Rps6 (ribosomal protein S6) - Rat Genome Database

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Gene: Rps6 (ribosomal protein S6) Rattus norvegicus
Analyze
Symbol: Rps6
Name: ribosomal protein S6
RGD ID: 3602
Description: Enables mRNA binding activity. A structural constituent of ribosome. Involved in several processes, including cellular response to ethanol; negative regulation of bicellular tight junction assembly; and ribosomal small subunit assembly. Part of cytosolic small ribosomal subunit. Is active in GABA-ergic synapse; presynapse; and ribosome. Used to study transient cerebral ischemia. Biomarker of vascular dementia. Orthologous to human RPS6 (ribosomal protein S6); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; insulin signaling pathway; INTERACTS WITH (+)-pilocarpine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 40S ribosomal protein S6; 40S ribosomal protein S6-like; LOC100911372; small ribosomal subunit protein eS6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Rps6-ps10  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85106,417,680 - 106,420,540 (-)NCBIGRCr8
mRatBN7.25101,371,716 - 101,374,576 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl566,681,075 - 66,681,919 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl5101,371,136 - 101,374,602 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5103,752,605 - 103,755,465 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05105,543,160 - 105,546,020 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05105,576,526 - 105,579,388 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05105,197,821 - 105,200,681 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5105,197,857 - 105,200,148 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl5105,209,846 - 105,212,173 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05109,184,689 - 109,187,549 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45106,165,612 - 106,168,472 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5101,709,190 - 101,712,050 (+)NCBICelera
Cytogenetic Map5q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
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Reference
Notes
Source
Original Reference(s)
Rps6RatExperimental Autoimmune Myocarditis  IDA 11041642 RGD 
Rps6RatLiver Failure  IEP 11040911 RGD 
Rps6RatTemporomandibular Joint Osteoarthritis  IEP 34888237 RGD 
Rps6Rattransient cerebral ischemia  IDA 11041643 RGD 
Rps6Ratvascular dementia treatmentIEP 11041644 RGD 
Object Symbol
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Reference
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Original Reference(s)
Rps6RatHemimegalencephaly  ISORPS6 (Homo sapiens)8554872ClinVar Annotator: match by term: HemimegalencephalyClinVar 
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Original Reference(s)
Rps6RatBreast Neoplasms  ISORPS6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20197467
Rps6RatDisease Progression  ISORPS6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21364753
Rps6Rathepatocellular carcinoma  ISORPS6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21147110
Rps6RatStomach Neoplasms  ISORPS6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21364753

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Object Symbol
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Original Reference(s)
Rps6Rat(+)-pilocarpine increases phosphorylationEXP 6480464Pilocarpine results in increased phosphorylation of RPS6 proteinCTDPMID:23211629
Rps6Rat(+)-pilocarpine multiple interactionsEXP 6480464dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein]] and Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein]CTDPMID:23211629
Rps6Rat(+)-Tetrandrine decreases expressionISORPS6 (Homo sapiens)6480464tetrandrine results in decreased expression of RPS6 protein modified formCTDPMID:25266202
Rps6Rat(-)-epigallocatechin 3-gallate multiple interactionsISORps6 (Mus musculus)6480464epigallocatechin gallate inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of RPS6 protein]CTDPMID:37286014
Rps6Rat(R,R,R)-alpha-tocopherol multiple interactionsISORPS6 (Homo sapiens)6480464alpha-Tocopherol inhibits the reaction [28-O-acetylbetulin-3-ylglucopyranoside results in decreased phosphorylation of RPS6 protein]CTDPMID:22343715
Rps6Rat(S)-nicotine multiple interactionsISORps6 (Mus musculus)6480464Cholesterol inhibits the reaction [Nicotine results in increased phosphorylation of RPS6 protein]CTDPMID:31629012
Rps6Rat(S)-nicotine increases phosphorylationISORps6 (Mus musculus)6480464Nicotine results in increased phosphorylation of RPS6 proteinCTDPMID:31629012
Rps6Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionEXP 6480464o and p'-DDT affects the expression of RPS6 mRNACTDPMID:17984292
Rps6Rat1,2-dimethylhydrazine multiple interactionsISORps6 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RPS6 mRNACTDPMID:22206623
Rps6Rat17beta-estradiol multiple interactionsISORPS6 (Homo sapiens)64804643 more ...CTDPMID:11179685 more ...
Rps6Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of RPS6 mRNACTDPMID:32145629
Rps6Rat17beta-estradiol increases phosphorylationISORPS6 (Homo sapiens)6480464Estradiol results in increased phosphorylation of RPS6 proteinCTDPMID:16033851 and PMID:30641053
Rps6Rat17beta-estradiol increases expressionISORPS6 (Homo sapiens)6480464Estradiol results in increased expression of RPS6 mRNACTDPMID:11179685
Rps6Rat17beta-hydroxy-17-methylestra-4,9,11-trien-3-one multiple interactionsISORPS6 (Homo sapiens)6480464Metribolone promotes the reaction [NDRG1 protein binds to RPS6 protein]CTDPMID:17220478
Rps6Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISORps6 (Mus musculus)64804642 more ...CTDPMID:30294300
Rps6Rat2,2,2-tetramine multiple interactionsEXP 6480464Trientine inhibits the reaction [Metformin results in decreased phosphorylation of RPS6 protein]CTDPMID:22492524
Rps6Rat2,2,2-tetramine increases phosphorylationEXP 6480464Trientine results in increased phosphorylation of RPS6 proteinCTDPMID:22492524
Rps6Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORPS6 (Homo sapiens)6480464Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in increased expression of RPS6 mRNA]CTDPMID:11179685
Rps6Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of RPS6 mRNACTDPMID:33387578
Rps6Rat2,3,7,8-tetrachlorodibenzodioxine decreases phosphorylationEXP 6480464Tetrachlorodibenzodioxin results in decreased phosphorylation of RPS6 proteinCTDPMID:23639626

