RGD Reference Report - mTOR signaling in growth control and disease. - Rat Genome Database

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mTOR signaling in growth control and disease.

Authors: Laplante, M  Sabatini, DM 
Citation: Laplante M and Sabatini DM, Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017.
RGD ID: 11535033
Pubmed: PMID:22500797   (View Abstract at PubMed)
PMCID: PMC3331679   (View Article at PubMed Central)
DOI: DOI:10.1016/j.cell.2012.03.017   (Journal Full-text)

The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration. Here, we review recent advances in our understanding of the mTOR pathway and its role in health, disease, and aging. We further discuss pharmacological approaches to treat human pathologies linked to mTOR deregulation.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AKT1S1HumanmTOR signaling pathway   TAS  RGD 
Akt1s1RatmTOR signaling pathway   ISOAKT1S1 (Homo sapiens) RGD 
Akt1s1MousemTOR signaling pathway   ISOAKT1S1 (Homo sapiens) RGD 
DEPTORHumanmTOR signaling pathway   TAS  RGD 
DeptorRatmTOR signaling pathway   ISODEPTOR (Homo sapiens) RGD 
DeptorMousemTOR signaling pathway   ISODEPTOR (Homo sapiens) RGD 
FKBP1AHumanmTOR signaling pathway   TAS  RGD 
Fkbp1aRatmTOR signaling pathway   ISOFKBP1A (Homo sapiens) RGD 
Fkbp1aMousemTOR signaling pathway   ISOFKBP1A (Homo sapiens) RGD 
MAPKAP1HumanmTOR signaling pathway   TAS  RGD 
MLST8HumanmTOR signaling pathway   TAS  RGD 
MTORHumanmTOR signaling pathway   TAS  RGD 
Mapkap1RatmTOR signaling pathway   ISOMAPKAP1 (Homo sapiens) RGD 
Mapkap1MousemTOR signaling pathway   ISOMAPKAP1 (Homo sapiens) RGD 
Mlst8RatmTOR signaling pathway   ISOMLST8 (Homo sapiens) RGD 
Mlst8MousemTOR signaling pathway   ISOMLST8 (Homo sapiens) RGD 
MtorRatmTOR signaling pathway   ISOMTOR (Homo sapiens) RGD 
MtorMousemTOR signaling pathway   ISOMTOR (Homo sapiens) RGD 
PRR5HumanmTOR signaling pathway   TAS  RGD 
PRR5LHumanmTOR signaling pathway   TAS  RGD 
Prr5RatmTOR signaling pathway   ISOPRR5 (Homo sapiens) RGD 
Prr5MousemTOR signaling pathway   ISOPRR5 (Homo sapiens) RGD 
Prr5lRatmTOR signaling pathway   ISOPRR5L (Homo sapiens) RGD 
Prr5lMousemTOR signaling pathway   ISOPRR5L (Homo sapiens) RGD 
RICTORHumanmTOR signaling pathway   TAS  RGD 
RPTORHumanmTOR signaling pathway   TAS  RGD 
RictorRatmTOR signaling pathway   ISORICTOR (Homo sapiens) RGD 
RictorMousemTOR signaling pathway   ISORICTOR (Homo sapiens) RGD 
RptorRatmTOR signaling pathway   ISORPTOR (Homo sapiens) RGD 
RptorMousemTOR signaling pathway   ISORPTOR (Homo sapiens) RGD 
TELO2HumanmTOR signaling pathway   TAS  RGD 
TTI1HumanmTOR signaling pathway   TAS  RGD 
Telo2RatmTOR signaling pathway   ISOTELO2 (Homo sapiens) RGD 
Telo2MousemTOR signaling pathway   ISOTELO2 (Homo sapiens) RGD 
Tti1MousemTOR signaling pathway   ISOTTI1 (Homo sapiens) RGD 
Tti1RatmTOR signaling pathway   ISOTTI1 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Akt1s1  (AKT1 substrate 1)
Deptor  (DEP domain containing MTOR-interacting protein)
Fkbp1a  (FKBP prolyl isomerase 1A)
Mapkap1  (MAPK associated protein 1)
Mlst8  (MTOR associated protein, LST8 homolog)
Mtor  (mechanistic target of rapamycin kinase)
Prr5  (proline rich 5)
Prr5l  (proline rich 5 like)
Rictor  (RPTOR independent companion of MTOR, complex 2)
Rptor  (regulatory associated protein of MTOR, complex 1)
Telo2  (telomere maintenance 2)
Tti1  (TELO2 interacting protein 1)

Genes (Mus musculus)
Akt1s1  (AKT1 substrate 1)
Deptor  (DEP domain containing MTOR-interacting protein)
Fkbp1a  (FK506 binding protein 1a)
Mapkap1  (mitogen-activated protein kinase associated protein 1)
Mlst8  (MTOR associated protein, LST8 homolog (S. cerevisiae))
Mtor  (mechanistic target of rapamycin kinase)
Prr5  (proline rich 5 (renal))
Prr5l  (proline rich 5 like)
Rictor  (RPTOR independent companion of MTOR, complex 2)
Rptor  (regulatory associated protein of MTOR, complex 1)
Telo2  (telomere maintenance 2)
Tti1  (TELO2 interacting protein 1)

Genes (Homo sapiens)
AKT1S1  (AKT1 substrate 1)
DEPTOR  (DEP domain containing MTOR interacting protein)
FKBP1A  (FKBP prolyl isomerase 1A)
MAPKAP1  (MAPK associated protein 1)
MLST8  (MTOR associated protein, LST8 homolog)
MTOR  (mechanistic target of rapamycin kinase)
PRR5  (proline rich 5)
PRR5L  (proline rich 5 like)
RICTOR  (RPTOR independent companion of MTOR complex 2)
RPTOR  (regulatory associated protein of MTOR complex 1)
TELO2  (telomere maintenance 2)
TTI1  (TELO2 interacting protein 1)


Additional Information