Mpdz (multiple PDZ domain crumbs cell polarity complex component) - Rat Genome Database

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Gene: Mpdz (multiple PDZ domain crumbs cell polarity complex component) Rattus norvegicus
Analyze
Symbol: Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
RGD ID: 3105
Description: Predicted to enable protein C-terminus binding activity. Involved in myelination. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; apical plasma membrane; and apicolateral plasma membrane. Predicted to be part of subapical complex. Predicted to be active in several cellular components, including apical part of cell; bicellular tight junction; and plasma membrane. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human MPDZ (multiple PDZ domain crumbs cell polarity complex component); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: multi-PDZ domain protein 1; multiple PDZ domain protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2595,766,112 - 95,920,531 (-)NCBI
Rnor_6.0 Ensembl599,413,187 - 99,566,318 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0599,413,184 - 99,566,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05103,442,806 - 103,596,600 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45100,008,984 - 100,170,202 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15100,014,212 - 100,175,428 (-)NCBI
Celera594,336,315 - 94,488,569 (-)NCBICelera
Cytogenetic Map5q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldrin  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
benzo[a]pyrene  (ISO)
bicuculline  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
chloroethene  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
folic acid  (ISO)
glafenine  (EXP)
hexadecanoic acid  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
kainic acid  (ISO)
L-methionine  (ISO)
N-nitrosodiethylamine  (EXP)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentetrazol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
topotecan  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10967549   PMID:11150294   PMID:11689568   PMID:11802782   PMID:15312654   PMID:15364909   PMID:15863617   PMID:17397395   PMID:17894389   PMID:18417361   PMID:18537874   PMID:19934217  
PMID:20237282   PMID:25977097  


Genomics

Comparative Map Data
Mpdz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2595,766,112 - 95,920,531 (-)NCBI
Rnor_6.0 Ensembl599,413,187 - 99,566,318 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0599,413,184 - 99,566,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05103,442,806 - 103,596,600 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45100,008,984 - 100,170,202 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15100,014,212 - 100,175,428 (-)NCBI
Celera594,336,315 - 94,488,569 (-)NCBICelera
Cytogenetic Map5q31NCBI
MPDZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl913,105,706 - 13,279,692 (-)EnsemblGRCh38hg38GRCh38
GRCh38913,105,296 - 13,279,692 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37913,105,706 - 13,279,691 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36913,095,703 - 13,240,365 (-)NCBINCBI36hg18NCBI36
Build 34913,096,575 - 13,240,357NCBI
Celera913,038,280 - 13,183,037 (-)NCBI
Cytogenetic Map9p23NCBI
HuRef913,069,879 - 13,214,632 (-)NCBIHuRef
CHM1_1913,105,992 - 13,279,791 (-)NCBICHM1_1
Mpdz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39481,196,736 - 81,361,112 (-)NCBIGRCm39mm39
GRCm39 Ensembl481,196,737 - 81,361,052 (-)Ensembl
GRCm38481,278,499 - 81,442,897 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl481,278,500 - 81,442,815 (-)EnsemblGRCm38mm10GRCm38
MGSCv37480,924,404 - 81,088,709 (-)NCBIGRCm37mm9NCBIm37
MGSCv36480,750,824 - 80,913,903 (-)NCBImm8
Celera479,839,558 - 79,997,048 (-)NCBICelera
Cytogenetic Map4C3NCBI
cM Map438.0NCBI
Mpdz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543416,284,123 - 16,418,092 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543416,284,123 - 16,431,853 (-)NCBIChiLan1.0ChiLan1.0
MPDZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1913,390,642 - 13,564,246 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl913,391,903 - 13,535,292 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0912,943,252 - 13,120,126 (-)NCBIMhudiblu_PPA_v0panPan3
MPDZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11133,691,434 - 33,826,500 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1133,692,296 - 33,826,437 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1132,400,323 - 32,561,595 (-)NCBI
ROS_Cfam_1.01134,595,030 - 34,756,348 (-)NCBI
UMICH_Zoey_3.11133,300,994 - 33,462,185 (-)NCBI
UNSW_CanFamBas_1.01133,086,512 - 33,254,154 (-)NCBI
UU_Cfam_GSD_1.01133,749,245 - 33,910,664 (-)NCBI
Mpdz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947148,481,482 - 148,631,516 (-)NCBI
SpeTri2.0NW_0049365396,934,180 - 7,084,117 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPDZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1209,181,465 - 209,349,295 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11209,181,441 - 209,351,797 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21233,122,084 - 233,215,771 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MPDZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11266,275,725 - 66,450,398 (+)NCBI
ChlSab1.1 Ensembl1266,304,514 - 66,449,110 (+)Ensembl
Vero_WHO_p1.0NW_02366603854,508,794 - 54,683,624 (+)NCBI
Mpdz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473617,392,132 - 17,555,612 (-)NCBI

