Pkm (pyruvate kinase M1/2) - Rat Genome Database

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Gene: Pkm (pyruvate kinase M1/2) Rattus norvegicus
Analyze
Symbol: Pkm
Name: pyruvate kinase M1/2
RGD ID: 3337
Description: Enables several functions, including ADP binding activity; pyruvate kinase activity; and thyroid hormone binding activity. Involved in several processes, including ATP biosynthetic process; pyruvate metabolic process; and response to insulin. Part of pyruvate kinase complex. Orthologous to human PKM (pyruvate kinase M1/2); PARTICIPATES IN glycolysis pathway; pyruvate metabolic pathway; hypoxia inducible factor pathway; INTERACTS WITH (R)-adrenaline; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: M2 pyruvate kinase; PK; Pk3; PKM12; Pkm2; pyruvate kinase isozymes M1/M2; Pyruvate kinase muscle; pyruvate kinase muscle isozyme; pyruvate kinase PKM; pyruvate kinase, muscle; threonine-protein kinase PKM2; tyrosine-protein kinase PKM2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC100364062  
Allele / Splice: Pkm_v2   Pkm_v1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2860,057,629 - 60,079,600 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl860,057,402 - 60,079,599 (+)Ensembl
Rnor_6.0864,480,963 - 64,502,957 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl864,481,172 - 64,502,722 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0864,243,957 - 64,265,970 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4863,486,492 - 63,508,016 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1863,505,545 - 63,527,070 (+)NCBI
Celera859,500,837 - 59,522,361 (+)NCBICelera
RH 3.4 Map8703.1RGD
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,4-benzoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (EXP)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-chlorobiphenyl  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-Hydroxyflavone  (ISO)
6-Hydroxyflavone  (ISO)
7-hydroxyflavone  (ISO)
7H-xanthine  (EXP)
9-cis-retinoic acid  (ISO)
9H-xanthine  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
ampicillin  (ISO)
apigenin  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
baicalein  (ISO)
baicalin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
carbon nanotube  (ISO)
CCCP  (ISO)
chloromethylisothiazolinone  (ISO)
choline  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDT  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dihydroartemisinin  (ISO)
diosmetin  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
flavone  (ISO)
flavonol  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
fructose  (EXP)
fulvestrant  (ISO)
Fusaric acid  (ISO)
galactose  (ISO)
genistein  (EXP)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 3965  (ISO)
haloperidol  (EXP)
hydrogen peroxide  (EXP,ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (ISO)
mercury dichloride  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methylazoxymethanol  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalene  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
niclosamide  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phosphoenolpyruvate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
promethazine  (EXP)
Propiverine  (EXP)
quartz  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SAICAR  (ISO)
SB 431542  (ISO)
scutellarin  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sodium nitrate  (ISO)
streptozocin  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tanespimycin  (ISO)
tangeretin  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenylstannane  (ISO)
Triptolide  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
warfarin  (ISO)
wogonin  (ISO)
Yessotoxin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Alteration in the capacities as well as in the zonal and cellular distributions of pyruvate kinase L and M2 in regenerating rat liver. Chatzipanagiotou S, etal., Biol Chem Hoppe Seyler. 1985 Mar;366(3):271-80.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Relationships between concentration of hepatic intermediary metabolites and induction of the key glycolytic enzymes in vivo. Gunn JM and Taylor CB, Biochem J. 1973 Nov;136(3):455-65.
5. Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 5. Interactions of adenosine 5'-triphosphate derivatives with rat pyruvate kinases, Escherichia coli thymidine kinase, and yeast and rat hexokinases. Hampton A, etal., J Med Chem. 1982 Apr;25(4):386-92.
6. Dominant negative role of the glutamic acid residue conserved in the pyruvate kinase M(1) isozyme in the heterotropic allosteric effect involving fructose-1,6-bisphosphate. Ikeda Y, etal., J Biol Chem. 2000 Mar 31;275(13):9150-6. doi: 10.1074/jbc.275.13.9150.
