FKBP1B (FKBP prolyl isomerase 1B) - Rat Genome Database
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Gene: FKBP1B (FKBP prolyl isomerase 1B) Homo sapiens
Analyze
Symbol: FKBP1B
Name: FKBP prolyl isomerase 1B
RGD ID: 735951
Description: Exhibits several functions, including FK506 binding activity; calcium channel inhibitor activity; and peptidyl-prolyl cis-trans isomerase activity. Predicted to contribute to ryanodine-sensitive calcium-release channel activity. Involved in several processes, including negative regulation of phosphoprotein phosphatase activity; protein peptidyl-prolyl isomerization; and regulation of release of sequestered calcium ion into cytosol. Localizes to Z disc and calcium channel complex. Implicated in Graves' disease.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; calstabin 2; FK506 binding protein 1B; FK506 binding protein 1B, 12.6 kDa; FK506-binding protein 1-like; FK506-binding protein 12.6; FK506-binding protein 1B; FKBP-12.6; FKBP-1B; FKBP12.6; FKBP1L; h-FKBP-12; immunophilin FKBP12.6; OTK4; peptidyl-prolyl cis-trans isomerase FKBP1B; PKBP1L; PPIase; PPIase FKBP1B; rotamase
Orthologs:
Mus musculus (house mouse) : Fkbp1b (FK506 binding protein 1b)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fkbp1b (FKBP prolyl isomerase 1B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fkbp1b (FKBP prolyl isomerase 1B)
Pan paniscus (bonobo/pygmy chimpanzee) : FKBP1B (FKBP prolyl isomerase 1B)
Canis lupus familiaris (dog) : FKBP1B (FKBP prolyl isomerase 1B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fkbp1b (FKBP prolyl isomerase 1B)
Sus scrofa (pig) : FKBP1B (FKBP prolyl isomerase 1B)
Chlorocebus sabaeus (African green monkey) : FKBP1B (FKBP prolyl isomerase 1B)
Heterocephalus glaber (naked mole-rat) : Fkbp1b (FKBP prolyl isomerase 1B)
more info ...
Related Pseudogenes: FKBP1BP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl224,049,701 - 24,063,681 (+)EnsemblGRCh38hg38GRCh38
GRCh38224,033,205 - 24,067,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37224,272,584 - 24,286,551 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36224,126,132 - 24,140,055 (+)NCBINCBI36hg18NCBI36
Build 34224,184,278 - 24,198,199NCBI
Celera224,112,915 - 24,126,882 (+)NCBI
Cytogenetic Map2p23.3NCBI
HuRef224,011,446 - 24,025,414 (+)NCBIHuRef
CHM1_1224,201,961 - 24,215,941 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
3,4-dichloroaniline  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
acetylcholine  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
atenolol  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
calcitriol  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
crocidolite asbestos  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
dexamethasone  (EXP)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
diuron  (EXP)
dofetilide  (ISO)
dorsomorphin  (EXP)
folic acid  (ISO)
indometacin  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
metoprolol  (EXP)
nickel sulfate  (EXP)
ochratoxin A  (ISO)
paracetamol  (ISO)
phenylmercury acetate  (EXP)
propanal  (EXP)
rotenone  (ISO)
ryanodine  (ISO)
SB 431542  (EXP)
streptozocin  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
'de novo' protein folding  (TAS)
calcium-mediated signaling using intracellular calcium source  (TAS)
cell communication by electrical coupling involved in cardiac conduction  (TAS)
chaperone-mediated protein folding  (IBA)
insulin secretion  (ISO)
ion transmembrane transport  (TAS)
negative regulation of heart rate  (ISS)
negative regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
negative regulation of phosphoprotein phosphatase activity  (IDA)
negative regulation of release of sequestered calcium ion into cytosol  (IDA)
negative regulation of ryanodine-sensitive calcium-release channel activity  (IDA)
neuronal action potential propagation  (ISO)
positive regulation of axon regeneration  (IEA)
positive regulation of cytosolic calcium ion concentration  (IEA)
positive regulation of sequestering of calcium ion  (IDA)
protein maturation by protein folding  (TAS)
protein peptidyl-prolyl isomerization  (IBA,IDA,IEA)
protein refolding  (TAS)
regulation of cardiac conduction  (TAS)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (IBA,ISS)
regulation of cytosolic calcium ion concentration  (IDA,IGI)
regulation of heart rate  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IDA)
regulation of ryanodine-sensitive calcium-release channel activity  (IDA,IMP)
release of sequestered calcium ion into cytosol  (ISO)
response to glucose  (ISO)
response to hydrogen peroxide  (IEA)
response to organic substance  (ISO)
response to redox state  (IDA)
response to vitamin E  (IEA)
smooth muscle contraction  (ISO)
T cell proliferation  (ISO)

Cellular Component

References

Additional References at PubMed
PMID:7513996   PMID:7592869   PMID:9013543   PMID:10713512   PMID:10830164   PMID:11237759   PMID:11322937   PMID:11598113   PMID:12443530   PMID:12446682   PMID:12459180   PMID:12477932  
PMID:12754204   PMID:14616768   PMID:15351706   PMID:15489334   PMID:15591045   PMID:15749201   PMID:15972811   PMID:16049346   PMID:16122887   PMID:17200109   PMID:17313373   PMID:17921453  
PMID:19197348   PMID:19226252   PMID:20404344   PMID:20431056   PMID:21262961   PMID:21873635   PMID:22087651   PMID:22236651   PMID:23233753   PMID:23747301   PMID:23887639   PMID:25416956  
PMID:26009182   PMID:26009186   PMID:26344197   PMID:27154203   PMID:27670942   PMID:27760856   PMID:32296183   PMID:32669538  


Genomics

Comparative Map Data
FKBP1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl224,049,701 - 24,063,681 (+)EnsemblGRCh38hg38GRCh38
GRCh38224,033,205 - 24,067,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37224,272,584 - 24,286,551 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36224,126,132 - 24,140,055 (+)NCBINCBI36hg18NCBI36
Build 34224,184,278 - 24,198,199NCBI
Celera224,112,915 - 24,126,882 (+)NCBI
Cytogenetic Map2p23.3NCBI
HuRef224,011,446 - 24,025,414 (+)NCBIHuRef
CHM1_1224,201,961 - 24,215,941 (+)NCBICHM1_1
Fkbp1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,883,174 - 4,891,736 (-)NCBI
GRCm38124,833,176 - 4,841,573 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl124,833,174 - 4,841,591 (-)EnsemblGRCm38mm10GRCm38
MGSCv37124,839,980 - 4,848,401 (-)NCBIGRCm37mm9NCBIm37
MGSCv36124,855,524 - 4,863,925 (-)NCBImm8
Celera124,764,579 - 4,773,000 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
Fkbp1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0629,975,863 - 29,987,252 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl629,977,797 - 29,987,451 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0639,899,242 - 39,908,337 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera627,309,253 - 27,318,232 (-)NCBICelera
Cytogenetic Map6q14NCBI
Fkbp1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554696,263,271 - 6,277,767 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554696,263,271 - 6,274,823 (+)NCBIChiLan1.0ChiLan1.0
FKBP1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A24,145,893 - 24,162,842 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A24,145,893 - 24,159,082 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A24,047,287 - 24,065,765 (+)NCBIMhudiblu_PPA_v0panPan3
FKBP1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1718,534,741 - 18,544,943 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11718,534,295 - 18,544,973 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Fkbp1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364937,916,002 - 7,922,747 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FKBP1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3114,623,529 - 114,634,628 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13114,623,529 - 114,636,200 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23121,888,309 - 121,899,459 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FKBP1B
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1483,606,454 - 83,620,205 (-)Ensembl
ChlSab1.11483,606,511 - 83,620,289 (-)NCBI
Fkbp1b
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247386,383,003 - 6,394,051 (+)NCBI

Position Markers
RH68268  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37224,286,268 - 24,286,456UniSTSGRCh37
Build 36224,139,772 - 24,139,960RGDNCBI36
Celera224,126,599 - 24,126,787RGD
Cytogenetic Map2p23.3UniSTS
HuRef224,025,131 - 24,025,319UniSTS
GeneMap99-GB4 RH Map287.9UniSTS
NCBI RH Map2117.7UniSTS