Position Markers
D5Rat98  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,774,194 - 95,774,399 (+)MAPPER
Rnor_6.0599,421,434 - 99,421,638NCBIRnor6.0
Rnor_5.05103,451,053 - 103,451,257UniSTSRnor5.0
RGSC_v3.45100,017,061 - 100,017,265UniSTSRGSC3.4
RGSC_v3.45100,017,060 - 100,017,265RGDRGSC3.4
RGSC_v3.15100,022,287 - 100,022,491RGD
Celera594,344,392 - 94,344,614UniSTS
RH 3.4 Map5724.1RGD
RH 3.4 Map5724.1UniSTS
RH 2.0 Map5603.7RGD
SHRSP x BN Map553.5899RGD
Cytogenetic Map5q31UniSTS
D5Got256  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,860,869 - 95,861,088 (+)MAPPER
Rnor_6.0599,506,864 - 99,507,082NCBIRnor6.0
Rnor_5.05103,537,072 - 103,537,290UniSTSRnor5.0
RGSC_v3.45100,111,273 - 100,111,491UniSTSRGSC3.4
Celera594,430,290 - 94,430,492UniSTS
Cytogenetic Map5q31UniSTS
D5Got312  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,793,950 - 95,794,214 (+)MAPPER
Rnor_6.0599,440,546 - 99,440,809NCBIRnor6.0
Rnor_5.05103,470,165 - 103,470,428UniSTSRnor5.0
RGSC_v3.45100,037,650 - 100,037,913UniSTSRGSC3.4
Celera594,363,928 - 94,364,189UniSTS
Cytogenetic Map5q31UniSTS
RH138353  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,782,346 - 95,782,503 (+)MAPPER
Rnor_6.0599,429,135 - 99,429,291NCBIRnor6.0
Rnor_5.05103,458,754 - 103,458,910UniSTSRnor5.0
RGSC_v3.45100,025,212 - 100,025,368UniSTSRGSC3.4
Celera594,352,561 - 94,352,717UniSTS
RH 3.4 Map5749.3UniSTS
Cytogenetic Map5q31UniSTS
RH134440  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,766,308 - 95,766,513 (+)MAPPER
Rnor_6.0599,413,381 - 99,413,585NCBIRnor6.0
Rnor_5.05103,443,000 - 103,443,204UniSTSRnor5.0
RGSC_v3.45100,009,178 - 100,009,382UniSTSRGSC3.4
Celera594,336,509 - 94,336,713UniSTS
RH 3.4 Map5749.5UniSTS
Cytogenetic Map5q31UniSTS
AU046394  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,793,950 - 95,794,188 (+)MAPPER
Rnor_6.0599,440,546 - 99,440,783NCBIRnor6.0
Rnor_5.05103,470,165 - 103,470,402UniSTSRnor5.0
RGSC_v3.45100,037,650 - 100,037,887UniSTSRGSC3.4
Celera594,363,928 - 94,364,163UniSTS
Cytogenetic Map5q31UniSTS
Mpdz  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,874,646 - 95,875,800 (+)MAPPER
Rnor_6.0599,520,641 - 99,521,794NCBIRnor6.0
Rnor_5.05103,550,849 - 103,552,002UniSTSRnor5.0
RGSC_v3.45100,125,050 - 100,126,203UniSTSRGSC3.4
Celera594,444,045 - 94,445,198UniSTS
Cytogenetic Map5q31UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51136640934Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)59514842103580403Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512651967117554267Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531926122136640934Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)535225432108092802Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)535661945117554267Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535788756147487820Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540777918154732375Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)544404276134502294Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)547745646167946134Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)551418671147487820Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)555903593100903593Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)556902367101902367Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)556991667137729065Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)560072951133313852Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)561086525149030144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)561086653117554114Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)561612600102331727Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)561612600168109659Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)565696672129038896Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)568838385113838385Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)571154828108092802Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)571154828108092802Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)571154828108092802Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)571154828108092802Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)571154828108092802Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)571552569157225114Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)583424556128424556Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)583424556128424556Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)583424556128424556Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)584963058173504662Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)585800910100745614Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589502294134502294Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)591585539136585539Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)591585539136585539Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)591585539136585539Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)591884213136884213Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)593037304133313852Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)593037304133313852Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)593273130138273130Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)597921932149030144Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:89