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Biological Process
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Original Reference(s)
Rps6Ratactivation-induced cell death of T cells acts_upstream_of_or_withinISORps6 (Mus musculus)1624291MGI:2387471 PMID:16357222RGDPMID:16357222
Rps6Ratcellular response to ethanol  IDA 11041645 RGD 
Rps6Ratcytoplasmic translation involved_inISSUniProtKB:P627531600115GO_REF:0000024UniProtGO_REF:0000024
Rps6Ratcytoplasmic translation involved_inIEAUniProtKB:P62753 and ensembl:ENSP000003697571600115GO_REF:0000107EnsemblGO_REF:0000107
Rps6Ratcytoplasmic translation involved_inISORPS6 (Homo sapiens)1624291 PMID:34314702 and PMID:8706699RGDPMID:34314702 and PMID:8706699
Rps6Raterythrocyte development acts_upstream_of_or_withinISORps6 (Mus musculus)1624291MGI:2387471 PMID:17000767RGDPMID:17000767
Rps6RatG1/S transition of mitotic cell cycle acts_upstream_of_or_withinISORps6 (Mus musculus)1624291MGI:2176073 more ...RGDPMID:10856218
Rps6Ratgastrulation acts_upstream_of_or_withinISORps6 (Mus musculus)1624291MGI:2387471 more ...RGDPMID:17000767
Rps6Ratglucose homeostasis involved_inISSUniProtKB:P627541600115GO_REF:0000024UniProtGO_REF:0000024
Rps6Ratglucose homeostasis involved_inISORps6 (Mus musculus)1624291 PMID:16166381RGDPMID:16166381
Rps6Ratmammalian oogenesis stage acts_upstream_of_or_withinISORps6 (Mus musculus)1624291MGI:2387471 PMID:17000767RGDPMID:17000767
Rps6Ratmitotic cell cycle acts_upstream_of_or_withinISORps6 (Mus musculus)1624291MGI:2387471 PMID:17000767RGDPMID:17000767
Rps6Ratnegative regulation of apoptotic process acts_upstream_of_or_withinISORps6 (Mus musculus)1624291MGI:2387471 PMID:17000767RGDPMID:17000767
Rps6Ratnegative regulation of bicellular tight junction assembly  IDA 11041641 RGD 
Rps6Ratplacenta development acts_upstream_of_or_withinISORps6 (Mus musculus)1624291MGI:2387471 PMID:17000767RGDPMID:17000767
Rps6Ratpositive regulation of apoptotic process involved_inISORPS6 (Homo sapiens)1624291 PMID:18362888RGDPMID:18362888
Rps6Ratpositive regulation of apoptotic process involved_inIEAUniProtKB:P62753 and ensembl:ENSP000003697571600115GO_REF:0000107EnsemblGO_REF:0000107
Rps6Ratpositive regulation of cell population proliferation involved_inISSUniProtKB:P627531600115GO_REF:0000024UniProtGO_REF:0000024
Rps6Ratpositive regulation of cell population proliferation involved_inIEAUniProtKB:P62753 and ensembl:ENSP000003697571600115GO_REF:0000107EnsemblGO_REF:0000107
