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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3337
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pkm
Name: pyruvate kinase M1/2
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pkmdecreases expressionISOPKM (Homo sapiens)6480464CTDQuercetin results in decreased expression of PKM proteinPMID:15221776 PMID:35945655
Pkmincreases expressionISOPKM (Homo sapiens)6480464CTDQuercetin results in increased expression of PKM mRNA; Quercetin results in increased expression of PKM proteinPMID:14750173 PMID:21632981
Pkmmultiple interactionsISOPKM (Homo sapiens)6480464CTDG3BP1 protein inhibits the reaction [Quercetin results in decreased expression of PKM protein]PMID:35945655
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