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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3337
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pkm
Name: pyruvate kinase M1/2
Acc ID: CHEBI:28358
Term: rac-lactic acid
Definition: A racemate comprising equimolar amounts of (R)- and (S)-lactic acid.
Chemical ID: MESH:D019344
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pkmincreases abundanceISOPKM (Homo sapiens)6480464CTDPKM protein results in increased abundance of Lactic AcidPMID:22574221
Pkmincreases expressionISOPKM (Homo sapiens)6480464CTDLactic Acid results in increased expression of PKM proteinPMID:36336208
Pkmmultiple interactionsISOPKM (Homo sapiens)6480464CTDLactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PKM protein]; PKM protein affects the reaction [[Lactic Acid promotes the reaction [Cadmium Chloride results in increased abundance of Cadmium]] which results in increased expression of CCND1 protein]; PKM protein affects the reaction [Lactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CCNE1 protein]]; PKM protein affects the reaction [Lactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP2 protein]]; PKM protein affects the reaction [Lactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP9 protein]]PMID:36336208
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