Slc24a2 (solute carrier family 24 member 2) - Rat Genome Database

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Gene: Slc24a2 (solute carrier family 24 member 2) Rattus norvegicus
Analyze
Symbol: Slc24a2
Name: solute carrier family 24 member 2
RGD ID: 628650
Description: Enables calcium, potassium:sodium antiporter activity. Involved in calcium ion transmembrane transport and protein-containing complex assembly. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human SLC24A2 (solute carrier family 24 member 2); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; visual phototransduction pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: na(+)/K(+)/Ca(2+)-exchange protein 2; Nckx2; potassium-dependent sodium-calcium exchanger; retinal cone Na-Ca+K exchanger; sodium/potassium/calcium exchanger 2; solute carrier family 24 (sodium/potassium/calcium exchanger), member 2; solute carrier family 24, member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25101,499,536 - 101,739,337 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5101,502,278 - 101,739,337 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5103,875,413 - 104,113,006 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05105,665,961 - 105,903,464 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05105,699,555 - 105,944,125 (-)NCBIRnor_WKY
Rnor_6.05105,336,287 - 105,579,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5105,336,262 - 105,582,375 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05109,323,070 - 109,564,102 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45106,295,254 - 106,537,714 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15106,300,479 - 106,542,940 (-)NCBI
Celera5101,349,538 - 101,587,410 (+)NCBICelera
Cytogenetic Map5q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Na+/Ca2+-K+ exchangers (NCKX): functional properties and physiological roles. Altimimi HF and Schnetkamp PP, Channels (Austin). 2007 Mar-Apr;1(2):62-9. Epub 2007 Apr 30.
2. Topological studies of the rat brain K+-dependent Na+/Ca2+ exchanger NCKX2. Cai X, etal., Ann N Y Acad Sci 2002 Nov;976:90-3.
3. A novel topology and redox regulation of the rat brain K+-dependent Na+/Ca2+ exchanger, NCKX2. Cai X, etal., J Biol Chem 2002 Dec 13;277(50):48923-30.
4. Electrophysiological characterization and ionic stoichiometry of the rat brain K(+)-dependent NA(+)/CA(2+) exchanger, NCKX2. Dong H, etal., J Biol Chem. 2001 Jul 13;276(28):25919-28. Epub 2001 May 7.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes. Kiedrowski L, etal., Neuroreport 2002 Aug 27;13(12):1529-32.
7. K+-dependent Na+/Ca2+ exchange is a major Ca2+ clearance mechanism in axon terminals of rat neurohypophysis. Lee SH, etal., J Neurosci 2002 Aug 15;22(16):6891-9.
8. Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport. Lytton J Biochem J. 2007 Sep 15;406(3):365-82.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Molecular cloning of a novel potassium-dependent sodium-calcium exchanger from rat brain. Tsoi M, etal., J Biol Chem 1998 Feb 13;273(7):4155-62.
12. Different cation sensitivities and binding site domains of Na+-Ca2+-K+ and Na+-Ca2+ exchangers. Uehara A, etal., J Cell Physiol. 2005 May;203(2):420-8.
Additional References at PubMed
PMID:10662833   PMID:16407245   PMID:17038313   PMID:18166528   PMID:22871113   PMID:26631410   PMID:32582988  


