Scp2 (sterol carrier protein 2) - Rat Genome Database

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Gene: Scp2 (sterol carrier protein 2) Rattus norvegicus
Analyze
Symbol: Scp2
Name: sterol carrier protein 2
RGD ID: 3642
Description: Enables several functions, including C-acyltransferase activity; lipid transfer activity; and propionyl-CoA C2-trimethyltridecanoyltransferase activity. Involved in several processes, including cellular response to cholesterol; monocarboxylic acid metabolic process; and positive regulation of cholesterol biosynthetic process. Located in several cellular components, including endoplasmic reticulum; mitochondrion; and peroxisomal matrix. Orthologous to human SCP2 (sterol carrier protein 2); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acetyl-CoA C-myristoyltransferase; non-specific lipid-transfer protein; NSL-TP; NSLIPTR; propanoyl-CoA C-acyltransferase; SCP-2; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-chi; SCP-X; SCPx; Sterol carrier protein 2 liver; Sterol carrier protein 2, liver; sterol carrier protein X; straight-chain acyl-CoA oxidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Scl14
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25122,806,949 - 122,881,259 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5122,776,549 - 122,881,287 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5125,426,714 - 125,500,816 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05127,149,765 - 127,223,865 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05127,201,077 - 127,275,181 (-)NCBIRnor_WKY
Rnor_6.05127,647,934 - 127,735,703 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5127,620,274 - 127,735,739 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05131,495,401 - 131,584,291 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45129,152,836 - 129,230,401 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15129,158,061 - 129,235,617 (-)NCBI
Celera5121,551,168 - 121,624,570 (-)NCBICelera
Cytogenetic Map5q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bexarotene  (EXP)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
caffeine  (ISO)
capsaicin  (ISO)
captan  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dicrotophos  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fonofos  (ISO)
furan  (EXP)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
hydrazine  (EXP)
hydrogen cyanide  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ivermectin  (ISO)
kojic acid  (ISO)
methapyrilene  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP,ISO)
nevirapine  (ISO)
O-methyleugenol  (ISO)
oleic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phytanic acid  (ISO)
pirinixic acid  (EXP,ISO)
potassium cyanide  (ISO)
pyrogallol  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vitamin E  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Substrate specificities of 3-oxoacyl-CoA thiolase A and sterol carrier protein 2/3-oxoacyl-CoA thiolase purified from normal rat liver peroxisomes. Sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in the metabolism of 2-methyl-branched fatty acids and bile acid intermediates. Antonenkov VD, etal., J Biol Chem. 1997 Oct 10;272(41):26023-31. doi: 10.1074/jbc.272.41.26023.
2. Isolation and subunit composition of native sterol carrier protein 2/3-oxoacyl-coenzyme A thiolase from normal rat liver peroxisomes. Antonenkov VD, etal., Protein Expr Purif. 2000 Apr;18(3):249-56.
3. Characterization of a cDNA encoding rat sterol carrier protein2. Billheimer JT, etal., DNA Cell Biol 1990 Apr;9(3):159-65.
4. Import of phosphatidylethanolamine for the assembly of rat brain mitochondrial membranes. Camici O and Corazzi L, J Membr Biol. 1995 Nov;148(2):169-76.
5. Sterol carrier protein2: further evidence for its role in adrenal steroidogenesis. Chanderbhan RF, etal., Endocr Res. 1986;12(4):351-70.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Regulation of sterol carrier protein 2 (SCP2) gene expression in rat peritoneal macrophages during foam cell formation. A key role for free cholesterol content. Hirai A, etal., J Clin Invest. 1994 Dec;94(6):2215-23.
9. Subcellular localization of sterol carrier protein-2 in rat hepatocytes: its primary localization to peroxisomes. Keller GA, etal., J Cell Biol. 1989 Apr;108(4):1353-61.
10. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
11. Cholesterol enrichment enhances expression of sterol-carrier protein-2: implications for its function in intracellular cholesterol trafficking. Kraemer R, etal., J Lipid Res. 1995 Dec;36(12):2630-8.
12. Intracellular dissemination of peroxidative stress. Internalization, transport, and lethal targeting of a cholesterol hydroperoxide species by sterol carrier protein-2-overexpressing hepatoma cells. Kriska T, etal., J Biol Chem. 2006 Aug 18;281(33):23643-51. Epub 2006 Jun 12.
13. Estradiol regulation of sterol carrier protein-2 independent of cytochrome P450 side-chain cleavage expression in the rat corpus luteum. McLean MP, etal., Endocrinology. 1989 Sep;125(3):1337-44.
