Slc24a2 (solute carrier family 24 member 2) - Rat Genome Database
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Gene: Slc24a2 (solute carrier family 24 member 2) Rattus norvegicus
Analyze
Symbol: Slc24a2
Name: solute carrier family 24 member 2
RGD ID: 628650
Description: Exhibits calcium, potassium:sodium antiporter activity. Involved in calcium ion transmembrane transport and protein-containing complex assembly. Localizes to intrinsic component of plasma membrane. Orthologous to human SLC24A2 (solute carrier family 24 member 2); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; visual phototransduction pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: na(+)/K(+)/Ca(2+)-exchange protein 2; Nckx2; potassium-dependent sodium-calcium exchanger; retinal cone Na-Ca+K exchanger; sodium/potassium/calcium exchanger 2; solute carrier family 24 (sodium/potassium/calcium exchanger), member 2; solute carrier family 24, member 2
Orthologs:
Homo sapiens (human) : SLC24A2 (solute carrier family 24 member 2)  HGNC  Alliance
Mus musculus (house mouse) : Slc24a2 (solute carrier family 24 (sodium/potassium/calcium exchanger), member 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc24a2 (solute carrier family 24 member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC24A2 (solute carrier family 24 member 2)
Canis lupus familiaris (dog) : SLC24A2 (solute carrier family 24 member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc24a2 (solute carrier family 24 member 2)
Sus scrofa (pig) : SLC24A2 (solute carrier family 24 member 2)
Chlorocebus sabaeus (African green monkey) : SLC24A2 (solute carrier family 24 member 2)
Heterocephalus glaber (naked mole-rat) : Slc24a2 (solute carrier family 24 member 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05105,336,287 - 105,579,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5105,336,262 - 105,582,375 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05109,323,070 - 109,564,102 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45106,295,254 - 106,537,714 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15106,300,479 - 106,542,940 (-)NCBI
Celera5101,349,538 - 101,587,410 (+)NCBICelera
Cytogenetic Map5q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10662833   PMID:16407245   PMID:17038313   PMID:18166528   PMID:22871113   PMID:26631410  


Genomics

Comparative Map Data
Slc24a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05105,336,287 - 105,579,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5105,336,262 - 105,582,375 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05109,323,070 - 109,564,102 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45106,295,254 - 106,537,714 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15106,300,479 - 106,542,940 (-)NCBI
Celera5101,349,538 - 101,587,410 (+)NCBICelera
Cytogenetic Map5q32NCBI
SLC24A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl919,507,452 - 19,786,928 (-)EnsemblGRCh38hg38GRCh38
GRCh38919,507,452 - 20,307,888 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37919,507,450 - 19,789,059 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36919,505,978 - 19,776,926 (-)NCBINCBI36hg18NCBI36
Build 34919,505,977 - 19,776,926NCBI
Celera919,433,508 - 19,714,554 (-)NCBI
Cytogenetic Map9p22.1-p21.3NCBI
HuRef919,468,902 - 19,749,276 (-)NCBIHuRef
CHM1_1919,507,294 - 19,786,814 (-)NCBICHM1_1
Slc24a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39486,901,361 - 87,148,780 (-)NCBI
GRCm38486,983,124 - 87,230,652 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl486,983,124 - 87,230,477 (-)EnsemblGRCm38mm10GRCm38
MGSCv37486,629,028 - 86,876,444 (-)NCBIGRCm37mm9NCBIm37
MGSCv36486,461,003 - 86,701,654 (-)NCBImm8
Celera485,505,583 - 85,755,220 (-)NCBICelera
Cytogenetic Map4C4NCBI
Slc24a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543421,873,091 - 22,091,177 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543421,871,319 - 22,091,125 (-)NCBIChiLan1.0ChiLan1.0
SLC24A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1919,808,591 - 20,251,387 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl919,814,244 - 20,249,225 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0919,317,132 - 19,593,503 (-)NCBIMhudiblu_PPA_v0panPan3
SLC24A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1139,278,370 - 39,519,222 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11139,273,285 - 39,521,223 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Slc24a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366521,375,292 - 1,585,718 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC24A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1203,059,588 - 203,333,792 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11203,059,563 - 203,336,442 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21226,912,944 - 226,979,819 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21226,645,477 - 226,845,623 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC24A2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1259,964,749 - 60,224,816 (+)Ensembl
ChlSab1.11259,962,744 - 60,229,539 (+)NCBI
