Ifna2 (interferon alpha 2) - Rat Genome Database

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Gene: Ifna2 (interferon alpha 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ifna2
Name: interferon alpha 2
RGD ID: 1311425
Description: Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Crimean-Congo hemorrhagic fever; common cold; hepatitis B; liver disease (multiple); and sarcoidosis. Orthologous to several human genes including IFNA1 (interferon alpha 1); IFNA10 (interferon alpha 10); and IFNA13 (interferon alpha 13); PARTICIPATES IN autoimmune thyroiditis pathway; autophagy pathway; cytokine mediated signaling pathway; INTERACTS WITH 2-acetamidofluorene; ammonium chloride; N-nitrosodiethylamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: If1ai9; interferon 1ai9; interferon alpha family, gene 2; LOC298213
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25103,258,617 - 103,259,195 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_WKY_Bbb_1.05107,457,649 - 107,458,227 (-)NCBIRnor_WKY
Rnor_6.05107,416,117 - 107,416,695 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5107,416,117 - 107,416,695 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05111,391,979 - 111,392,557 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45108,117,536 - 108,118,114 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15108,122,755 - 108,123,366 (-)NCBI
Cytogenetic Map5q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Efficacy and tolerance of a 6-month treatment course of daily interferon-alpha 2a for chronic hepatitis C with cirrhosis. The Australian Hepatitis C Study Group. Farrell G, etal., J Viral Hepat. 1997 Sep;4(5):317-23. doi: 10.1046/j.1365-2893.1997.00062.x.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Mutations in the interferon sensitivity-determining region of hepatitis C virus genotype 2a correlate with response to pegylated-interferon-alpha 2a monotherapy. Hayashi K, etal., J Med Virol. 2009 Mar;81(3):459-66. doi: 10.1002/jmv.21407.
4. Intranasal interferon-alpha 2 treatment of experimental rhinoviral colds. Hayden FG and Gwaltney JM, J Infect Dis. 1984 Aug;150(2):174-80. doi: 10.1093/infdis/150.2.174.
5. [Association between the influential factors and the effectiveness of pegylated interferon alpha-2a plus ribavirin as a combination treatment for chronic hepatitis C patients]. He LL, etal., Zhonghua Gan Zang Bing Za Zhi. 2011 Jan;19(1):34-7. doi: 10.3760/cma.j.issn.1007-3418.2011.01.010.
6. Pegylated interferon alpha-2a versus standard interferon alpha-2a for treatment-naive dialysis patients with chronic hepatitis C: a randomised study. Liu CH, etal., Gut. 2008 Apr;57(4):525-30. doi: 10.1136/gut.2007.133884. Epub 2007 Sep 19.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Genotype, serum level of hepatitis C virus RNA and liver histology as predictors of response to interferon-alpha 2a therapy in Japanese patients with chronic hepatitis C. Mizokami M, etal., Liver. 1996 Feb;16(1):23-7. doi: 10.1111/j.1600-0676.1996.tb00699.x.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Long-term titrated recombinant interferon-alpha 2a in chronic hepatitis C: a randomized controlled trial. Rumi MG, etal., J Viral Hepat. 1995;2(2):73-6. doi: 10.1111/j.1365-2893.1995.tb00009.x.
13. To treat or not to treat? The judicious use of interferon-alpha-2a for the treatment of chronic hepatitis B. Ryff JC, J Hepatol. 1993;17 Suppl 3:S42-6. doi: 10.1016/s0168-8278(05)80422-2.
14. Does the presence of serum autoantibodies influence the responsiveness to interferon-alpha 2a treatment in chronic hepatitis C? Wada M, etal., Intern Med. 1997 Apr;36(4):248-54. doi: 10.2169/internalmedicine.36.248.
15. Rare inborn errors associated with chronic hepatitis B virus infection. Zhao Q, etal., Hepatology. 2012 Nov;56(5):1661-70. doi: 10.1002/hep.25850. Epub 2012 Oct 14.
Additional References at PubMed
PMID:19003557   PMID:24289330   PMID:32160960  


Genomics

Variants

.
Variants in Ifna2
14 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)599016066119085810Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)599485997103690167Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)599753548113061097Rat

Markers in Region
Ifna1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system musculoskeletal system nervous system reproductive system respiratory system
High
Medium
Low
Below cutoff 2 1 5 6 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000045433   ⟹   ENSRNOP00000072648
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5107,416,117 - 107,416,695 (-)Ensembl
RefSeq Acc Id: NM_001271218   ⟹   NP_001258147
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25103,258,617 - 103,259,195 (-)NCBI
Rnor_6.05107,416,117 - 107,416,695 (-)NCBI
Rnor_5.05111,391,979 - 111,392,557 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258147 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAB0000189 (Get FASTA)   NCBI Sequence Viewer  
  EDL82699 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001258147   ⟸   NM_001271218
- Peptide Label: precursor
- UniProtKB: A0A0G2K3I2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072648   ⟸   ENSRNOT00000045433

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K3I2-F1-model_v2 AlphaFold A0A0G2K3I2 1-192 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311425 AgrOrtholog
BioCyc Gene G2FUF-40813 BioCyc
Ensembl Genes ENSRNOG00000058365 Ensembl
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  Interferon_alpha/beta/delta UniProtKB/TrEMBL
KEGG Report rno:298213 UniProtKB/TrEMBL
NCBI Gene 298213 ENTREZGENE
PANTHER Interferon_abd UniProtKB/TrEMBL
Pfam Interferon UniProtKB/TrEMBL
PhenoGen Ifna2 PhenoGen
PRINTS INTERFERONAB UniProtKB/TrEMBL
PROSITE INTERFERON_A_B_D UniProtKB/TrEMBL
SMART IFabd UniProtKB/TrEMBL
Superfamily-SCOP 4_helix_cytokine UniProtKB/TrEMBL
UniProt A0A0G2K3I2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-01 Ifna2  interferon alpha 2  Ifna2  interferon alpha family, gene 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ifna2  interferon alpha family, gene 2   Ifna2_predicted  interferon alpha family, gene 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ifna2_predicted  interferon alpha family, gene 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED