Hspa8 (heat shock protein family A (Hsp70) member 8) - Rat Genome Database

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Gene: Hspa8 (heat shock protein family A (Hsp70) member 8) Ictidomys tridecemlineatus
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Symbol: Hspa8
Name: heat shock protein family A (Hsp70) member 8
RGD ID: 12637538
Description: ENCODES a protein that exhibits A1 adenosine receptor binding (ortholog); ATP hydrolysis activity (ortholog); ATP-dependent protein disaggregase activity (ortholog); INVOLVED IN ATP metabolic process (ortholog); axo-dendritic transport (ortholog); cellular response to cadmium ion (ortholog); PARTICIPATES IN androgen signaling pathway; chaperone mediated autophagy pathway; clathrin-dependent synaptic vesicle endocytosis; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute kidney failure (ortholog); Acute Liver Failure (ortholog); FOUND IN asymmetric synapse (ortholog); autophagosome (ortholog); axon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947104,655,786 - 104,660,238 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365427,577,149 - 7,581,923 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365427,577,192 - 7,581,598 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (ISO)
autophagy  (IEA)
axo-dendritic transport  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to heat  (ISO)
cellular response to hydrogen peroxide  (ISO)
cerebellum development  (ISO)
chaperone-mediated autophagy  (ISO)
chaperone-mediated autophagy translocation complex disassembly  (ISO)
clathrin coat disassembly  (IEA,ISO)
estrous cycle  (ISO)
forebrain development  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
host-mediated activation of viral genome replication  (IEA)
host-mediated perturbation of viral process  (IEA)
kidney development  (ISO)
late endosomal microautophagy  (IEA)
maintenance of postsynaptic specialization structure  (ISO)
mRNA processing  (IEA)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of NLRP3 inflammasome complex assembly  (ISO)
negative regulation of supramolecular fiber organization  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of lysosomal membrane permeability  (ISO)
positive regulation of mRNA splicing, via spliceosome  (IEA)
positive regulation of phagocytosis  (ISO)
positive regulation of protein refolding  (ISO)
positive regulation of proteolysis  (ISO)
positive regulation of T cell mediated cytotoxicity  (ISO)
protein autophosphorylation  (ISO)
protein catabolic process  (ISO)
protein folding  (IEA,ISO)
protein import into nucleus  (ISO)
protein refolding  (ISO)
protein targeting to lysosome involved in chaperone-mediated autophagy  (ISO)
protein transmembrane import into intracellular organelle  (ISO)
protein-containing complex disassembly  (ISO)
regulation of cell cycle  (IEA)
regulation of postsynapse organization  (IEA)
regulation of protein complex stability  (ISO)
regulation of protein stability  (ISO)
response to activity  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to nickel cation  (ISO)
response to odorant  (ISO)
response to progesterone  (ISO)
response to starvation  (ISO)
response to xenobiotic stimulus  (ISO)
RNA splicing  (IEA)
skeletal muscle tissue development  (ISO)
slow axonal transport  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Hspa8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947104,655,786 - 104,660,238 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365427,577,149 - 7,581,923 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365427,577,192 - 7,581,598 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811123,057,489 - 123,062,462 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11123,057,489 - 123,063,230 (-)Ensemblhg38GRCh38
GRCh3711122,928,197 - 122,932,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611122,433,410 - 122,438,054 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3411122,433,410 - 122,438,054NCBI
Celera11120,087,529 - 120,092,173 (-)NCBICelera
Cytogenetic Map11q24.1NCBI
HuRef11118,870,278 - 118,875,122 (-)NCBIHuRef
CHM1_111122,814,192 - 122,819,035 (-)NCBICHM1_1
T2T-CHM13v2.011123,086,071 - 123,093,285 (-)NCBIT2T-CHM13v2.0
Hspa8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39940,712,572 - 40,716,498 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl940,712,280 - 40,721,383 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38940,801,276 - 40,805,202 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl940,800,984 - 40,810,087 (+)Ensemblmm10GRCm38
MGSCv37940,609,356 - 40,613,282 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3658,102,053 - 8,104,168 (+)NCBIMGSCv36mm8
MGSCv36940,552,355 - 40,556,269 (+)NCBIMGSCv36mm8
Celera938,034,609 - 38,038,251 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map921.55NCBI