Slc24a2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473623,488,228 - 23,735,657 (-)NCBI

Position Markers
D5Got28  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05105,500,674 - 105,500,812NCBIRnor6.0
Rnor_5.05109,485,162 - 109,485,300UniSTSRnor5.0
RGSC_v3.45106,457,415 - 106,457,554RGDRGSC3.4
RGSC_v3.45106,457,416 - 106,457,554UniSTSRGSC3.4
RGSC_v3.15106,462,642 - 106,462,780RGD
Celera5101,428,245 - 101,428,383UniSTS
Cytogenetic Map5q32UniSTS
RH 3.4 Map5738.9UniSTS
RH 3.4 Map5738.9RGD
RH 2.0 Map5657.6RGD
D5Got31  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05105,544,278 - 105,544,509NCBIRnor6.0
Rnor_5.05109,528,421 - 109,528,652UniSTSRnor5.0
RGSC_v3.45106,502,032 - 106,502,264RGDRGSC3.4
RGSC_v3.45106,502,033 - 106,502,264UniSTSRGSC3.4
Celera5101,384,977 - 101,385,208UniSTS
Cytogenetic Map5q32UniSTS
RH 3.4 Map5745.4RGD
RH 3.4 Map5745.4UniSTS
D5Uwm23  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05105,444,977 - 105,445,160NCBIRnor6.0
Rnor_5.05109,431,760 - 109,431,943UniSTSRnor5.0
RGSC_v3.45106,403,190 - 106,403,373UniSTSRGSC3.4
Celera5101,479,696 - 101,479,879UniSTS
Cytogenetic Map5q32UniSTS
D5Wox41  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05105,338,953 - 105,339,126NCBIRnor6.0
Rnor_5.05109,325,736 - 109,325,909UniSTSRnor5.0
RGSC_v3.45106,297,920 - 106,298,093UniSTSRGSC3.4
Celera5101,584,497 - 101,584,744UniSTS
Cytogenetic Map5q32UniSTS
AU047371  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05105,461,768 - 105,461,870NCBIRnor6.0
Rnor_5.05109,446,256 - 109,446,358UniSTSRnor5.0
RGSC_v3.45106,418,860 - 106,418,962UniSTSRGSC3.4
Celera5101,466,670 - 101,466,742UniSTS
Cytogenetic Map5q32UniSTS
AI007603  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05105,342,067 - 105,342,258NCBIRnor6.0
Rnor_5.05109,328,850 - 109,329,041UniSTSRnor5.0
RGSC_v3.45106,301,034 - 106,301,225UniSTSRGSC3.4
Celera5101,581,365 - 101,581,556UniSTS
Cytogenetic Map5q32UniSTS
RH 3.4 Map5741.6UniSTS
AU048745  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q32UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map13q26UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map7q11UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map5q21UniSTS
Cytogenetic Map4q24UniSTS
Cytogenetic Map2q11UniSTS
Cytogenetic Map1q54UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map18p11UniSTS
Cytogenetic Map13q13UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map13p13UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map10q31UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map3p13UniSTS
BE113849  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05105,380,626 - 105,380,836NCBIRnor6.0
Rnor_5.05109,367,409 - 109,367,619UniSTSRnor5.0
RGSC_v3.45106,338,841 - 106,339,051UniSTSRGSC3.4
Celera5101,543,885 - 101,544,095UniSTS
Cytogenetic Map5q32UniSTS
RH 3.4 Map5742.0UniSTS
BF415948  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05105,544,693 - 105,544,884NCBIRnor6.0
Rnor_5.05109,528,836 - 109,529,027UniSTSRnor5.0
RGSC_v3.45106,502,448 - 106,502,639UniSTSRGSC3.4
Celera5101,384,602 - 101,384,793UniSTS
Cytogenetic Map5q32UniSTS
RH 3.4 Map5739.4UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51136640934Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512651967117554267Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531926122136640934Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)535225432108092802Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)535661945117554267Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535788756147487820Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540777918154732375Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)544404276134502294Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)547745646167946134Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)551418671147487820Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)556991667137729065Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)560072951133313852Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)561086525149030144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)561086653117554114Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)561612600168109659Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)565696672129038896Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)568838385113838385Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)571154828108092802Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)571154828108092802Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)571154828108092802Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)571154828108092802Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)571154828108092802Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)571552569157225114Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)583424556128424556Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)583424556128424556Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)583424556128424556Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)584963058173504662Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589502294134502294Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)591585539136585539Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)591585539136585539Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)591585539136585539Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)591884213136884213Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)593037304133313852Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)593037304133313852Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)593273130138273130Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)597921932149030144Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5100723739153577831Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5101265591141912026Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight as percentage of body weight (CMO:0000141)5102498468123852688Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5102945579154732228Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5103265614107119704Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5103580245117037276Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:935
Count of miRNA genes:308
Interacting mature miRNAs:434
Transcripts:ENSRNOT00000010827
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 33
Low 1 19 3 16 3 3 4 41 8 13 9 3
Below cutoff 3 31 14 14 3 14 5 6 19 26 2 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07049102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07049103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07049104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01038261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01038262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01038263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01038264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01038265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01038266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01038267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01038268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01038269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01038270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01038271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01038272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF021923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF027506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000010827   ⟹   ENSRNOP00000010827
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5105,336,262 - 105,579,959 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083373   ⟹   ENSRNOP00000074180
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5105,342,727 - 105,582,375 (-)Ensembl
RefSeq Acc Id: NM_031743   ⟹   NP_113931
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05105,336,287 - 105,579,959 (-)NCBI
Rnor_5.05109,323,070 - 109,564,102 (-)NCBI
RGSC_v3.45106,295,254 - 106,537,714 (-)RGD
Celera5101,349,538 - 101,587,410 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113931 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC19404 (Get FASTA)   NCBI Sequence Viewer  
  AAC19405 (Get FASTA)   NCBI Sequence Viewer  
  EDL76005 (Get FASTA)   NCBI Sequence Viewer  
  O54701 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_113931   ⟸   NM_031743
- UniProtKB: O54701 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074180   ⟸   ENSRNOT00000083373
RefSeq Acc Id: ENSRNOP00000010827   ⟸   ENSRNOT00000010827

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693831
Promoter ID:EPDNEW_R4352
Type:single initiation site
Name:Slc24a2_1
Description:solute carrier family 24 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05105,582,428 - 105,582,488EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628650 AgrOrtholog
Ensembl Genes ENSRNOG00000008169 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000010827 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000074180 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010827 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000083373 UniProtKB/Swiss-Prot
InterPro K/Na/Ca-exchanger UniProtKB/Swiss-Prot
  NaCa_Exmemb UniProtKB/Swiss-Prot
  SLC24A2 UniProtKB/Swiss-Prot
KEGG Report rno:84550 UniProtKB/Swiss-Prot
NCBI Gene 84550 ENTREZGENE
PANTHER PTHR10846 UniProtKB/Swiss-Prot
  PTHR10846:SF41 UniProtKB/Swiss-Prot
Pfam Na_Ca_ex UniProtKB/Swiss-Prot
PhenoGen Slc24a2 PhenoGen
TIGRFAMs TIGR00367 UniProtKB/Swiss-Prot
UniGene Rn.208755 ENTREZGENE
UniProt NCKX2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O54706 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc24a2  solute carrier family 24 member 2  Slc24a2  solute carrier family 24 (sodium/potassium/calcium exchanger), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Slc24a2  solute carrier family 24 (sodium/potassium/calcium exchanger), member 2      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Slc24a2  solute carrier family 24 (sodium/potassium/calcium exchanger), member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the brain 625729
gene_process mediates K+-dependent Ca2+ clearance; may mediate 90% of Na+/Ca2+ exchanger activity in axon terminals of neurohypophysis 625729