HSPA8 (heat shock protein family A (Hsp70) member 8) - Rat Genome Database

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Gene: HSPA8 (heat shock protein family A (Hsp70) member 8) Homo sapiens
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Symbol: HSPA8
Name: heat shock protein family A (Hsp70) member 8
RGD ID: 736219
HGNC Page HGNC
Description: Enables several functions, including ATP binding activity; C3HC4-type RING finger domain binding activity; and chaperone binding activity. Involved in several processes, including protein refolding; protein targeting to lysosome involved in chaperone-mediated autophagy; and regulation of protein stability. Located in cytosol; extracellular exosome; and nucleus. Part of Prp19 complex; chaperone complex; and ribonucleoprotein complex. Implicated in Parkinson's disease and renal hypertension. Biomarker of several diseases, including Parkinson's disease; cervical cancer; colorectal cancer; hypertension; and multiple sclerosis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: constitutive heat shock protein 70; epididymis luminal protein 33; epididymis secretory sperm binding protein Li 72p; heat shock 70kd protein 10; heat shock 70kD protein 8; heat shock 70kDa protein 8; heat shock cognate 71 kDa protein; heat shock cognate protein 54; heat shock cognate protein, 71-kDa; heat shock protein 8; HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; LAP-1; LAP1; lipopolysaccharide-associated protein 1; LPS-associated protein 1; MGC131511; MGC29929; N-myristoyltransferase inhibitor protein 71; NIP71
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: HSPA8P1   HSPA8P10   HSPA8P11   HSPA8P12   HSPA8P13   HSPA8P14   HSPA8P15   HSPA8P16   HSPA8P17   HSPA8P18   HSPA8P19   HSPA8P2   HSPA8P20   HSPA8P3   HSPA8P4   HSPA8P5   HSPA8P6   HSPA8P7   HSPA8P8   HSPA8P9   LOC343165  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11123,057,489 - 123,063,230 (-)EnsemblGRCh38hg38GRCh38
GRCh3811123,057,489 - 123,062,366 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711122,928,197 - 122,932,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611122,433,410 - 122,438,054 (-)NCBINCBI36hg18NCBI36
Build 3411122,433,410 - 122,438,054NCBI
Celera11120,087,529 - 120,092,173 (-)NCBI
Cytogenetic Map11q24.1NCBI
HuRef11118,870,278 - 118,875,122 (-)NCBIHuRef
CHM1_111122,814,192 - 122,819,035 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(R)-adrenaline  (ISO)
(S)-amphetamine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methylcholine  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
7H-xanthine  (ISO)
8-Br-cAMP  (EXP)
9H-xanthine  (ISO)
acrolein  (EXP)
acrylamide  (EXP,ISO)
afimoxifene  (EXP)
albendazole  (EXP)
aldrin  (ISO)
all-trans-retinoic acid  (EXP)
alpha-naphthoflavone  (ISO)
alpha-pinene  (EXP)
AM-251  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (EXP)
amphotericin B  (EXP)
antimonite  (EXP)
apigenin  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
astemizole  (ISO)
atrazine  (EXP)
azoxystrobin  (EXP)
bathocuproine disulfonic acid  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (ISO)
bifenthrin  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
casticin  (ISO)
ceruletide  (ISO)
chlordecone  (ISO)
chloromethylisothiazolinone  (EXP)
chloropicrin  (EXP)
chloroprene  (ISO)
chloroquine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
crocidolite asbestos  (EXP)
CU-O LINKAGE  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
Deguelin  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (EXP)
diethyl maleate  (ISO)
dihydroartemisinin  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
disodium selenite  (EXP)
disulfiram  (EXP)
diuron  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
enzyme inhibitor  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
fenofibrate  (ISO)
fenvalerate  (ISO)
ferric oxide  (ISO)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
formetanate  (EXP)
fulvestrant  (EXP)
furan  (ISO)
gallic acid  (EXP)
gamma-poly(L-glutamic acid) macromolecule  (ISO)
gentamycin  (ISO)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hyaluronic acid  (ISO)
hydralazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxyurea  (EXP)
ibuprofen  (EXP)
imipramine  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (EXP,ISO)
iodide salt  (ISO)
ionomycin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isobutanol  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
Licochalcone B  (EXP)
lovastatin  (ISO)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
mercury dichloride  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methomyl  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (EXP)
microcystin-LR  (ISO)
mitomycin C  (EXP)
monocrotaline  (ISO)
morphine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methylformamide  (ISO)
N-nitrosomorpholine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrofurantoin  (ISO)
ochratoxin A  (ISO)
oxidopamine  (EXP,ISO)
ozone  (EXP,ISO)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorododecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phorone  (ISO)
pirimicarb  (EXP)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
Propiverine  (ISO)
prostaglandin A1  (ISO)
pyrimidifen  (EXP)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
quercitrin  (EXP)
quinolin-8-ol  (EXP)
quizartinib  (EXP)
rac-lactic acid  (EXP)
raloxifene  (EXP)
rifampicin  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sarin  (ISO)
sertraline  (EXP,ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (EXP)
thifluzamide  (EXP)
thiostrepton  (EXP)
titanium dioxide  (ISO)
triadimefon  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
triphenylstannane  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)
vorinostat  (EXP)
warfarin  (ISO)
Yessotoxin  (EXP)
zinc pyrithione  (EXP)
zinc sulfate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
ATP metabolic process  (IDA)
axo-dendritic transport  (ISO)
cellular protein complex disassembly  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to heat  (ISO)
