Symbol:
Cltb
Name:
clathrin, light chain B
Description:
Exhibits peptide binding activity. Predicted to be involved in clathrin coat assembly and clathrin-dependent endocytosis. Localizes to the clathrin coat; presynaptic endocytic zone membrane; and synaptic vesicle membrane. Orthologous to human CLTB (clathrin light chain B); PARTICIPATES IN Arf family mediated signaling pathway; clathrin-dependent synaptic vesicle endocytosis; endocytosis pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
clathrin light chain B; clathrin, light chain (Lcb); clathrin, light polypeptide (Lcb); lcb
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CLTB (clathrin light chain B) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Cltb (clathrin, light polypeptide (Lcb)) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Cltb (clathrin light chain B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CLTB (clathrin light chain B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CLTB (clathrin light chain B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cltb (clathrin light chain B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CLTB (clathrin light chain B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
CLTA (clathrin light chain A) HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
CLTB (clathrin light chain B)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Cltb (clathrin, light polypeptide (Lcb))
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
cltb (clathrin, light chain B)
Alliance
DIOPT (Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
CLC1
Alliance
DIOPT (Hieranoid, OrthoFinder, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
Clc
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
clic-1
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 17 10,537,348 - 10,554,999 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 17 10,537,365 - 10,554,989 (+) Ensembl Rnor_5.0 17 12,665,115 - 12,682,779 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 17 16,063,715 - 16,081,277 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 17 16,063,714 - 16,081,277 (+) NCBI Celera 17 10,074,602 - 10,092,160 (+) NCBI Celera Cytogenetic Map 17 p14 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of CLTB mRNA] CTD PMID:31150632 17beta-estradiol affects expression ISO RGD:733395 6480464 Estradiol affects the expression of CLTB mRNA CTD PMID:14699072 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1550649 6480464 [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of CLTB gene CTD PMID:21212295 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1550649 6480464 Tetrachlorodibenzodioxin affects the expression of CLTB mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of CLTB protein CTD PMID:16548065 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:23196670 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of CLTB mRNA CTD PMID:21346803 acrylamide affects expression EXP 6480464 Acrylamide affects the expression of CLTB mRNA CTD PMID:28959563 aflatoxin B1 increases expression ISO RGD:733395 6480464 Aflatoxin B1 results in increased expression of CLTB mRNA CTD PMID:27153756 all-trans-retinoic acid increases expression ISO RGD:733395 6480464 Tretinoin results in increased expression of CLTB mRNA CTD PMID:15498508 , PMID:16054129 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CLTB mRNA CTD PMID:16483693 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of CLTB mRNA CTD PMID:30779732 arsenous acid increases expression ISO RGD:733395 6480464 Arsenic Trioxide results in increased expression of CLTB mRNA CTD PMID:17258074 benzo[a]pyrene increases expression ISO RGD:733395 6480464 Benzo(a)pyrene results in increased expression of CLTB mRNA CTD PMID:20106945 , PMID:21632981 benzo[b]fluoranthene increases expression ISO RGD:1550649 6480464 benzo(b)fluoranthene results in increased expression of CLTB mRNA CTD PMID:26377693 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:1550649 6480464 Diethylhexyl Phthalate results in decreased expression of CLTB mRNA CTD PMID:28085963 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:733395 6480464 Diethylhexyl Phthalate results in decreased expression of CLTB protein CTD PMID:31163220 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of CLTB mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:733395 6480464 bisphenol A results in decreased expression of CLTB mRNA CTD PMID:29275510 bromobenzene increases expression EXP 6480464 bromobenzene results in increased expression of CLTB mRNA CTD PMID:12628495 buspirone increases expression EXP 6480464 Buspirone results in increased expression of CLTB mRNA CTD PMID:24136188 butanal increases expression ISO RGD:733395 6480464 butyraldehyde results in increased expression of CLTB mRNA CTD PMID:26079696 carbon nanotube increases expression ISO RGD:1550649 6480464 Nanotubes, Carbon analog results in increased expression of CLTB mRNA, Nanotubes, Carbon results in increased expression of CLTB mRNA CTD PMID:25554681 , PMID:25620056 choline multiple interactions ISO RGD:1550649 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CLTB mRNA CTD PMID:20938992 clozapine decreases expression EXP 6480464 Clozapine results in decreased expression of CLTB mRNA CTD PMID:15860345 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of CLTB mRNA CTD PMID:24386269 cobalt dichloride increases expression ISO RGD:733395 6480464 cobaltous chloride results in increased expression of CLTB mRNA CTD PMID:19376846 cocaine decreases expression ISO RGD:733395 6480464 Cocaine results in decreased expression of CLTB mRNA CTD PMID:12629581 , PMID:15009677 copper(II) sulfate increases expression ISO RGD:733395 6480464 Copper Sulfate results in increased expression of CLTB mRNA CTD PMID:19549813 cyclosporin A increases expression ISO RGD:733395 6480464 Cyclosporine results in increased expression of CLTB mRNA CTD PMID:25562108 cyclosporin A decreases expression ISO RGD:733395 