7. Control of glucose utilization in working perfused rat heart. Kashiwaya Y, etal., J Biol Chem. 1994 Oct 14;269(41):25502-14.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
10. Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7. Mazurek S, etal., Oncogene. 2001 Oct 18;20(47):6891-8. doi: 10.1038/sj.onc.1204792.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Dietary whey protein increases liver and skeletal muscle glycogen levels in exercise-trained rats. Morifuji M, etal., Br J Nutr. 2005 Apr;93(4):439-45.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins. Nilsson A, etal., J Proteome Res. 2007 Oct;6(10):3952-61. Epub 2007 Sep 18.
15. The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. Noguchi T, etal., J Biol Chem 1986 Oct 15;261(29):13807-12.
16. The monomer of pyruvate kinase, subtype M1, is both a kinase and a cytosolic thyroid hormone binding protein. Parkison C, etal., Biochem Biophys Res Commun. 1991 Aug 30;179(1):668-74.
17. The nucleotide sequence of a full length cDNA encoding rat pituitary pyruvate kinase. Parkison C, etal., Nucleic Acids Res 1989 Sep 12;17(17):7106.
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. Response of rat cerebral glycolytic enzymes to hyperammonemic states. Ratnakumari L and Murthy CR, Neurosci Lett. 1993 Oct 14;161(1):37-40.
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Metabolic adaptation of muscles to exercise, vibration and raised temperature under the influence of cernitins. Sawicka TJ, etal., Acta Physiol Pol. 1984 Mar-Apr;35(2):141-50.
22. Energy metabolism pathways in rat muscle under conditions of simulated microgravity. Stein T, etal., J Nutr Biochem. 2002 Aug;13(8):471.
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Effect of immobilization on some glycolytic enzymes of skeletal muscle. Vereb G, etal., Acta Physiol Hung. 1984;63(1):55-61.
26. Developmental patterns of glycolytic enzymes in regenerating skeletal muscle after autogenous free grafting. Wagner KR, etal., J Neurol Sci. 1977 Dec;34(3):373-90.
27. Regulation of glycolytic enzyme RNA transcriptional rates by oxygen availability in skeletal muscle cells. Webster KA Mol Cell Biochem. 1987 Sep;77(1):19-28.
28. Biosynthesis of pyruvate kinase isozymes in rat liver. Wu SW, etal., Eur J Biochem. 1981 Dec;121(1):59-63.
Additional References at PubMed
PMID:2914912   PMID:7262549   PMID:7295297   PMID:11487543   PMID:11960989   PMID:12519789   PMID:14651853   PMID:15682487   PMID:15996096   PMID:16132722   PMID:16687649   PMID:17308100  
PMID:17634366   PMID:18050275   PMID:18191611   PMID:18298799   PMID:18418703   PMID:18587448   PMID:19056867   PMID:19182904   PMID:19190083   PMID:19199708   PMID:20005212   PMID:20458337  
PMID:20833797   PMID:21362503   PMID:21630459   PMID:22658674   PMID:22871113   PMID:23106098   PMID:23376485   PMID:23533145   PMID:23620342   PMID:23658023   PMID:23979707   PMID:24481450  
PMID:24497038   PMID:24625528   PMID:24769233   PMID:25457184   PMID:25468996   PMID:25990228   PMID:26151495   PMID:26774701   PMID:26780311   PMID:27199445   PMID:29476059   PMID:30738168  
PMID:30911983   PMID:31086462   PMID:31202897   PMID:31505169   PMID:31916291   PMID:32017072   PMID:32357304   PMID:32503893   PMID:33130045   PMID:33147380   PMID:33744886   PMID:34240478  
PMID:35087114   PMID:35232222   PMID:35563621  


Genomics

Comparative Map Data
Pkm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2860,057,629 - 60,079,600 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl860,057,402 - 60,079,599 (+)Ensembl
Rnor_6.0864,480,963 - 64,502,957 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl864,481,172 - 64,502,722 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0864,243,957 - 64,265,970 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4863,486,492 - 63,508,016 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1863,505,545 - 63,527,070 (+)NCBI
Celera859,500,837 - 59,522,361 (+)NCBICelera
RH 3.4 Map8703.1RGD
Cytogenetic Map8q24NCBI
PKM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381572,199,029 - 72,231,591 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1572,199,029 - 72,231,819 (-)EnsemblGRCh38hg38GRCh38
GRCh371572,491,370 - 72,523,531 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361570,278,424 - 70,310,738 (-)NCBINCBI36hg18NCBI36
Build 341570,278,423 - 70,310,738NCBI