cellular response to starvation  (TAS)
cellular response to unfolded protein  (IBA)
cerebellum development  (ISO)
chaperone cofactor-dependent protein refolding  (IBA,ISO)
chaperone-mediated autophagy  (ISO,ISS,TAS)
chaperone-mediated autophagy translocation complex disassembly  (IBA,ISS)
chaperone-mediated protein folding  (ISO)
clathrin coat disassembly  (IEA,ISO)
estrous cycle  (ISO)
forebrain development  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
kidney development  (ISO)
late endosomal microautophagy  (IBA)
maintenance of postsynaptic specialization structure  (ISO)
membrane organization  (TAS)
modulation by host of viral process  (ISO)
mRNA processing  (IEA)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of hydrogen peroxide-induced cell death  (ISO)
negative regulation of supramolecular fiber organization  (IDA)
negative regulation of transcription, DNA-templated  (IDA)
positive regulation by host of viral genome replication  (IEA)
positive regulation of catalytic activity  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of lysosomal membrane permeability  (ISO)
positive regulation of mRNA splicing, via spliceosome  (IEA,ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of protein refolding  (ISO)
positive regulation of proteolysis  (ISO)
positive regulation of T cell mediated cytotoxicity  (ISO)
protein autophosphorylation  (ISO)
protein folding  (ISO,NAS)
protein import into nucleus  (ISO)
protein refolding  (IBA,IDA)
protein targeting to lysosome involved in chaperone-mediated autophagy  (IBA,IMP,TAS)
protein transmembrane import into intracellular organelle  (ISO)
regulation of cell cycle  (IEA,ISO)
regulation of postsynapse organization  (IEA)
regulation of protein complex stability  (ISS)
regulation of protein import  (TAS)
regulation of protein stability  (IMP)
regulation of protein-containing complex assembly  (TAS)
response to activity  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to heat  (ISO)
response to nickel cation  (ISO)
response to odorant  (ISO)
response to progesterone  (ISO)
response to starvation  (ISO)
response to unfolded protein  (NAS)
response to xenobiotic stimulus  (ISO)
RNA splicing  (IEA)
sensory perception of smell  (ISO)
skeletal muscle tissue development  (ISO)
slow axonal transport  (IBA,ISO)
vesicle-mediated transport  (IBA)

Cellular Component
asymmetric synapse  (ISO)
autophagosome  (IBA,ISO)
axon  (ISO)
blood microparticle  (HDA)
cell surface  (ISO)
chaperone complex  (IPI)
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane  (TAS)
cytoplasm  (IBA,ISO)
cytosol  (IBA,IDA,ISO,TAS)
dendrite  (IBA,ISO)
dendritic shaft  (ISO)
dendritic spine  (ISO)
extracellular exosome  (HDA,IDA,ISO)
extracellular region  (TAS)
extracellular space  (HDA)
ficolin-1-rich granule lumen  (TAS)
focal adhesion  (HDA)
glutamatergic synapse  (IEA,ISO)
glycinergic synapse  (IEA,ISO)
intermediate filament  (ISO)
late endosome  (IEA)
lumenal side of lysosomal membrane  (TAS)
lysosomal lumen  (TAS)
lysosomal matrix  (ISO)
lysosomal membrane  (ISO,ISS)
lysosome  (IBA,ISO)
melanosome  (IEA)
membrane  (HDA)
membrane raft  (ISO)
messenger ribonucleoprotein complex  (ISO)
microtubule  (ISO)
neuron projection  (ISO)
neuron spine  (ISO)
neuronal cell body  (ISO)
nucleolus  (IEA)
nucleoplasm  (TAS)
nucleus  (IBA,IDA,ISO)
perikaryon  (ISO)
perinuclear region of cytoplasm  (IEA,ISO)
photoreceptor inner segment  (ISO)
photoreceptor ribbon synapse  (IEA)
plasma membrane  (IBA,TAS)
postsynapse  (ISO)
postsynaptic cytosol  (IBA,ISO)
postsynaptic density  (ISO)
postsynaptic specialization membrane  (IEA,ISO)
presynapse  (ISO)
presynaptic cytosol  (IBA,ISO)
protein-containing complex  (ISO)
Prp19 complex  (IDA)
ribonucleoprotein complex  (IDA)
secretory granule lumen  (TAS)
spliceosomal complex  (IEA)
synaptic vesicle  (ISO)
terminal bouton  (IBA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
1. Alvarez-Erviti L, etal., Arch Neurol. 2010 Dec;67(12):1464-72. Epub 2010 Aug 9.
2. Calabrese V, etal., J Neurochem. 2007 May;101(3):709-17. Epub 2007 Jan 4.
3. Chanarat S and Strasser K, Biochim Biophys Acta. 2013 Oct;1833(10):2126-34. doi: 10.1016/j.bbamcr.2013.05.023. Epub 2013 Jun 3.
4. Chiba S, etal., J Neurol Sci. 2006 Feb 15;241(1-2):39-43. Epub 2005 Nov 21.
5. Cuervo AM and Wong E, Cell Res. 2014 Jan;24(1):92-104. doi: 10.1038/cr.2013.153. Epub 2013 Nov 26.
6. GOA_HUMAN data from the GO Consortium
7. Goral J, etal., Clin Immunol Immunopathol. 1998 Mar;86(3):252-8.
8. Hu BR, etal., J Neurosci. 1998 Jan 15;18(2):625-33.
9. Kocsis J, etal., Cell Stress Chaperones. 2010 Mar;15(2):143-51. Epub 2009 Jul 4.
10. Koga H, etal., J Neurosci. 2011 Dec 14;31(50):18492-505.
11. Komatsuda A, etal., Pathol Int. 1999 Jun;49(6):513-8.
12. Lederman M, etal., Invest Ophthalmol Vis Sci. 2010 Jan;51(1):53-8. Epub 2009 Aug 13.
13. Lee KJ, etal., Cell Stress Chaperones. 2004 Mar;9(1):58-68.
14. Lee MJ, etal., Hum Mol Genet 2003 Aug 1;12(15):1917-25.
15. Lo Bianco C, etal., J Clin Invest. 2008 Sep;118(9):3087-97.
16. Lomnytska MI, etal., Proteomics Clin Appl. 2010 Jan;4(1):17-31. doi: 10.1002/prca.200900086. Epub 2009 Nov 11.
17. Mashukova A, etal., Mol Cell Biol. 2011 Feb;31(4):756-65. Epub 2010 Dec 6.
18. Miyazaki T, etal., J Biol Chem. 2004 Apr 23;279(17):17295-300. Epub 2004 Feb 13.
19. Morita K, etal., Ren Fail. 1995 Jul;17(4):405-19.
20. Oguri M, etal., Mol Med Rep. 2009 Mar-Apr;2(2):205-11. doi: 10.3892/mmr_00000085.
21. Ohguro H, etal., Invest Ophthalmol Vis Sci. 1999 Dec;40(13):3160-7.
22. Pennisi G, etal., Biochem Pharmacol. 2011 Nov 15;82(10):1490-9. Epub 2011 Jul 30.
23. Pipeline to import KEGG annotations from KEGG into RGD
24. Prescott J and Coetzee GA, Cancer Lett. 2006 Jan 8;231(1):12-9.
25. RGD automated import pipeline for gene-chemical interactions
26. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
27. Tessari P, etal., J Proteome Res. 2007 Mar;6(3):976-86.
28. Timofeeva AV, etal., Ann N Y Acad Sci. 2006 Dec;1091:319-35.
29. Xilouri M and Stefanis L, Mol Cell Neurosci. 2015 May;66(Pt A):29-36. doi: 10.1016/j.mcn.2015.01.003. Epub 2015 Feb 25.
