RGD Reference Report - A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains. - Rat Genome Database

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A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains.

Authors: Wuertenberger, S  Groemping, Y 
Citation: Wuertenberger S and Groemping Y, FEBS Lett. 2015 Apr 28;589(10):1156-63. doi: 10.1016/j.febslet.2015.03.014. Epub 2015 Mar 24.
RGD ID: 10047166
Pubmed: PMID:25819436   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2015.03.014   (Journal Full-text)

The Slit-Robo GTPase-activating protein 3 (srGAP3) has been implicated in different critical aspects of neuronal development. These findings have mainly been based on the characterisation of the three conserved globular N-terminal domains, while the function of the C-terminal region (CTR) is still unknown. We show that this predicted unstructured region acts as an adaptor by binding to the endocytic proteins Amphiphysin, Endophilin-A2, Endophilin-A1, as well as the Ras signalling protein Grb2. All these interactions depend on a single proline-rich motif in the CTR and the Src-homology 3 domains of the binding partners. Via these interactions srGAP3 could link receptor signalling events to the endocytic machinery.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding enablesIPIUniProtKB:O4329510047166; 10047166; 10047166PMID:25819436IntAct 

Objects Annotated

Genes (Rattus norvegicus)
Amph  (amphiphysin)
Sh3gl1  (SH3 domain containing GRB2 like 1, endophilin A2)
Sh3gl2  (SH3 domain containing GRB2 like 2, endophilin A1)


Additional Information