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Gene: Cdkn1b (cyclin-dependent kinase inhibitor 1B) Rattus norvegicus
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Symbol: Cdkn1b
Name: cyclin-dependent kinase inhibitor 1B
Description: Exhibits Hsp70 protein binding activity and chaperone binding activity. Involved in several processes, including cell death; regulation of cyclin-dependent protein serine/threonine kinase activity; and response to estradiol. Localizes to the cytoplasm; nucleus; and protein-containing complex. Used to study cataract and myocardial infarction. Biomarker of several diseases, including acute kidney failure; glomerulonephritis (multiple); obesity; pulmonary hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B); PARTICIPATES IN forkhead class A signaling pathway; G1/S transition pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (Z)-3-butylidenephthalide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cdki1b; CDKN4; Cyclin-dependent kinase inhibitor 1B (p27 Kip1); Cyclin-dependent kinase inhibitor 1B (p27); Cyclin-dependent kinase inhibitor 1B (p27, Kip1); cyclin-dependent kinase inhibitor p27; cyclin-dependent kinase inhibitor p27/Kip1; Kip1; p27; P27KIP1
Orthologs:
Homo sapiens (human) : CDKN1B (cyclin dependent kinase inhibitor 1B)  HGNC  Alliance
Mus musculus (house mouse) : Cdkn1b (cyclin-dependent kinase inhibitor 1B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdkn1b (cyclin dependent kinase inhibitor 1B)
Pan paniscus (bonobo/pygmy chimpanzee) : CDKN1B (cyclin dependent kinase inhibitor 1B)
Canis lupus familiaris (dog) : CDKN1B (cyclin dependent kinase inhibitor 1B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdkn1b (cyclin dependent kinase inhibitor 1B)
Sus scrofa (pig) : CDKN1B (cyclin dependent kinase inhibitor 1B)
more info ...
Allele / Splice: Cdkn1bwe  
Genetic Models: SD-Cdkn1bwe
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04168,689,043 - 168,694,159 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04232,962,218 - 232,967,323 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44171,841,705 - 171,846,506 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14172,086,631 - 172,091,508 (+)NCBI
Celera4156,357,827 - 156,362,628 (+)NCBICelera
Cytogenetic Map4q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cdkn1b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69062
Created: 2001-11-08
Species: Rattus norvegicus
Last Modified: 2019-06-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.