6480464 Cyclosporine results in decreased expression of CLTB mRNA CTD PMID:27989131 diarsenic trioxide increases expression ISO RGD:733395 6480464 Arsenic Trioxide results in increased expression of CLTB mRNA CTD PMID:17258074 dioxygen multiple interactions ISO RGD:1550649 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of CLTB mRNA CTD PMID:30529165 dorsomorphin multiple interactions ISO RGD:733395 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLTB mRNA CTD PMID:27188386 doxorubicin affects expression ISO RGD:733395 6480464 Doxorubicin affects the expression of CLTB protein CTD PMID:29385562 doxorubicin increases expression ISO RGD:733395 6480464 Doxorubicin results in increased expression of CLTB mRNA CTD PMID:29803840 elemental selenium increases expression ISO RGD:733395 6480464 Selenium results in increased expression of CLTB mRNA CTD PMID:19244175 enzyme inhibitor multiple interactions ISO RGD:733395 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CLTB protein CTD PMID:23301498 ethanol affects splicing ISO RGD:1550649 6480464 Ethanol affects the splicing of CLTB mRNA CTD PMID:30319688 finasteride increases expression EXP 6480464 Finasteride results in increased expression of CLTB mRNA CTD PMID:24136188 flutamide increases expression EXP 6480464 Flutamide results in increased expression of CLTB mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:1550649 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CLTB mRNA CTD PMID:20938992 furan increases methylation EXP 6480464 furan results in increased methylation of CLTB gene CTD PMID:22079235 haloperidol decreases expression EXP 6480464 Haloperidol results in decreased expression of CLTB mRNA CTD PMID:15860345 L-methionine multiple interactions ISO RGD:1550649 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CLTB mRNA CTD PMID:20938992 leflunomide increases expression EXP 6480464 leflunomide results in increased expression of CLTB mRNA CTD PMID:24136188 lipopolysaccharide multiple interactions ISO RGD:1550649 6480464 [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of CLTB gene CTD PMID:21212295 methotrexate increases expression ISO RGD:733395 6480464 Methotrexate results in increased expression of CLTB mRNA CTD PMID:21678067 methyl methanesulfonate increases expression ISO RGD:733395 6480464 Methyl Methanesulfonate results in increased expression of CLTB mRNA CTD PMID:23649840 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of CLTB mRNA CTD PMID:24136188 nickel sulfate decreases expression ISO RGD:733395 6480464 nickel sulfate results in decreased expression of CLTB mRNA CTD PMID:16780908 nickel sulfate increases expression ISO RGD:733395 6480464 nickel sulfate results in increased expression of CLTB mRNA CTD PMID:18651567 nimesulide increases expression EXP 6480464 nimesulide results in increased expression of CLTB mRNA CTD PMID:24136188 paracetamol affects expression ISO RGD:1550649 6480464 Acetaminophen affects the expression of CLTB mRNA CTD PMID:17562736 pentachlorophenol increases expression ISO RGD:1550649 6480464 Pentachlorophenol results in increased expression of CLTB mRNA CTD PMID:23892564 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of CLTB mRNA CTD PMID:19162173 piperonyl butoxide increases expression EXP 6480464 Piperonyl Butoxide results in increased expression of CLTB mRNA CTD PMID:22484513 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of CLTB mRNA CTD PMID:19162173 pregnenolone 16alpha-carbonitrile increases expression EXP 6480464 Pregnenolone Carbonitrile results in increased expression of CLTB mRNA CTD PMID:19162173 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:1550649 6480464 Pregnenolone Carbonitrile results in increased expression of CLTB mRNA CTD PMID:28903501 propiconazole increases expression ISO RGD:1550649 6480464 propiconazole results in increased expression of CLTB mRNA CTD PMID:21278054 quercetin increases expression ISO RGD:733395 6480464 Quercetin results in increased expression of CLTB mRNA CTD PMID:21632981 raloxifene affects expression ISO RGD:733395 6480464 Raloxifene Hydrochloride affects the expression of CLTB mRNA CTD PMID:14699072 SB 431542 multiple interactions ISO RGD:733395 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLTB mRNA CTD PMID:27188386 selenium atom increases expression ISO RGD:733395 6480464 Selenium results in increased expression of CLTB mRNA CTD PMID:19244175 tamibarotene increases expression ISO RGD:733395 6480464 tamibarotene results in increased expression of CLTB mRNA CTD PMID:15498508 tamoxifen affects expression ISO RGD:733395 6480464 Tamoxifen affects the expression of CLTB mRNA CTD PMID:14699072 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of CLTB mRNA CTD PMID:12832660 , PMID:16644059 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of CLTB mRNA CTD PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of CLTB mRNA] CTD PMID:31150632 titanium dioxide increases expression ISO RGD:1550649 6480464 titanium dioxide results in increased expression of CLTB mRNA CTD PMID:27760801 valdecoxib increases expression EXP 6480464 valdecoxib results in increased expression of CLTB mRNA CTD PMID:24136188 valproic acid affects expression ISO RGD:1550649 6480464 Valproic Acid affects the expression of CLTB mRNA CTD PMID:17292431 valproic acid increases expression ISO RGD:1550649 6480464 Valproic Acid results in increased expression of CLTB mRNA CTD PMID:19136453 valproic acid affects expression ISO RGD:733395 6480464 Valproic Acid affects the expression of CLTB mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:733395 6480464 Valproic Acid results in increased expression of CLTB mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO RGD:733395 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLTB mRNA CTD PMID:27188386 vitamin E increases expression ISO RGD:733395 6480464 Vitamin E results in increased expression of CLTB mRNA CTD PMID:19244175 
Gene-Chemical Interaction Annotations
