Abca1 (ATP binding cassette subfamily A member 1) - Rat Genome Database

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Gene: Abca1 (ATP binding cassette subfamily A member 1) Rattus norvegicus
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Symbol: Abca1
Name: ATP binding cassette subfamily A member 1
RGD ID: 631344
Description: Enables ATPase-coupled transmembrane transporter activity and high-density lipoprotein particle binding activity. Involved in several processes, including cellular response to cholesterol; lipoprotein biosynthetic process; and response to vitamin B3. Located in basolateral plasma membrane and cell surface. Biomarker of several diseases, including end stage renal disease; extrahepatic cholestasis; liver disease (multiple); membranous glomerulonephritis; and premature menopause. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hypolipoproteinemia (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human ABCA1 (ATP binding cassette subfamily A member 1); PARTICIPATES IN altered reverse cholesterol transport pathway; retinol metabolic pathway; reverse cholesterol transport pathway; INTERACTS WITH (25R)-cholest-5-ene-3beta,26-diol; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP-binding cassette sub-family A member 1; ATP-binding cassette, sub-family A (ABC1), member 1; ATP-binding cassette, subfamily A (ABC1), member 1; phospholipid-transporting ATPase ABCA1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8572,473,676 - 72,596,563 (-)NCBIGRCr8
mRatBN7.2567,678,267 - 67,801,162 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl567,681,297 - 67,801,170 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx569,563,415 - 69,686,148 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0571,378,268 - 71,502,004 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0571,352,251 - 71,474,997 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0569,857,717 - 69,983,042 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl569,857,771 - 69,983,015 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0574,023,652 - 74,112,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4570,493,357 - 70,583,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1570,498,469 - 70,588,842 (-)NCBI
Celera566,575,764 - 66,665,022 (-)NCBICelera
Cytogenetic Map5q23-q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2,3-trilinolenoylglycerol  (ISO)
1,2,3-trilinoleoylglycerol  (ISO)
1-Oleoyl-2-acetyl-sn-glycerol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
22-Hydroxycholesterol  (EXP,ISO)
25-hydroxycholesterol  (EXP,ISO)
26-hydroxycholesterol  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID  (ISO)
6-propyl-2-thiouracil  (EXP)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (EXP,ISO)
9-cis-retinoic acid  (EXP,ISO)
acetazolamide  (ISO)
acetylsalicylic acid  (ISO)
Adiponectin  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amentoflavone  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
Aranidipine  (ISO)
Archazolid B  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atorvastatin calcium  (ISO)
azoxystrobin  (ISO)
BAPTA  (ISO)
beauvericin  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
beta-hexachlorocyclohexane  (ISO)
bexarotene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
buspirone  (EXP)
butan-1-ol  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calciol  (EXP)
calcitriol  (ISO)
capsaicin  (ISO)
carbamazepine  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chitosan  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
cholic acid  (EXP,ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
cilostazol  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
Colestilan  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
daidzein  (ISO)
DDT  (ISO)
desmosterol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
difenoconazole  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
efonidipine hydrochloride  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
ethanol  (EXP,ISO)
ezetimibe  (ISO)
fenamidone  (ISO)
fenarimol  (EXP)
fenofibrate  (ISO)
fenpyroximate  (ISO)
fentin chloride  (ISO)
fingolimod hydrochloride  (ISO)
fluoxetine  (ISO)
flusilazole  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
fonofos  (ISO)
fructose  (EXP)
furan  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gemfibrozil  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
glutathione  (ISO)
glycerol 2-phosphate  (ISO)
glycitein  (ISO)
glycolaldehyde  (ISO)
glyoxal  (ISO)
graphene oxide  (ISO)
GW 3965  (EXP,ISO)