SHGC-31628  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371442,212,197 - 42,212,405UniSTSGRCh37
GRCh37224,286,090 - 24,286,298UniSTSGRCh37
Build 36224,139,594 - 24,139,802RGDNCBI36
Celera1422,072,918 - 22,073,126UniSTS
Celera224,126,421 - 24,126,629RGD
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map14q21.1UniSTS
HuRef224,024,953 - 24,025,161UniSTS
HuRef1422,322,580 - 22,322,788UniSTS
Stanford-G3 RH Map2849.0UniSTS
GeneMap99-GB4 RH Map274.69UniSTS
Whitehead-RH Map2128.4UniSTS
NCBI RH Map2146.5UniSTS
GeneMap99-G3 RH Map2844.0UniSTS
FKBP1B_2367  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37224,285,923 - 24,286,585UniSTSGRCh37
Build 36224,139,427 - 24,140,089RGDNCBI36
Celera224,126,254 - 24,126,916RGD
HuRef224,024,786 - 24,025,448UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1781
Count of miRNA genes:478
Interacting mature miRNAs:531
Transcripts:ENST00000380986, ENST00000380991, ENST00000421839, ENST00000438630, ENST00000452109, ENST00000496149
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 531 435 555 109 92 65 1048 97 3088 60 432 985 47 118 729
Low 1854 2543 1159 505 1562 390 3151 1925 643 335 1021 603 127 1 1086 1908 4 2
Below cutoff 42 13 12 10 228 10 151 166 3 24 5 22 146

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001322963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_054033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_136536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_136538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_136539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011532699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017003593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017003594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017003595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017003596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB190793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC104665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF322070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF216711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF969580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI546013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM802489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU147063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU508033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D38037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB868428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC925837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L37086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S69800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S69815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000380986   ⟹   ENSP00000370373
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl224,049,741 - 24,063,681 (+)Ensembl
RefSeq Acc Id: ENST00000380991   ⟹   ENSP00000370379
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl224,049,701 - 24,063,681 (+)Ensembl
RefSeq Acc Id: ENST00000421839   ⟹   ENSP00000397444
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl224,053,911 - 24,063,681 (+)Ensembl
RefSeq Acc Id: ENST00000438630   ⟹   ENSP00000416349
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl224,049,731 - 24,063,681 (+)Ensembl
RefSeq Acc Id: ENST00000452109   ⟹   ENSP00000406593
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl224,049,771 - 24,063,671 (+)Ensembl
RefSeq Acc Id: ENST00000496149
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl224,049,752 - 24,063,656 (+)Ensembl
RefSeq Acc Id: NM_001322963   ⟹   NP_001309892
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38224,049,741 - 24,063,681 (+)NCBI
CHM1_1224,201,961 - 24,215,941 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001322964   ⟹   NP_001309893
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38224,049,741 - 24,063,681 (+)NCBI
CHM1_1224,201,961 - 24,215,941 (+)NCBI
Sequence:
RefSeq Acc Id: NM_004116   ⟹   NP_004107
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38224,049,741 - 24,063,681 (+)NCBI
GRCh37224,272,584 - 24,286,551 (+)ENTREZGENE
Build 36224,126,132 - 24,140,055 (+)NCBI Archive
HuRef224,011,446 - 24,025,414 (+)ENTREZGENE