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000051028
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 41 19 11 1 11 8 10 74 28 34 11 8
Low 3 2 38 30 18 30 1 7 6
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000051028   ⟹   ENSRNOP00000051321
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl599,413,190 - 99,566,317 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089235   ⟹   ENSRNOP00000072433
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl599,413,187 - 99,566,318 (-)Ensembl
RefSeq Acc Id: NM_019196   ⟹   NP_062069
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2595,766,115 - 95,920,499 (-)NCBI
Rnor_6.0599,413,187 - 99,566,317 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
RGSC_v3.45100,008,984 - 100,170,202 (-)RGD
Celera594,336,315 - 94,488,569 (-)RGD
Sequence:
RefSeq Acc Id: XM_006238340   ⟹   XP_006238402
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2595,766,112 - 95,920,527 (-)NCBI
Rnor_6.0599,413,184 - 99,566,356 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238341   ⟹   XP_006238403
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2595,766,973 - 95,920,526 (-)NCBI
Rnor_6.0599,414,045 - 99,566,356 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238342   ⟹   XP_006238404
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2595,766,973 - 95,920,527 (-)NCBI
Rnor_6.0599,414,045 - 99,566,356 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238343   ⟹   XP_006238405
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2595,766,973 - 95,920,525 (-)NCBI
Rnor_6.0599,414,045 - 99,566,355 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238344   ⟹   XP_006238406
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2595,766,973 - 95,920,526 (-)NCBI
Rnor_6.0599,414,045 - 99,566,355 (-)NCBI
Rnor_5.05103,442,806 - 103,596,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109363   ⟹   XP_038965291
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2595,766,973 - 95,920,528 (-)NCBI
RefSeq Acc Id: XM_039109364   ⟹   XP_038965292
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2595,766,973 - 95,920,527 (-)NCBI
RefSeq Acc Id: XM_039109365   ⟹   XP_038965293
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2595,766,973 - 95,920,531 (-)NCBI
RefSeq Acc Id: XM_039109366   ⟹   XP_038965294
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2595,766,973 - 95,846,788 (-)NCBI
RefSeq Acc Id: XM_039109367   ⟹   XP_038965295
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2595,803,927 - 95,920,530 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_062069   ⟸   NM_019196
- UniProtKB: O55164 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006238404   ⟸   XM_006238342
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006238405   ⟸   XM_006238343
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006238406   ⟸   XM_006238344
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006238403   ⟸   XM_006238341
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006238402   ⟸   XM_006238340
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2Y8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072433   ⟸   ENSRNOT00000089235
RefSeq Acc Id: ENSRNOP00000051321   ⟸   ENSRNOT00000051028
RefSeq Acc Id: XP_038965293   ⟸   XM_039109365
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038965291   ⟸   XM_039109363
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038965292   ⟸   XM_039109364
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038965294   ⟸   XM_039109366
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038965295   ⟸   XM_039109367
- Peptide Label: isoform X10
Protein Domains
L27   PDZ

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693818
Promoter ID:EPDNEW_R4340
Type:initiation region
Name:Mpdz_1
Description:multiple PDZ domain crumbs cell polarity complex component
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0599,566,344 - 99,566,404EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3105 AgrOrtholog
Ensembl Genes ENSRNOG00000007894 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000051321 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000072433 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051028 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000089235 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro L27_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MPDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29365 UniProtKB/Swiss-Prot
NCBI Gene 29365 ENTREZGENE
Pfam L27_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MPDZ_u10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mpdz PhenoGen
PROSITE L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101288 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC231731
UniProt A0A0G2K2Y8 ENTREZGENE, UniProtKB/TrEMBL
  MPDZ_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Mpdz  multiple PDZ domain crumbs cell polarity complex component  Mpdz  multiple PDZ domain protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mpdz  multiple PDZ domain protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains thirteen PDZ domains and no obvious catalytic domain 69894
gene_expression abundant in the brain 69894
gene_physical_interaction interacts with the C-terminal domain of the 5-HT2C receptor 69894