold P11142 1-646 view protein structure

Promoters
RGD ID:6788993
Promoter ID:HG_KWN:14443
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   Lymphoblastoid,   NB4
Transcripts:UC009ZBC.1
Position:
Human AssemblyChrPosition (strand)Source
Build 3611122,436,211 - 122,436,852 (-)MPROMDB
RGD ID:6789017
Promoter ID:HG_KWN:14444
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000392773,   NM_006597,   NM_153201,   UC009ZBD.1
Position:
Human AssemblyChrPosition (strand)Source
Build 3611122,437,971 - 122,439,042 (-)MPROMDB
RGD ID:6850316
Promoter ID:EP17089
Type:single initiation site
Name:HS_HSPA8
Description:Heat shock 70kD protein 8.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 114; Mammalian, avian HSP70 family.
Tissues & Cell Lines:constitutive
Experiment Methods:Primer extension; NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 3611122,438,054 - 122,438,114EPD
RGD ID:7222469
Promoter ID:EPDNEW_H16980
Type:initiation region
Name:HSPA8_2
Description:heat shock protein family A member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16981  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811123,061,254 - 123,061,314EPDNEW
RGD ID:7222471
Promoter ID:EPDNEW_H16981
Type:initiation region
Name:HSPA8_1
Description:heat shock protein family A member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16980  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811123,062,136 - 123,062,196EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5241 AgrOrtholog
COSMIC HSPA8 COSMIC
Ensembl Genes ENSG00000109971 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000227378.7 UniProtKB/Swiss-Prot
  ENST00000453788 ENTREZGENE
  ENST00000453788.6 UniProtKB/Swiss-Prot
  ENST00000524552.5 UniProtKB/TrEMBL
  ENST00000524590.5 UniProtKB/TrEMBL
  ENST00000525463.5 UniProtKB/TrEMBL
  ENST00000525624.5 UniProtKB/TrEMBL
  ENST00000526110.5 UniProtKB/TrEMBL
  ENST00000526686.1 UniProtKB/TrEMBL
  ENST00000527387.5 UniProtKB/TrEMBL
  ENST00000528292.5 UniProtKB/TrEMBL
  ENST00000530391.1 UniProtKB/TrEMBL
  ENST00000532182.5 UniProtKB/TrEMBL
  ENST00000532636.5 UniProtKB/Swiss-Prot
  ENST00000533540.5 UniProtKB/TrEMBL
  ENST00000534319.5 UniProtKB/TrEMBL
  ENST00000534567.5 UniProtKB/TrEMBL
  ENST00000534624 ENTREZGENE
  ENST00000534624.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.30.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000109971 GTEx
HGNC ID HGNC:5241 ENTREZGENE
Human Proteome Map HSPA8 Human Proteome Map
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3312 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 3312 ENTREZGENE
OMIM 600816 OMIM
PANTHER HEAT SHOCK COGNATE 71 KDA PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29507 PharmGKB
PRINTS HEATSHOCK70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HSP70_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K7Q2_HUMAN UniProtKB/TrEMBL
  E9PI65_HUMAN UniProtKB/TrEMBL
  E9PK54_HUMAN UniProtKB/TrEMBL
  E9PKE3_HUMAN UniProtKB/TrEMBL
  E9PLF4_HUMAN UniProtKB/TrEMBL
  E9PM13_HUMAN UniProtKB/TrEMBL
  E9PN25_HUMAN UniProtKB/TrEMBL
  E9PN89_HUMAN UniProtKB/TrEMBL
  E9PNE6_HUMAN UniProtKB/TrEMBL
  E9PPY6_HUMAN UniProtKB/TrEMBL
  E9PQK7_HUMAN UniProtKB/TrEMBL
  E9PQQ4_HUMAN UniProtKB/TrEMBL
  E9PS65_HUMAN UniProtKB/TrEMBL
  HSP7C_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q53GZ6 ENTREZGENE, UniProtKB/TrEMBL
  Q53HF2 ENTREZGENE, UniProtKB/TrEMBL
  Q96H53_HUMAN UniProtKB/TrEMBL
  Q96IS6_HUMAN UniProtKB/TrEMBL
  Q9H3R6 ENTREZGENE
  V9HW22 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q9H3R6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 HSPA8  heat shock protein family A (Hsp70) member 8    heat shock 70kDa protein 8  Symbol and/or name change 5135510 APPROVED