CHM1_1224,201,961 - 24,215,941 (+)NCBI
Sequence:
RefSeq Acc Id: NM_054033   ⟹   NP_473374
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38224,049,741 - 24,063,681 (+)NCBI
GRCh37224,272,584 - 24,286,551 (+)ENTREZGENE
Build 36224,126,132 - 24,140,055 (+)NCBI Archive
HuRef224,011,446 - 24,025,414 (+)ENTREZGENE
CHM1_1224,201,961 - 24,215,941 (+)NCBI
Sequence:
RefSeq Acc Id: NR_136536
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38224,049,741 - 24,063,681 (+)NCBI
CHM1_1224,201,961 - 24,215,941 (+)NCBI
Sequence:
RefSeq Acc Id: NR_136538
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38224,049,741 - 24,063,681 (+)NCBI
CHM1_1224,201,961 - 24,215,941 (+)NCBI
Sequence:
RefSeq Acc Id: NR_136539
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38224,049,741 - 24,063,681 (+)NCBI
CHM1_1224,201,961 - 24,215,941 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011532699   ⟹   XP_011531001
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38224,049,691 - 24,067,743 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017003593   ⟹   XP_016859082
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38224,049,696 - 24,063,681 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017003594   ⟹   XP_016859083
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38224,033,205 - 24,063,681 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017003595   ⟹   XP_016859084
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38224,049,696 - 24,063,681 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017003596   ⟹   XP_016859085
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38224,049,856 - 24,063,681 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_473374   ⟸   NM_054033
- Peptide Label: isoform b
- UniProtKB: P68106 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_004107   ⟸   NM_004116
- Peptide Label: isoform a
- UniProtKB: P68106 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011531001   ⟸   XM_011532699
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001309892   ⟸   NM_001322963
- Peptide Label: isoform c
- UniProtKB: F8W6G9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309893   ⟸   NM_001322964
- Peptide Label: isoform c
- UniProtKB: F8W6G9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016859083   ⟸   XM_017003594
- Peptide Label: isoform X2
- UniProtKB: F8W6G9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016859085   ⟸   XM_017003596
- Peptide Label: isoform X2
- UniProtKB: F8W6G9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016859082   ⟸   XM_017003593
- Peptide Label: isoform X2
- UniProtKB: F8W6G9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016859084   ⟸   XM_017003595
- Peptide Label: isoform X2
- UniProtKB: F8W6G9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000416349   ⟸   ENST00000438630
RefSeq Acc Id: ENSP00000406593   ⟸   ENST00000452109
RefSeq Acc Id: ENSP00000370373   ⟸   ENST00000380986
RefSeq Acc Id: ENSP00000370379   ⟸   ENST00000380991
RefSeq Acc Id: ENSP00000397444   ⟸   ENST00000421839
Protein Domains
PPIase FKBP-type

Promoters
RGD ID:6859750
Promoter ID:EPDNEW_H3039
Type:initiation region
Name:FKBP1B_1
Description:FK506 binding protein 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3040  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38224,049,743 - 24,049,803EPDNEW
RGD ID:6859752
Promoter ID:EPDNEW_H3040
Type:initiation region
Name:FKBP1B_2
Description:FK506 binding protein 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3039  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38224,063,083 - 24,063,143EPDNEW
RGD ID:6797489
Promoter ID:HG_KWN:31747
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:OTTHUMT00000207622,   OTTHUMT00000207623,   OTTHUMT00000324275,   OTTHUMT00000324277,   OTTHUMT00000324278,   OTTHUMT00000324348
Position:
Human AssemblyChrPosition (strand)Source
Build 36224,125,739 - 24,126,239 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p25.3-23.1(chr2:30141-31766749)x3 copy number gain See cases [RCV000052929] Chr2:30141..31766749 [GRCh38]
Chr2:30141..31991818 [GRCh37]
Chr2:20141..31845322 [NCBI36]
Chr2:2p25.3-23.1
pathogenic
GRCh38/hg38 2p25.3-16.1(chr2:66097-55570637)x3 copy number gain See cases [RCV000052933] Chr2:66097..55570637 [GRCh38]