Rps6Ratpositive regulation of cell population proliferation involved_inISORPS6 (Homo sapiens)1624291 PMID:17220279RGDPMID:17220279
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Cellular Component
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Original Reference(s)
Rps6Ratcell body located_inISORPS6 (Homo sapiens)1624291 PMID:15121898RGDPMID:15121898
Rps6Ratcell body located_inIEAUniProtKB:P62753 and ensembl:ENSP000003697571600115GO_REF:0000107EnsemblGO_REF:0000107
Rps6Ratcytoplasm located_inISORPS6 (Sus scrofa)1624291 PMID:24508636RGDPMID:24508636
Rps6Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Rps6Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Rps6Ratcytoplasm located_inISORps6 (Mus musculus)1624291 PMID:12388085RGDPMID:12388085
Rps6Ratcytoplasmic ribonucleoprotein granule located_inISORPS6 (Homo sapiens)1624291 PMID:15121898RGDPMID:15121898
Rps6Ratcytoplasmic ribonucleoprotein granule located_inIEAUniProtKB:P62753 and ensembl:ENSP000003697571600115GO_REF:0000107EnsemblGO_REF:0000107
Rps6Ratcytosol located_inISORPS6 (Homo sapiens)1624291 RGDGO_REF:0000052
Rps6Ratcytosol located_inIEAUniProtKB:P62753 and ensembl:ENSP000003697571600115GO_REF:0000107EnsemblGO_REF:0000107
Rps6Ratcytosol located_inIEAUniProtKB:A2A3R6 and ensembl:ENSP000003697571600115GO_REF:0000107EnsemblGO_REF:0000107
Rps6Ratcytosolic ribosome is_active_inISORPS6 (Homo sapiens)1624291 PMID:8706699RGDPMID:8706699
Rps6Ratcytosolic ribosome is_active_inIEAUniProtKB:P62753 and ensembl:ENSP000003697571600115GO_REF:0000107EnsemblGO_REF:0000107
Rps6Ratcytosolic ribosome part_ofISORPS6 (Homo sapiens)1624291 PMID:23636399RGDPMID:23636399
Rps6Ratcytosolic small ribosomal subunit  IDA 2300010 RGD 
Rps6Ratcytosolic small ribosomal subunit  IDA 2299075 RGD 
Rps6Ratcytosolic small ribosomal subunit part_ofIEAUniProtKB:P62753 and ensembl:ENSP000003697571600115GO_REF:0000107EnsemblGO_REF:0000107
Rps6Ratcytosolic small ribosomal subunit part_ofISORPS6 (Homo sapiens)1624291 PMID:8706699RGDPMID:8706699
Rps6Ratcytosolic small ribosomal subunit part_ofISORps6 (Mus musculus)1624291 PMID:23500592 and PMID:36517592RGDPMID:23500592 and PMID:36517592
Rps6Ratcytosolic small ribosomal subunit  IDA 2299087 RGD 
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Molecular Function
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RGD Manual Annotations