Celera1549,377,704 - 49,410,018 (-)NCBI
Cytogenetic Map15q23NCBI
HuRef1549,321,965 - 49,354,312 (-)NCBIHuRef
CHM1_11572,609,505 - 72,641,870 (-)NCBICHM1_1
T2T-CHM13v2.01570,015,755 - 70,047,883 (-)NCBI
Pkm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39959,563,859 - 59,586,655 (+)NCBIGRCm39mm39
GRCm39 Ensembl959,563,651 - 59,586,658 (+)Ensembl
GRCm38959,656,576 - 59,679,372 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl959,656,368 - 59,679,375 (+)EnsemblGRCm38mm10GRCm38
MGSCv37959,504,415 - 59,527,182 (+)NCBIGRCm37mm9NCBIm37
MGSCv36959,454,614 - 59,477,381 (+)NCBImm8
Celera956,883,742 - 56,906,668 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map932.03NCBI
Pkm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554504,907,788 - 4,936,199 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554504,907,962 - 4,935,179 (+)NCBIChiLan1.0ChiLan1.0
PKM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11569,913,455 - 69,946,070 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1569,913,455 - 69,945,832 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01551,149,584 - 51,182,193 (-)NCBIMhudiblu_PPA_v0panPan3
PKM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13035,712,853 - 35,737,643 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3035,649,842 - 35,676,381 (-)NCBI
ROS_Cfam_1.03035,917,488 - 35,942,263 (-)NCBI
ROS_Cfam_1.0 Ensembl3035,912,436 - 35,944,108 (-)Ensembl
UMICH_Zoey_3.13035,870,513 - 35,897,163 (-)NCBI
UNSW_CanFamBas_1.03035,898,407 - 35,923,216 (-)NCBI
UU_Cfam_GSD_1.03036,153,315 - 36,179,852 (-)NCBI
Pkm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640113,741,261 - 113,769,688 (-)NCBI
SpeTri2.0NW_00493647131,589,322 - 31,617,891 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PKM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1760,971,807 - 61,032,780 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2765,514,303 - 65,575,391 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PKM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12611,224,332 - 11,255,538 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048130,316,867 - 130,349,792 (-)NCBIVero_WHO_p1.0
Pkm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247811,796,801 - 1,824,144 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247811,796,909 - 1,823,787 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH94821  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2860,072,412 - 60,072,686 (+)MAPPERmRatBN7.2
Rnor_6.0864,495,746 - 64,496,019NCBIRnor6.0
Rnor_5.0864,258,759 - 64,259,032UniSTSRnor5.0
RGSC_v3.4863,501,064 - 63,501,337UniSTSRGSC3.4
Celera859,515,409 - 59,515,682UniSTS
RH 3.4 Map8703.1UniSTS
Cytogenetic Map8q24UniSTS
Pkm2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera859,519,198 - 59,519,266UniSTS
Cytogenetic Map8q24UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:326
Count of miRNA genes:185
Interacting mature miRNAs:200
Transcripts:ENSRNOT00000015332
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2 3 4
Medium 3 41 40 24 19 24 8 8 70 35 41 11 8
Low 17 17 17
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY724474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB883753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB883769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC941162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC941178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000015332   ⟹   ENSRNOP00000015331
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl860,057,798 - 60,079,590 (+)Ensembl
Rnor_6.0 Ensembl864,481,172 - 64,502,722 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083666   ⟹   ENSRNOP00000069474
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl860,057,402 - 60,079,594 (+)Ensembl
Rnor_6.0 Ensembl864,489,942 - 64,502,429 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098634   ⟹   ENSRNOP00000079846
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl860,059,124 - 60,079,594 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118042   ⟹   ENSRNOP00000089941
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl860,059,124 - 60,079,599 (+)Ensembl
RefSeq Acc Id: NM_053297   ⟹   NP_445749
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2860,057,840 - 60,079,365 (+)NCBI
Rnor_6.0864,481,174 - 64,502,722 (+)NCBI
Rnor_5.0864,243,957 - 64,265,970 (+)NCBI