Chr2:66097..55797773 [GRCh37]
Chr2:56097..55651277 [NCBI36]
Chr2:2p25.3-16.1
pathogenic
GRCh38/hg38 2p25.3-23.2(chr2:30341-28419664)x3 copy number gain See cases [RCV000135398] Chr2:30341..28419664 [GRCh38]
Chr2:30341..28642531 [GRCh37]
Chr2:20341..28496035 [NCBI36]
Chr2:2p25.3-23.2
pathogenic
GRCh38/hg38 2p24.1-23.3(chr2:23789282-24087112)x1 copy number loss See cases [RCV000137161] Chr2:23789282..24087112 [GRCh38]
Chr2:24012152..24309982 [GRCh37]
Chr2:23865656..24163486 [NCBI36]
Chr2:2p24.1-23.3
uncertain significance
GRCh38/hg38 2p25.3-23.3(chr2:17019-26318846)x3 copy number gain See cases [RCV000137344] Chr2:17019..26318846 [GRCh38]
Chr2:17019..26541714 [GRCh37]
Chr2:7019..26395218 [NCBI36]
Chr2:2p25.3-23.3
pathogenic
GRCh38/hg38 2p25.3-22.3(chr2:12770-33711509)x3 copy number gain See cases [RCV000141829] Chr2:12770..33711509 [GRCh38]
Chr2:12770..33936576 [GRCh37]
Chr2:2770..33790080 [NCBI36]
Chr2:2p25.3-22.3
pathogenic
GRCh38/hg38 2p25.3-23.3(chr2:12770-25039694)x3 copy number gain See cases [RCV000141877] Chr2:12770..25039694 [GRCh38]
Chr2:12770..25262563 [GRCh37]
Chr2:2770..25116067 [NCBI36]
Chr2:2p25.3-23.3
pathogenic
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2
benign
GRCh38/hg38 2p24.1-23.2(chr2:22579652-28525186)x1 copy number loss See cases [RCV000142071] Chr2:22579652..28525186 [GRCh38]
Chr2:22802524..28748053 [GRCh37]
Chr2:22656029..28601557 [NCBI36]
Chr2:2p24.1-23.2
pathogenic
GRCh38/hg38 2p25.3-21(chr2:236816-45983232)x3 copy number gain See cases [RCV000143682] Chr2:236816..45983232 [GRCh38]
Chr2:236816..46210371 [GRCh37]
Chr2:226816..46063875 [NCBI36]
Chr2:2p25.3-21
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p23.3(chr2:24235780-25700427)x1 copy number loss not provided [RCV000509286] Chr2:24235780..25700427 [GRCh37]
Chr2:2p23.3
not provided
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p23.3(chr2:24058035-24283976)x1 copy number loss not provided [RCV000682038] Chr2:24058035..24283976 [GRCh37]
Chr2:2p23.3
uncertain significance
GRCh37/hg19 2p24.1-23.3(chr2:19905995-24762790)x1 copy number loss not provided [RCV000682157] Chr2:19905995..24762790 [GRCh37]
Chr2:2p24.1-23.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p24.1-16.3(chr2:22665048-52850368)x3 copy number gain not provided [RCV000752875] Chr2:22665048..52850368 [GRCh37]
Chr2:2p24.1-16.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3712 AgrOrtholog
COSMIC FKBP1B COSMIC
Ensembl Genes ENSG00000119782 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000370373 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000370379 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000397444 UniProtKB/TrEMBL
  ENSP00000406593 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000416349 UniProtKB/TrEMBL
Ensembl Transcript ENST00000380986 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000380991 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000421839 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000438630 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000452109 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000496149 ENTREZGENE
GTEx ENSG00000119782 GTEx
HGNC ID HGNC:3712 ENTREZGENE
Human Proteome Map FKBP1B Human Proteome Map
InterPro PPIase_FKBP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2281 UniProtKB/Swiss-Prot
NCBI Gene 2281 ENTREZGENE
OMIM 600620 OMIM
Pfam FKBP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB FKBP1B RGD, PharmGKB
PROSITE FKBP_PPIASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.709461 ENTREZGENE
UniProt F8W6G9 ENTREZGENE, UniProtKB/TrEMBL
  FKB1B_HUMAN UniProtKB/Swiss-Prot
  G5E9U6_HUMAN UniProtKB/TrEMBL
  H7C0Y3_HUMAN UniProtKB/TrEMBL
  P68106 ENTREZGENE
UniProt Secondary Q13664 UniProtKB/Swiss-Prot
  Q16645 UniProtKB/Swiss-Prot
  Q53TM2 UniProtKB/Swiss-Prot
  Q9BQ40 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-11-06 FKBP1B  FKBP prolyl isomerase 1B    FK506 binding protein 1B  Symbol and/or name change 5135510 APPROVED
2015-11-17 FKBP1B  FK506 binding protein 1B    FK506 binding protein 1B, 12.6 kDa  Symbol and/or name change 5135510 APPROVED
2011-08-17 FKBP1B  FK506 binding protein 1B, 12.6 kDa  FKBP1B  FK506 binding protein 1B, 12.6 kDa  Symbol and/or name change 5135510 APPROVED