  
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Original Reference(s)
Rps6Ratribosome biogenesis pathway   ISORPS6 (Homo sapiens)9068941 RGDPMID:20819938 more ...
Rps6Rattranslation pathway   ISORPS6 (Homo sapiens)9068941 RGDPMID:23636399 and REF_RGD_ID:10002762

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Rps6Ratinsulin signaling pathway   IEA 6907045 KEGGrno:04910
Rps6RatmTOR signaling pathway   IEA 6907045 KEGGrno:04150

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#
Reference Title
Reference Citation
1. The primary structure of rat ribosomal protein S6. Chan YL and Wool IG, J Biol Chem 1988 Feb 25;263(6):2891-6.
2. Roles of Sestrin2 and Ribosomal Protein S6 in Transient Global Ischemia-Induced Hippocampal Neuronal Injury. Chuang YC, etal., Int J Mol Sci. 2015 Nov 4;16(11):26406-16. doi: 10.3390/ijms161125963.
3. Proteomic and biochemical analyses reveal the activation of unfolded protein response, ERK-1/2 and ribosomal protein S6 signaling in experimental autoimmune myocarditis rat model. Chung JH, etal., BMC Genomics. 2011 Oct 20;12:520. doi: 10.1186/1471-2164-12-520.
4. The isolation of eukaryotic ribosomal proteins. The purification and characterization of the 40 S ribosomal subunit proteins S2, S3, S4, S5, S6, S7, S8, S9, S13, S23/S24, S27, and S28. Collatz E, etal., J Biol Chem. 1976 Aug 10;251(15):4666-72.
5. Two-dimensional electrophoretic analysis of ribosomal proteins from chronically injured liver. Gressner AM J Clin Chem Clin Biochem. 1979 Aug;17(8):541-5.
6. The mammalian RPS6 gene, homolog of the Drosophila air8 tumor suppressor gene: is it an oncosuppressor gene? Lecomte F, etal., Somat Cell Mol Genet 1995 Nov;21(6):443-50.
7. Electron microscopic investigations on the location of rat liver ribosomal proteins S3a, S5, S6, S7 and S9 by means of antibody labeling. Lutsch G, etal., Biomed Biochim Acta. 1983;42(6):705-23.
8. Ribosomal proteins S2, S6, S10, S14, S15 and S25 are localized on the surface of mammalian 40 S subunits and stabilize their conformation. A study with immobilized trypsin. Marion MJ and Marion C, FEBS Lett. 1988 May 23;232(2):281-5.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Effects of contraction and insulin on protein synthesis, AMP-activated protein kinase and phosphorylation state of translation factors in rat skeletal muscle. Miranda L, etal., Pflugers Arch. 2008 Mar;455(6):1129-40. Epub 2007 Oct 24.
11. rpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9. Mok KW, etal., J Cell Sci. 2014 Nov 15;127(Pt 22):4870-82. doi: 10.1242/jcs.152231. Epub 2014 Sep 12.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry. Peng J, etal., J Biol Chem. 2004 May 14;279(20):21003-11. doi: 10.1074/jbc.M400103200. Epub 2004 Mar 12.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Continuous ethanol exposure inhibits agonist-stimulated phosphorylation of p70S6 kinase and ribosomal S6 protein in cultured rat astrocytes. Smith TL and Eaton MC, Brain Res Mol Brain Res. 2004 Nov 24;131(1-2):145-8.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. Ribosomal proteins cross-linked to natural mRNA by UV irradiation of rat liver polysomes. Takahashi Y and Ogata K, J Biochem. 1981 Nov;90(5):1549-52.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
1 to 20 of 23 rows
PMID:2106518   PMID:2334893   PMID:8590812   PMID:8706699   PMID:10856218   PMID:12388085   PMID:14681305   PMID:14993145   PMID:14993219   PMID:15121898   PMID:15489334   PMID:15590835  
PMID:15883184   PMID:16166381   PMID:16286931   PMID:16357222   PMID:16428328   PMID:16854843   PMID:17000767   PMID:17182729   PMID:18362888   PMID:18697920   PMID:18809582   PMID:19946888  
PMID:21418524   PMID:21630459   PMID:21700703   PMID:22022532   PMID:22658674   PMID:22948214   PMID:23285266   PMID:23500592   PMID:24508636   PMID:24625528   PMID:27194793   PMID:30053369  
PMID:31112404   PMID:31157869   PMID:35352799  



