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Gene: Cltc (clathrin, heavy polypeptide (Hc)) Mus musculus
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Symbol: Cltc
Name: clathrin, heavy polypeptide (Hc)
Description: Exhibits protein kinase binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; endocytosis; and negative regulation of hyaluronan biosynthetic process. Localizes to the membrane coat; photoreceptor ribbon synapse; and presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 56. Is expressed in 8-cell stage embryo; brain; placenta; and unsegmented mesenchyme. Orthologous to human CLTC (clathrin heavy chain); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; FasL mediated signaling pathway; endocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3110065L21Rik; CHC; clathrin heavy chain 1; MGC92975; R74732
Orthologs:
Homo sapiens (human) : CLTC (clathrin heavy chain)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cltc (clathrin heavy chain)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cltc (clathrin heavy chain)
Pan paniscus (bonobo/pygmy chimpanzee) : CLTC (clathrin heavy chain)
Canis lupus familiaris (dog) : CLTC (clathrin heavy chain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cltc (clathrin heavy chain)
Sus scrofa (pig) : CLTC (clathrin heavy chain)
Chlorocebus sabaeus (African green monkey) : CLTC (clathrin heavy chain)
Heterocephalus glaber (naked mole-rat) : Cltc (clathrin heavy chain)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1186,694,351 - 86,757,565 (-)Ensembl
GRCm381186,694,352 - 86,757,567 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371186,508,155 - 86,570,994 (-)NCBIGRCm37mm9NCBIm37
MGSCv361186,510,848 - 86,573,687 (-)NCBImm8
Celera1196,310,083 - 96,376,089 (-)NCBICelera
Cytogenetic Map11CNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cltc
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737521
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.