Dennd4c (DENN domain containing 4C)

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Gene: Dennd4c (DENN domain containing 4C) Rattus norvegicus

Analyze

Symbol:

Dennd4c

Name:

DENN domain containing 4C

RGD ID:

1308489

Description:

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to insulin stimulus and protein localization to plasma membrane. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and insulin-responsive compartment. Predicted to be part of retromer complex. Orthologous to human DENND4C (DENN domain containing 4C); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DENN domain-containing protein 4C; DENN/MADD domain containing 4C; LOC102555797; LOC313340; RGD1308489; similar to hypothetical protein; uncharacterized LOC102555797

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DENND4C (DENN domain containing 4C)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Dennd4c (DENN domain containing 4C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dennd4c (DENN domain containing 4C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DENND4C (DENN domain containing 4C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DENND4C (DENN domain containing 4C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dennd4c (DENN domain containing 4C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DENND4C (DENN domain containing 4C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DENND4C (DENN domain containing 4C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dennd4c (DENN domain containing 4C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ZNF383 (zinc finger protein 383)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	DENND4C (DENN domain containing 4C)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dennd4c (DENN domain containing 4C)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dennd4c (DENN/MADD domain containing 4C)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Crag	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	denn-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dennd4c	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	101,272,298 - 101,369,529 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	101,272,005 - 101,368,118 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	5	105,100,081 - 105,195,634 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	105,114,433 - 105,193,988 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	109,085,833 - 109,182,502 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	106,090,415 - 106,162,420 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	106,090,717 - 106,167,026 (+)	NCBI
Celera	5	101,714,237 - 101,809,916 (-)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

caffeine (ISO)

calcitriol (ISO)

chloroprene (EXP)

coumarin (ISO)

crocidolite asbestos (ISO)

dexamethasone (ISO)

dicrotophos (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

ethyl methanesulfonate (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

indometacin (ISO)

ivermectin (ISO)

melphalan (ISO)

methyl methanesulfonate (ISO)

nefazodone (EXP)

oxaliplatin (EXP)

paracetamol (EXP)

pentachlorophenol (ISO)

potassium chromate (ISO)

propiconazole (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tetrachloroethene (ISO)

thapsigargin (ISO)

topotecan (EXP)

trichloroethene (EXP)

valdecoxib (EXP)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cellular response to insulin stimulus (ISO)

protein localization to plasma membrane (ISO)

regulation of Rab protein signal transduction (IBA)

Cellular Component

cytoplasmic vesicle (IBA)

cytosol (ISO)

Golgi apparatus (IEA,ISO)

insulin-responsive compartment (ISO)

intracellular membrane-bounded organelle (ISO)

plasma membrane (ISO)

retromer complex (ISO)

Molecular Function

guanyl-nucleotide exchange factor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

insulin responsive facilitative sugar transporter mediated glucose transport pathway (ISO)

Rab family mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation.	Klip A, etal., Am J Physiol Cell Physiol. 2014 May 15;306(10):C879-86. doi: 10.1152/ajpcell.00069.2014. Epub 2014 Mar 5.
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:20937701	PMID:21454697	PMID:22472443	PMID:33090893

Genomics

Comparative Map Data

Dennd4c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	101,272,298 - 101,369,529 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	101,272,005 - 101,368,118 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	5	105,100,081 - 105,195,634 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	105,114,433 - 105,193,988 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	109,085,833 - 109,182,502 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	106,090,415 - 106,162,420 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	106,090,717 - 106,167,026 (+)	NCBI
Celera	5	101,714,237 - 101,809,916 (-)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI

DENND4C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	19,230,513 - 19,374,281 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	19,230,435 - 19,374,281 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	19,230,511 - 19,374,279 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	19,280,749 - 19,364,139 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	19,288,065 - 19,362,856	NCBI
Celera	9	19,216,854 - 19,300,236 (+)	NCBI		Celera
Cytogenetic Map	9	p22.1	NCBI
HuRef	9	19,192,829 - 19,335,696 (+)	NCBI		HuRef
CHM1_1	9	19,230,600 - 19,373,937 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	19,243,303 - 19,387,084 (+)	NCBI		T2T-CHM13v2.0