14. Differential expression of hepatic sterol carrier proteins in the streptozotocin-treated diabetic rat. McLean MP, etal., Endocrinology. 1995 Aug;136(8):3360-8.
15. The role of sterol carrier protein 2 in stimulation of steroidogenesis in rat adrenal mitochondria by adrenal cytosol. McNamara BC and Jefcoate CR, Arch Biochem Biophys. 1989 Nov 15;275(1):53-62.
16. Nonspecific lipid transfer protein (sterol carrier protein 2) is bound to rat liver mitochondria: its role in spontaneous intermembrane phospholipid transfer. Megli FM, etal., Biochim Biophys Acta. 1986 Oct 23;861(3):463-70.
17. Luteinizing hormone causes rapid and transient changes in rat Leydig cell peroxisome volume and intraperoxisomal sterol carrier protein-2 content. Mendis-Handagama SM, etal., Endocrinology. 1990 Dec;127(6):2947-54.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Molecular cloning and deduced amino acid sequence of nonspecific lipid transfer protein (sterol carrier protein 2) of rat liver: a higher molecular mass (60 kDa) protein contains the primary sequence of nonspecific lipid transfer protein as its C-terminal part. Mori T, etal., Proc Natl Acad Sci U S A 1991 May 15;88(10):4338-42.
20. Effect of age and cholestyramine feeding on rat liver 3-hydroxy-3-methyl glutaryl CoA reductase, sterol carrier protein 1 and sterol carrier protein 2 activities. Morin RJ, etal., Lipids. 1982 Jul;17(7):507-10.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. The amino acid sequence of rat liver non-specific lipid transfer protein (sterol carrier protein 2) is present in a high molecular weight protein: evidence from cDNA analysis. Ossendorp BC, etal., Biochem Biophys Res Commun 1990 Apr 30;168(2):631-6.
24. Identification of the cDNA clone which encodes the 58-kDa protein containing the amino acid sequence of rat liver non-specific lipid-transfer protein (sterol-carrier protein 2). Homology with rat peroxisomal and mitochondrial 3-oxoacyl-CoA thiolases. Ossendorp BC, etal., Eur J Biochem 1991 Oct 1;201(1):233-9.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Cloning, expression, and nucleotide sequence of rat liver sterol carrier protein 2 cDNAs. Seedorf U and Assmann G, J Biol Chem 1991 Jan 5;266(1):630-6.
30. Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity. Seedorf U, etal., J Biol Chem. 1994 Aug 19;269(33):21277-83.
31. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
32. Purification of nonspecific lipid transfer protein (sterol carrier protein 2) from human liver and its deficiency in livers from patients with cerebro-hepato-renal (Zellweger) syndrome. van Amerongen A, etal., Biochim Biophys Acta. 1987 Jun 2;919(2):149-55.
33. Sterol carrier protein 2 (non-specific lipid transfer protein) is localized in membranous fractions of Leydig cells and Sertoli cells but not in germ cells. van Haren L, etal., Biochim Biophys Acta. 1992 Mar 25;1124(3):288-96.
34. The occurrence of soluble and membrane-bound non-specific lipid transfer protein (sterol carrier protein 2) in rat tissues. Van Heusden GP, etal., Biochim Biophys Acta. 1990 Oct 1;1046(3):315-21.
35. Sterol carrier protein X (SCPx) is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: a new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes. Wanders RJ, etal., Biochem Biophys Res Commun. 1997 Jul 30;236(3):565-9. doi: 10.1006/bbrc.1997.7007.
36. Cloning and expression of a cDNA encoding human sterol carrier protein 2. Yamamoto R, etal., Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):463-7.