Rps6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85106,417,680 - 106,420,540 (-)NCBIGRCr8
mRatBN7.25101,371,716 - 101,374,576 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl566,681,075 - 66,681,919 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl5101,371,136 - 101,374,602 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5103,752,605 - 103,755,465 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05105,543,160 - 105,546,020 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05105,576,526 - 105,579,388 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05105,197,821 - 105,200,681 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5105,197,857 - 105,200,148 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl5105,209,846 - 105,212,173 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05109,184,689 - 109,187,549 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45106,165,612 - 106,168,472 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5101,709,190 - 101,712,050 (+)NCBICelera
Cytogenetic Map5q32NCBI
RPS6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38919,375,715 - 19,380,236 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl919,375,715 - 19,380,236 (-)EnsemblGRCh38hg38GRCh38
GRCh37919,375,713 - 19,380,234 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36919,366,254 - 19,370,235 (-)NCBINCBI36Build 36hg18NCBI36
Build 34919,366,253 - 19,370,235NCBI
Celera919,302,350 - 19,306,331 (-)NCBICelera
Cytogenetic Map9p22.1NCBI
HuRef919,337,814 - 19,341,795 (-)NCBIHuRef
CHM1_1919,376,051 - 19,380,032 (-)NCBICHM1_1
T2T-CHM13v2.0919,388,517 - 19,393,023 (-)NCBIT2T-CHM13v2.0
Rps6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39486,772,336 - 86,775,604 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl486,772,897 - 86,775,649 (-)EnsemblGRCm39 Ensembl
GRCm38486,854,099 - 86,857,367 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl486,854,660 - 86,857,412 (-)EnsemblGRCm38mm10GRCm38
MGSCv37486,500,003 - 86,503,271 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36486,325,893 - 86,328,588 (-)NCBIMGSCv36mm8
Celera485,374,929 - 85,378,195 (-)NCBICelera
Cytogenetic Map4C4NCBI
cM Map440.69NCBI
Rps6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543421,744,082 - 21,746,626 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543421,744,045 - 21,745,646 (-)NCBIChiLan1.0ChiLan1.0
RPS6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211105,135,133 - 105,170,654 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19105,141,077 - 105,176,598 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0919,185,455 - 19,189,504 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1919,674,380 - 19,678,397 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl919,674,380 - 19,677,722 (-)Ensemblpanpan1.1panPan2
RPS6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11139,161,422 - 39,165,148 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1139,161,422 - 39,165,148 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1137,819,139 - 37,822,865 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01140,094,843 - 40,098,569 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1140,094,843 - 40,098,569 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11138,787,210 - 38,790,959 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01138,584,732 - 38,588,458 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01139,218,708 - 39,222,435 (-)NCBIUU_Cfam_GSD_1.0
Rps6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947153,583,479 - 153,586,550 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366521,253,025 - 1,255,906 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366521,252,986 - 1,255,987 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPS6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1203,444,450 - 203,451,468 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11203,444,360 - 203,447,643 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21227,094,866 - 227,098,139 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPS6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11260,353,800 - 60,357,797 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1260,353,817 - 60,357,759 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603848,467,090 - 48,471,105 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rps6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473623,328,002 - 23,336,140 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473623,332,556 - 23,336,234 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Rps6
21 total Variants

Predicted Target Of
Summary Value
Count of predictions:10
Count of miRNA genes:10
Interacting mature miRNAs:10
Transcripts:ENSRNOT00000073270
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 43 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat

1 to 10 of 43 rows
D5Hmgc1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85106,420,042 - 106,420,210 (+)Marker Load Pipeline
mRatBN7.25101,374,078 - 101,374,246 (+)MAPPERmRatBN7.2
Rnor_6.05105,200,184 - 105,200,351NCBIRnor6.0
Rnor_6.05105,212,209 - 105,212,376NCBIRnor6.0
Rnor_5.05109,199,077 - 109,199,244UniSTSRnor5.0
Rnor_5.05109,187,052 - 109,187,219UniSTSRnor5.0
RGSC_v3.45106,167,975 - 106,168,142UniSTSRGSC3.4
RH 3.4 Map5737.5UniSTS
RH 3.4 Map5737.5RGD
Cytogenetic Map5q22-q23UniSTS
RH131255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25101,375,192 - 101,375,395 (+)MAPPERmRatBN7.2
Rnor_6.05105,213,323 - 105,213,525NCBIRnor6.0
Rnor_6.05105,201,298 - 105,201,500NCBIRnor6.0
Rnor_5.05109,200,191 - 109,200,393UniSTSRnor5.0
Rnor_5.05109,188,166 - 109,188,368UniSTSRnor5.0
RGSC_v3.45106,169,089 - 106,169,291UniSTSRGSC3.4
Celera5101,708,371 - 101,708,573UniSTS
RH 3.4 Map5741.1UniSTS
Cytogenetic Map5q22-q23UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 11 43 82 57 60 41 19 41 160 73 74 35 41 19


