Cer1 (cerberus 1, DAN family BMP antagonist) - Rat Genome Database

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Gene: Cer1 (cerberus 1, DAN family BMP antagonist) Rattus norvegicus
Analyze
Symbol: Cer1
Name: cerberus 1, DAN family BMP antagonist
RGD ID: 1563046
Description: Predicted to enable BMP binding activity; morphogen activity; and protein homodimerization activity. Predicted to be involved in several processes, including determination of bilateral symmetry; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and signal transduction involved in regulation of gene expression. Predicted to act upstream of or within several processes, including cellular response to cadmium ion; growth plate cartilage chondrocyte proliferation; and negative regulation of BMP signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CER1 (cerberus 1, DAN family BMP antagonist); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; INTERACTS WITH bisphenol A; trichloroethene; 1,2-dichloroethane (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cerberus; cerberus 1, cysteine knot superfamily, homolog; cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis); hypothetical protein LOC500485; LOC500485; RGD1563046; similar to cerberus-like; uncharacterized protein LOC500485
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2597,306,427 - 97,309,783 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl597,306,431 - 97,309,783 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx599,684,785 - 99,688,121 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05101,483,102 - 101,486,442 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05101,495,639 - 101,498,975 (-)NCBIRnor_WKY
Rnor_6.05101,003,019 - 101,006,375 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5101,003,023 - 101,006,375 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05105,024,882 - 105,028,238 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45101,756,095 - 101,759,451 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera595,858,921 - 95,862,277 (-)NCBICelera
Cytogenetic Map5q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Systemically administered bone morphogenetic protein-6 restores bone in aged ovariectomized rats by increasing bone formation and suppressing bone resorption. Simic P, etal., J Biol Chem. 2006 Sep 1;281(35):25509-21. Epub 2006 Jun 23.
5. Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with BMD and fracture in southern Chinese women. Tang PL, etal., J Bone Miner Res. 2009 Jun;24(6):1013-21. doi: 10.1359/jbmr.081258.
Additional References at PubMed
PMID:9431803   PMID:9501024   PMID:9660951   PMID:10748465   PMID:12477932   PMID:15004567   PMID:18241853   PMID:18462699   PMID:22114682  


