Sh3gl1 (SH3 domain containing GRB2 like 1, endophilin A2) - Rat Genome Database

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Gene: Sh3gl1 (SH3 domain containing GRB2 like 1, endophilin A2) Rattus norvegicus
Analyze
Symbol: Sh3gl1
Name: SH3 domain containing GRB2 like 1, endophilin A2
RGD ID: 708456
Description: Enables several functions, including SH3 domain binding activity; beta-1 adrenergic receptor binding activity; and enzyme binding activity. Involved in modulation of excitatory postsynaptic potential and positive regulation of synaptic vesicle endocytosis. Located in membrane. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density, intracellular component. Used to study high grade glioma. Human ortholog(s) of this gene implicated in acute myeloid leukemia and high grade glioma. Orthologous to human SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; endocytosis pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endophilin-2; endophilin-A2; LOC81922; SH3 domain protein 2B; SH3 domain-containing GRB2-like 1; SH3 domain-containing GRB2-like protein 1; SH3-domain GRB2-like 1; SH3P8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.29842,285 - 869,753 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl9842,288 - 869,716 (-)Ensembl
Rnor_6.0911,031,847 - 11,055,285 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl911,031,841 - 11,055,285 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0910,018,274 - 10,040,574 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,637,327 - 7,660,492 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Chen Y, etal., Cell. 2003 Oct 3;115(1):37-48.
2. Chowdhury S, etal., Neuron. 2006 Nov 9;52(3):445-59.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Matsutani T, etal., J Exp Clin Cancer Res. 2012 Oct 11;31:85. doi: 10.1186/1756-9966-31-85.
5. MGD data from the GO Consortium
6. Nemoto Y, etal., J Biol Chem 2001 Nov 2;276(44):41133-42.
7. OMIM Disease Annotation Pipeline
8. Pipeline to import KEGG annotations from KEGG into RGD
9. RGD automated data pipeline
10. RGD automated import pipeline for gene-chemical interactions
11. RGD comprehensive gene curation
12. Ringstad N, etal., J Biol Chem. 2001 Nov 2;276(44):40424-30. doi: 10.1074/jbc.M106338200. Epub 2001 Aug 22.
13. Ringstad N, etal., Proc Natl Acad Sci U S A 1997 Aug 5;94(16):8569-74.
14. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
15. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Tian Q, etal., Neurosci Bull. 2012 Oct;28(5):483-92. doi: 10.1007/s12264-012-1257-z. Epub 2012 Jul 13.
17. Vehlow A, etal., EMBO J. 2013 Oct 16;32(20):2722-34. doi: 10.1038/emboj.2013.212. Epub 2013 Sep 27.
18. Voglmaier SM, etal., Neuron. 2006 Jul 6;51(1):71-84. doi: 10.1016/j.neuron.2006.05.027.
19. Wuertenberger S and Groemping Y, FEBS Lett. 2015 Apr 28;589(10):1156-63. doi: 10.1016/j.febslet.2015.03.014. Epub 2015 Mar 24.
20. Zhang J, etal., Cell Signal. 2012 Nov;24(11):2043-50. doi: 10.1016/j.cellsig.2012.06.006. Epub 2012 Jun 27.
Additional References at PubMed
PMID:15489334   PMID:15659545   PMID:16115810   PMID:16189514   PMID:21900206   PMID:22099461   PMID:25468996   PMID:25517096   PMID:28235806   PMID:28758034   PMID:29574155   PMID:29923351  
PMID:30053369   PMID:33504785  


