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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3337
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pkm
Name: pyruvate kinase M1/2
Acc ID: CHEBI:18319
Term: SAICAR
Definition: A 1-(phosphoribosyl)imidazolecarboxamide resulting from the formal condesation of the darboxy group of 5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole-4-carboxylic acid with the amino group of L-aspartic acid.
Chemical ID: MESH:C020635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pkmmultiple interactionsISOPKM (Homo sapiens)6480464CTDGlucose deficiency promotes the reaction [SAICAR binds to and results in increased activity of PKM protein]PMID:23086999
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