Fkbp1a (FKBP prolyl isomerase 1A) - Rat Genome Database

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Gene: Fkbp1a (FKBP prolyl isomerase 1A) Rattus norvegicus
Analyze
Symbol: Fkbp1a
Name: FKBP prolyl isomerase 1A
RGD ID: 2617
Description: Enables several functions, including FK506 binding activity; Hsp70 protein binding activity; and type I transforming growth factor beta receptor binding activity. Involved in response to iron ion. Located in axon terminus. Biomarker of Parkinsonism. Orthologous to several human genes including FKBP1A (FKBP prolyl isomerase 1A); PARTICIPATES IN activin signaling pathway; mTOR signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 12 kDa FK506-binding protein; 12 kDa FKBP; FK506 binding protein 1a; FK506 binding protein 2; FK506 binding protein 2 (13 kDa); FK506-binding protein 1 (12kD); FK506-binding protein 1a; FKBP-12; FKBP-1A; FKBP12; Fkbp2; immunophilin FKBP12; MGC156543; peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; rotamase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83160,500,748 - 160,520,492 (+)NCBIGRCr8
mRatBN7.23140,040,359 - 140,060,107 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,040,278 - 140,060,743 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3143,944,928 - 143,964,668 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03152,528,701 - 152,548,443 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03150,269,170 - 150,288,910 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03147,042,944 - 147,062,725 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,042,944 - 147,062,724 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03153,399,455 - 153,418,857 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43141,861,237 - 141,880,797 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13141,766,809 - 141,786,369 (+)NCBI
Celera3138,799,643 - 138,819,482 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
Aflatoxin B2 alpha  (ISO)
amitrole  (EXP)
arsenite(3-)  (ISO)
asbestos  (ISO)
ascomycin  (EXP,ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP)
bleomycin A5  (ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcidiol  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carmustine  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
dantrolene  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
disulfiram  (ISO)
diuron  (EXP,ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
halothane  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
ivermectin  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
propiconazole  (EXP,ISO)
Rebamipide  (EXP)
rotenone  (ISO)
ryanodine  (ISO)
selenium atom  (ISO)
simvastatin  (EXP)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulindac  (EXP)
tacrolimus (anhydrous)  (ISO)
tacrolimus hydrate  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
Tetrachlorobisphenol A  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
wortmannin  (ISO)
zoledronic acid  (ISO)
zotarolimus  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Perinatal iron deficiency results in altered developmental expression of genes mediating energy metabolism and neuronal morphogenesis in hippocampus. Carlson ES, etal., Hippocampus. 2007;17(8):679-91.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. mTOR signaling in growth control and disease. Laplante M and Sabatini DM, Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins. Nilsson A, etal., J Proteome Res. 2007 Oct;6(10):3952-61. Epub 2007 Sep 18.
7. Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes. Noguchi N, etal., J Biol Chem 1997 Feb 7;272(6):3133-6.
8. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Rapamycin inhibits vascular smooth muscle cell migration. Poon M, etal., J Clin Invest 1996 Nov 15;98(10):2277-83.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. FK506 binding protein 12 is expressed in rat penile innervation and upregulated after cavernous nerve injury. Sezen SF, etal., Int J Impot Res. 2002 Dec;14(6):506-12.
14. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
15. Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12. Shou W, etal., Nature. 1998 Jan 29;391(6666):489-92.
16. FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. Spiekerkoetter E, etal., J Clin Invest. 2013 Aug;123(8):3600-13. doi: 10.1172/JCI65592. Epub 2013 Jul 15.
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12. Wang T, etal., Science. 1994 Jul 29;265(5172):674-6.
Additional References at PubMed
PMID:1696686   PMID:1701173   PMID:1722474   PMID:2477715   PMID:7592869   PMID:9880681   PMID:12443530   PMID:12704193   PMID:12761501   PMID:14592808   PMID:14605212   PMID:15199065  
PMID:15289441   PMID:15467718   PMID:15489334   PMID:16720724   PMID:17313373   PMID:17921453   PMID:17962721   PMID:18346205   PMID:18684528   PMID:19198614   PMID:20431056   PMID:21255728  
PMID:22363773   PMID:22750946   PMID:22871113   PMID:23376485   PMID:24499793   PMID:24534009   PMID:29229832  


Genomics

Comparative Map Data
Fkbp1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83160,500,748 - 160,520,492 (+)NCBIGRCr8
mRatBN7.23140,040,359 - 140,060,107 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,040,278 - 140,060,743 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3143,944,928 - 143,964,668 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03152,528,701 - 152,548,443 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03150,269,170 - 150,288,910 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03147,042,944 - 147,062,725 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,042,944 - 147,062,724 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03153,399,455 - 153,418,857 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43141,861,237 - 141,880,797 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13141,766,809 - 141,786,369 (+)NCBI
Celera3138,799,643 - 138,819,482 (+)NCBICelera
Cytogenetic Map3q41NCBI
FKBP1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38201,368,978 - 1,393,054 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl201,368,977 - 1,393,164 (-)EnsemblGRCh38hg38GRCh38
GRCh37201,349,622 - 1,373,698 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36201,297,622 - 1,321,745 (-)NCBINCBI36Build 36hg18NCBI36
Build 34201,300,375 - 1,321,745NCBI
Celera201,445,967 - 1,470,163 (-)NCBICelera
Cytogenetic Map20p13NCBI
HuRef201,302,109 - 1,326,302 (-)NCBIHuRef
CHM1_1201,349,285 - 1,373,817 (-)NCBICHM1_1
T2T-CHM13v2.0201,418,161 - 1,442,241 (-)NCBIT2T-CHM13v2.0
Fkbp1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392151,384,403 - 151,403,611 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2151,384,403 - 151,403,612 (+)EnsemblGRCm39 Ensembl
GRCm382151,542,483 - 151,561,691 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2151,542,483 - 151,561,692 (+)EnsemblGRCm38mm10GRCm38
MGSCv372151,368,235 - 151,387,427 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362151,234,062 - 151,253,132 (+)NCBIMGSCv36mm8
Celera2157,359,901 - 157,379,075 (+)NCBICelera
Cytogenetic Map2G3NCBI
cM Map274.83NCBI
Fkbp1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955596580,106 - 603,255 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955596580,106 - 606,210 (-)NCBIChiLan1.0ChiLan1.0
FKBP1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2212,399,937 - 2,432,330 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1202,396,766 - 2,426,602 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0201,519,330 - 1,548,473 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1201,292,519 - 1,298,888 (-)NCBIpanpan1.1PanPan1.1panPan2
FKBP1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12419,618,581 - 19,643,685 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2419,618,558 - 19,643,046 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.02420,310,591 - 20,335,863 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2420,310,075 - 20,335,863 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12419,587,096 - 19,612,324 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02419,692,087 - 19,717,321 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02420,122,927 - 20,148,189 (+)NCBIUU_Cfam_GSD_1.0
Fkbp1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640168,873,992 - 168,880,432 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648517,305,376 - 17,311,797 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FKBP1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11733,910,047 - 33,935,212 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21738,470,202 - 38,495,226 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FKBP1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1255,170,816 - 55,195,380 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660871,575,983 - 1,600,558 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fkbp1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247412,666,636 - 2,692,938 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247412,669,909 - 2,692,959 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fkbp1a