GW 4064  (ISO)
GW 501516  (ISO)
GW 6471  (EXP,ISO)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (ISO)
high-density lipoprotein cholesterol  (ISO)
Insulin-like growth factor I  (ISO)
isoprenaline  (ISO)
isosilybin A  (ISO)
isotretinoin  (EXP)
ketamine  (EXP)
ketoconazole  (EXP)
KT 5720  (ISO)
L-ascorbic acid  (ISO)
lansoprazole  (ISO)
lead diacetate  (EXP)
Licochalcone B  (ISO)
lidocaine  (EXP)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
malonaldehyde  (ISO)
mastoparan  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
metronidazole  (ISO)
mevalonic acid  (ISO)
mevastatin  (EXP,ISO)
miconazole  (ISO)
mifepristone  (EXP)
mitoxantrone  (ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (ISO)
Morroniside  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-(2,2,2-TRIFLUOROETHYL)-N-\{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL\}BENZENESULFONAMIDE  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
neomycin  (ISO)
nickel dichloride  (ISO)
nicotinamide  (IEP)
nicotine  (EXP,ISO)
nicotinic acid  (EXP,ISO)
nimesulide  (EXP)
NS-398  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
oleic acid  (ISO)
omeprazole  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
palbociclib  (ISO)
palmitoleic acid  (ISO)
pantoprazole  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
picolinic acid  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pitavastatin  (EXP,ISO)
pitavastatin(1-)  (EXP,ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
propiconazole  (EXP)
prostaglandin J2  (ISO)
prothioconazole  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
Ro 31-8220  (ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silychristin  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sulfluramid  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
tetramethylpyrazine  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
triacsin C  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triolein  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vecuronium bromide  (ISO)
vincristine  (ISO)
vitexin  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
apolipoprotein A-I-mediated signaling pathway  (IEA)
cellular response to cholesterol  (IEP)
cellular response to cytokine stimulus  (IEP)
cellular response to high density lipoprotein particle stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to xenobiotic stimulus  (IEP)
cholesterol efflux  (ISO)
cholesterol homeostasis  (ISO)
cholesterol metabolic process  (ISO)
cholesterol transport  (IDA,IMP)
endosomal transport  (ISO)
establishment of localization in cell  (ISO)
export across plasma membrane  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
high-density lipoprotein particle assembly  (ISO)
intracellular cholesterol transport  (ISO)
lipoprotein biosynthetic process  (IEP,IMP,ISO)
lipoprotein metabolic process  (ISO)
lysosome organization  (ISO)
peptide secretion  (ISO)
phagocytosis, engulfment  (ISO)
phospholipid efflux  (IBA,ISO)
phospholipid homeostasis  (ISO)
phospholipid translocation  (ISO)
phospholipid transport  (IDA,TAS)
platelet dense granule organization  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of high-density lipoprotein particle assembly  (ISO)
protein lipidation  (ISO)
protein secretion  (ISO)
protein transmembrane transport  (ISO)
regulation of Cdc42 protein signal transduction  (ISO)
response to laminar fluid shear stress  (ISO)
response to nutrient  (IEP)
response to nutrient levels  (IEP)
response to vitamin B3  (IEP)
response to xenobiotic stimulus  (IEP)
reverse cholesterol transport  (ISO)
signal release  (ISO)
sphingolipid translocation  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Identification and characterization of rodent ABCA1 in isolated type II pneumocytes. Bortnick AE, etal., Am J Physiol Lung Cell Mol Physiol 2003 Oct;285(4):L869-78. Epub 2003 Aug 08.
3. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Brooks-Wilson A, etal., Nat Genet 1999 Aug;22(4):336-45.
4. Cellular localization and interaction of ABCA1 and caveolin-1 in aortic endothelial cells after HDL incubation. Chao WT, etal., Biochem Biophys Res Commun. 2005 Jul 8;332(3):743-9.
5. Association of ATP-Binding Cassette Transporter (ABC) Gene Polymorphisms with Viral Load in Patients with Genotype 1 Hepatitis C Virus Infection. Chen L, etal., Clin Lab. 2016 Sep 1;62(9):1643-1649. doi: 10.7754/Clin.Lab.2016.160105.
6. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
7. Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes. Clee SM, etal., J Clin Invest. 2000 Nov;106(10):1263-70.
