Pkm_v2 (pyruvate kinase M1/2, variant 2) - Rat Genome Database

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Gene: Pkm_v2 (pyruvate kinase M1/2, variant 2) Rattus norvegicus
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Symbol: Pkm_v2
Name: pyruvate kinase M1/2, variant 2
RGD ID: 728317
Description: M2 isoform of pyruvate kinase
ENCODES an splice that exhibits identical protein binding; pyruvate kinase activity; thyroid hormone binding; INVOLVED IN glycolytic process; positive regulation of cytoplasmic translation (ortholog); positive regulation of sprouting angiogenesis (ortholog); FOUND IN pyruvate kinase complex; rough endoplasmic reticulum (ortholog)
Type: splice  of Pkm  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. Noguchi T, etal., J Biol Chem 1986 Oct 15;261(29):13807-12.
3. The monomer of pyruvate kinase, subtype M1, is both a kinase and a cytosolic thyroid hormone binding protein. Parkison C, etal., Biochem Biophys Res Commun. 1991 Aug 30;179(1):668-74.
4. GOA pipeline RGD automated data pipeline

Genomics


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
GenBank Nucleotide M24359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11980-F1-model_v2 AlphaFold P11980 1-531 view protein structure


Additional Information

Database Acc Id Source(s)
UniProt P11980


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Pkm2_v2  pyruvate kinase, muscle, variant 2      Symbol and Name status set to approved 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in early fetal tissues and in most adult tissues; replaced by skeletal muscle, heart, and brain during development 633549