RGD Reference Report - Assembly of proteins to postsynaptic densities after transient cerebral ischemia. - Rat Genome Database

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Assembly of proteins to postsynaptic densities after transient cerebral ischemia.

Authors: Hu, BR  Park, M  Martone, ME  Fischer, WH  Ellisman, MH  Zivin, JA 
Citation: Hu BR, etal., J Neurosci. 1998 Jan 15;18(2):625-33.
RGD ID: 10059344
Pubmed: PMID:9425004   (View Abstract at PubMed)
PMCID: PMC6792532   (View Article at PubMed Central)

Transient ischemia leads to changes in synaptic efficacy and results in selective neuronal damage during the postischemic phase, although the mechanisms are not fully understood. The protein composition and ultrastructure of postsynaptic densities (PSDs) were studied by using a rat transient ischemic model. We found that a brief ischemic episode induced a marked accumulation in PSDs of the protein assembly ATPases, N-ethylmaleimide-sensitive fusion protein, and heat-shock cognate protein-70 as well as the BDNF receptor (trkB) and protein kinases, as determined by protein microsequencing. The changes in PSD composition were accompanied by a 2.5-fold increase in the yield of PSD protein relative to controls. Biochemical modification of PSDs correlated well with an increase in PSD thickness observed in vivo by electron microscopy. We conclude that a brief ischemic episode modifies the molecular composition and ultrastructure of synapses by assembly of proteins to the postsynaptic density, which may underlie observed changes in synaptic function and selective neuronal damage.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HSPA8Humantransient cerebral ischemia  ISOHspa8 (Rattus norvegicus)protein:increased expression:brain and postsynaptic density (rat)RGD 
Hspa8Mousetransient cerebral ischemia  ISOHspa8 (Rattus norvegicus)protein:increased expression:brain and postsynaptic density (rat)RGD 
Hspa8Rattransient cerebral ischemia  IEP protein:increased expression:brain and postsynaptic density (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hspa8  (heat shock protein family A (Hsp70) member 8)

Genes (Mus musculus)
Hspa8  (heat shock protein 8)

Genes (Homo sapiens)
HSPA8  (heat shock protein family A (Hsp70) member 8)


Additional Information