Hspa8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8850,080,514 - 50,084,376 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl850,080,199 - 50,084,372 (+)EnsemblGRCr8
mRatBN7.2841,183,397 - 41,187,260 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl841,183,264 - 41,187,259 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx846,682,619 - 46,686,480 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0844,961,220 - 44,965,081 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0842,828,805 - 42,832,666 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0844,989,401 - 44,993,261 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl844,990,014 - 44,993,179 (+)Ensemblrn6Rnor6.0
Rnor_5.0846,005,304 - 46,006,864 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0843,478,238 - 43,480,456 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4843,784,035 - 43,787,760 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera840,782,916 - 40,786,778 (+)NCBICelera
RGSC_v3.1843,792,829 - 43,796,525 (+)NCBI
Cytogenetic Map8q22NCBI
Hspa8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541223,862,590 - 23,867,984 (-)Ensembl
ChiLan1.0NW_00495541223,863,513 - 23,867,984 (-)NCBIChiLan1.0ChiLan1.0
HSPA8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29123,758,689 - 123,764,231 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111124,863,401 - 124,868,370 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011117,890,545 - 117,895,262 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111121,809,800 - 121,814,628 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11121,809,800 - 121,815,773 (-)EnsemblpanPan2panpan1.1
HSPA8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1511,292,219 - 11,296,851 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl511,292,262 - 11,296,797 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha511,348,073 - 11,352,702 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0511,243,037 - 11,247,671 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl511,242,826 - 11,307,583 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1511,346,458 - 11,351,078 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0511,279,270 - 11,283,884 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0511,323,539 - 11,328,166 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
HSPA8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl949,982,284 - 49,990,508 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1949,982,278 - 49,986,760 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2955,405,395 - 55,409,839 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSPA8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11114,447,348 - 114,452,693 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1114,446,544 - 114,451,562 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604311,677,166 - 11,681,993 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspa8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248802,070,523 - 2,079,421 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248802,070,410 - 2,075,069 (+)NCBIHetGla 1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005328392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000003757   ⟹   ENSSTOP00000003365
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365427,577,149 - 7,581,923 (-)Ensembl
RefSeq Acc Id: XM_005328392   ⟹   XP_005328449
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947104,655,786 - 104,660,238 (-)NCBI
SpeTri2.0NW_0049365427,577,192 - 7,581,598 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005328449 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000003365.2
  ENSSTOP00015006373
GenBank Protein KAG3286769 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005328449   ⟸   XM_005328392
- UniProtKB: I3M2W9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000003365   ⟸   ENSSTOT00000003757


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003756 Ensembl, UniProtKB/TrEMBL
  ENSSTOG00015005282 ENTREZGENE
Ensembl Transcript ENSSTOT00000003757.3 UniProtKB/TrEMBL
  ENSSTOT00015007051 ENTREZGENE
Gene3D-CATH 1.20.1270.10 UniProtKB/TrEMBL
  3.30.30.30 UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/TrEMBL
  Actin, Chain A, domain 4 UniProtKB/TrEMBL
  Substrate Binding Domain Of DNAk, Chain A, domain 1 UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/TrEMBL
KEGG Report iti:101977008 UniProtKB/TrEMBL
NCBI Gene Hspa8 ENTREZGENE
PANTHER PTHR19375 UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/TrEMBL
PRINTS HEATSHOCK70 UniProtKB/TrEMBL
PROSITE HSP70_1 UniProtKB/TrEMBL
  HSP70_2 UniProtKB/TrEMBL
  HSP70_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/TrEMBL
  SSF100934 UniProtKB/TrEMBL
  SSF53067 UniProtKB/TrEMBL
UniProt I3M2W9 ENTREZGENE, UniProtKB/TrEMBL