30. Zborek A, etal., Histochem Cell Biol. 2002 Oct;118(4):311-9. Epub 2002 Sep 5.
31. Zhang F, etal., J Neurochem. 2006 Jul;98(1):102-12.
32. Zou N, etal., Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2805-13. Epub 2008 Apr 25.
Additional References at PubMed
PMID:1286667   PMID:1586970   PMID:1975516   PMID:2155506   PMID:2799391   PMID:2966179   PMID:3037489   PMID:7545947   PMID:7559589   PMID:7578144   PMID:7639722   PMID:7673249  
PMID:7826371   PMID:7906708   PMID:7954368   PMID:8125298   PMID:8530083   PMID:8663341   PMID:8713105   PMID:8729618   PMID:8892974   PMID:8940078   PMID:9235949   PMID:9269769  
PMID:9305631   PMID:9463375   PMID:9499401   PMID:9675148   PMID:9694898   PMID:9738006   PMID:9774640   PMID:9830037   PMID:9873016   PMID:9920821   PMID:10075921   PMID:10197448  
PMID:10205060   PMID:10330192   PMID:10567422   PMID:10617616   PMID:10625686   PMID:10635329   PMID:10666020   PMID:10671488   PMID:10722728   PMID:10954706   PMID:10964507   PMID:10976766  
PMID:10982807   PMID:11031247   PMID:11093761   PMID:11101529   PMID:11116152   PMID:11146634   PMID:11222862   PMID:11230127   PMID:11241348   PMID:11252894   PMID:11276205   PMID:11297531  
PMID:11500375   PMID:11557750   PMID:11584023   PMID:11679576   PMID:11687574   PMID:11707401   PMID:11707406   PMID:11741305   PMID:11790298   PMID:11909948   PMID:11932435   PMID:12150907  
PMID:12297498   PMID:12356871   PMID:12391170   PMID:12417652   PMID:12421917   PMID:12471035   PMID:12477932   PMID:12481031   PMID:12493773   PMID:12502735   PMID:12517784   PMID:12670868  
PMID:12724406   PMID:12750892   PMID:12832005   PMID:12840151   PMID:12850307   PMID:12874020   PMID:12890148   PMID:14499622   PMID:14532270   PMID:14557246   PMID:14612456   PMID:14684748  
PMID:14702039   PMID:14744259   PMID:14752510   PMID:14760703   PMID:14978028   PMID:14991745   PMID:14993262   PMID:15009096   PMID:15047060   PMID:15048123   PMID:15086793   PMID:15194794  
PMID:15198682   PMID:15215316   PMID:15254225   PMID:15292236   PMID:15302935   PMID:15324660   PMID:15336565   PMID:15344906   PMID:15358145   PMID:15456888   PMID:15489334   PMID:15492215  
PMID:15497503   PMID:15538384   PMID:15592455   PMID:15596450   PMID:15611333   PMID:15625011   PMID:15635413   PMID:15644312   PMID:15647277   PMID:15657067   PMID:15694383   PMID:15708368  
PMID:15795242   PMID:15802566   PMID:15870294   PMID:15936278   PMID:15952740   PMID:15963462   PMID:15972823   PMID:16009940   PMID:16027165   PMID:16037132   PMID:16049941   PMID:16093354  
PMID:16100000   PMID:16169070   PMID:16189514   PMID:16196087   PMID:16207813   PMID:16212417   PMID:16225871   PMID:16236267   PMID:16275660   PMID:16293251   PMID:16335966   PMID:16365278  
PMID:16497536   PMID:16501598   PMID:16502470   PMID:16531398   PMID:16621797   PMID:16696853   PMID:16712842   PMID:16740632   PMID:16777091   PMID:16815975   PMID:16817320   PMID:16857740  
PMID:16903783   PMID:17022977   PMID:17081065   PMID:17110338   PMID:17127076   PMID:17139257   PMID:17178836   PMID:17182002   PMID:17240362   PMID:17272822   PMID:17284448   PMID:17289661  
PMID:17296233   PMID:17332742   PMID:17342744   PMID:17397964   PMID:17400507   PMID:17569659   PMID:17601350   PMID:17620599   PMID:17636261   PMID:17643375   PMID:17683050   PMID:17725712  
PMID:17765891   PMID:17785435   PMID:17876681   PMID:17878160   PMID:17893145   PMID:17929041   PMID:17934269   PMID:17947705   PMID:17954934   PMID:17955473   PMID:17979178   PMID:18094050  
PMID:18097041   PMID:18172692   PMID:18231578   PMID:18261988   PMID:18299791   PMID:18307834   PMID:18320024   PMID:18367605   PMID:18380807   PMID:18408180   PMID:18434395   PMID:18457437  
PMID:18458804   PMID:18493267   PMID:18500754   PMID:18537972   PMID:18550537   PMID:18573886   PMID:18600213   PMID:18635949   PMID:18667436   PMID:18684711   PMID:18685789   PMID:18772114  
PMID:18781797   PMID:18977241   PMID:18988734   PMID:19009367   PMID:19014922   PMID:19019082   PMID:19028452   PMID:19041431   PMID:19056482   PMID:19056867   PMID:19098309   PMID:19110265  
PMID:19148187   PMID:19167051   PMID:19193609   PMID:19199708   PMID:19233847   PMID:19254810   PMID:19275587   PMID:19287380   PMID:19299420   PMID:19321452   PMID:19338310   PMID:19380743  
PMID:19394292   PMID:19397879   PMID:19551494   PMID:19578796   PMID:19654187   PMID:19686046   PMID:19738201   PMID:19800331   PMID:19802014   PMID:19815544   PMID:19826009   PMID:19875381  
PMID:19912576   PMID:19913121   PMID:19931244   PMID:19946888   PMID:20003465   PMID:20018937   PMID:20020773   PMID:20026656   PMID:20029029   PMID:20032463   PMID:20039095   PMID:20053985  
PMID:20084477   PMID:20111909   PMID:20164180   PMID:20176123   PMID:20176811   PMID:20195357   PMID:20300519   PMID:20308691   PMID:20391533   PMID:20457599   PMID:20458337   PMID:20467437  
PMID:20471030   PMID:20473970   PMID:20516061   PMID:20540933   PMID:20618441   PMID:20628086   PMID:20639865   PMID:20642807   PMID:20675402   PMID:20729196   PMID:20804732   PMID:20806039  
PMID:20850016   PMID:20884878   PMID:20890123   PMID:20930503   PMID:20953179   PMID:20972266   PMID:21050049   PMID:21103899   PMID:21139048   PMID:21145461   PMID:21148293   PMID:21150129  
PMID:21182203   PMID:21182205   PMID:21183741   PMID:21231916   PMID:21233200   PMID:21235781   PMID:21319273   PMID:21360678   PMID:21362503   PMID:21382349   PMID:21423176   PMID:21423662  
PMID:21454478   PMID:21487019   PMID:21532586   PMID:21565169   PMID:21565611   PMID:21575865   PMID:21697503   PMID:21719532   PMID:21738476   PMID:21763498   PMID:21832061   PMID:21853274  
PMID:21873635   PMID:21890473   PMID:21900206   PMID:21906983   PMID:21911421   PMID:21942715   PMID:21951318   PMID:21963094   PMID:21987572   PMID:21988832   PMID:22039833   PMID:22053931  
PMID:22074182   PMID:22079093   PMID:22085931   PMID:22090113   PMID:22170045   PMID:22178446   PMID:22234250   PMID:22268729   PMID:22337587   PMID:22365833   PMID:22504172   PMID:22505724  
PMID:22516433   PMID:22536838   PMID:22623428   PMID:22645275   PMID:22658674   PMID:22681889   PMID:22743058   PMID:22776201   PMID:22842575   PMID:22843682   PMID:22863883   PMID:22904065  
PMID:22939629   PMID:22990239   PMID:23000965   PMID:23018488   PMID:23042605   PMID:23065205   PMID:23065523   PMID:23071649   PMID:23084401   PMID:23125841   PMID:23184937   PMID:23217712  
PMID:23224638   PMID:23235156   PMID:23246001   PMID:23272104   PMID:23333597   PMID:23349634   PMID:23376485   PMID:23383273   PMID:23398456   PMID:23414517   PMID:23431407   PMID:23434281  
