Mcs19 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Mcs19 (Mammary carcinoma susceptibility QTL 19) Rattus norvegicus

Symbol: Mcs19
Name: Mammary carcinoma susceptibility QTL 19
RGD ID: 1600362
Previously known as: Chr 5 QTL
Trait: mammary gland integrity trait   (VT:0010552)    
Measurement Type: mammary tumor number   (CMO:0000343)    
LOD Score: 2.5
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8582,032,155 - 127,032,155RGD_MAPPER_PIPELINE
mRatBN7.2599,485,997 - 103,690,167RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.05103,265,614 - 107,119,704RGD_MAPPER_PIPELINERnor6.0
Rnor_5.05107,265,415 - 111,096,270RGDRnor5.0
RGSC_v3.45103,956,411 - 108,590,465RGDRGSC3.4
RGSC_v3.15103,961,587 - 108,595,691RGD
Cross Type: backcross
Strains Crossed: WKY/Ztm SPRD/Ztm 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mcs19Ratadenocarcinoma  IAGP 1599317 RGD 
Mcs19RatExperimental Mammary Neoplasms  IDA 1599317 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mcs19Ratincreased mammary adenocarcinoma incidence  IDA 1599317 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mcs19Ratmammary tumor number  IDA 1599317 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mcs19Rat7,12-dimethyltetraphene  IDA 1599317 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mcs19Ratmanual palpation method  IDA 1599317 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mcs19RatSPRD/Ztm  IEA 1599317 RGD 
Mcs19RatWKY/Ztm  IEA 1599317 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mcs19Ratmammary gland integrity trait  IDA 1581951 RGD 


#
Reference Title
Reference Citation
1. The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an allele-specific imbalance. Cotroneo MS, etal., Oncogene. 2006 Aug 17;25(36):5011-7. Epub 2006 Mar 27.
2. Genetic identification of distinct loci controlling mammary tumor multiplicity, latency, and aggressiveness in the rat. Quan X, etal., Mamm Genome. 2006 Apr;17(4):310-21. Epub 2006 Apr 4.


1 to 20 of 53 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1308101Cntlncentlein59929586599576402Rat
1585925Ppia-ps11peptidylprolyl isomerase A, pseudogene 1159961185299612369Rat
620276Sh3gl2SH3 domain containing GRB2 like 2, endophilin A159965318999827500Rat
41170419Pgam1-ps6phosphoglycerate mutase 1, pseudogene 659968598999686573Rat
1306439Adamtsl1ADAMTS-like 1599964406100919786Rat
1583685Saxo1stabilizer of axonemal microtubules 15100937134101093308Rat
619804RragaRas-related GTP binding A5101113341101114936Rat
15203474Haus6HAUS augmin like complex subunit 65101116532101156396Rat
41394140Scarna8small Cajal body-specific RNA 85101124125101124255Rat
728889Plin2perilipin 25101156648101211738Rat
7660377LOC102547623uncharacterized LOC1025476235101226928101245243Rat
1308489Dennd4cDENN domain containing 4C5101272298101369529Rat
3602Rps6ribosomal protein S65101371716101374576Rat
1304629Acer2alkaline ceramidase 25101391830101442615Rat
628650Slc24a2solute carrier family 24 member 25101497916101741840Rat
11459931LOC108350995uncharacterized LOC1083509955102119628102128446Rat
620940Mllt3MLLT3, super elongation complex subunit5102259075102515447Rat
41316176LOC120103312small nucleolar RNA SNORA175102483194102483318Rat
1311849Focadfocadhesin5102564560102886587Rat
1310339Hacd43-hydroxyacyl-CoA dehydratase 45102887597102915376Rat