83 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:708
Count of miRNA genes:273
Interacting mature miRNAs:335
Transcripts:ENSRNOT00000012608
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
RH141052  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23140,057,991 - 140,059,161 (+)MAPPERmRatBN7.2
mRatBN7.2178,470,296 - 78,470,512 (+)MAPPERmRatBN7.2
Rnor_6.0179,729,111 - 79,729,326NCBIRnor6.0
Rnor_6.03147,060,614 - 147,061,783NCBIRnor6.0
Rnor_5.03153,416,746 - 153,417,915UniSTSRnor5.0
Rnor_5.0180,991,514 - 80,991,729UniSTSRnor5.0
RGSC_v3.43141,878,686 - 141,879,855UniSTSRGSC3.4
RGSC_v3.4178,174,294 - 78,174,509UniSTSRGSC3.4
Celera172,937,410 - 72,937,625UniSTS
Celera3138,817,371 - 138,818,540UniSTS
RH 3.4 Map1791.5UniSTS
Cytogenetic Map3q41UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000012608   ⟹   ENSRNOP00000012608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3140,040,278 - 140,060,743 (+)Ensembl
Rnor_6.0 Ensembl3147,042,944 - 147,062,724 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105280   ⟹   ENSRNOP00000097913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3140,040,309 - 140,060,100 (+)Ensembl
RefSeq Acc Id: NM_013102   ⟹   NP_037234
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83160,500,748 - 160,520,492 (+)NCBI
mRatBN7.23140,040,359 - 140,060,103 (+)NCBI
Rnor_6.03147,042,944 - 147,062,725 (+)NCBI
Rnor_5.03153,399,455 - 153,418,857 (+)NCBI
RGSC_v3.43141,861,237 - 141,880,797 (+)RGD
Celera3138,799,643 - 138,819,482 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104385   ⟹   XP_038960313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83160,503,464 - 160,520,492 (+)NCBI
mRatBN7.23140,043,135 - 140,060,107 (+)NCBI
RefSeq Acc Id: NP_037234   ⟸   NM_013102
- UniProtKB: A0JN04 (UniProtKB/Swiss-Prot),   P97533 (UniProtKB/Swiss-Prot),   Q62658 (UniProtKB/Swiss-Prot),   A6KHI5 (UniProtKB/TrEMBL),   A0A8L2UIH3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012608   ⟸   ENSRNOT00000012608
RefSeq Acc Id: XP_038960313   ⟸   XM_039104385
- Peptide Label: isoform X1
- UniProtKB: A6KHI7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097913   ⟸   ENSRNOT00000105280
Protein Domains
PPIase FKBP-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62658-F1-model_v2 AlphaFold Q62658 1-108 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692523
Promoter ID:EPDNEW_R3048
Type:initiation region
Name:Fkbp1a_1
Description:FK506 binding protein 1a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03147,042,900 - 147,042,960EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2617 AgrOrtholog
BioCyc Gene G2FUF-47311 BioCyc
Ensembl Genes ENSRNOG00000008822 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012608.5 UniProtKB/TrEMBL
  ENSRNOT00000105280.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7103884 IMAGE-MGC_LOAD
  IMAGE:8363608 IMAGE-MGC_LOAD
InterPro FKBP-type_PPIase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPIase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPIase_FKBP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25639 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:156543 IMAGE-MGC_LOAD
  MGC:91525 IMAGE-MGC_LOAD
NCBI Gene 25639 ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FKBP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fkbp1a PhenoGen
PROSITE FKBP_PPIASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008822 RatGTEx
Superfamily-SCOP FKBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ANT3_RAT UniProtKB/TrEMBL
  A0A8L2UIH3 ENTREZGENE, UniProtKB/TrEMBL
  A0JN04 ENTREZGENE
  A6KHI5 ENTREZGENE, UniProtKB/TrEMBL
  A6KHI7 ENTREZGENE, UniProtKB/TrEMBL
  A6KHJ0_RAT UniProtKB/TrEMBL
  FKB1A_RAT UniProtKB/Swiss-Prot
  P97533 ENTREZGENE
  Q62658 ENTREZGENE
UniProt Secondary A0JN04 UniProtKB/Swiss-Prot
  P97533 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-11-09 Fkbp1a  FKBP prolyl isomerase 1A  Fkbp1a  FK506 binding protein 1a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-28 Fkbp1a  FK506-binding protein 1a  Fkbp2  FK506 binding protein 2  Data merged from RGD:2618 737654 APPROVED
2002-11-06 Fkbp1a  FK506-binding protein 1a    FK506-binding protein 1 (12kD)  Name updated 625702 APPROVED
2002-06-10 Fkbp1a  FK506-binding protein 1 (12kD)      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Fkbp2  FK506 binding protein 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process inhibits aortic vascular smooth muscle cell proliferation and migration 69838
gene_protein 108 amino acids 61587