RGSC_v3.4863,486,492 - 63,508,016 (+)RGD
Celera859,500,837 - 59,522,361 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243188   ⟹   XP_006243250
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2860,057,629 - 60,079,600 (+)NCBI
Rnor_6.0864,480,963 - 64,502,957 (+)NCBI
Rnor_5.0864,243,957 - 64,265,970 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243190   ⟹   XP_006243252
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2860,059,758 - 60,079,600 (+)NCBI
Rnor_6.0864,483,092 - 64,502,957 (+)NCBI
Rnor_5.0864,243,957 - 64,265,970 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080894   ⟹   XP_038936822
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2860,063,048 - 60,079,600 (+)NCBI
RefSeq Acc Id: XM_039080895   ⟹   XP_038936823
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2860,059,318 - 60,079,600 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_445749   ⟸   NM_053297
- UniProtKB: P11980 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006243250   ⟸   XM_006243188
- Peptide Label: isoform X1
- UniProtKB: P11980 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006243252   ⟸   XM_006243190
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000069474   ⟸   ENSRNOT00000083666
RefSeq Acc Id: ENSRNOP00000015331   ⟸   ENSRNOT00000015332
RefSeq Acc Id: XP_038936823   ⟸   XM_039080895
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038936822   ⟸   XM_039080894
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000089941   ⟸   ENSRNOT00000118042
RefSeq Acc Id: ENSRNOP00000079846   ⟸   ENSRNOT00000098634

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11980-F1-model_v2 AlphaFold P11980 1-531 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696042
Promoter ID:EPDNEW_R6566
Type:multiple initiation site
Name:Pkm_1
Description:pyruvate kinase M1/2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0864,481,166 - 64,481,226EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3337 AgrOrtholog
BioCyc Gene G2FUF-30234 BioCyc
Ensembl Genes ENSRNOG00000011329 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015331 ENTREZGENE
  ENSRNOP00000069474.2 UniProtKB/TrEMBL
  ENSRNOP00000079846.1 UniProtKB/TrEMBL
  ENSRNOP00000089941 ENTREZGENE
  ENSRNOP00000089941.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015332 ENTREZGENE
  ENSRNOT00000083666.2 UniProtKB/TrEMBL
  ENSRNOT00000098634.1 UniProtKB/TrEMBL
  ENSRNOT00000118042 ENTREZGENE
  ENSRNOT00000118042.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.33.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.1380.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6888187 IMAGE-MGC_LOAD
InterPro Pyr_Knase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv/PenolPyrv_Kinase-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase-like_insert_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase_AS UniProtKB/Swiss-Prot
  Pyrv_Knase_brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase_insert_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25630 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72751 IMAGE-MGC_LOAD
NCBI Gene 25630 ENTREZGENE
PANTHER PTHR11817 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00224 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pkm PhenoGen
PRINTS PYRUVTKNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PYRUVATE_KINASE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50800 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51621 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52935 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204001
  TC204002
TIGRFAMs pyruv_kin UniProtKB/Swiss-Prot
UniProt A0A0G2JVG3_RAT UniProtKB/TrEMBL
  A0A8I6ABE3_RAT UniProtKB/TrEMBL
  A0A8I6G5T6_RAT UniProtKB/TrEMBL
  KPYM_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P11981 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-28 Pkm  pyruvate kinase M1/2  Pkm  pyruvate kinase, muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-05-23 Pkm  pyruvate kinase, muscle  Pkm2  pyruvate kinase, muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Pkm2  pyruvate kinase, muscle    Pyruvate kinase, muscle  Name updated 625702 APPROVED
2002-06-10 Pkm2  Pyruvate kinase, muscle      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression M1 isoform replaces M2 during development in skeletal muscle, heart, and brain 633549