1 to 21 of 21 rows
RefSeq Transcripts NM_017160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC058149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M29358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X89057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 21 of 21 rows

Ensembl Acc Id: ENSRNOT00000010383   ⟹   ENSRNOP00000010383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5101,371,136 - 101,374,098 (-)Ensembl
Rnor_6.0 Ensembl5105,209,846 - 105,212,173 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000073270   ⟹   ENSRNOP00000067572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5101,371,136 - 101,374,602 (-)Ensembl
Rnor_6.0 Ensembl5105,197,857 - 105,200,148 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096848   ⟹   ENSRNOP00000077015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl566,681,075 - 66,681,919 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104045   ⟹   ENSRNOP00000092962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5101,371,136 - 101,374,590 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107590   ⟹   ENSRNOP00000097987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5101,371,136 - 101,374,533 (-)Ensembl
RefSeq Acc Id: NM_017160   ⟹   NP_058856
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85106,417,680 - 106,420,540 (-)NCBI
mRatBN7.25101,371,716 - 101,374,576 (-)NCBI
Rnor_6.05105,197,821 - 105,200,681 (-)NCBI
Rnor_5.05109,184,689 - 109,187,549 (-)NCBI
RGSC_v3.45106,165,612 - 106,168,472 (-)RGD
Celera5101,709,190 - 101,712,050 (+)RGD
Sequence:
Protein RefSeqs NP_058856 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42079 (Get FASTA)   NCBI Sequence Viewer  
  AAH58149 (Get FASTA)   NCBI Sequence Viewer  
  EDL76012 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067572
  ENSRNOP00000067572.2
GenBank Protein P62755 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058856   ⟸   NM_017160
- UniProtKB: P62755 (UniProtKB/Swiss-Prot),   A6KRB6 (UniProtKB/TrEMBL),   M0RD75 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067572   ⟸   ENSRNOT00000073270
Ensembl Acc Id: ENSRNOP00000010383   ⟸   ENSRNOT00000010383
Ensembl Acc Id: ENSRNOP00000092962   ⟸   ENSRNOT00000104045
Ensembl Acc Id: ENSRNOP00000077015   ⟸   ENSRNOT00000096848

Name Modeler Protein Id AA Range Protein Structure
AF-P62755-F1-model_v2 AlphaFold P62755 1-249 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-40838 BioCyc
Ensembl Genes ENSRNOG00000007663 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000049025 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000073270 ENTREZGENE
  ENSRNOT00000073270.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.2650 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6918741 IMAGE-MGC_LOAD
InterPro Ribosomal_S6_euk UniProtKB/Swiss-Prot
  Ribosomal_S6e UniProtKB/Swiss-Prot
  Ribosomal_S6e_CS UniProtKB/Swiss-Prot
KEGG Report rno:29304 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72867 IMAGE-MGC_LOAD
NCBI Gene 29304 ENTREZGENE
PANTHER PTHR11502 UniProtKB/Swiss-Prot
Pfam Ribosomal_S6e UniProtKB/Swiss-Prot
PhenoGen Rps6 PhenoGen
PIRSF Ribosom_S6_euk UniProtKB/Swiss-Prot
PROSITE RIBOSOMAL_S6E UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007663 RatGTEx
  ENSRNOG00000049025 RatGTEx
SMART Ribosomal_S6e UniProtKB/Swiss-Prot
TIGR TC204150
UniProt A0A0H2UHF7_RAT UniProtKB/TrEMBL
  A0A8I5Y594_RAT UniProtKB/TrEMBL
  A0A8I6GK15_RAT UniProtKB/TrEMBL
  A6KRB6 ENTREZGENE, UniProtKB/TrEMBL
  M0RD75 ENTREZGENE, UniProtKB/TrEMBL
  P62755 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P08227 UniProtKB/Swiss-Prot
  P10660 UniProtKB/Swiss-Prot
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Rps6  ribosomal protein S6  LOC100911372  40S ribosomal protein S6-like  Data merged from RGD:6493116 737654 PROVISIONAL
2012-07-05 LOC100911372  40S ribosomal protein S6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Rps6  ribosomal protein S6      Name updated 70584 APPROVED