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Gene: Pklr (pyruvate kinase L/R) Rattus norvegicus
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Symbol: Pklr
Name: pyruvate kinase L/R
Description: Exhibits pyruvate kinase activity. Involved in several processes, including cellular response to organonitrogen compound; pyruvate metabolic process; and response to purine-containing compound. Localizes to cytosol. Biomarker of hyperglycemia. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R); PARTICIPATES IN glycolysis pathway; pyruvate metabolic pathway; Fanconi syndrome pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: L-PK; PK1; PKL; Pklg; pyruvate kinase isozymes L/R; pyruvate kinase isozymes R/L; pyruvate kinase PKLR; pyruvate kinase, liver and RBC; pyruvate kinase, liver and red blood cell
Orthologs:
Homo sapiens (human) : PKLR (pyruvate kinase L/R)  HGNC  Alliance
Mus musculus (house mouse) : Pklr (pyruvate kinase liver and red blood cell)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pklr (pyruvate kinase L/R)
Pan paniscus (bonobo/pygmy chimpanzee) : PKLR (pyruvate kinase L/R)
Canis lupus familiaris (dog) : PKLR (pyruvate kinase L/R)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pklr (pyruvate kinase L/R)
Sus scrofa (pig) : PKLR (pyruvate kinase L/R)
Chlorocebus sabaeus (African green monkey) : PKLR (pyruvate kinase L/R)
Heterocephalus glaber (naked mole-rat) : Pklr (pyruvate kinase L/R)
more info ...
Is Marker For: Strains:   WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc   WKY.SHRSP-(Fst-Pklr)/Gcrc  
QTLs:   Niddm8  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02188,449,158 - 188,458,034 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,449,210 - 188,459,592 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,865,529 - 207,874,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,214,853 - 181,223,505 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12181,164,961 - 181,173,618 (+)NCBI
Celera2168,486,468 - 168,494,841 (+)NCBICelera
Cytogenetic Map2q34NCBI
RH 3.4 Map21154.4RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pklr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3336
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.