Mcs19 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Mcs19 (Mammary carcinoma susceptibility QTL 19) Rattus norvegicus

Symbol: Mcs19
Name: Mammary carcinoma susceptibility QTL 19
RGD ID: 1600362
Previously known as: Chr 5 QTL
Trait: mammary gland integrity trait   (VT:0010552)    
Measurement Type: mammary tumor number   (CMO:0000343)    
LOD Score: 2.5
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2599,485,997 - 103,690,167RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.05103,265,614 - 107,119,704RGD_MAPPER_PIPELINERnor6.0
Rnor_5.05107,265,415 - 111,096,270RGDRnor5.0
RGSC_v3.45103,956,411 - 108,590,465RGDRGSC3.4
RGSC_v3.15103,961,587 - 108,595,691RGD
Cross Type: backcross
Strains Crossed: WKY/Ztm SPRD/Ztm 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
SPRD/Ztm  (IEA)
WKY/Ztm  (IEA)

References

References - curated
# Reference Title Reference Citation
1. The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an allele-specific imbalance. Cotroneo MS, etal., Oncogene. 2006 Aug 17;25(36):5011-7. Epub 2006 Mar 27.
2. Genetic identification of distinct loci controlling mammary tumor multiplicity, latency, and aggressiveness in the rat. Quan X, etal., Mamm Genome. 2006 Apr;17(4):310-21. Epub 2006 Apr 4.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1308101Cntlncentlein59929586599576402Rat
1585925Ppia-ps11peptidylprolyl isomerase A, pseudogene 1159961185299612369Rat
620276Sh3gl2SH3 domain containing GRB2 like 2, endophilin A159965318999827500Rat
41170419Pgam1-ps6phosphoglycerate mutase 1, pseudogene 659968598999686573Rat
1306439Adamtsl1ADAMTS-like 1599964406100919786Rat
1583685Saxo1stabilizer of axonemal microtubules 15100937134101093308Rat
619804RragaRas-related GTP binding A5101113341101114936Rat
15203474Haus6HAUS augmin like complex subunit 65101116532101156396Rat
41394140Scarna8small Cajal body-specific RNA 85101124125101124255Rat
728889Plin2perilipin 25101156648101211738Rat
7660377LOC102547623uncharacterized LOC1025476235101226928101245243Rat
1308489Dennd4cDENN domain containing 4C5101272298101369529Rat
3602Rps6ribosomal protein S65101371716101374576Rat
1304629Acer2alkaline ceramidase 25101391830101442615Rat
628650Slc24a2solute carrier family 24 member 25101497916101741840Rat
11459931LOC108350995uncharacterized LOC1083509955102119628102128446Rat
620940Mllt3MLLT3, super elongation complex subunit5102259075102515447Rat
41316176LOC120103312small nucleolar RNA SNORA175102483194102483318Rat
1311849Focadfocadhesin5102564560102886587Rat
1310339Hacd43-hydroxyacyl-CoA dehydratase 45102887597102915376Rat
2865Ifnb1interferon beta 15103020758103021595Rat
1306334Ifna4interferon, alpha 45103069174103070120Rat
1306135Ifna1interferon, alpha 15103097356103097925Rat
1589875Ifna7l-ps1interferon, alpha 7 like, pseudogene 15103104672103105585Rat
41171666LOC120103203U6 spliceosomal RNA5103109366103109474Rat
1561246Ifna1l1interferon, alpha 1 like 15103144515103145269Rat
1359312Ifna5interferon, alpha 55103187852103188430Rat
1561827Ifna2l1interferon alpha 2 like 15103196737103197803Rat
1565225Ifna16l1interferon, alpha 16-like 15103216368103216984Rat
6487214LOC100912356interferon alpha-1-like5103227820103230500Rat
1311425Ifna2interferon alpha 25103258617103259195Rat
6502836LOC100909643interferon alpha-1-like5103273737103275988Rat
6487699LOC100912314interferon alpha-1-like5103285510103288640Rat
1559679Ifna4l2interferon, alpha 4 like 25103305221103305862Rat
41029367Rpl27a-ps12ribosomal protein L27a, pseudogene 125103328721103329166Rat
1304814Klhl9kelch-like family member 95103333747103337931Rat
1591738Rps24-ps10ribosomal protein S24, pseudogene 105103343786103344309Rat
41279671LOC120103158interferon alpha-12-like5103378576103379147Rat
41164037LOC120103159interferon alpha-12-like5103407135103407884Rat
41162071LOC120103160interferon alpha-12-like5103426092103427016Rat
41097131LOC120103161interferon alpha-12-like5103441204103442180Rat
40975974LOC120103162interferon alpha-1-like5103455380103455934Rat
1560539Ifna12linterferon alpha 12 like5103476362103477427Rat
41024711LOC120103163interferon alpha-12-like5103494442103495077Rat
41140167LOC120103164interferon alpha-12-like5103509610103510260Rat
6492384Ifna4l1interferon, alpha 4 like 15103524733103525302Rat
41074433LOC120103372U4 spliceosomal RNA5103532146103532302Rat
1565065Ifneinterferon, epsilon5103571630103572290Rat
329845494LOC130062807uncharacterized LOC1300628075103598328103627530Rat
4888605Mir3554microRNA 35545103599032103599149Rat
2325391Mir31microRNA 315103599038103599143Rat
329845392LOC130062808uncharacterized LOC1300628085103627694103629756Rat
1583723Nmt1-ps1N-myristoyltransferase 1, pseudogene 15103658873103662295Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
35074D5Rat232055102084761102084960Ratregion
35785D5Rat242965101278414101278701Ratregion
40574D5Rat19615059948599799486133Ratregion
38508D5Rat602465101467719101467963Ratregion
42750D5Rat23123759988536199885595Ratregion
41192D5Rat1522205102816790102817014Ratregion
41560D5Rat1531635103689353103689768Ratregion
41560D5Rat1531635103689674103690167Ratregion
41560D5Rat1531635103689997103690167Ratregion
41576D5Rat15115959975354899753708Ratregion
43932D5Got12914959961461499614763Ratregion
43934D5Got301335100749175100749308Ratregion
43935D5Got281395101660429101660568Ratregion
43936D5Got1311535101112265101112414Ratregion
60481D5Got312325101703657101703889Ratregion
69515D5Uwm231865101607489101607673Ratregion
69519D5Uwm251865101387969101388153Ratregion
69521D5Uwm261335101847538101847681Ratregion
69523D5Uwm271455103005080103005247Ratregion
629614D5Hmgc11675101374078101374246Ratregion
1627770D5Wox415101502201101502377Ratregion
1634628D5Got2411955100113215100113410Ratregion
7365003rs6578575005101612333101612333Ratregion
5036097UniSTS:1412181755102623667102623851Ratregion
5033877RH1404521655101169318101169483Ratregion
5031478AU0481911105100713273100713383Ratregion
5031720AU0473711035101621882101621985Ratregion
5032109RH94433975103020870103020967Ratregion
5032361AI12049013159982813699828474Ratregion
5032361AI12049013159982834399828474Ratregion
5035338BM3864221555102106356102106511Ratregion
5035410AI0076031925101505317101505509Ratregion
502786315.MMHAP53FRE9.seq2095101174343101174552Ratregion
5025424RH1282621915102623675102623875Ratregion
5033567RH1392971715102402584102402755Ratregion
5033769RH1400532195101169322101169541Ratregion
5056839RH1446102065102284069102284275Ratregion
5053447RH1426542545101125772101126026Ratregion
5047482RH1323532135102224612102224827Ratregion
5045572RH1312552035101375192101375395Ratregion
5047704RH1324801975102886291102886488Ratregion