Additional References at PubMed
PMID:1347505   PMID:3115977   PMID:3395344   PMID:7713503   PMID:9553048   PMID:11734571   PMID:12641450   PMID:12890579   PMID:14651853   PMID:15342684   PMID:15449949   PMID:17418802  
PMID:18187312   PMID:18465878   PMID:18614015   PMID:19584060   PMID:19946888   PMID:20178365   PMID:21375735   PMID:23376485   PMID:27863214  


Genomics

Comparative Map Data
Scp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25122,806,949 - 122,881,259 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5122,776,549 - 122,881,287 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5125,426,714 - 125,500,816 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05127,149,765 - 127,223,865 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05127,201,077 - 127,275,181 (-)NCBIRnor_WKY
Rnor_6.05127,647,934 - 127,735,703 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5127,620,274 - 127,735,739 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05131,495,401 - 131,584,291 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45129,152,836 - 129,230,401 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15129,158,061 - 129,235,617 (-)NCBI
Celera5121,551,168 - 121,624,570 (-)NCBICelera
Cytogenetic Map5q34NCBI
SCP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38152,927,276 - 53,051,698 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl152,927,276 - 53,051,698 (+)EnsemblGRCh38hg38GRCh38
GRCh37153,392,948 - 53,517,370 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36153,165,536 - 53,289,870 (+)NCBINCBI36Build 36hg18NCBI36
Build 34153,104,968 - 53,229,303NCBI
Celera151,680,710 - 51,805,264 (+)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef151,508,548 - 51,632,772 (+)NCBIHuRef
CHM1_1153,510,076 - 53,634,447 (+)NCBICHM1_1
T2T-CHM13v2.0152,808,787 - 52,933,201 (+)NCBIT2T-CHM13v2.0
Scp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394107,901,027 - 108,002,168 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4107,901,036 - 108,002,195 (-)EnsemblGRCm39 Ensembl
GRCm384108,043,830 - 108,144,971 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4108,043,839 - 108,144,998 (-)EnsemblGRCm38mm10GRCm38
MGSCv374107,716,444 - 107,791,104 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364107,541,771 - 107,616,433 (-)NCBIMGSCv36mm8
Celera4106,393,462 - 106,469,326 (-)NCBICelera
Cytogenetic Map4C7NCBI
cM Map450.2NCBI
Scp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554646,094,758 - 6,224,287 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554646,097,241 - 6,224,287 (-)NCBIChiLan1.0ChiLan1.0
SCP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1153,797,256 - 53,924,939 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl153,797,254 - 53,924,939 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0152,195,491 - 52,324,227 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SCP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1555,860,053 - 55,971,657 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl555,860,549 - 55,964,014 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha555,925,974 - 56,029,762 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0556,049,398 - 56,153,726 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl556,049,398 - 56,153,708 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1556,041,491 - 56,145,154 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0555,932,897 - 56,036,796 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0556,322,159 - 56,425,975 (-)NCBIUU_Cfam_GSD_1.0
Scp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505867,305,291 - 67,411,787 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365228,005,442 - 8,110,889 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365228,004,503 - 8,110,995 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.16159,191,045 - 159,314,985 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26147,007,365 - 147,077,789 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12079,868,825 - 79,993,906 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2079,865,332 - 79,993,835 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603337,285,653 - 37,412,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624859107,258 - 252,756 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624859106,405 - 252,870 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Scp2
414 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:64
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000015420
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
7794739Bp372Blood pressure QTL 3720.0058arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5117913688125222967Rat
1582230Bw78Body weight QTL 783.20.0016epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)5119085612128034027Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat

Markers in Region
D4Rat90  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24156,653,369 - 156,653,578 (+)MAPPERmRatBN7.2
Rnor_6.05127,732,102 - 127,732,300NCBIRnor6.0
Rnor_6.04156,316,324 - 156,316,532NCBIRnor6.0
Rnor_5.04223,333,188 - 223,333,396UniSTSRnor5.0
Rnor_5.05131,580,690 - 131,580,888UniSTSRnor5.0
RGSC_v3.44159,949,127 - 159,949,335UniSTSRGSC3.4
RGSC_v3.45129,226,800 - 129,226,998UniSTSRGSC3.4
RGSC_v3.44159,949,126 - 159,949,335RGDRGSC3.4
RGSC_v3.45129,226,799 - 129,226,998RGDRGSC3.4
RGSC_v3.15129,232,026 - 129,232,224RGD
