Epn1 (Epsin 1) - Rat Genome Database

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Gene: Epn1 (Epsin 1) Rattus norvegicus
Analyze
Symbol: Epn1
Name: Epsin 1
RGD ID: 619772
Description: Enables clathrin adaptor activity and transmembrane transporter binding activity. Involved in endocytosis; membrane fission; and positive regulation of clathrin coat assembly. Located in cytosol; nucleus; and presynapse. Is extrinsic component of cytoplasmic side of plasma membrane; extrinsic component of postsynaptic membrane; and extrinsic component of presynaptic membrane. Is active in Schaffer collateral - CA1 synapse and postsynapse. Biomarker of middle cerebral artery infarction. Orthologous to human EPN1 (epsin 1); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; endocytosis pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EPS-15-interacting protein 1; epsin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2168,742,491 - 68,760,507 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,742,789 - 68,758,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,087,576 - 74,105,651 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0182,651,885 - 82,669,960 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0175,800,539 - 75,818,619 (-)NCBIRnor_WKY
Rnor_6.0172,294,153 - 72,310,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,294,153 - 72,311,856 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0176,226,173 - 76,242,237 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,479,998 - 67,496,066 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1167,558,113 - 67,574,177 (-)NCBI
Celera168,360,140 - 68,376,208 (+)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Epsin N-terminal homology domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase-activating proteins. Aguilar RC, etal., Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4116-21. Epub 2006 Mar 6.
2. Accessory protein recruitment motifs in clathrin-mediated endocytosis. Brett TJ, etal., Structure. 2002 Jun;10(6):797-809.
3. Single particle fluorescence burst analysis of epsin induced membrane fission. Brooks A, etal., PLoS One. 2015 Mar 23;10(3):e0119563. doi: 10.1371/journal.pone.0119563. eCollection 2015.
4. Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. Chen H, etal., Nature 1998 Aug 20;394(6695):793-7.
5. Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites. Drake MT, etal., J Biol Chem. 2000 Mar 3;275(9):6479-89.
6. Curvature of clathrin-coated pits driven by epsin. Ford MG, etal., Nature 2002 Sep 26;419(6905):361-6.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF). Hyman J, etal., J Cell Biol. 2000 May 1;149(3):537-46.
9. Unusual structural organization of the endocytic proteins AP180 and epsin 1. Kalthoff C, etal., J Biol Chem. 2002 Mar 8;277(10):8209-16. Epub 2001 Dec 26.
10. Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat. Liska F, etal., Dev Dyn. 2009 Mar;238(3):673-84.
11. Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin. Meloty-Kapella L, etal., Dev Cell. 2012 Jun 12;22(6):1299-312. doi: 10.1016/j.devcel.2012.04.005. Epub 2012 May 31.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Purification of an EH domain-binding protein from rat brain that modulates the gating of the rat ether-a-go-go channel. Piros ET, etal., J Biol Chem. 1999 Nov 19;274(47):33677-83.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. The NECAP PHear domain increases clathrin accessory protein binding potential. Ritter B, etal., EMBO J. 2007 Sep 19;26(18):4066-77. Epub 2007 Aug 30.
19. The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. Rosenthal JA, etal., J Biol Chem 1999 Nov 26;274(48):33959-65.
20. Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration. Rudinskiy N, etal., J Biol Chem. 2009 May 1;284(18):12447-58. doi: 10.1074/jbc.M804740200. Epub 2009 Feb 24.
21. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
22. Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly. Traub LM, etal., Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8907-12.
23. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
24. Partially overlapping distribution of epsin1 and HIP1 at the synapse: analysis by immunoelectron microscopy. Yao PJ, etal., J Comp Neurol. 2006 Jan 10;494(2):368-79.
Additional References at PubMed
PMID:9920862   PMID:11161217   PMID:11382783   PMID:11919637   PMID:12234931   PMID:12750376   PMID:14657369   PMID:16885233   PMID:16903783   PMID:19536136   PMID:19666558   PMID:20366178  
PMID:22871113   PMID:25837255   PMID:28717225   PMID:29476059   PMID:32337703  


