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Gene: Eno1 (enolase 1) Rattus norvegicus
Symbol: Eno1
Name: enolase 1
RGD ID: 2553
Description: Exhibits several functions, including heat shock protein binding activity; phosphopyruvate hydratase activity; and protein homodimerization activity. Involved in ERK1 and ERK2 cascade; canonical glycolysis; and cellular response to hypoxia. Localizes to several cellular components, including growth cone; membrane raft; and phosphopyruvate hydratase complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human ENO1 (enolase 1); PARTICIPATES IN gluconeogenesis pathway; Fanconi syndrome pathway; fructose-1,6-bisphosphatase deficiency pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2-phospho-D-glycerate hydro-lyase; alpha enolase; alpha-enolase; enolase 1, (alpha); enolase 1, alpha; enolase 1, alpha non-neuron; NNE; non-neural enolase
Homo sapiens (human) : ENO1 (enolase 1)  HGNC  Alliance
Mus musculus (house mouse) : Eno1 (enolase 1, alpha non-neuron)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Eno1 (enolase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ENO1 (enolase 1)
Canis lupus familiaris (dog) : ENO1 (enolase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Eno1 (enolase 1)
Sus scrofa (pig) : ENO1 (enolase 1)
Chlorocebus sabaeus (African green monkey) : ENO1 (enolase 1)
Heterocephalus glaber (naked mole-rat) : Eno1 (enolase 1)
more info ...
Related Pseudogenes: Eno1-ps1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05167,288,223 - 167,299,610 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,288,223 - 167,299,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05170,915,874 - 170,927,267 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45167,394,131 - 167,405,516 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15167,404,823 - 167,415,701 (+)NCBI
Celera5158,976,607 - 158,987,992 (+)NCBICelera
Cytogenetic Map5q36NCBI
RH 3.4 Map51122.0RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Eno1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2553
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-10-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.