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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3337
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pkm
Name: pyruvate kinase M1/2
Acc ID: CHEBI:18021
Term: phosphoenolpyruvate
Definition: A monocarboxylic acid anion resuting from selective deprotonation of the carboxy group of phosphoenolpyruvic acid.
Chemical ID: MESH:D010728
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pkmincreases metabolic processingISOPKM (Homo sapiens)6480464CTDPKM protein results in increased metabolism of PhosphoenolpyruvatePMID:25388478
Pkmmultiple interactionsISOPKM (Homo sapiens)6480464CTD3-hydroxyflavone inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate]; 5-hydroxyflavone inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate]; 6-hydroxyflavone inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate]; 7-hydroxyflavone inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate]; Apigenin inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate]; flavone inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate]; wogonin inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate]PMID:25388478
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