PMID:23443559   PMID:23455607   PMID:23455922   PMID:23457305   PMID:23482560   PMID:23523103   PMID:23533145   PMID:23539416   PMID:23569223   PMID:23695238   PMID:23703321   PMID:23801752  
PMID:23824909   PMID:23825951   PMID:23865999   PMID:23880665   PMID:23921388   PMID:23948933   PMID:23956138   PMID:23979707   PMID:23990462   PMID:24030972   PMID:24056538   PMID:24122553  
PMID:24136289   PMID:24147044   PMID:24169447   PMID:24175631   PMID:24189400   PMID:24239288   PMID:24244333   PMID:24260102   PMID:24318877   PMID:24327656   PMID:24332808   PMID:24361989  
PMID:24386440   PMID:24457600   PMID:24462114   PMID:24510904   PMID:24515614   PMID:24548631   PMID:24550385   PMID:24625528   PMID:24657165   PMID:24658140   PMID:24718257   PMID:24736948  
PMID:24740910   PMID:24787902   PMID:24801886   PMID:24816145   PMID:24891511   PMID:24947832   PMID:25015289   PMID:25036637   PMID:25144556   PMID:25147182   PMID:25178676   PMID:25192599  
PMID:25202009   PMID:25258038   PMID:25281747   PMID:25324306   PMID:25330109   PMID:25352667   PMID:25402006   PMID:25416956   PMID:25437307   PMID:25451919   PMID:25458010   PMID:25468996  
PMID:25496916   PMID:25499913   PMID:25502805   PMID:25527454   PMID:25535373   PMID:25609649   PMID:25640309   PMID:25670202   PMID:25684577   PMID:25719862   PMID:25737151   PMID:25756610  
PMID:25760597   PMID:25864199   PMID:25882706   PMID:25910212   PMID:25921289   PMID:25944111   PMID:25953005   PMID:25959826   PMID:25963833   PMID:26010904   PMID:26115316   PMID:26186194  
PMID:26209609   PMID:26212789   PMID:26217791   PMID:26229111   PMID:26232501   PMID:26264872   PMID:26335814   PMID:26344197   PMID:26425554   PMID:26446488   PMID:26460568   PMID:26481195  
PMID:26496610   PMID:26499835   PMID:26526034   PMID:26549023   PMID:26549849   PMID:26561776   PMID:26596547   PMID:26618866   PMID:26638075   PMID:26641092   PMID:26643866   PMID:26657153  
PMID:26687479   PMID:26693507   PMID:26725010   PMID:26735018   PMID:26752685   PMID:26775844   PMID:26831064   PMID:26871637   PMID:26972000   PMID:27025967   PMID:27103069   PMID:27107014  
PMID:27129234   PMID:27129302   PMID:27158335   PMID:27183383   PMID:27217568   PMID:27225940   PMID:27248496   PMID:27261198   PMID:27283392   PMID:27375898   PMID:27437069   PMID:27462432  
PMID:27474739   PMID:27477512   PMID:27483141   PMID:27545878   PMID:27591049   PMID:27593939   PMID:27637333   PMID:27664236   PMID:27684187   PMID:27708256   PMID:27709416   PMID:27916661  
PMID:27976729   PMID:27998983   PMID:28025138   PMID:28026090   PMID:28065597   PMID:28117675   PMID:28137758   PMID:28215707   PMID:28225217   PMID:28302793   PMID:28320779   PMID:28356524  
PMID:28366632   PMID:28396517   PMID:28416769   PMID:28443643   PMID:28465257   PMID:28514442   PMID:28515276   PMID:28533407   PMID:28559423   PMID:28561026   PMID:28581483   PMID:28603283  
PMID:28685749   PMID:28731191   PMID:28814508   PMID:28855508   PMID:28927264   PMID:28977666   PMID:28978466   PMID:29104064   PMID:29107085   PMID:29111377   PMID:29117863   PMID:29180285  
PMID:29180619   PMID:29218503   PMID:29228324   PMID:29229926   PMID:29242247   PMID:29298432   PMID:29298892   PMID:29300467   PMID:29317501   PMID:29331416   PMID:29408378   PMID:29449217  
PMID:29467282   PMID:29507755   PMID:29519959   PMID:29531219   PMID:29563501   PMID:29564676   PMID:29568061   PMID:29601588   PMID:29615496   PMID:29665387   PMID:29676528   PMID:29721183  
PMID:29735542   PMID:29764935   PMID:29777862   PMID:29791506   PMID:29844126   PMID:29845934   PMID:29859926   PMID:29863498   PMID:29872149   PMID:29875314   PMID:29884807   PMID:29930177  
PMID:29969578   PMID:30009671   PMID:30021884   PMID:30135474   PMID:30209976   PMID:30258100   PMID:30309841   PMID:30349055   PMID:30404004   PMID:30442662   PMID:30455355   PMID:30459231  
PMID:30463901   PMID:30532072   PMID:30559338   PMID:30559450   PMID:30575818   PMID:30591555   PMID:30607818   PMID:30699358   PMID:30711629   PMID:30719818   PMID:30737378   PMID:30745168  
PMID:30792309   PMID:30804502   PMID:30809309   PMID:30816582   PMID:30940648   PMID:30948266   PMID:30997501   PMID:31005254   PMID:31010829   PMID:31027880   PMID:31046837   PMID:31048545  
PMID:31059266   PMID:31073027   PMID:31091453   PMID:31152661   PMID:31180492   PMID:31205025   PMID:31221799   PMID:31239290   PMID:31253590   PMID:31273097   PMID:31276277   PMID:31300519  
PMID:31353912   PMID:31408507   PMID:31501420   PMID:31504778   PMID:31527668   PMID:31536960   PMID:31586073   PMID:31597739   PMID:31620119   PMID:31663379   PMID:31665637   PMID:31669268  
PMID:31792442   PMID:31796584   PMID:31797533   PMID:31901637   PMID:31980649   PMID:31992359   PMID:31995728   PMID:32041737   PMID:32129710   PMID:32162334   PMID:32176739   PMID:32205407  
PMID:32206096   PMID:32296183   PMID:32322062   PMID:32360748   PMID:32382008   PMID:32457219   PMID:32490574   PMID:32529326   PMID:32552912   PMID:32572027   PMID:32645369   PMID:32687490  
PMID:32712350   PMID:32723828   PMID:32751253   PMID:32783943   PMID:32786267   PMID:32807901   PMID:32814053   PMID:32850835   PMID:32888949   PMID:32905556   PMID:32908313   PMID:32929329  
PMID:32989256   PMID:32994395   PMID:33022573   PMID:33024031   PMID:33077711   PMID:33087562   PMID:33139698   PMID:33186656   PMID:33194618   PMID:33306668   PMID:33320087   PMID:33390792  
PMID:33493517   PMID:33845483   PMID:33857403   PMID:33887528   PMID:33926391   PMID:33957083   PMID:34079125  


Genomics

Comparative Map Data
HSPA8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11123,057,489 - 123,063,230 (-)EnsemblGRCh38hg38GRCh38
GRCh3811123,057,489 - 123,062,366 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711122,928,197 - 122,932,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611122,433,410 - 122,438,054 (-)NCBINCBI36hg18NCBI36
Build 3411122,433,410 - 122,438,054NCBI
Celera11120,087,529 - 120,092,173 (-)NCBI
Cytogenetic Map11q24.1NCBI
HuRef11118,870,278 - 118,875,122 (-)NCBIHuRef
CHM1_111122,814,192 - 122,819,035 (-)NCBICHM1_1
Hspa8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39940,712,572 - 40,716,498 (+)NCBIGRCm39mm39
GRCm39 Ensembl940,712,280 - 40,721,383 (+)Ensembl
GRCm38940,801,276 - 40,805,202 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl940,800,984 - 40,810,087 (+)EnsemblGRCm38mm10GRCm38
MGSCv37940,609,356 - 40,613,282 (+)NCBIGRCm37mm9NCBIm37