Genomics

Comparative Map Data
Cer1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2597,306,427 - 97,309,783 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl597,306,431 - 97,309,783 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx599,684,785 - 99,688,121 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05101,483,102 - 101,486,442 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05101,495,639 - 101,498,975 (-)NCBIRnor_WKY
Rnor_6.05101,003,019 - 101,006,375 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5101,003,023 - 101,006,375 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05105,024,882 - 105,028,238 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45101,756,095 - 101,759,451 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera595,858,921 - 95,862,277 (-)NCBICelera
Cytogenetic Map5q31NCBI
CER1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38914,717,326 - 14,722,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl914,719,724 - 14,722,733 (-)EnsemblGRCh38hg38GRCh38
GRCh37914,719,722 - 14,722,731 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36914,709,731 - 14,712,715 (-)NCBINCBI36Build 36hg18NCBI36
Build 34914,710,087 - 14,712,670NCBI
Celera914,653,168 - 14,656,152 (-)NCBICelera
Cytogenetic Map9p22.3NCBI
HuRef914,683,023 - 14,686,007 (-)NCBIHuRef
CHM1_1914,719,774 - 14,722,758 (-)NCBICHM1_1
T2T-CHM13v2.0914,729,432 - 14,732,441 (-)NCBIT2T-CHM13v2.0
Cer1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39482,799,988 - 82,803,388 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl482,799,988 - 82,803,385 (-)EnsemblGRCm39 Ensembl
GRCm38482,881,751 - 82,885,151 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl482,881,751 - 82,885,148 (-)EnsemblGRCm38mm10GRCm38
MGSCv37482,527,655 - 82,531,055 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36482,352,982 - 82,356,382 (-)NCBIMGSCv36mm8
Celera481,416,868 - 81,420,261 (-)NCBICelera
Cytogenetic Map4C3NCBI
cM Map439.4NCBI
Cer1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543417,734,495 - 17,740,823 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543417,738,281 - 17,740,823 (-)NCBIChiLan1.0ChiLan1.0
CER1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1915,063,766 - 15,066,776 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl915,063,766 - 15,066,776 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0914,552,062 - 14,559,632 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CER1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11135,155,568 - 35,159,085 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1135,156,430 - 35,158,942 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1133,798,715 - 33,801,938 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01136,059,810 - 36,063,033 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1136,060,121 - 36,063,033 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11134,763,936 - 34,767,159 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01134,556,198 - 34,559,421 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01135,213,081 - 35,216,304 (-)NCBIUU_Cfam_GSD_1.0
Cer1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947149,868,745 - 149,871,378 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365398,321,432 - 8,323,909 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CER1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1207,818,175 - 207,822,291 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11207,817,095 - 207,821,800 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CER1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11264,859,301 - 64,865,676 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1264,860,958 - 64,863,544 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603853,077,361 - 53,083,528 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cer1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473618,958,069 - 18,960,617 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473618,958,081 - 18,960,617 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cer1
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:490
Count of miRNA genes:270
Interacting mature miRNAs:333
Transcripts:ENSRNOT00000014008
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 6 24 8 16 8 2 2 12 28 21 10 2
Below cutoff 1 35 12 12 3 12 6 8 58 7 17 1 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014008   ⟹   ENSRNOP00000014008
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl597,306,431 - 97,309,783 (-)Ensembl
Rnor_6.0 Ensembl5101,003,023 - 101,006,375 (-)Ensembl
RefSeq Acc Id: NM_001115031   ⟹   NP_001108503
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2597,306,427 - 97,309,783 (-)NCBI
Rnor_6.05101,003,019 - 101,006,375 (-)NCBI
Rnor_5.05105,024,882 - 105,028,238 (-)NCBI
RGSC_v3.45101,756,095 - 101,759,451 (-)RGD
Celera595,858,921 - 95,862,277 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001108503 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58727 (Get FASTA)   NCBI Sequence Viewer  
  EDM10464 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001108503   ⟸   NM_001115031
- Peptide Label: precursor
- UniProtKB: B0BN87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014008   ⟸   ENSRNOT00000014008
Protein Domains
CTCK

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BN87-F1-model_v2 AlphaFold B0BN87 1-267 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563046 AgrOrtholog
BioCyc Gene G2FUF-40889 BioCyc
Ensembl Genes ENSRNOG00000010518 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014008 ENTREZGENE
  ENSRNOP00000014008.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014008 ENTREZGENE
  ENSRNOT00000014008.4 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9091451 IMAGE-MGC_LOAD
InterPro Cerberus UniProtKB/TrEMBL
  Cys_knot_C UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  DAN UniProtKB/TrEMBL
KEGG Report rno:500485 UniProtKB/TrEMBL
MGC_CLONE MGC:187879 IMAGE-MGC_LOAD
NCBI Gene 500485 ENTREZGENE
PANTHER PTHR15273 UniProtKB/TrEMBL
Pfam DAN UniProtKB/TrEMBL
PhenoGen Cer1 PhenoGen
PIRSF Cerberus UniProtKB/TrEMBL
PROSITE CTCK_2 UniProtKB/TrEMBL
SMART SM00041 UniProtKB/TrEMBL
UniProt B0BN87 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-06 Cer1  cerberus 1, DAN family BMP antagonist  Cer1  cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-12 Cer1  cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)  RGD1563046  similar to cerberus-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1563046  similar to cerberus-like   RGD1563046_predicted  similar to cerberus-like (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563046_predicted  similar to cerberus-like (predicted)  LOC500485  similar to cerberus-like  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500485  similar to cerberus-like      Symbol and Name status set to provisional 70820 PROVISIONAL