1 to 20 of 53 rows
1 to 20 of 65 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
35074D5Rat231995102084761102084960Ratregion
35785D5Rat242965101278414101278701Ratregion
40574D5Rat19613659948599799486133Ratregion
38508D5Rat602445101467719101467963Ratregion
42750D5Rat23123659988536199885595Ratregion
41192D5Rat1522265102816790102817014Ratregion
41560D5Rat1531635103689353103689768Ratregion
41560D5Rat1531635103689674103690167Ratregion
41560D5Rat1531635103689997103690167Ratregion
41576D5Rat15115959975354899753708Ratregion
43932D5Got12914959961461499614763Ratregion
43934D5Got301335100749175100749308Ratregion
43935D5Got281395101660429101660568Ratregion
43936D5Got1311535101112265101112414Ratregion
60481D5Got312325101703657101703889Ratregion
69515D5Uwm231845101607489101607673Ratregion
69519D5Uwm251865101387969101388153Ratregion
69521D5Uwm261415101847538101847681Ratregion
69523D5Uwm271655103005080103005247Ratregion
629614D5Hmgc11685101374078101374246Ratregion
1 to 20 of 65 rows

Flank 1: (D5Rat196)
Rat AssemblyChrPosition (strand)Source
GRCr85104,532,087 - 104,532,223 (+)Marker Load Pipeline
mRatBN7.2599,485,997 - 99,486,133 (+)MAPPER
Rnor_6.05103,265,614 - 103,265,749NCBI
Rnor_5.05107,265,415 - 107,265,550UniSTS
RGSC_v3.45103,956,412 - 103,956,547UniSTS
RGSC_v3.45103,956,411 - 103,956,547RGD
RGSC_v3.15103,961,587 - 103,961,975RGD
Celera597,999,166 - 97,999,301UniSTS
SHRSP x BN Map558.1599UniSTS
SHRSP x BN Map558.1599RGD
Cytogenetic Map5q31UniSTS
Peak: (D5Rat196)
Rat AssemblyChrPosition (strand)Source
GRCr85104,532,087 - 104,532,223 (+)Marker Load Pipeline
mRatBN7.2599,485,997 - 99,486,133 (+)MAPPER
Rnor_6.05103,265,614 - 103,265,749NCBI
Rnor_5.05107,265,415 - 107,265,550UniSTS
RGSC_v3.45103,956,412 - 103,956,547UniSTS
RGSC_v3.45103,956,411 - 103,956,547RGD
RGSC_v3.15103,961,587 - 103,961,975RGD
Celera597,999,166 - 97,999,301UniSTS
SHRSP x BN Map558.1599UniSTS
SHRSP x BN Map558.1599RGD
Cytogenetic Map5q31UniSTS
Flank 2: (D5Rat153)
Rat AssemblyChrPosition (strand)Source
mRatBN7.25103,689,353 - 103,689,768 (-)MAPPER
mRatBN7.25103,689,997 - 103,690,167 (-)MAPPER
mRatBN7.25103,689,674 - 103,690,167 (-)MAPPER
Rnor_6.05107,119,214 - 107,119,704NCBI
Rnor_6.05107,119,214 - 107,119,383NCBI
Rnor_5.05111,095,780 - 111,096,270UniSTS
Rnor_5.05111,095,780 - 111,095,949UniSTS
RGSC_v3.45108,590,296 - 108,590,465UniSTS
RGSC_v3.45108,589,975 - 108,590,465UniSTS
RGSC_v3.45108,590,295 - 108,590,465RGD
RGSC_v3.15108,595,522 - 108,595,691RGD
Celera5102,415,516 - 102,416,037UniSTS
Celera5102,415,837 - 102,416,037UniSTS
RH 3.4 Map5744.7UniSTS
RH 3.4 Map5744.7RGD
SHRSP x BN Map558.2299UniSTS
SHRSP x BN Map558.2299RGD
Cytogenetic Map5q32UniSTS


1 to 10 of 46 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat

1 to 10 of 46 rows


Note Type Note Reference
qtl_cross_type backcross  
qtl_general inducing agent and dosage: single dosage of DMBA, 65mg/kg 1599317
qtl_general spans 60 cM 1599317
qtl_general number of animals used: 187 1599317
qtl_general allele responsible: SPRD allele increases tumor number 1599317
qtl_general gender: 53-58 days old virgin females 1599317