Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3337
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pkm
Name: pyruvate kinase M1/2
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pkmdecreases expressionISOPKM (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of PKM mRNA; Arsenic Trioxide results in decreased expression of PKM proteinPMID:31003765
Pkmincreases expressionISOPKM (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of PKM proteinPMID:25419056
Pkmmultiple interactionsISOPKM (Homo sapiens)6480464CTD[Tretinoin co-treated with Arsenic Trioxide] results in increased expression of PKM mRNA; MEG3 protein affects the reaction [Arsenic Trioxide results in decreased expression of PKM mRNA]; MEG3 protein affects the reaction [Arsenic Trioxide results in decreased expression of PKM protein]; PKM protein inhibits the reaction [Arsenic Trioxide results in decreased expression of CDH2 mRNA]; PKM protein inhibits the reaction [Arsenic Trioxide results in decreased expression of CDH2 protein]; PKM protein inhibits the reaction [Arsenic Trioxide results in decreased expression of VIM mRNA]; PKM protein inhibits the reaction [Arsenic Trioxide results in decreased expression of VIM protein]; PKM protein inhibits the reaction [Arsenic Trioxide results in increased expression of CDH1 mRNA]; PKM protein inhibits the reaction [Arsenic Trioxide results in increased expression of CDH1 protein]; PKM protein inhibits the reaction [Arsenic Trioxide results in increased expression of MEG3 mRNA]PMID:15894607 PMID:31003765
Go Back to source page   Continue to Ontology report