Genomics

Comparative Map Data
Slc24a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25101,499,536 - 101,739,337 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5101,502,278 - 101,739,337 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5103,875,413 - 104,113,006 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05105,665,961 - 105,903,464 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05105,699,555 - 105,944,125 (-)NCBIRnor_WKY
Rnor_6.05105,336,287 - 105,579,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5105,336,262 - 105,582,375 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05109,323,070 - 109,564,102 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45106,295,254 - 106,537,714 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15106,300,479 - 106,542,940 (-)NCBI
Celera5101,349,538 - 101,587,410 (+)NCBICelera
Cytogenetic Map5q32NCBI
SLC24A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38919,507,455 - 20,307,892 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl919,507,452 - 19,789,037 (-)EnsemblGRCh38hg38GRCh38
GRCh37919,507,453 - 19,789,035 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36919,505,978 - 19,776,926 (-)NCBINCBI36Build 36hg18NCBI36
Build 34919,505,977 - 19,776,926NCBI
Celera919,433,508 - 19,714,554 (-)NCBICelera
Cytogenetic Map9p22.1-p21.3NCBI
HuRef919,468,902 - 19,749,276 (-)NCBIHuRef
CHM1_1919,507,294 - 19,786,814 (-)NCBICHM1_1
T2T-CHM13v2.0919,520,160 - 19,802,944 (-)NCBIT2T-CHM13v2.0
Slc24a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39486,901,361 - 87,148,780 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl486,901,361 - 87,148,714 (-)EnsemblGRCm39 Ensembl
GRCm38486,983,124 - 87,230,652 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl486,983,124 - 87,230,477 (-)EnsemblGRCm38mm10GRCm38
MGSCv37486,629,028 - 86,876,444 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36486,461,003 - 86,701,654 (-)NCBIMGSCv36mm8
Celera485,505,583 - 85,755,220 (-)NCBICelera
Cytogenetic Map4C4NCBI
Slc24a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543421,873,091 - 22,091,177 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543421,871,319 - 22,091,125 (-)NCBIChiLan1.0ChiLan1.0
SLC24A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1919,808,591 - 20,251,387 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl919,814,244 - 20,249,225 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0919,317,132 - 19,593,503 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC24A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11139,273,285 - 39,521,223 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1139,278,370 - 39,519,222 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1137,927,494 - 38,178,882 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01140,203,164 - 40,454,628 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1140,209,212 - 40,454,579 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11138,895,568 - 39,147,258 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01138,693,264 - 38,938,019 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01139,327,164 - 39,578,919 (-)NCBIUU_Cfam_GSD_1.0
Slc24a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947153,700,301 - 153,916,436 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366521,378,045 - 1,583,403 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366521,375,292 - 1,585,718 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC24A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1203,059,588 - 203,333,781 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11203,059,563 - 203,336,442 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21226,912,944 - 226,979,819 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21226,645,477 - 226,845,623 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC24A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11259,962,744 - 60,229,539 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1259,964,749 - 60,224,816 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603848,071,391 - 48,345,344 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc24a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473623,496,268 - 23,733,259 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473623,488,228 - 23,735,657 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc24a2
1196 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:935
Count of miRNA genes:308
Interacting mature miRNAs:434
Transcripts:ENSRNOT00000010827
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)599016066119085810Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)599485997103690167Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)599753548113061097Rat