Dennd4c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	86,666,761 - 86,768,841 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	86,666,792 - 86,768,840 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	86,748,518 - 86,850,603 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	86,748,555 - 86,850,603 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	86,394,459 - 86,476,071 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	86,219,786 - 86,321,834 (+)	NCBI		MGSCv36	mm8
Celera	4	85,265,548 - 85,350,171 (+)	NCBI		Celera
Cytogenetic Map	4	C4	NCBI
cM Map	4	40.69	NCBI

Dennd4c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955434	21,639,986 - 21,740,842 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955434	21,640,068 - 21,740,842 (+)	NCBI	ChiLan1.0	ChiLan1.0

DENND4C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	9	105,178,690 - 105,315,282 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	19,046,857 - 19,183,364 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	19,537,938 - 19,672,299 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	19,537,997 - 19,672,299 (+)	Ensembl	panpan1.1		panPan2

DENND4C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	39,035,241 - 39,161,135 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	39,072,944 - 39,159,611 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	37,693,992 - 37,818,852 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	39,968,568 - 40,094,556 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	39,968,663 - 40,093,014 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	38,661,590 - 38,786,923 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	38,456,479 - 38,584,445 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	39,093,527 - 39,218,421 (+)	NCBI		UU_Cfam_GSD_1.0

Dennd4c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	153,479,598 - 153,581,391 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936652	1,149,099 - 1,250,921 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936652	1,149,106 - 1,250,571 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DENND4C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	203,449,835 - 203,601,292 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	203,449,832 - 203,601,298 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	227,100,329 - 227,251,158 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DENND4C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	60,359,979 - 60,499,631 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	60,361,914 - 60,499,713 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	48,473,266 - 48,616,996 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dennd4c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	23,233,444 - 23,326,780 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624736	23,206,686 - 23,328,391 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dennd4c
315 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	106
Count of miRNA genes:	82
Interacting mature miRNAs:	89
Transcripts:	ENSRNOT00000058429
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	34730116	104251008	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	34944474	113558310	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	43726656	129132602	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55805606	132207589	Rat
1358895	Bp254	Blood pressure QTL 254	3.6	0.0003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	58829236	128034027	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	59793399	143070159	Rat
2316957	Pur21	Proteinuria QTL 21	6.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	5	59793528	113558156	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
2290005	Mcs24	Mammary carcinoma susceptibility QTL 24			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	64719390	109719390	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	66174080	124160948	Rat
2312671	Scl64	Serum cholesterol level QTL 64		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	68984307	104251008	Rat
61380	Edpm5	Estrogen-dependent pituitary mass QTL 5	4.5	0.92	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	5	68984307	104251008	Rat
1357396	Bw44	Body weight QTL 44	4.19		body mass (VT:0001259)	body weight (CMO:0000012)	5	68984307	104251008	Rat
1357402	Bw46	Body weight QTL 46	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	68984307	104251008	Rat
2302381	Bw84	Body weight QTL 84	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	68984307	104251008	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat
1298070	Scl18	Serum cholesterol level QTL 18	3.7		blood LDL cholesterol amount (VT:0000181)	calculated plasma low density lipoprotein cholesterol level (CMO:0001245)	5	79584860	124584860	Rat
1598846	Bp293	Blood pressure QTL 293	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	79584860	124584860	Rat
1598859	Cm66	Cardiac mass QTL 66	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	79584860	124584860	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1298086	Bp156	Blood pressure QTL 156			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	84132602	129132602	Rat
7411601	Foco12	Food consumption QTL 12	19.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	87468046	132468046	Rat
7411564	Bw135	Body weight QTL 135		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	87468046	132468046	Rat
7411582	Foco3	Food consumption QTL 3	7.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	87468046	132468046	Rat
6903316	Bw113	Body weight QTL 113	2	0.0103	body mass (VT:0001259)	body weight (CMO:0000012)	5	87765973	132765973	Rat
1358889	Bp261	Blood pressure QTL 261	2.86		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	90067849	128034027	Rat
1358909	Kidm25	Kidney mass QTL 25	1.87		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	90067849	128034027	Rat
631527	Tls1	T-lymphoma susceptibility QTL 1	0	0.001	thymus integrity trait (VT:0010555)	post-insult time to onset of T-cell lymphoma (CMO:0001907)	5	90450144	135450144	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	94858972	143070159	Rat
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	97059760	147465714	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	97570330	136479578	Rat
1582212	Livw2	Liver weight QTL 2	3.5	0.0004	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	5	99016066	119085810	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	99216724	148607142	Rat
1600362	Mcs19	Mammary carcinoma susceptibility QTL 19	2.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	99485997	103690167	Rat
7394708	Emca11	Estrogen-induced mammary cancer QTL 11			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	99753548	113061097	Rat

