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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3337
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pkm
Name: pyruvate kinase M1/2
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pkmmultiple interactionsISOPKM (Homo sapiens)6480464CTDFulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PKM mRNA]; Fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PKM protein]; Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of and affects the localization of PKM protein]; Fulvestrant inhibits the reaction [Glucose promotes the reaction [Estradiol results in increased phosphorylation of PKM protein]]PMID:28284859 PMID:32078667
Pkmmultiple interactionsISOPkm (Mus musculus)6480464CTDFulvestrant inhibits the reaction [bisphenol F results in increased expression of PKM protein]PMID:34147605
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