 Gene Ontology Annotations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cellular Component
Molecular Function
Molecular Pathway Annotations |
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Analyze GeneStrainQTL List |
 Gene Annotator (Functional Annotation) unavailable |
 Gene Annotator (Annotation Distribution) unavailable |
 Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable |
Gene Annotator (Functional Annotation) |
Gene Annotator (Annotation Distribution) |
Variant Visualizer (Genomic Variants) |
 InterViewer (Protein-Protein Interactions) unavailable |
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 Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable |
InterViewer (Protein-Protein Interactions) |
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 Gene Annotator (Annotation Comparison) unavailable |
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Gene Annotator (Annotation Comparison) |
OLGA (Gene List Generator) |
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MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
Cellular Component
Molecular Function
Molecular Pathway AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology AnnotationsBiological Process
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Cellular Component
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Molecular Function
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Molecular Pathway AnnotationsReferences - curated| 1. | Chen H, etal., J Biol Chem. 1999 Feb 5;274(6):3257-60. |
| 2. | Duncker SV, etal., J Neurosci. 2013 May 29;33(22):9508-19. doi: 10.1523/JNEUROSCI.5689-12.2013. |
| 3. | GOA data from the GO Consortium |
| 4. | Kamiguchi H and Yoshihara F, J Neurosci. 2001 Dec 1;21(23):9194-203. |
| 5. | Legendre-Guillemin V, etal., J Biol Chem 2002 May 31;277(22):19897-904. |
| 6. | MGD data from the GO Consortium |
| 7. | Nashida T, etal., Arch Histol Cytol. 2003 Mar;66(1):45-52. |
| 8. | Pipeline to import KEGG annotations from KEGG into RGD |
| 9. | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 10. | RGD automated data pipeline |
| 11. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 12. | RGD automated import pipeline for gene-chemical interactions |
| 13. | RGD comprehensive gene curation |
| 14. | Rotem-Yehudar R, etal., J Biol Chem. 2001 Aug 31;276(35):33054-60. Epub 2001 Jun 21. |
| 15. | Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645. |
| 16. | Wasiak S, etal., J Cell Biol 2002 Sep 2;158(5):855-62. Epub 2002 Sep 03. |
References - uncurated| PubMed | 9259551 9694653 11382783 11879655 12234931 16903783 19946888 21307259 21499258 21700703 22262466 23509262 23676497 24251095 24305805 26005850 26771574 |
Genomics
Comparative Map Data| Ap2a1 (Rattus norvegicus - Norway rat) |
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| AP2A1 (Homo sapiens - human) |
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| Ap2a1 (Mus musculus - house mouse) |
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| Ap2a1 (Chinchilla lanigera - long-tailed chinchilla) |
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| AP2A1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| AP2A1 (Canis lupus familiaris - dog) |
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| Ap2a1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| AP2A1 (Sus scrofa - pig) |
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| AP2A1 (Chlorocebus sabaeus - African green monkey) |
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| Ap2a1 (Heterocephalus glaber - naked mole-rat) |
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Position Markers| Ap2a1 |
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| AW530045 |
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| MARC_23449-23450:1027106382:1 |
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QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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Expression
RNA-SEQ ExpressionHigh: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM
| alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
| High | |||||||||||||
| Medium | 3 | 36 | 49 | 33 | 19 | 33 | 3 | 6 | 74 | 35 | 41 | 11 | 3 |
| Low | 7 | 8 | 8 | 8 | 5 | 5 | 5 | ||||||
| Below cutoff |
View RNA-SEQ Expression Data
Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_001107511 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_006229064 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006229065 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AAHX01004991 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AAHX01004992 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AC094894 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473979 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | ENSRNOT00000020304 ⟹ ENSRNOP00000020304 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | NM_001107511 ⟹ NP_001100981 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Position: |
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| Sequence: |
ATGCCGGCTGTATCCAAAGGCGATGGCATGCGTGGGCTTGCCGTGTTCATCTCCGACATCCGGAhide sequence |
| RefSeq Acc Id: | XM_006229064 ⟹ XP_006229126 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
GCCCTCCCCCGGCCGGCTCCTCGGCGCCGTCTGGGGTCCTTTCCGCCCGGTGCTGCCAGCCAGChide sequence |
| RefSeq Acc Id: | XM_006229065 ⟹ XP_006229127 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
GCCCTCCCCCGGCCGGCTCCTCGGCGCCGTCTGGGGTCCTTTCCGCCCGGTGCTGCCAGCCAGChide sequence |
Protein Sequences| Protein RefSeqs | NP_001100981 | (Get FASTA) | NCBI Sequence Viewer |
| XP_006229126 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006229127 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | EDM07441 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| RefSeq Acc Id: | NP_001100981 ⟸ NM_001107511 |
| - UniProtKB: | D3ZUY8 (UniProtKB/TrEMBL) |
| - Sequence: |
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFhide sequence |
| RefSeq Acc Id: | XP_006229127 ⟸ XM_006229065 |
| - Peptide Label: | isoform X2 |
| - Sequence: |
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFhide sequence |
| RefSeq Acc Id: | XP_006229126 ⟸ XM_006229064 |
| - Peptide Label: | isoform X1 |
| - Sequence: |
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFhide sequence |
| RefSeq Acc Id: | ENSRNOP00000020304 ⟸ ENSRNOT00000020304 |
Protein Domains
Alpha_adaptinC2
TranscriptomeStrain Variation
Strain Sequence Variants (Rnor 6.0)
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Damaging VariantsAssembly: Rnor_5.0
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 1 | 101966589 | 101966590 | C | T | snv | SBH/Ygl (MCW), SBH/Ygl (KNAW) |
Assembly: Rnor_6.0
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 1 | 100901971 | 100901972 | C | T | snv | SBH/Ygl (RGD), SBH/Ygl (MCW) |
Assembly: RGSC_v3.4
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 1 | 95379127 | 95379128 | C | T | snv | SBH/Ygl (ICL) |
Additional Information
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:1306254 | AgrOrtholog |
| Ensembl Genes | ENSRNOG00000026243 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000020304 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000020304 | ENTREZGENE, UniProtKB/TrEMBL |
| Gene3D-CATH | 1.25.10.10 | UniProtKB/TrEMBL |
| 3.30.310.10 | UniProtKB/TrEMBL | |
| InterPro | AP2_complex_asu | UniProtKB/TrEMBL |
| ARM-like | UniProtKB/TrEMBL | |
| ARM-type_fold | UniProtKB/TrEMBL | |
| Calthrin/coatomer_app_sub_C | UniProtKB/TrEMBL | |
| Clathrin/coatomer_adapt-like_N | UniProtKB/TrEMBL | |
| Clathrin/coatomer_app_Ig-like | UniProtKB/TrEMBL | |
| Clathrin_a-adaptin_app_sub_C | UniProtKB/TrEMBL | |
| Clathrin_a/b/g-adaptin_app_Ig | UniProtKB/TrEMBL | |
| TBP_dom_sf | UniProtKB/TrEMBL | |
| KEGG Report | rno:308578 | UniProtKB/TrEMBL |
| NCBI Gene | 308578 | ENTREZGENE |
| Pfam | Adaptin_N | UniProtKB/TrEMBL |
| Alpha_adaptin_C | UniProtKB/TrEMBL | |
| Alpha_adaptinC2 | UniProtKB/TrEMBL | |
| PhenoGen | Ap2a1 | PhenoGen |
| PIRSF | AP2_complex_alpha | UniProtKB/TrEMBL |
| SMART | Alpha_adaptinC2 | UniProtKB/TrEMBL |
| Superfamily-SCOP | AP2_adap_app | UniProtKB/TrEMBL |
| ARM-type_fold | UniProtKB/TrEMBL | |
| Clath_adapt | UniProtKB/TrEMBL | |
| UniGene | Rn.162416 | ENTREZGENE |
| UniProt | D3ZUY8 | ENTREZGENE, UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2018-05-03 | Ap2a1 | adaptor related protein complex 2 subunit alpha 1 | Ap2a1 | adaptor-related protein complex 2, alpha 1 subunit | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2008-09-25 | Ap2a1 | adaptor-related protein complex 2, alpha 1 subunit | Ap2a1 | adaptor protein complex AP-2, alpha 1 subunit | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2008-04-30 | Ap2a1 | adaptor protein complex AP-2, alpha 1 subunit | Ap2a1_predicted | adaptor protein complex AP-2, alpha 1 subunit (predicted) | 'predicted' is removed | 2292626 | APPROVED |
| 2005-01-12 | Ap2a1_predicted | adaptor protein complex AP-2, alpha 1 subunit (predicted) | Symbol and Name status set to approved | 70820 | APPROVED |
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| More on Ap2a1 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 1306254 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2020-03-04 |
| Status: | ACTIVE |