Genomics

Comparative Map Data
Epn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2168,742,491 - 68,760,507 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,742,789 - 68,758,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,087,576 - 74,105,651 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0182,651,885 - 82,669,960 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0175,800,539 - 75,818,619 (-)NCBIRnor_WKY
Rnor_6.0172,294,153 - 72,310,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,294,153 - 72,311,856 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0176,226,173 - 76,242,237 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,479,998 - 67,496,066 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1167,558,113 - 67,574,177 (-)NCBI
Celera168,360,140 - 68,376,208 (+)NCBICelera
Cytogenetic Map1q12NCBI
EPN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,675,226 - 55,709,533 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1955,675,226 - 55,709,858 (+)EnsemblGRCh38hg38GRCh38
GRCh371956,186,592 - 56,220,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,878,404 - 60,898,945 (+)NCBINCBI36Build 36hg18NCBI36
Build 341960,878,403 - 60,898,944NCBI
Celera1953,228,855 - 53,249,427 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1952,497,593 - 52,517,630 (+)NCBIHuRef
CHM1_11956,180,226 - 56,200,825 (+)NCBICHM1_1
T2T-CHM13v2.01958,772,202 - 58,806,505 (+)NCBIT2T-CHM13v2.0
Epn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3975,083,136 - 5,101,178 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl75,083,234 - 5,101,177 (+)EnsemblGRCm39 Ensembl
GRCm3875,080,137 - 5,098,179 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl75,080,235 - 5,098,178 (+)EnsemblGRCm38mm10GRCm38
MGSCv3775,031,907 - 5,049,778 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3674,683,392 - 4,701,263 (+)NCBIMGSCv36mm8
Celera74,822,389 - 4,840,262 (+)NCBICelera
Cytogenetic Map7A1NCBI
Epn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955567669,685 - 682,852 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955567669,333 - 683,283 (-)NCBIChiLan1.0ChiLan1.0
EPN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11961,408,678 - 61,428,058 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1961,408,695 - 61,427,647 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01952,722,107 - 52,743,321 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
EPN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,059,022 - 102,073,665 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,059,181 - 102,073,561 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,116,113 - 102,130,802 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01102,712,494 - 102,727,183 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1102,712,496 - 102,727,223 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,350,090 - 102,364,779 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,061,977 - 102,076,667 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01102,825,037 - 102,839,725 (-)NCBIUU_Cfam_GSD_1.0
Epn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093491,684,602 - 1,703,390 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936981194,157 - 213,066 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936981194,176 - 213,021 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,789,946 - 59,802,299 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,789,952 - 59,802,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,762,216 - 54,768,439 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1648,265,498 - 48,287,817 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl648,267,365 - 48,288,296 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045922,638 - 944,920 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248321,732,571 - 1,746,888 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248321,732,895 - 1,746,963 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Epn1
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:56
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000021286
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021286   ⟹   ENSRNOP00000021286
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,742,789 - 68,758,874 (-)Ensembl
Rnor_6.0 Ensembl172,294,153 - 72,311,856 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119836   ⟹   ENSRNOP00000092218
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,742,789 - 68,758,874 (-)Ensembl
RefSeq Acc Id: NM_057136   ⟹   NP_476477
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2168,742,779 - 68,758,868 (-)NCBI
Rnor_6.0172,294,153 - 72,310,217 (-)NCBI
Rnor_5.0176,226,173 - 76,242,237 (+)NCBI
RGSC_v3.4167,479,998 - 67,496,066 (-)RGD
Celera168,360,140 - 68,376,208 (+)RGD
Sequence:
RefSeq Acc Id: XM_039079254   ⟹   XP_038935182
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2168,742,491 - 68,760,507 (-)NCBI
RefSeq Acc Id: XM_039079295   ⟹   XP_038935223
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2168,742,491 - 68,760,344 (-)NCBI
RefSeq Acc Id: XM_039079330   ⟹   XP_038935258
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2168,742,491 - 68,760,507 (-)NCBI
RefSeq Acc Id: XM_039079361   ⟹   XP_038935289
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2168,742,491 - 68,760,339 (-)NCBI
RefSeq Acc Id: XM_039079399   ⟹   XP_038935327
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2168,742,491 - 68,760,507 (-)NCBI
RefSeq Acc Id: XM_039079437   ⟹   XP_038935365
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2168,742,491 - 68,760,507 (-)NCBI
RefSeq Acc Id: XM_039079493   ⟹   XP_038935421
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2168,742,491 - 68,760,507 (-)NCBI
RefSeq Acc Id: XM_039079530   ⟹   XP_038935458
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2168,742,491 - 68,760,507 (-)NCBI
RefSeq Acc Id: XM_039079574   ⟹   XP_038935502
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2168,742,491 - 68,760,507 (-)NCBI
RefSeq Acc Id: XM_039079617   ⟹   XP_038935545
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2168,742,491 - 68,757,188 (-)NCBI
RefSeq Acc Id: XM_039079656   ⟹   XP_038935584
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2168,742,491 - 68,757,188 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_476477   ⟸   NM_057136
- UniProtKB: O88339 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021286   ⟸   ENSRNOT00000021286
RefSeq Acc Id: XP_038935258   ⟸   XM_039079330
- Peptide Label: isoform X1
- UniProtKB: A0A140TAC3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935421   ⟸   XM_039079493
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038935365   ⟸   XM_039079437
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GJL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935502   ⟸   XM_039079574
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038935327   ⟸   XM_039079399
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038935458   ⟸   XM_039079530
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038935182   ⟸   XM_039079254
- Peptide Label: isoform X1
- UniProtKB: A0A140TAC3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935223   ⟸   XM_039079295
- Peptide Label: isoform X1
- UniProtKB: A0A140TAC3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935289   ⟸   XM_039079361
- Peptide Label: isoform X1
- UniProtKB: A0A140TAC3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935584   ⟸   XM_039079656
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038935545   ⟸   XM_039079617
- Peptide Label: isoform X7
RefSeq Acc Id: ENSRNOP00000092218   ⟸   ENSRNOT00000119836
Protein Domains
ENTH   UIM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88339-F1-model_v2 AlphaFold O88339 1-575 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689688
Promoter ID:EPDNEW_R212
Type:initiation region
Name:Epn1_1
Description:Epsin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0172,311,945 - 72,312,005EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619772 AgrOrtholog
BIND 144372
BioCyc Gene G2FUF-60884 BioCyc
Ensembl Genes ENSRNOG00000015753 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000021286 ENTREZGENE
  ENSRNOP00000021286.4 UniProtKB/TrEMBL
  ENSRNOP00000092218 ENTREZGENE
  ENSRNOP00000092218.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021286 ENTREZGENE
  ENSRNOT00000021286.6 UniProtKB/TrEMBL
  ENSRNOT00000119836 ENTREZGENE
  ENSRNOT00000119836.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ENTH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENTH_VHS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UIM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117277 UniProtKB/Swiss-Prot
NCBI Gene 117277 ENTREZGENE
Pfam ENTH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Epn1 PhenoGen
PROSITE ENTH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ENTH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48464 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TAC3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GJL1 ENTREZGENE, UniProtKB/TrEMBL
  EPN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Epn1  Epsin 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Epn1  Epsin 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in brain 632726