Cltc (clathrin heavy chain) - Rat Genome Database

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Gene: Cltc (clathrin heavy chain) Mus musculus
Analyze
Symbol: Cltc
Name: clathrin heavy chain
RGD ID: 737521
MGI Page MGI
Description: Enables protein kinase binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; endocytosis; and negative regulation of hyaluronan biosynthetic process. Predicted to act upstream of or within mitotic spindle assembly. Located in clathrin-coated pit. Part of membrane coat. Is active in several cellular components, including photoreceptor ribbon synapse; postsynaptic endocytic zone; and presynaptic endocytic zone membrane. Is expressed in several structures, including brain; early embryo; placenta; and unsegmented mesenchyme. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Orthologous to human CLTC (clathrin heavy chain).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3110065L21Rik; CHC; clathrin heavy chain 1; clathrin, heavy polypeptide (Hc); MGC92975; R74732
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,585,178 - 86,648,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1186,585,177 - 86,648,391 (-)EnsemblGRCm39 Ensembl
GRCm381186,694,352 - 86,757,567 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,694,351 - 86,757,565 (-)EnsemblGRCm38mm10GRCm38
MGSCv371186,508,155 - 86,570,994 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361186,510,848 - 86,573,687 (-)NCBIMGSCv36mm8
Celera1196,310,083 - 96,376,089 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dimethoxyphenol  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-ethoxyethanol  (ISO)
2-methoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
entacapone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
fenvalerate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP)
furfural  (ISO)
gentamycin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (ISO)
methylparaben  (ISO)
nefazodone  (ISO)
nilotinib  (ISO)
Nutlin-3  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pyrogallol  (EXP)
resveratrol  (ISO)
rimonabant  (EXP)
rotenone  (ISO)
Salinomycin  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (EXP)
succimer  (EXP)
sulfadimethoxine  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
tolcapone  (ISO)
tremolite asbestos  (EXP)
triptonide  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice. Di Paolo G, etal., Neuron 2002 Feb 28;33(5):789-804.
2. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, etal., Nature 2002 Dec 5;420(6915):586-90.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
Additional References at PubMed
PMID:8889548   PMID:9463375   PMID:10349636   PMID:10613908   PMID:10862698   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11544199   PMID:12477932   PMID:12520002   PMID:12693553  
PMID:12904583   PMID:12960147   PMID:14610273   PMID:14648851   PMID:15215307   PMID:15294912   PMID:15489334   PMID:15747579   PMID:15907472   PMID:16141072   PMID:16141073   PMID:16263766  
PMID:16571680   PMID:16720641   PMID:16944949   PMID:16959763   PMID:17005174   PMID:17028301   PMID:17182860   PMID:17634366   PMID:17664336   PMID:17785434   PMID:18307411   PMID:18434600  
PMID:18448421   PMID:18548008   PMID:18614564   PMID:18670435   PMID:18799693   PMID:19423638   PMID:19666558   PMID:19834059   PMID:19951918   PMID:20080761   PMID:20114047   PMID:20427320  
PMID:20682309   PMID:21169560   PMID:21266579   PMID:21307259   PMID:21725061   PMID:21873635   PMID:21936565   PMID:22342749   PMID:22423098   PMID:22491013   PMID:22935703   PMID:22976293  
PMID:23453806   PMID:23640057   PMID:23746204   PMID:23785143   PMID:23816345   PMID:24431429   PMID:24457600   PMID:24798732   PMID:24849652   PMID:25107275   PMID:25127994   PMID:25196998  
PMID:25737280   PMID:26345367   PMID:26420826   PMID:26437238   PMID:26507506   PMID:26771574   PMID:26809587   PMID:26857994   PMID:26884322   PMID:27160897   PMID:28177917   PMID:28261837  
PMID:28378742   PMID:28634551   PMID:28671696   PMID:28706196   PMID:29158485   PMID:29222402   PMID:29262337   PMID:29361518   PMID:29459677   PMID:29472841   PMID:29669786   PMID:29962937  
PMID:30061390   PMID:30068389   PMID:30196744   PMID:30249793   PMID:30333137   PMID:30409884   PMID:30550785   PMID:30562941   PMID:30601711   PMID:30692166   PMID:30713523   PMID:31162944  
PMID:31300538   PMID:31562907   PMID:31672988   PMID:31932847   PMID:32325033   PMID:32341099   PMID:32554809   PMID:32888949   PMID:33144400   PMID:34018922   PMID:34865123   PMID:35449600  
PMID:36108743   PMID:36114006   PMID:36293380   PMID:36417873   PMID:36808153   PMID:36894047   PMID:37142655   PMID:37442135  


Genomics

Comparative Map Data
Cltc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,585,178 - 86,648,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1186,585,177 - 86,648,391 (-)EnsemblGRCm39 Ensembl
GRCm381186,694,352 - 86,757,567 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,694,351 - 86,757,565 (-)EnsemblGRCm38mm10GRCm38
MGSCv371186,508,155 - 86,570,994 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361186,510,848 - 86,573,687 (-)NCBIMGSCv36mm8
Celera1196,310,083 - 96,376,089 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.82NCBI
CLTC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381759,619,895 - 59,696,956 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1759,619,680 - 59,696,956 (+)EnsemblGRCh38hg38GRCh38
GRCh371757,697,256 - 57,774,317 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,051,832 - 55,129,099 (+)NCBINCBI36Build 36hg18NCBI36
Build 341755,052,037 - 55,127,254NCBI
Celera1754,160,824 - 54,238,068 (+)NCBICelera
Cytogenetic Map17q23.1NCBI
HuRef1753,069,465 - 53,146,980 (+)NCBIHuRef
CHM1_11757,762,115 - 57,839,338 (+)NCBICHM1_1
T2T-CHM13v2.01760,488,657 - 60,565,708 (+)NCBIT2T-CHM13v2.0
Cltc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81072,014,984 - 72,073,308 (-)NCBIGRCr8
mRatBN7.21071,517,661 - 71,574,591 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1071,517,663 - 71,573,737 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1076,138,748 - 76,194,184 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01075,643,625 - 75,699,059 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01071,108,176 - 71,163,608 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01074,014,560 - 74,070,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1074,014,562 - 74,070,266 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01076,029,919 - 76,085,924 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41074,976,825 - 75,032,529 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11074,991,194 - 75,046,899 (-)NCBI
Celera1070,438,273 - 70,493,354 (-)NCBICelera
Cytogenetic Map10q26NCBI
Cltc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554513,380,304 - 3,445,973 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554513,380,304 - 3,445,973 (-)NCBIChiLan1.0ChiLan1.0
CLTC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21975,779,299 - 75,857,191 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11780,593,228 - 80,668,583 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01753,685,865 - 53,761,008 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11758,528,630 - 58,603,636 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1758,529,750 - 58,603,636 (+)Ensemblpanpan1.1panPan2
CLTC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1934,116,344 - 34,183,023 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl934,116,634 - 34,182,719 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha933,348,834 - 33,415,377 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0934,925,162 - 34,993,363 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl934,925,099 - 34,993,353 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1933,708,907 - 33,777,008 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0933,995,028 - 34,063,165 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0934,082,574 - 34,149,196 (+)NCBIUU_Cfam_GSD_1.0
Cltc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560233,348,899 - 33,415,096 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364903,657,242 - 3,726,274 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364903,659,682 - 3,726,222 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLTC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1235,848,540 - 35,926,015 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11235,848,894 - 35,926,028 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21236,559,496 - 36,602,612 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21237,145,840 - 37,192,985 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CLTC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11633,751,641 - 33,826,415 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1633,752,556 - 33,799,102 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660774,541,834 - 4,618,343 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cltc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248711,439,838 - 1,510,911 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248711,439,975 - 1,507,514 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cltc
1790 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1570
Count of miRNA genes:586
Interacting mature miRNAs:730
Transcripts:ENSMUST00000060766, ENSMUST00000103186, ENSMUST00000124385, ENSMUST00000133501, ENSMUST00000134999, ENSMUST00000141152
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
15092049Wsigrme3_mweek six growth rate, maternal effect 3 (mouse)118487732496629512Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
15092057Lgrme3_mlate growth rate, maternal effect 3 (mouse)118487732496629512Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse

Markers in Region
RH125101  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381186,704,933 - 86,705,217UniSTSGRCm38
MGSCv371186,518,435 - 86,518,719UniSTSGRCm37
Celera1196,320,385 - 96,320,669UniSTS
Cytogenetic Map11CUniSTS
Cltc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381077,049,797 - 77,050,192UniSTSGRCm38
MGSCv371076,512,542 - 76,512,937UniSTSGRCm37
Celera1078,093,797 - 78,094,192UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map11CUniSTS
cM Map11 UniSTS
RH25272  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381186,702,228 - 86,702,343UniSTSGRCm38
MGSCv371186,515,730 - 86,515,845UniSTSGRCm37
Celera1196,317,674 - 96,317,789UniSTS
Cytogenetic Map11CUniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001003908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001356393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006533983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006533985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK014236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK039453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL592222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB840649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP758029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF745318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ103480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LXEJ02004109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000060766   ⟹   ENSMUSP00000050220
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1186,585,481 - 86,648,327 (-)Ensembl
GRCm38.p6 Ensembl1186,694,655 - 86,757,501 (-)Ensembl
Ensembl Acc Id: ENSMUST00000103186   ⟹   ENSMUSP00000099475
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1186,585,177 - 86,648,391 (-)Ensembl
GRCm38.p6 Ensembl1186,694,351 - 86,757,565 (-)Ensembl
Ensembl Acc Id: ENSMUST00000124385   ⟹   ENSMUSP00000117674
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1186,586,143 - 86,594,523 (-)Ensembl
GRCm38.p6 Ensembl1186,695,317 - 86,703,697 (-)Ensembl
Ensembl Acc Id: ENSMUST00000133501
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1186,615,024 - 86,617,278 (-)Ensembl
GRCm38.p6 Ensembl1186,724,198 - 86,726,452 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134999
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1186,591,764 - 86,593,256 (-)Ensembl
GRCm38.p6 Ensembl1186,700,938 - 86,702,430 (-)Ensembl
Ensembl Acc Id: ENSMUST00000141152
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1186,614,104 - 86,617,309 (-)Ensembl
GRCm38.p6 Ensembl1186,723,278 - 86,726,483 (-)Ensembl
RefSeq Acc Id: NM_001003908   ⟹   NP_001003908
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391186,585,178 - 86,648,393 (-)NCBI
GRCm381186,694,352 - 86,757,567 (-)NCBI
MGSCv371186,508,155 - 86,570,994 (-)RGD
Celera1196,310,083 - 96,376,089 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001356393   ⟹   NP_001343322
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391186,585,178 - 86,648,393 (-)NCBI
GRCm381186,694,352 - 86,757,567 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006533983   ⟹   XP_006534046
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391186,585,436 - 86,648,637 (-)NCBI
GRCm381186,694,614 - 86,757,463 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006533985   ⟹   XP_006534048
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391186,585,436 - 86,648,637 (-)NCBI
GRCm381186,694,614 - 86,757,463 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001003908   ⟸   NM_001003908
- Peptide Label: isoform 2
- UniProtKB: Q68FD5 (UniProtKB/Swiss-Prot),   Q5SXR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006534048   ⟸   XM_006533985
- Peptide Label: isoform X2
- UniProtKB: Q5SXR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006534046   ⟸   XM_006533983
- Peptide Label: isoform X1
- UniProtKB: Q5SXR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001343322   ⟸   NM_001356393
- Peptide Label: isoform 1
- UniProtKB: Q5SXR6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000117674   ⟸   ENSMUST00000124385
Ensembl Acc Id: ENSMUSP00000050220   ⟸   ENSMUST00000060766
Ensembl Acc Id: ENSMUSP00000099475   ⟸   ENSMUST00000103186
Protein Domains
Clathrin heavy chain linker core motif

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q68FD5-F1-model_v2 AlphaFold Q68FD5 1-1675 view protein structure

Promoters
RGD ID:6820627
Promoter ID:MM_KWN:9030
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Liver,   MEF_B6
Transcripts:OTTMUST00000002424
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361186,515,771 - 86,516,271 (-)MPROMDB
RGD ID:6820628
Promoter ID:MM_KWN:9031
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   MEF_B6
Transcripts:OTTMUST00000002423
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361186,516,996 - 86,517,587 (-)MPROMDB
RGD ID:6820629
Promoter ID:MM_KWN:9032
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B6
Transcripts:OTTMUST00000002425,   OTTMUST00000002426
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361186,539,586 - 86,540,086 (-)MPROMDB
RGD ID:6820664
Promoter ID:MM_KWN:9033
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000100663,   LINCRNA_177,   OTTMUST00000002422,   OTTMUST00000002427
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361186,570,346 - 86,571,837 (-)MPROMDB
RGD ID:8676026
Promoter ID:EPDNEW_M16044
Type:initiation region
Name:Cltc_1
Description:Mus musculus clathrin, heavy polypeptide , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381186,757,520 - 86,757,580EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2388633 AgrOrtholog
Ensembl Genes ENSMUSG00000047126 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000060766.16 UniProtKB/TrEMBL
  ENSMUST00000103186 ENTREZGENE
  ENSMUST00000103186.11 UniProtKB/Swiss-Prot
  ENSMUST00000124385.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.130.10.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin_H-chain/VPS_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin_H-chain_linker_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin_H-chain_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin_H-chain_propeller_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin_heavy_chain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67300 UniProtKB/Swiss-Prot
MGD MGI:2388633 ENTREZGENE
NCBI Gene 67300 ENTREZGENE
PANTHER CLATHRIN HEAVY CHAIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLATHRIN HEAVY CHAIN RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Clathrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin-link UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin_H_link UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin_propel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cltc PhenoGen
PIRSF Clathrin_H_chain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CHCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50989 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CLH1_MOUSE UniProtKB/Swiss-Prot
  F6Z1R4_MOUSE UniProtKB/TrEMBL
  Q3TAN1_MOUSE UniProtKB/TrEMBL
  Q3TJ98_MOUSE UniProtKB/TrEMBL
  Q3TYQ2_MOUSE UniProtKB/TrEMBL
  Q3U0H2_MOUSE UniProtKB/TrEMBL
  Q3UPJ3_MOUSE UniProtKB/TrEMBL
  Q5SXR6 ENTREZGENE, UniProtKB/TrEMBL
  Q68FD5 ENTREZGENE
  Q8K2I5_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Cltc  clathrin heavy chain  Cltc  clathrin, heavy polypeptide (Hc)  Symbol and/or name change 5135510 APPROVED