5048222RH1327782175102889671102889888Ratregion
5042318RH1293652165101442257101442473Ratregion
5042388RH1294052045101498022101498226Ratregion
5076520RH1392232415102501070102501311Ratregion
5075550RH1386581965101369075101369271Ratregion
5076478RH1391981605102262097102262257Ratregion
5072876RH1371052015101442267101442468Ratregion
5079352RH1409441815101114607101114788Ratregion
5067534AU04768722459992333099923552Ratregion
5067706AU04758419659980089399801089Ratregion
5067706AU04758419659980093299801089Ratregion
5063654BE1079192105100937532100937742Ratregion
5063724BF4047741805102581935102582115Ratregion
5062790AW5344381645101118667101118831Ratregion
5061504BE1119052085102326902102327110Ratregion
5063176BE1138492115101543131101543342Ratregion
5086991BE1068091635103627756103627919Ratregion
5082077BF4159481925101704072101704264Ratregion
5087516PMC26775P15865103021015103021601Ratregion
5090323AU0496832035101194455101194502Ratregion
5081284RH1420722095101439761101439970Ratregion
5503845Nmt12795103658564103658845Ratregion
5506873G4707122259981947399819695Ratregion
5502311RH1243872305101369255101369485Ratregion
Position Markers

Flank 1: (D5Rat196)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2599,485,997 - 99,486,133 (+)MAPPER
Rnor_6.05103,265,614 - 103,265,749NCBI
Rnor_5.05107,265,415 - 107,265,550UniSTS
RGSC_v3.45103,956,411 - 103,956,547RGD
RGSC_v3.45103,956,412 - 103,956,547UniSTS
RGSC_v3.15103,961,587 - 103,961,975RGD
Celera597,999,166 - 97,999,301UniSTS
SHRSP x BN Map558.1599UniSTS
SHRSP x BN Map558.1599RGD
Cytogenetic Map5q31UniSTS
Peak: (D5Rat196)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2599,485,997 - 99,486,133 (+)MAPPER
Rnor_6.05103,265,614 - 103,265,749NCBI
Rnor_5.05107,265,415 - 107,265,550UniSTS
RGSC_v3.45103,956,411 - 103,956,547RGD
RGSC_v3.45103,956,412 - 103,956,547UniSTS
RGSC_v3.15103,961,587 - 103,961,975RGD
Celera597,999,166 - 97,999,301UniSTS
SHRSP x BN Map558.1599UniSTS
SHRSP x BN Map558.1599RGD
Cytogenetic Map5q31UniSTS
Flank 2: (D5Rat153)
Rat AssemblyChrPosition (strand)Source
mRatBN7.25103,689,353 - 103,689,768 (-)MAPPER
mRatBN7.25103,689,997 - 103,690,167 (-)MAPPER
mRatBN7.25103,689,674 - 103,690,167 (-)MAPPER
Rnor_6.05107,119,214 - 107,119,704NCBI
Rnor_6.05107,119,214 - 107,119,383NCBI
Rnor_5.05111,095,780 - 111,096,270UniSTS
Rnor_5.05111,095,780 - 111,095,949UniSTS
RGSC_v3.45108,590,296 - 108,590,465UniSTS
RGSC_v3.45108,589,975 - 108,590,465UniSTS
RGSC_v3.45108,590,295 - 108,590,465RGD
RGSC_v3.15108,595,522 - 108,595,691RGD
Celera5102,415,516 - 102,416,037UniSTS
Celera5102,415,837 - 102,416,037UniSTS
RH 3.4 Map5744.7UniSTS
RH 3.4 Map5744.7RGD
SHRSP x BN Map558.2299UniSTS
SHRSP x BN Map558.2299RGD
Cytogenetic Map5q32UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)599016066119085810Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)599753548113061097Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)599485997103690167Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_cross_type backcross  
qtl_general inducing agent and dosage: single dosage of DMBA, 65mg/kg 1599317
qtl_general spans 60 cM 1599317
qtl_general number of animals used: 187 1599317
qtl_general allele responsible: SPRD allele increases tumor number 1599317
qtl_general gender: 53-58 days old virgin females 1599317