MGSCv3658,102,053 - 8,104,168 (+)NCBImm8
MGSCv36940,552,355 - 40,556,269 (+)NCBImm8
Celera938,034,609 - 38,038,251 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map921.55NCBI
Hspa8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2841,183,397 - 41,187,260 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl841,183,264 - 41,187,259 (+)Ensembl
Rnor_6.0844,989,401 - 44,993,261 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl844,990,014 - 44,993,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0846,005,304 - 46,006,864 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0843,478,238 - 43,480,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4843,784,035 - 43,787,760 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1843,792,829 - 43,796,525 (+)NCBI
Celera840,782,916 - 40,786,778 (+)NCBICelera
Cytogenetic Map8q22NCBI
Hspa8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541223,862,590 - 23,867,984 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541223,863,513 - 23,867,984 (-)NCBIChiLan1.0ChiLan1.0
HSPA8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111121,809,800 - 121,814,628 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11121,809,800 - 121,815,773 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011117,890,545 - 117,895,262 (-)NCBIMhudiblu_PPA_v0panPan3
HSPA8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1511,292,219 - 11,296,851 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl511,292,262 - 11,296,797 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha511,348,073 - 11,352,702 (+)NCBI
ROS_Cfam_1.0511,243,037 - 11,247,671 (+)NCBI
UMICH_Zoey_3.1511,346,458 - 11,351,078 (+)NCBI
UNSW_CanFamBas_1.0511,279,270 - 11,283,884 (+)NCBI
UU_Cfam_GSD_1.0511,323,539 - 11,328,166 (+)NCBI
Hspa8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947104,655,786 - 104,660,238 (-)NCBI
SpeTri2.0NW_0049365427,577,192 - 7,581,598 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl949,982,284 - 49,990,508 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1949,982,278 - 49,986,760 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2955,405,395 - 55,409,839 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSPA8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11114,447,348 - 114,452,693 (-)NCBI
ChlSab1.1 Ensembl1114,446,544 - 114,451,562 (-)Ensembl
Vero_WHO_p1.0NW_02366604311,677,166 - 11,681,993 (+)NCBI
Hspa8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248802,070,410 - 2,075,069 (+)NCBI

Position Markers
HSPA8  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711122,927,754 - 122,928,382UniSTSGRCh37
Build 3611122,432,964 - 122,433,592RGDNCBI36
Celera11120,087,083 - 120,087,711RGD
Cytogenetic Map11q24.1UniSTS
HuRef5124,668,546 - 124,668,765UniSTS
HuRef11118,869,832 - 118,870,460UniSTS
GeneMap99-GB4 RH Map11373.28UniSTS
RH27394  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711122,928,271 - 122,928,441UniSTSGRCh37
Build 3611122,433,481 - 122,433,651RGDNCBI36
Celera11120,087,600 - 120,087,770RGD
Cytogenetic Map11q24.1UniSTS
Cytogenetic Map11q23.3-q25UniSTS
HuRef11118,870,349 - 118,870,519UniSTS
RH104170  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711122,933,797 - 122,933,916UniSTSGRCh37
Build 3611122,439,007 - 122,439,126RGDNCBI36
Celera11120,093,126 - 120,093,245RGD
Cytogenetic Map11q24.1UniSTS
HuRef11118,875,876 - 118,875,995UniSTS
GeneMap99-GB4 RH Map11410.2UniSTS
WI-12733  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711122,928,778 - 122,928,927UniSTSGRCh37
Build 3611122,433,988 - 122,434,137RGDNCBI36
Celera11120,088,107 - 120,088,256RGD
Cytogenetic Map11q24.1UniSTS
Cytogenetic Map11q23.3-q25UniSTS
HuRef11118,870,856 - 118,871,005UniSTS
GeneMap99-GB4 RH Map11410.2UniSTS
Whitehead-RH Map11573.8UniSTS
NCBI RH Map111052.1UniSTS
SHGC-8077  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q24.1UniSTS
SHGC-8020  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q24.1UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3228
Count of miRNA genes:963
Interacting mature miRNAs:1177
Transcripts:ENST00000227378, ENST00000453788, ENST00000524552, ENST00000524590, ENST00000525463, ENST00000525624, ENST00000526110, ENST00000526686, ENST00000526862, ENST00000527387, ENST00000527983, ENST00000528292, ENST00000530391, ENST00000531063, ENST00000532091, ENST00000532167, ENST00000532182, ENST00000532636, ENST00000532780, ENST00000533238, ENST00000533540, ENST00000534319, ENST00000534567, ENST00000534624
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 139 71 92 30 538 31 272 103 219 68 185 275 8 28 45 2
Medium 2293 2912 1631 592 1410 433 4084 2090 3490 348 1263 1333 163 1176 2743 2
Low 7 8 3 2 2 1 4 25 3 12 5 4 1 2 2
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_153201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011542798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB034951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB073886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF217511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF352832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK000571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC312904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC395565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU668349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ224294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S72464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000227378   ⟹   ENSP00000227378
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,057,497 - 123,061,332 (-)Ensembl
RefSeq Acc Id: ENST00000453788   ⟹   ENSP00000404372
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,057,489 - 123,062,335 (-)Ensembl
RefSeq Acc Id: ENST00000524552   ⟹   ENSP00000435908
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,057,779 - 123,059,448 (-)Ensembl
RefSeq Acc Id: ENST00000524590   ⟹   ENSP00000434565
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,060,593 - 123,062,032 (-)Ensembl
RefSeq Acc Id: ENST00000525463   ⟹   ENSP00000436762
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,059,965 - 123,062,136 (-)Ensembl
RefSeq Acc Id: ENST00000525624   ⟹   ENSP00000435154
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,060,118 - 123,063,230 (-)Ensembl
RefSeq Acc Id: ENST00000526110   ⟹   ENSP00000433584
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,057,701 - 123,061,331 (-)Ensembl
RefSeq Acc Id: ENST00000526686   ⟹   ENSP00000435019