Genomics

Comparative Map Data
Sh3gl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.29842,285 - 869,753 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl9842,288 - 869,716 (-)Ensembl
Rnor_6.0911,031,847 - 11,055,285 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl911,031,841 - 11,055,285 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0910,018,274 - 10,040,574 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,637,327 - 7,660,492 (+)NCBICelera
Cytogenetic Map9q12NCBI
SH3GL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,360,370 - 4,400,547 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl194,360,370 - 4,400,547 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,360,367 - 4,400,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,311,367 - 4,351,471 (-)NCBINCBI36hg18NCBI36
Build 34194,311,367 - 4,351,471NCBI
Celera194,298,613 - 4,338,694 (-)NCBI
Cytogenetic Map19p13.3NCBI
HuRef194,122,883 - 4,162,918 (-)NCBIHuRef
CHM1_1194,360,010 - 4,400,159 (-)NCBICHM1_1
Sh3gl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,323,750 - 56,343,659 (-)NCBIGRCm39mm39
GRCm39 Ensembl1756,323,750 - 56,343,635 (-)Ensembl
GRCm381756,016,750 - 56,036,659 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,016,750 - 56,036,635 (-)EnsemblGRCm38mm10GRCm38
MGSCv371756,156,173 - 56,175,999 (-)NCBIGRCm37mm9NCBIm37
MGSCv361755,610,043 - 55,629,869 (-)NCBImm8
Celera1759,435,412 - 59,455,238 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.11NCBI
Sh3gl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,502,173 - 4,531,758 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,502,173 - 4,531,758 (+)NCBIChiLan1.0ChiLan1.0
SH3GL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1194,329,750 - 4,336,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,329,750 - 4,340,121 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0193,383,267 - 3,423,165 (-)NCBIMhudiblu_PPA_v0panPan3
SH3GL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,279,622 - 55,311,579 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,279,621 - 55,311,536 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,007,793 - 55,039,737 (+)NCBI
ROS_Cfam_1.02055,938,684 - 55,970,631 (+)NCBI
ROS_Cfam_1.0 Ensembl2055,938,677 - 55,980,136 (+)Ensembl
UMICH_Zoey_3.12054,999,266 - 55,031,183 (+)NCBI
UNSW_CanFamBas_1.02055,480,162 - 55,512,107 (+)NCBI
UU_Cfam_GSD_1.02055,678,880 - 55,710,790 (+)NCBI
Sh3gl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,298,810 - 215,330,409 (+)NCBI
SpeTri2.0NW_0049365882,504,372 - 2,535,993 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH3GL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,414,465 - 74,449,433 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,414,453 - 74,445,450 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2274,907,406 - 74,938,402 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SH3GL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.164,090,800 - 4,130,566 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl64,091,359 - 4,130,578 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660814,072,672 - 4,112,482 (+)NCBIVero_WHO_p1.0
Sh3gl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248285,304,887 - 5,330,440 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH137013  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29846,570 - 846,720 (-)MAPPERmRatBN7.2
Rnor_6.0911,055,096 - 11,055,245NCBIRnor6.0
Rnor_5.0910,040,385 - 10,040,534UniSTSRnor5.0
Celera97,660,303 - 7,660,452UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:383
Count of miRNA genes:195
Interacting mature miRNAs:225
Transcripts:ENSRNOT00000074695
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 57 41 19 41 4 7 74 35 41 11 4
Low 2 4 4 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000074695   ⟹   ENSRNOP00000066789
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9846,578 - 869,691 (-)Ensembl
Rnor_6.0 Ensembl911,031,841 - 11,055,285 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105687   ⟹   ENSRNOP00000094441
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9842,288 - 869,716 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107608   ⟹   ENSRNOP00000083818
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9846,578 - 855,251 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110808   ⟹   ENSRNOP00000084032
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9846,578 - 869,691 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117244   ⟹   ENSRNOP00000078072
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9846,578 - 850,438 (-)Ensembl
RefSeq Acc Id: NM_031239   ⟹   NP_112518
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29846,530 - 869,716 (-)NCBI
Rnor_6.0911,031,847 - 11,055,285 (+)NCBI
Rnor_5.0910,018,274 - 10,040,574 (+)NCBI
Celera97,637,327 - 7,660,492 (+)RGD
Sequence:
RefSeq Acc Id: XM_039084250   ⟹   XP_038940178
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29846,530 - 869,751 (-)NCBI
RefSeq Acc Id: XM_039084251   ⟹   XP_038940179
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29846,530 - 869,747 (-)NCBI
RefSeq Acc Id: XM_039084252   ⟹   XP_038940180
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29846,530 - 869,753 (-)NCBI
RefSeq Acc Id: XM_039084253   ⟹   XP_038940181
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29842,285 - 869,750 (-)NCBI
RefSeq Acc Id: XM_039084254   ⟹   XP_038940182
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29846,530 - 869,752 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_112518   ⟸   NM_031239
- UniProtKB: O35964 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066789   ⟸   ENSRNOT00000074695
RefSeq Acc Id: XP_038940181   ⟸   XM_039084253
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038940180   ⟸   XM_039084252
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038940182   ⟸   XM_039084254
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038940178   ⟸   XM_039084250
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038940179   ⟸   XM_039084251
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000083818   ⟸   ENSRNOT00000107608
RefSeq Acc Id: ENSRNOP00000094441   ⟸   ENSRNOT00000105687
RefSeq Acc Id: ENSRNOP00000084032   ⟸   ENSRNOT00000110808
RefSeq Acc Id: ENSRNOP00000078072   ⟸   ENSRNOT00000117244
Protein Domains
BAR   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35964-F1-model_v2 AlphaFold O35964 1-368 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696472
Promoter ID:EPDNEW_R6997
Type:initiation region
Name:Sh3gl1_1
Description:SH3 domain containing GRB2 like 1, endophilin A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0911,031,802 - 11,031,862EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708456 AgrOrtholog
BIND 130567
  134433
BioCyc Gene G2FUF-28567 BioCyc
Ensembl Genes ENSRNOG00000049683 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000066789 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000094441 ENTREZGENE
Ensembl Transcript ENSRNOT00000074695 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000105687 ENTREZGENE
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7099223 IMAGE-MGC_LOAD
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot
  BAR_dom UniProtKB/Swiss-Prot
  Endophilin-A UniProtKB/Swiss-Prot
  Endophilin_A_SH3 UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report rno:81922 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91401 IMAGE-MGC_LOAD
NCBI Gene 81922 ENTREZGENE
PANTHER PTHR14167:SF63 UniProtKB/Swiss-Prot
Pfam BAR UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Sh3gl1 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE BAR UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
SMART BAR UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
UniProt O35964 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-19 Sh3gl1  SH3 domain containing GRB2 like 1, endophilin A2  Sh3gl1  SH3 domain-containing GRB2-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-04 Sh3gl1  SH3 domain-containing GRB2-like 1  Sh3gl1  SH3-domain GRB2-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Sh3gl1  SH3-domain GRB2-like 1  LOC81922    Symbol updated 1299863 APPROVED