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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3337
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pkm
Name: pyruvate kinase M1/2
Acc ID: CHEBI:16509
Term: 1,4-benzoquinone
Definition: The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
Chemical ID: MESH:C004532
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pkmincreases expressionISOPKM (Homo sapiens)6480464CTDquinone results in increased expression of PKM proteinPMID:30448556
Pkmmultiple interactionsISOPKM (Homo sapiens)6480464CTD[HIF1A protein co-treated with quinone] results in increased expression of PKM proteinPMID:30448556
Pkmmultiple interactionsISOPkm (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [quinone results in increased degradation of PKM protein]; quinone results in increased degradation of and results in decreased expression of PKM protein; Reactive Oxygen Species affects the reaction [quinone results in increased degradation of PKM protein]PMID:25437431
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