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,057,879 - 123,059,097 (-)Ensembl
RefSeq Acc Id: ENST00000526862
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,059,156 - 123,060,223 (-)Ensembl
RefSeq Acc Id: ENST00000527387   ⟹   ENSP00000436183
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,060,146 - 123,062,352 (-)Ensembl
RefSeq Acc Id: ENST00000527983
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,059,233 - 123,062,207 (-)Ensembl
RefSeq Acc Id: ENST00000528292   ⟹   ENSP00000432884
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,059,476 - 123,062,124 (-)Ensembl
RefSeq Acc Id: ENST00000530391   ⟹   ENSP00000434851
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,060,607 - 123,061,833 (-)Ensembl
RefSeq Acc Id: ENST00000531063
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,060,825 - 123,062,136 (-)Ensembl
RefSeq Acc Id: ENST00000532091
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,057,496 - 123,060,426 (-)Ensembl
RefSeq Acc Id: ENST00000532167
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,059,982 - 123,062,136 (-)Ensembl
RefSeq Acc Id: ENST00000532182   ⟹   ENSP00000434415
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,060,165 - 123,062,022 (-)Ensembl
RefSeq Acc Id: ENST00000532636   ⟹   ENSP00000437125
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,057,489 - 123,061,789 (-)Ensembl
RefSeq Acc Id: ENST00000532780
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,059,814 - 123,062,669 (-)Ensembl
RefSeq Acc Id: ENST00000533238
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,058,791 - 123,062,139 (-)Ensembl
RefSeq Acc Id: ENST00000533540   ⟹   ENSP00000437189
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,057,489 - 123,062,136 (-)Ensembl
RefSeq Acc Id: ENST00000534319   ⟹   ENSP00000433316
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,057,498 - 123,060,386 (-)Ensembl
RefSeq Acc Id: ENST00000534567   ⟹   ENSP00000431641
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,060,129 - 123,061,483 (-)Ensembl
RefSeq Acc Id: ENST00000534624   ⟹   ENSP00000432083
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11123,057,489 - 123,062,136 (-)Ensembl
RefSeq Acc Id: NM_006597   ⟹   NP_006588
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811123,057,489 - 123,062,136 (-)NCBI
GRCh3711122,928,200 - 122,933,074 (-)NCBI
Build 3611122,433,410 - 122,438,054 (-)NCBI Archive
HuRef11118,870,278 - 118,875,122 (-)NCBI
CHM1_111122,814,192 - 122,819,035 (-)NCBI
Sequence:
RefSeq Acc Id: NM_153201   ⟹   NP_694881
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811123,057,489 - 123,062,136 (-)NCBI
GRCh3711122,928,200 - 122,933,074 (-)NCBI
Build 3611122,433,410 - 122,438,054 (-)NCBI Archive
HuRef11118,870,278 - 118,875,122 (-)NCBI
CHM1_111122,814,192 - 122,819,035 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011542798   ⟹   XP_011541100
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811123,057,492 - 123,062,366 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_006588 (Get FASTA)   NCBI Sequence Viewer  
  NP_694881 (Get FASTA)   NCBI Sequence Viewer  
  XP_011541100 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF67622 (Get FASTA)   NCBI Sequence Viewer  
  AAH07276 (Get FASTA)   NCBI Sequence Viewer  
  AAH08907 (Get FASTA)   NCBI Sequence Viewer  
  AAH15699 (Get FASTA)   NCBI Sequence Viewer  
  AAH16179 (Get FASTA)   NCBI Sequence Viewer  
  AAH16660 (Get FASTA)   NCBI Sequence Viewer  
  AAH19816 (Get FASTA)   NCBI Sequence Viewer  
  AAK17898 (Get FASTA)   NCBI Sequence Viewer  
  ACF94502 (Get FASTA)   NCBI Sequence Viewer  
  ACI45986 (Get FASTA)   NCBI Sequence Viewer  
  ADO22186 (Get FASTA)   NCBI Sequence Viewer  
  ADO22260 (Get FASTA)   NCBI Sequence Viewer  
  BAA91262 (Get FASTA)   NCBI Sequence Viewer  
  BAB18615 (Get FASTA)   NCBI Sequence Viewer  
  BAD96348 (Get FASTA)   NCBI Sequence Viewer  
  BAD96505 (Get FASTA)   NCBI Sequence Viewer  
  BAF84756 (Get FASTA)   NCBI Sequence Viewer  
  BAG53212 (Get FASTA)   NCBI Sequence Viewer  
  BAG62134 (Get FASTA)   NCBI Sequence Viewer  
  BAG64863 (Get FASTA)   NCBI Sequence Viewer  
  CAA68445 (Get FASTA)   NCBI Sequence Viewer  
  EAW67539 (Get FASTA)   NCBI Sequence Viewer  
  EAW67540 (Get FASTA)   NCBI Sequence Viewer  
  EAW67541 (Get FASTA)   NCBI Sequence Viewer  
  EAW67542 (Get FASTA)   NCBI Sequence Viewer  
  P11142 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_694881   ⟸   NM_153201
- Peptide Label: isoform 2
- UniProtKB: P11142 (UniProtKB/Swiss-Prot),   Q53HF2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_006588   ⟸   NM_006597
- Peptide Label: isoform 1
- UniProtKB: P11142 (UniProtKB/Swiss-Prot),   Q53HF2 (UniProtKB/TrEMBL),   V9HW22 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011541100   ⟸   XM_011542798
- Peptide Label: isoform X1
- UniProtKB: P11142 (UniProtKB/Swiss-Prot),   V9HW22 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000227378   ⟸   ENST00000227378
RefSeq Acc Id: ENSP00000434851   ⟸   ENST00000530391
RefSeq Acc Id: ENSP00000404372   ⟸   ENST00000453788
RefSeq Acc Id: ENSP00000434415   ⟸   ENST00000532182
RefSeq Acc Id: ENSP00000437125   ⟸   ENST00000532636
RefSeq Acc Id: ENSP00000437189   ⟸   ENST00000533540
RefSeq Acc Id: ENSP00000432083   ⟸   ENST00000534624
RefSeq Acc Id: ENSP00000431641   ⟸   ENST00000534567
RefSeq Acc Id: ENSP00000433316   ⟸   ENST00000534319
RefSeq Acc Id: ENSP00000434565   ⟸   ENST00000524590
RefSeq Acc Id: ENSP00000435908   ⟸   ENST00000524552
RefSeq Acc Id: ENSP00000435154   ⟸   ENST00000525624
RefSeq Acc Id: ENSP00000436762   ⟸   ENST00000525463
RefSeq Acc Id: ENSP00000433584   ⟸   ENST00000526110
RefSeq Acc Id: ENSP00000435019   ⟸   ENST00000526686
RefSeq Acc Id: ENSP00000436183   ⟸   ENST00000527387
RefSeq Acc Id: ENSP00000432884   ⟸   ENST00000528292

Promoters
RGD ID:6788993
Promoter ID:HG_KWN:14443
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   Lymphoblastoid,   NB4
Transcripts:UC009ZBC.1
Position:
Human AssemblyChrPosition (strand)Source
Build 3611122,436,211 - 122,436,852 (-)MPROMDB
RGD ID:6789017
Promoter ID:HG_KWN:14444
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000392773,   NM_006597,   NM_153201,   UC009ZBD.1
Position:
Human AssemblyChrPosition (strand)Source
Build 3611122,437,971 - 122,439,042 (-)MPROMDB
RGD ID:6850316
Promoter ID:EP17089
Type:single initiation site
Name:HS_HSPA8
Description:Heat shock 70kD protein 8.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 114; Mammalian, avian HSP70 family.
