Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Cltc (clathrin, heavy polypeptide (Hc)) Mus musculus
Symbol: Cltc
Name: clathrin, heavy polypeptide (Hc)
Description: Exhibits protein kinase binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; endocytosis; and negative regulation of hyaluronan biosynthetic process. Localizes to the membrane coat; photoreceptor ribbon synapse; and presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 56. Is expressed in 8-cell stage embryo; brain; placenta; and unsegmented mesenchyme. Orthologous to human CLTC (clathrin heavy chain); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; FasL mediated signaling pathway; endocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3110065L21Rik; CHC; clathrin heavy chain 1; MGC92975; R74732
Homo sapiens (human) : CLTC (clathrin heavy chain)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cltc (clathrin heavy chain)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cltc (clathrin heavy chain)
Pan paniscus (bonobo/pygmy chimpanzee) : CLTC (clathrin heavy chain)
Canis lupus familiaris (dog) : CLTC (clathrin heavy chain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cltc (clathrin heavy chain)
Sus scrofa (pig) : CLTC (clathrin heavy chain)
Chlorocebus sabaeus (African green monkey) : CLTC (clathrin heavy chain)
Heterocephalus glaber (naked mole-rat) : Cltc (clathrin heavy chain)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1186,694,351 - 86,757,565 (-)Ensembl
GRCm381186,694,352 - 86,757,567 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371186,508,155 - 86,570,994 (-)NCBIGRCm37mm9NCBIm37
MGSCv361186,510,848 - 86,573,687 (-)NCBImm8
Celera1196,310,083 - 96,376,089 (-)NCBICelera
Cytogenetic Map11CNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cltc
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737521
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.