Celera5121,620,969 - 121,621,167UniSTS
Celera4145,443,177 - 145,443,385UniSTS
RH 3.4 Map5806.7UniSTS
RH 3.4 Map5806.7RGD
SHRSP x BN Map478.1999RGD
SHRSP x BN Map478.1999UniSTS
Cytogenetic Map5q35UniSTS
RH141299  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25122,834,610 - 122,834,822 (+)MAPPERmRatBN7.2
Rnor_6.05127,675,556 - 127,675,767NCBIRnor6.0
Rnor_5.05131,523,023 - 131,523,234UniSTSRnor5.0
RGSC_v3.45129,181,957 - 129,182,168UniSTSRGSC3.4
Celera5121,578,494 - 121,578,705UniSTS
RH 3.4 Map5808.9UniSTS
Cytogenetic Map5q35UniSTS
RH128646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25122,807,657 - 122,807,866 (+)MAPPERmRatBN7.2
Rnor_6.05127,648,643 - 127,648,851NCBIRnor6.0
Rnor_5.05131,496,110 - 131,496,318UniSTSRnor5.0
RGSC_v3.45129,153,545 - 129,153,753UniSTSRGSC3.4
Celera5121,551,877 - 121,552,085UniSTS
Cytogenetic Map5q35UniSTS
RH140895  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25122,807,001 - 122,807,209 (+)MAPPERmRatBN7.2
Rnor_6.05127,647,987 - 127,648,194NCBIRnor6.0
Rnor_5.05131,495,454 - 131,495,661UniSTSRnor5.0
RGSC_v3.45129,152,889 - 129,153,096UniSTSRGSC3.4
Celera5121,551,221 - 121,551,428UniSTS
RH 3.4 Map5808.7UniSTS
Cytogenetic Map5q35UniSTS
SCP2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25122,868,632 - 122,868,728 (+)MAPPERmRatBN7.2
Rnor_6.05127,723,816 - 127,723,911NCBIRnor6.0
Rnor_5.05131,572,404 - 131,572,499UniSTSRnor5.0
RGSC_v3.45129,217,920 - 129,218,015UniSTSRGSC3.4
Celera5121,611,940 - 121,612,035UniSTS
Cytogenetic Map5q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 39 11 8
Low 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015420   ⟹   ENSRNOP00000015420
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5122,806,948 - 122,881,287 (-)Ensembl
Rnor_6.0 Ensembl5127,647,934 - 127,735,703 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000015466   ⟹   ENSRNOP00000015466
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5122,776,549 - 122,819,912 (-)Ensembl
Rnor_6.0 Ensembl5127,620,274 - 127,661,028 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088049   ⟹   ENSRNOP00000075342
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5122,809,930 - 122,881,279 (-)Ensembl
Rnor_6.0 Ensembl5127,648,555 - 127,735,739 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094900   ⟹   ENSRNOP00000084030
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5122,818,027 - 122,881,279 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111786   ⟹   ENSRNOP00000084259
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5122,776,549 - 122,796,769 (-)Ensembl
RefSeq Acc Id: NM_138508   ⟹   NP_612517
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25122,806,949 - 122,881,259 (-)NCBI
Rnor_6.05127,647,934 - 127,735,703 (-)NCBI
Rnor_5.05131,495,401 - 131,584,291 (-)NCBI
RGSC_v3.45129,152,836 - 129,230,401 (-)RGD
Celera5121,551,168 - 121,624,570 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_612517   ⟸   NM_138508
- UniProtKB: F1LQ55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075342   ⟸   ENSRNOT00000088049
RefSeq Acc Id: ENSRNOP00000015466   ⟸   ENSRNOT00000015466
RefSeq Acc Id: ENSRNOP00000015420   ⟸   ENSRNOT00000015420
RefSeq Acc Id: ENSRNOP00000084259   ⟸   ENSRNOT00000111786
RefSeq Acc Id: ENSRNOP00000084030   ⟸   ENSRNOT00000094900
Protein Domains
SCP2   Thiolase_C   Thiolase_N

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11915-F1-model_v2 AlphaFold P11915 1-547 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693897
Promoter ID:EPDNEW_R4422
Type:initiation region
Name:Scp2_1
Description:sterol carrier protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05127,735,723 - 127,735,783EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3642 AgrOrtholog
BioCyc Gene G2FUF-40395 BioCyc
Ensembl Genes ENSRNOG00000011413 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015420 ENTREZGENE
  ENSRNOP00000015420.6 UniProtKB/TrEMBL
  ENSRNOP00000015466.5 UniProtKB/TrEMBL
  ENSRNOP00000075342.2 UniProtKB/TrEMBL
  ENSRNOP00000084030.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015420 ENTREZGENE
  ENSRNOT00000015420.6 UniProtKB/TrEMBL
  ENSRNOT00000015466.6 UniProtKB/TrEMBL
  ENSRNOT00000088049.2 UniProtKB/TrEMBL
  ENSRNOT00000094900.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1050.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.47.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109192 IMAGE-MGC_LOAD
InterPro L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  SCP2_sterol-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCP2_sterol-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_acyl_enz_int_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25541 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93120 IMAGE-MGC_LOAD
NCBI Gene 25541 ENTREZGENE
Pfam LRR_8 UniProtKB/TrEMBL
  SCP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Scp2 PhenoGen
PROSITE LRR UniProtKB/TrEMBL
  THIOLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55718 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2KAC1_RAT UniProtKB/TrEMBL
  A0A8I6G9S8_RAT UniProtKB/TrEMBL
  F1LQ55 ENTREZGENE, UniProtKB/TrEMBL
  NLTP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6QI48_RAT UniProtKB/TrEMBL
UniProt Secondary F7F3K6 UniProtKB/TrEMBL
  Q63383 UniProtKB/Swiss-Prot
  Q642G0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Scp2  Sterol carrier protein 2, liver      Symbol and Name status set to approved 70586 APPROVED