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Gene: HSPA8 (heat shock protein family A (Hsp70) member 8) Homo sapiens
Symbol: HSPA8
Name: heat shock protein family A (Hsp70) member 8
Description: Exhibits several functions, including ATP binding activity; C3HC4-type RING finger domain binding activity; and chaperone binding activity. Involved in several processes, including protein refolding; protein targeting to lysosome involved in chaperone-mediated autophagy; and regulation of protein stability. Localizes to several cellular components, including Prp19 complex; chaperone complex; and extracellular exosome. Implicated in Parkinson's disease and renal hypertension. Biomarker of several diseases, including Parkinson's disease; cervical cancer; colorectal cancer; hypertension; and multiple sclerosis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: constitutive heat shock protein 70; epididymis luminal protein 33; epididymis secretory sperm binding protein Li 72p; heat shock 70kd protein 10; heat shock 70kD protein 8; heat shock 70kDa protein 8; heat shock cognate 71 kDa protein; heat shock cognate protein 54; heat shock cognate protein, 71-kDa; heat shock protein 8; HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; LAP-1; LAP1; lipopolysaccharide-associated protein 1; LPS-associated protein 1; MGC131511; MGC29929; N-myristoyltransferase inhibitor protein 71; NIP71
Mus musculus (house mouse) : Hspa8 (heat shock protein 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hspa8 (heat shock protein family A (Hsp70) member 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hspa8 (heat shock protein family A (Hsp70) member 8)
Pan paniscus (bonobo/pygmy chimpanzee) : HSPA8 (heat shock protein family A (Hsp70) member 8)
Canis lupus familiaris (dog) : HSPA8 (heat shock protein family A (Hsp70) member 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspa8 (heat shock protein family A (Hsp70) member 8)
Sus scrofa (pig) : HSPA8 (heat shock protein family A (Hsp70) member 8)
Chlorocebus sabaeus (African green monkey) : HSPA8 (heat shock protein family A (Hsp70) member 8)
Heterocephalus glaber (naked mole-rat) : Hspa8 (heat shock protein family A (Hsp70) member 8)
more info ...
Related Pseudogenes: HSPA8P1   HSPA8P10   HSPA8P11   HSPA8P12   HSPA8P13   HSPA8P14   HSPA8P15   HSPA8P16   HSPA8P17   HSPA8P18   HSPA8P19   HSPA8P2   HSPA8P20   HSPA8P3   HSPA8P4   HSPA8P5   HSPA8P6   HSPA8P7   HSPA8P8   HSPA8P9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl11123,057,489 - 123,063,230 (-)EnsemblGRCh38hg38GRCh38
GRCh3811123,057,489 - 123,062,366 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711122,928,200 - 122,933,074 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611122,433,410 - 122,438,054 (-)NCBINCBI36hg18NCBI36
Build 3411122,433,410 - 122,438,054NCBI
Celera11120,087,529 - 120,092,173 (-)NCBI
Cytogenetic Map11q24.1NCBI
HuRef11118,870,278 - 118,875,122 (-)NCBIHuRef
CHM1_111122,814,192 - 122,819,035 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HSPA8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736219
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.