Markers in Region
D5Got28  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25101,660,429 - 101,660,568 (+)MAPPERmRatBN7.2
Rnor_6.05105,500,674 - 105,500,812NCBIRnor6.0
Rnor_5.05109,485,162 - 109,485,300UniSTSRnor5.0
RGSC_v3.45106,457,415 - 106,457,554RGDRGSC3.4
RGSC_v3.45106,457,416 - 106,457,554UniSTSRGSC3.4
RGSC_v3.15106,462,642 - 106,462,780RGD
Celera5101,428,245 - 101,428,383UniSTS
RH 3.4 Map5738.9UniSTS
RH 3.4 Map5738.9RGD
RH 2.0 Map5657.6RGD
Cytogenetic Map5q32UniSTS
D5Got31  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25101,703,657 - 101,703,889 (+)MAPPERmRatBN7.2
Rnor_6.05105,544,278 - 105,544,509NCBIRnor6.0
Rnor_5.05109,528,421 - 109,528,652UniSTSRnor5.0
RGSC_v3.45106,502,032 - 106,502,264RGDRGSC3.4
RGSC_v3.45106,502,033 - 106,502,264UniSTSRGSC3.4
Celera5101,384,977 - 101,385,208UniSTS
RH 3.4 Map5745.4UniSTS
RH 3.4 Map5745.4RGD
Cytogenetic Map5q32UniSTS
D5Uwm23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25101,607,489 - 101,607,673 (+)MAPPERmRatBN7.2
Rnor_6.05105,444,977 - 105,445,160NCBIRnor6.0
Rnor_5.05109,431,760 - 109,431,943UniSTSRnor5.0
RGSC_v3.45106,403,190 - 106,403,373UniSTSRGSC3.4
Celera5101,479,696 - 101,479,879UniSTS
Cytogenetic Map5q32UniSTS
D5Wox41  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25101,502,201 - 101,502,377 (+)MAPPERmRatBN7.2
Rnor_6.05105,338,953 - 105,339,126NCBIRnor6.0
Rnor_5.05109,325,736 - 109,325,909UniSTSRnor5.0
RGSC_v3.45106,297,920 - 106,298,093UniSTSRGSC3.4
Celera5101,584,497 - 101,584,744UniSTS
Cytogenetic Map5q32UniSTS
AU047371  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25101,621,882 - 101,621,985 (+)MAPPERmRatBN7.2
Rnor_6.05105,461,768 - 105,461,870NCBIRnor6.0
Rnor_5.05109,446,256 - 109,446,358UniSTSRnor5.0
RGSC_v3.45106,418,860 - 106,418,962UniSTSRGSC3.4
Celera5101,466,670 - 101,466,742UniSTS
Cytogenetic Map5q32UniSTS
AI007603  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25101,505,317 - 101,505,509 (+)MAPPERmRatBN7.2
Rnor_6.05105,342,067 - 105,342,258NCBIRnor6.0
Rnor_5.05109,328,850 - 109,329,041UniSTSRnor5.0
RGSC_v3.45106,301,034 - 106,301,225UniSTSRGSC3.4
Celera5101,581,365 - 101,581,556UniSTS
RH 3.4 Map5741.6UniSTS
Cytogenetic Map5q32UniSTS
AU048745  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q32UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map13q26UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map7q11UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map5q21UniSTS
Cytogenetic Map4q24UniSTS
Cytogenetic Map2q11UniSTS
Cytogenetic Map1q54UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map18p11UniSTS
Cytogenetic Map13q13UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map13p13UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map10q31UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map3p13UniSTS
BE113849  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25101,543,131 - 101,543,342 (+)MAPPERmRatBN7.2
Rnor_6.05105,380,626 - 105,380,836NCBIRnor6.0
Rnor_5.05109,367,409 - 109,367,619UniSTSRnor5.0
RGSC_v3.45106,338,841 - 106,339,051UniSTSRGSC3.4
Celera5101,543,885 - 101,544,095UniSTS
RH 3.4 Map5742.0UniSTS
Cytogenetic Map5q32UniSTS
BF415948  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25101,704,072 - 101,704,264 (+)MAPPERmRatBN7.2
Rnor_6.05105,544,693 - 105,544,884NCBIRnor6.0
Rnor_5.05109,528,836 - 109,529,027UniSTSRnor5.0
RGSC_v3.45106,502,448 - 106,502,639UniSTSRGSC3.4
Celera5101,384,602 - 101,384,793UniSTS
RH 3.4 Map5739.4UniSTS
Cytogenetic Map5q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 33
Low 1 19 3 16 3 3 4 41 8 13 9 3
Below cutoff 3 31 14 14 3 14 5 6 19 26 2 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010827   ⟹   ENSRNOP00000010827
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5101,502,278 - 101,739,337 (-)Ensembl
Rnor_6.0 Ensembl5105,336,262 - 105,579,959 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083373   ⟹   ENSRNOP00000074180
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5101,502,278 - 101,739,337 (-)Ensembl
Rnor_6.0 Ensembl5105,342,727 - 105,582,375 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114418   ⟹   ENSRNOP00000092960
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5101,502,278 - 101,739,337 (-)Ensembl
RefSeq Acc Id: NM_031743   ⟹   NP_113931
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25101,499,536 - 101,739,337 (-)NCBI
Rnor_6.05105,336,287 - 105,579,959 (-)NCBI
Rnor_5.05109,323,070 - 109,564,102 (-)NCBI
RGSC_v3.45106,295,254 - 106,537,714 (-)RGD
Celera5101,349,538 - 101,587,410 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113931 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC19404 (Get FASTA)   NCBI Sequence Viewer  
  AAC19405 (Get FASTA)   NCBI Sequence Viewer  
  EDL76005 (Get FASTA)   NCBI Sequence Viewer  
  O54701 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_113931   ⟸   NM_031743
- UniProtKB: O54706 (UniProtKB/Swiss-Prot),   O54701 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074180   ⟸   ENSRNOT00000083373
RefSeq Acc Id: ENSRNOP00000010827   ⟸   ENSRNOT00000010827
RefSeq Acc Id: ENSRNOP00000092960   ⟸   ENSRNOT00000114418
Protein Domains
Na_Ca_ex

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54701-F1-model_v2 AlphaFold O54701 1-670 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693831
Promoter ID:EPDNEW_R4352
Type:single initiation site
Name:Slc24a2_1
Description:solute carrier family 24 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05105,582,428 - 105,582,488EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628650 AgrOrtholog
BioCyc Gene G2FUF-40835 BioCyc
Ensembl Genes ENSRNOG00000008169 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010827 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000074180 UniProtKB/Swiss-Prot
  ENSRNOP00000092960.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010827 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000083373 UniProtKB/Swiss-Prot
  ENSRNOT00000114418.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1420.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro K/Na/Ca-exchanger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NaCa_Exmemb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCX_ion-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC24A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84550 UniProtKB/Swiss-Prot
NCBI Gene 84550 ENTREZGENE
PANTHER PTHR10846 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10846:SF41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Na_Ca_ex UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc24a2 PhenoGen
TIGRFAMs TIGR00367 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GKF7_RAT UniProtKB/TrEMBL
  NCKX2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  O54706 ENTREZGENE
UniProt Secondary O54706 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc24a2  solute carrier family 24 member 2  Slc24a2  solute carrier family 24 (sodium/potassium/calcium exchanger), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Slc24a2  solute carrier family 24 (sodium/potassium/calcium exchanger), member 2      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Slc24a2  solute carrier family 24 (sodium/potassium/calcium exchanger), member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the brain 625729
gene_process mediates K+-dependent Ca2+ clearance; may mediate 90% of Na+/Ca2+ exchanger activity in axon terminals of neurohypophysis 625729