Tissues & Cell Lines:constitutive
Experiment Methods:Primer extension; NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 3611122,438,054 - 122,438,114EPD
RGD ID:7222469
Promoter ID:EPDNEW_H16980
Type:initiation region
Name:HSPA8_2
Description:heat shock protein family A member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16981  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811123,061,254 - 123,061,314EPDNEW
RGD ID:7222471
Promoter ID:EPDNEW_H16981
Type:initiation region
Name:HSPA8_1
Description:heat shock protein family A member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16980  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811123,062,136 - 123,062,196EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q23.3-25(chr11:116851395-134998513)x3 copy number gain See cases [RCV000050331] Chr11:116851395..134998513 [GRCh38]
Chr11:116722111..134868407 [GRCh37]
Chr11:116227321..134373617 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:119433909-134998513)x1 copy number loss See cases [RCV000050905] Chr11:119433909..134998513 [GRCh38]
Chr11:119304619..134868407 [GRCh37]
Chr11:118809829..134373617 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:118789765-134998513)x3 copy number gain See cases [RCV000051213] Chr11:118789765..134998513 [GRCh38]
Chr11:118660474..134868407 [GRCh37]
Chr11:118165684..134373617 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:119215032-134998654)x1 copy number loss See cases [RCV000052715] Chr11:119215032..134998654 [GRCh38]
Chr11:119085742..134868548 [GRCh37]
Chr11:118590952..134373758 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:120507265-134576266)x1 copy number loss See cases [RCV000052716] Chr11:120507265..134576266 [GRCh38]
Chr11:120377974..134446160 [GRCh37]
Chr11:119883184..133951370 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:120236432-135040246)x3 copy number gain See cases [RCV000053643] Chr11:120236432..135040246 [GRCh38]
Chr11:120107141..134910140 [GRCh37]
Chr11:119612351..134415350 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.3-24.2(chr11:120426093-124771213)x1 copy number loss See cases [RCV000134405] Chr11:120426093..124771213 [GRCh38]
Chr11:120296802..124641109 [GRCh37]
Chr11:119802012..124146319 [NCBI36]
Chr11:11q23.3-24.2
pathogenic
GRCh38/hg38 11q23.3-25(chr11:116851372-134998526)x3 copy number gain See cases [RCV000134064] Chr11:116851372..134998526 [GRCh38]
Chr11:116722088..134868420 [GRCh37]
Chr11:116227298..134373630 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q24.1-24.2(chr11:122182443-125957977)x1 copy number loss See cases [RCV000136594] Chr11:122182443..125957977 [GRCh38]
Chr11:122053151..125827872 [GRCh37]
Chr11:121558361..125333082 [NCBI36]
Chr11:11q24.1-24.2
pathogenic
GRCh38/hg38 11q23.2-25(chr11:112864326-131189315)x3 copy number gain See cases [RCV000137582] Chr11:112864326..131189315 [GRCh38]
Chr11:112832130..131059210 [GRCh37]
Chr11:112240259..130564420 [NCBI36]
Chr11:11q23.2-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:116868935-135075271)x3 copy number gain See cases [RCV000137453] Chr11:116868935..135075271 [GRCh38]
Chr11:116739651..134945165 [GRCh37]
Chr11:116244861..134450377 [NCBI36]
Chr11:11q23.3-25
pathogenic|conflicting data from submitters
GRCh38/hg38 11q24.1-25(chr11:121780459-135075271)x1 copy number loss See cases [RCV000138014] Chr11:121780459..135075271 [GRCh38]
Chr11:121651167..134945165 [GRCh37]
Chr11:121156377..134450377 [NCBI36]
Chr11:11q24.1-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:120515759-135075271)x1 copy number loss See cases [RCV000138373] Chr11:120515759..135075271 [GRCh38]
Chr11:120386468..134945165 [GRCh37]
Chr11:119891678..134450377 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:116806268-135075271)x3 copy number gain See cases [RCV000138307] Chr11:116806268..135075271 [GRCh38]
Chr11:116676984..134945165 [GRCh37]
Chr11:116182194..134450377 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.3-24.2(chr11:117333952-127709156)x3 copy number gain See cases [RCV000139362] Chr11:117333952..127709156 [GRCh38]
Chr11:117204668..127579051 [GRCh37]
Chr11:116709878..127084261 [NCBI36]
Chr11:11q23.3-24.2
pathogenic
GRCh38/hg38 11q23.3-25(chr11:119424297-135075271)x1 copy number loss See cases [RCV000138947] Chr11:119424297..135075271 [GRCh38]
Chr11:119295007..134945165 [GRCh37]
Chr11:118800217..134450377 [NCBI36]
Chr11:11q23.3-25
pathogenic|likely benign
GRCh38/hg38 11q23.3-24.2(chr11:120080142-125829106)x1 copy number loss See cases [RCV000140070] Chr11:120080142..125829106 [GRCh38]
Chr11:119950851..125699001 [GRCh37]
Chr11:119456061..125204211 [NCBI36]
Chr11:11q23.3-24.2
pathogenic
GRCh38/hg38 11q24.1-25(chr11:121689052-135075271)x1 copy number loss See cases [RCV000139622] Chr11:121689052..135075271 [GRCh38]
Chr11:121559760..134945165 [GRCh37]
Chr11:121064970..134450377 [NCBI36]
Chr11:11q24.1-25
pathogenic|likely benign
GRCh38/hg38 11q24.1-25(chr11:121806547-135068576)x1 copy number loss See cases [RCV000142210] Chr11:121806547..135068576 [GRCh38]
Chr11:121677255..134938470 [GRCh37]
Chr11:121182465..134443680 [NCBI36]
Chr11:11q24.1-25
pathogenic
GRCh38/hg38 11q24.1-25(chr11:121611476-135068576)x1 copy number loss See cases [RCV000142185] Chr11:121611476..135068576 [GRCh38]
Chr11:121482185..134938470 [GRCh37]
Chr11:120987395..134443680 [NCBI36]
Chr11:11q24.1-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:116851395-134998513)x3 copy number gain See cases [RCV000148276] Chr11:116851395..134998513 [GRCh38]
Chr11:116722111..134868407 [GRCh37]
Chr11:116227321..134373617 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:119807473-134868407)x1 copy number loss See cases [RCV000240237] Chr11:119807473..134868407 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:120615374-134868407)x1 copy number loss See cases [RCV000239781] Chr11:120615374..134868407 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q24.1-25(chr11:121416261-134938470)x1 copy number loss See cases [RCV000511335] Chr11:121416261..134938470 [GRCh37]
Chr11:11q24.1-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116691675-134889485) copy number gain not provided [RCV000767667] Chr11:116691675..134889485 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3 copy number gain See cases [RCV000449449] Chr11:116681007..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:119513909-134938470)x1 copy number loss See cases [RCV000447077] Chr11:119513909..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q24.1-25(chr11:121501072-134868348)x1 copy number loss See cases [RCV000445814] Chr11:121501072..134868348 [GRCh37]
Chr11:11q24.1-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116684163-134938470)x3 copy number gain See cases [RCV000447848] Chr11:116684163..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q24.1-25(chr11:121559102-134938470)x1 copy number loss See cases [RCV000449003] Chr11:121559102..134938470 [GRCh37]
Chr11:11q24.1-25
pathogenic
GRCh37/hg19 11q24.1-25(chr11:122403610-134938470)x1 copy number loss See cases [RCV000448215] Chr11:122403610..134938470 [GRCh37]
Chr11:11q24.1-25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q24.1-25(chr11:122884694-134938470)x3 copy number gain See cases [RCV000511146] Chr11:122884694..134938470 [GRCh37]
Chr11:11q24.1-25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:120527021-134938470)x1 copy number loss See cases [RCV000511283] Chr11:120527021..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:121136603-134938470)x1 copy number loss See cases [RCV000510856] Chr11:121136603..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3 copy number gain See cases [RCV000512291] Chr11:116681007..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:119538664-134938470)x1 copy number loss not provided [RCV000683371] Chr11:119538664..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3 copy number gain not provided [RCV000683373] Chr11:116681007..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
Single allele duplication Schizophrenia [RCV000754124] Chr11:118989374..135076622 [GRCh38]
Chr11:11q23.3-25
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116697066-134934063)x3 copy number gain not provided [RCV000737686] Chr11:116697066..134934063 [GRCh37]
Chr11:11q23.3-25
pathogenic
NM_006597.6(HSPA8):c.375A>G (p.Thr125=) single nucleotide variant not provided [RCV000965857] Chr11:123060629 [GRCh38]
Chr11:122931337 [GRCh37]
Chr11:11q24.1
benign
NM_006597.6(HSPA8):c.333C>G (p.Thr111=) single nucleotide variant not provided [RCV000905420] Chr11:123060671 [GRCh38]
Chr11:122931379 [GRCh37]
Chr11:11q24.1
benign
NM_006597.6(HSPA8):c.1074A>G (p.Glu358=) single nucleotide variant not provided [RCV000968241] Chr11:123059519 [GRCh38]
Chr11:122930227 [GRCh37]
Chr11:11q24.1
benign
GRCh37/hg19 11q23.3-25(chr11:116700253-134904063) copy number gain not provided [RCV000767816] Chr11:116700253..134904063 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:117830263-134938470)x3 copy number gain not provided [RCV000848151] Chr11:117830263..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:120576984-134934063)x1 copy number loss See cases [RCV000790567] Chr11:120576984..134934063 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:120742540-134938470)x1 copy number loss not provided [RCV001006452] Chr11:120742540..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
NM_006597.6(HSPA8):c.1005C>T (p.Val335=) single nucleotide variant not provided [RCV000974107] Chr11:123059588 [GRCh38]
Chr11:122930296 [GRCh37]
Chr11:11q24.1
benign
Single allele deletion Short stature [RCV001003892] Chr11:114433313..131230466 [GRCh37]
Chr11:11q23.2-25
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5241 AgrOrtholog
COSMIC HSPA8 COSMIC
Ensembl Genes ENSG00000109971 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000227378 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000404372 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000431641 UniProtKB/TrEMBL
  ENSP00000432083 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000432884 UniProtKB/TrEMBL
  ENSP00000433316 UniProtKB/TrEMBL
  ENSP00000433584 UniProtKB/TrEMBL
  ENSP00000434415 UniProtKB/TrEMBL
  ENSP00000434565 UniProtKB/TrEMBL
  ENSP00000434851 UniProtKB/TrEMBL
  ENSP00000435019 UniProtKB/TrEMBL
  ENSP00000435154 UniProtKB/TrEMBL
  ENSP00000435908 UniProtKB/TrEMBL
  ENSP00000436183 UniProtKB/TrEMBL
  ENSP00000436762 UniProtKB/TrEMBL
  ENSP00000437125 UniProtKB/Swiss-Prot
  ENSP00000437189 UniProtKB/TrEMBL
Ensembl Transcript ENST00000227378 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000453788 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000524552 UniProtKB/TrEMBL
  ENST00000524590 UniProtKB/TrEMBL
  ENST00000525463 UniProtKB/TrEMBL
  ENST00000525624 UniProtKB/TrEMBL
  ENST00000526110 UniProtKB/TrEMBL
  ENST00000526686 UniProtKB/TrEMBL
  ENST00000527387 UniProtKB/TrEMBL
  ENST00000528292 UniProtKB/TrEMBL
  ENST00000530391 UniProtKB/TrEMBL
  ENST00000532182 UniProtKB/TrEMBL
  ENST00000532636 UniProtKB/Swiss-Prot
  ENST00000533540 UniProtKB/TrEMBL
  ENST00000534319 UniProtKB/TrEMBL
  ENST00000534567 UniProtKB/TrEMBL
  ENST00000534624 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.34.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000109971 GTEx
HGNC ID HGNC:5241 ENTREZGENE
Human Proteome Map HSPA8 Human Proteome Map
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3312 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 3312 ENTREZGENE
OMIM 600816 OMIM
PANTHER PTHR19375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29507 PharmGKB
PROSITE HSP70_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K7Q2_HUMAN UniProtKB/TrEMBL
  E9PI65_HUMAN UniProtKB/TrEMBL
  E9PK54_HUMAN UniProtKB/TrEMBL
  E9PKE3_HUMAN UniProtKB/TrEMBL
  E9PLF4_HUMAN UniProtKB/TrEMBL
  E9PM13_HUMAN UniProtKB/TrEMBL
  E9PN25_HUMAN UniProtKB/TrEMBL
  E9PN89_HUMAN UniProtKB/TrEMBL
  E9PNE6_HUMAN UniProtKB/TrEMBL
  E9PPY6_HUMAN UniProtKB/TrEMBL
  E9PQK7_HUMAN UniProtKB/TrEMBL
  E9PQQ4_HUMAN UniProtKB/TrEMBL
  E9PS65_HUMAN UniProtKB/TrEMBL
  HSP7C_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q53HF2 ENTREZGENE, UniProtKB/TrEMBL
  Q96H53_HUMAN UniProtKB/TrEMBL
  Q96IS6_HUMAN UniProtKB/TrEMBL
  V9HW22 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q9H3R6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 HSPA8  heat shock protein family A (Hsp70) member 8    heat shock 70kDa protein 8  Symbol and/or name change 5135510 APPROVED