Markers in Region

D5Rat24

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	101,278,414 - 101,278,701 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	105,106,199 - 105,106,485	NCBI	Rnor6.0
Rnor_5.0	5	109,093,330 - 109,093,616	UniSTS	Rnor5.0
Celera	5	101,803,513 - 101,803,799	UniSTS
RH 3.4 Map	5	737.3	UniSTS
RH 3.4 Map	5	737.3	RGD
RH 2.0 Map	5	649.9	RGD
SHRSP x BN Map	5	58.1899	RGD
Cytogenetic Map	5	q32	UniSTS

RH138658

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	101,369,075 - 101,369,271 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	105,207,206 - 105,207,401	NCBI	Rnor6.0
Rnor_6.0	5	105,195,181 - 105,195,376	NCBI	Rnor6.0
Rnor_5.0	5	109,194,074 - 109,194,269	UniSTS	Rnor5.0
Rnor_5.0	5	109,182,049 - 109,182,244	UniSTS	Rnor5.0
RGSC_v3.4	5	106,162,972 - 106,163,167	UniSTS	RGSC3.4
Celera	5	101,714,495 - 101,714,690	UniSTS
RH 3.4 Map	5	737.5	UniSTS
Cytogenetic Map	5	q32	UniSTS

RH124387

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	101,369,255 - 101,369,485 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	105,207,386 - 105,207,615	NCBI	Rnor6.0
Rnor_6.0	5	105,195,361 - 105,195,590	NCBI	Rnor6.0
Rnor_5.0	5	109,182,229 - 109,182,458	UniSTS	Rnor5.0
Rnor_5.0	5	109,194,254 - 109,194,483	UniSTS	Rnor5.0
RGSC_v3.4	5	106,163,152 - 106,163,381	UniSTS	RGSC3.4
Celera	5	101,714,281 - 101,714,510	UniSTS
Cytogenetic Map	5	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	34	28	12	18	12	8	8	68	34	38	11	8
Low	1	9	29	29	1	29		3	6	1	3
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_006225392	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACYVU010000162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000058429 ⟹ ENSRNOP00000055230

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	105,114,433 - 105,177,988 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000082596 ⟹ ENSRNOP00000071348

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	101,272,005 - 101,368,118 (+)	Ensembl
Rnor_6.0 Ensembl	5	105,114,433 - 105,193,988 (+)	Ensembl

RefSeq Acc Id:

XM_039111087 ⟹ XP_038967015

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	101,272,299 - 101,369,529 (+)	NCBI

RefSeq Acc Id:

XM_039111088 ⟹ XP_038967016

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	101,272,299 - 101,366,928 (+)	NCBI

RefSeq Acc Id:

XM_039111089 ⟹ XP_038967017

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	101,272,299 - 101,369,529 (+)	NCBI

RefSeq Acc Id:

XM_039111090 ⟹ XP_038967018

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	101,296,295 - 101,369,529 (+)	NCBI

RefSeq Acc Id:

XM_039111091 ⟹ XP_038967019

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	101,329,451 - 101,369,529 (+)	NCBI

RefSeq Acc Id:

XM_039111092 ⟹ XP_038967020

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	101,272,298 - 101,334,837 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_038967015	(Get FASTA)	NCBI Sequence Viewer
	XP_038967016	(Get FASTA)	NCBI Sequence Viewer
	XP_038967017	(Get FASTA)	NCBI Sequence Viewer
	XP_038967018	(Get FASTA)	NCBI Sequence Viewer
	XP_038967019	(Get FASTA)	NCBI Sequence Viewer
	XP_038967020	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

ENSRNOP00000071348 ⟸ ENSRNOT00000082596

RefSeq Acc Id:

ENSRNOP00000055230 ⟸ ENSRNOT00000058429

RefSeq Acc Id:	XP_038967020 ⟸ XM_039111092
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_038967015 ⟸ XM_039111087
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K089 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038967017 ⟸ XM_039111089
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038967016 ⟸ XM_039111088
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038967018 ⟸ XM_039111090
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038967019 ⟸ XM_039111091
- Peptide Label:	isoform X5
- UniProtKB:	A6KRC4 (UniProtKB/TrEMBL)

Protein Domains

MABP uDENN

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K089-F1-model_v2	AlphaFold	A0A0G2K089	1-1901	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308489	AgrOrtholog
BioCyc Gene	G2FUF-40839	BioCyc
Ensembl Genes	ENSRNOG00000008036	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000071348	ENTREZGENE
	ENSRNOP00000071348.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000082596	ENTREZGENE
	ENSRNOT00000082596.2	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.10	UniProtKB/TrEMBL
	2.100.10.50	UniProtKB/TrEMBL
	3.40.50.11500	UniProtKB/TrEMBL
InterPro	dDENN_dom	UniProtKB/TrEMBL
	DENN_C	UniProtKB/TrEMBL
	DENN_dom	UniProtKB/TrEMBL
	MABP	UniProtKB/TrEMBL
	TPR-like_helical_dom_sf	UniProtKB/TrEMBL
	Tripartite_DENN	UniProtKB/TrEMBL
	uDENN_dom	UniProtKB/TrEMBL
NCBI Gene	313340	ENTREZGENE
PANTHER	DENN DOMAIN-CONTAINING PROTEIN 4	UniProtKB/TrEMBL
	DENN DOMAIN-CONTAINING PROTEIN 4C	UniProtKB/TrEMBL
Pfam	dDENN	UniProtKB/TrEMBL
	DENN	UniProtKB/TrEMBL
	uDENN	UniProtKB/TrEMBL
PhenoGen	Dennd4c	PhenoGen
PROSITE	DENN	UniProtKB/TrEMBL
	MABP	UniProtKB/TrEMBL
SMART	dDENN	UniProtKB/TrEMBL
	DENN	UniProtKB/TrEMBL
	uDENN	UniProtKB/TrEMBL
UniProt	A0A0G2K089	ENTREZGENE, UniProtKB/TrEMBL
	A6KRC4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Dennd4c	DENN domain containing 4C	LOC102555797	uncharacterized LOC102555797	Data Merged	737654	PROVISIONAL
2016-02-17	Dennd4c	DENN domain containing 4C	Dennd4c	DENN/MADD domain containing 4C	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-07-29	Dennd4c	DENN/MADD domain containing 4C	RGD1308489	similar to hypothetical protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-12-17	LOC102555797	uncharacterized LOC102555797			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-04-30	RGD1308489	similar to hypothetical protein	RGD1308489_predicted	similar to hypothetical protein (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1308489_predicted	similar to hypothetical protein (predicted)	LOC313340_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC313340_predicted	similar to hypothetical protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

RGD Manual Annotations