8. IGF1 suppresses cholesterol accumulation in the liver of growth hormone-deficient mice via the activation of ABCA1. Fukunaga K, etal., Am J Physiol Endocrinol Metab. 2018 Dec 1;315(6):E1232-E1241. doi: 10.1152/ajpendo.00134.2018. Epub 2018 Aug 21.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Effect of a high-fat diet on the hepatic expression of nuclear receptors and their target genes: relevance to drug disposition. Ghoneim RH, etal., Br J Nutr. 2015 Feb 14;113(3):507-16. doi: 10.1017/S0007114514003717. Epub 2015 Jan 23.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Clofibrate, a peroxisome-proliferator, enhances reverse cholesterol transport through cytochrome P450 activation and oxysterol generation. Guan JZ, etal., Tohoku J Exp Med. 2003 Dec;201(4):251-9.
13. Anti-hyperlipidemic properties of CM108 (a flavone derivative) in vitro and in vivo. Guo L, etal., Eur J Pharmacol. 2006 Dec 3;551(1-3):80-6. Epub 2006 Sep 6.
14. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Harrison EH Biochim Biophys Acta. 2012 Jan;1821(1):70-7. Epub 2011 Jun 12.
15. Hypercholesterolemia in rats with hepatomas: increased oxysterols accelerate efflux but do not inhibit biosynthesis of cholesterol. Hirayama T, etal., Hepatology. 2006 Sep;44(3):602-11.
16. Diet induced regulation of genes involved in cholesterol metabolism in rat liver parenchymal and Kupffer cells. Hoekstra M, etal., J Hepatol. 2005 Mar;42(3):400-7.
17. Increased expression of ATP-binding cassette transporter A1 (ABCA1) as a possible mechanism for the protective effect of cilostazol against hepatic steatosis. Jeon BH, etal., Metabolism. 2015 Nov;64(11):1444-53. doi: 10.1016/j.metabol.2015.07.014. Epub 2015 Jul 26.
18. Experimental glomerulopathy alters renal cortical cholesterol, SR-B1, ABCA1, and HMG CoA reductase expression. Johnson AC, etal., Am J Pathol. 2003 Jan;162(1):283-91.
19. Pim-1L Protects Cell Surface-Resident ABCA1 From Lysosomal Degradation in Hepatocytes and Thereby Regulates Plasma High-Density Lipoprotein Level. Katsube A, etal., Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2304-2314. doi: 10.1161/ATVBAHA.116.308472. Epub 2016 Oct 20.
20. Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism. Katzov H, etal., Hum Mutat 2004 Apr;23(4):358-67.
21. Regulation mechanism of ABCA1 expression by statins in hepatocytes. Kobayashi M, etal., Eur J Pharmacol. 2011 Jul 15;662(1-3):9-14. doi: 10.1016/j.ejphar.2011.04.043. Epub 2011 May 1.
22. Adipose tissue regulates hepatic cholesterol metabolism via adiponectin. Li Y, etal., Life Sci. 2014 Nov 18;118(1):27-33. doi: 10.1016/j.lfs.2014.10.003.
23. Berberine alleviates hepatic lipid accumulation by increasing ABCA1 through the protein kinase C δ pathway. Liang H and Wang Y, Biochem Biophys Res Commun. 2018 Apr 6;498(3):473-480. doi: 10.1016/j.bbrc.2018.03.003. Epub 2018 Mar 2.
24. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. McNeish J, etal., Proc Natl Acad Sci U S A 2000 Apr 11;97(8):4245-50.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Moon SH, etal., Cell. 2019 Jan 24;176(3):564-580.e19. doi: 10.1016/j.cell.2018.11.011. Epub 2018 Dec 20.
27. Comparative effect of fish oil feeding and other dietary fatty acids on plasma lipoproteins, biliary lipids, and hepatic expression of proteins involved in reverse cholesterol transport in the rat. Morgado N, etal., Ann Nutr Metab. 2005 Nov-Dec;49(6):397-406. Epub 2005 Oct 14.
28. LDL receptor and Pcsk9 transcripts are decreased in liver of ovariectomized rats: effects of exercise training. Ngo Sock ET, etal., Horm Metab Res. 2014 Jul;46(8):550-5. doi: 10.1055/s-0034-1370910. Epub 2014 Mar 11.
29. Reverse cholesterol transport and cholesterol efflux in atherosclerosis. Ohashi R, etal., QJM. 2005 Dec;98(12):845-56. Epub 2005 Oct 28.
30. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes. Sahoo D, etal., J Lipid Res 2004 Jun;45(6):1122-31. Epub 2004 Mar 1.
35. Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1. Singaraja RR, etal., J Biol Chem 2001 Sep 7;276(36):33969-79. Epub 2001 Jun 21.
36. Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1. Tachibana M, etal., Exp Neurol. 2016 Mar;277:1-9. doi: 10.1016/j.expneurol.2015.12.003. Epub 2015 Dec 11.
37. Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo. Tai LM, etal., J Biol Chem. 2014 Oct 31;289(44):30538-55. doi: 10.1074/jbc.M114.600833. Epub 2014 Sep 12.
38. Increased hepatic ABCA1 transporter is associated with hypercholesterolemia in a cholestatic rat model and primary biliary cholangitis patients. Takeyama Y, etal., Med Mol Morphol. 2017 Dec;50(4):227-237. doi: 10.1007/s00795-017-0166-7. Epub 2017 Jun 28.
39. Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status. Tamehiro N, etal., J Biol Chem. 2007 Jul 20;282(29):21090-9. Epub 2007 May 27.
40. Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. Timmins JM, etal., J Clin Invest. 2005 May;115(5):1333-42. doi: 10.1172/JCI23915. Epub 2005 Apr 7.
41. Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats. Tovar AR, etal., J Lipid Res. 2005 Sep;46(9):1823-32. Epub 2005 Jul 1.
42. The ABCA1 R230C Variant Affects HDL-cholesterol Levels and Body Mass Index in the Mexican Population: Association with Obesity and Obesity-Related Comorbidities. Villarreal-Molina MT, etal., Diabetes. 2007 Feb 7;.
43. Association of the ATP-binding cassette transporter A1 R230C variant with early-onset type 2 diabetes in a Mexican population. Villarreal-Molina MT, etal., Diabetes. 2008 Feb;57(2):509-13. Epub 2007 Nov 14.
44. [Regulatory functions of electroacupuncture at fenglong (ST40) on blood lipids and hepatic ABCA1 and PPARalpha in hyperlipidemia rats]. Wang Q, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Sep;32(9):1245-8.
45. (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B. Wang W, etal., Front Pharmacol. 2018 Mar 9;9:195. doi: 10.3389/fphar.2018.00195. eCollection 2018.
46. Mediation of annexin 1 secretion by a probenecid-sensitive ABC-transporter in rat inflamed mucosa. Wein S, etal., Biochem Pharmacol 2004 Mar 15;67(6):1195-202.
47. Lipoprotein enhancement of ovarian theca-interstitial cell steroidogenesis: relative contribution of scavenger receptor class B (type I) and adenosine 5'-triphosphate- binding cassette (type A1) transporter in high-density lipoprotein-cholesterol transport and androgen synthesis. Wu Q, etal., Endocrinology 2003 Jun;144(6):2437-45.
48. Myocardin suppression increases lipid retention and atherosclerosis via downregulation of ABCA1 in vascular smooth muscle cells. Xia XD, etal., Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Apr;1866(4):158824. doi: 10.1016/j.bbalip.2020.158824. Epub 2020 Oct 7.
Additional References at PubMed
PMID:9006906   PMID:10525055   PMID:10878804   PMID:11162594   PMID:11559713   PMID:11700048   PMID:11855831   PMID:12084722   PMID:12859204   PMID:12869555   PMID:14701824   PMID:14747463  
PMID:14754908   PMID:15163665   PMID:15210959   PMID:15269218   PMID:15358760   PMID:15469992   PMID:15520446   PMID:15520449   PMID:16204232   PMID:16443932   PMID:16702602   PMID:17148552  
PMID:17241464   PMID:17305370   PMID:17657311   PMID:17689492   PMID:17884990   PMID:19041881   PMID:19275878   PMID:19427182   PMID:19528336   PMID:19752193   PMID:19874424   PMID:20137471  
PMID:20215580   PMID:20584649   PMID:20643408   PMID:21402379   PMID:21605865   PMID:21957962   PMID:22179027   PMID:23220274   PMID:23931754   PMID:24097981   PMID:24117066   PMID:24719980  
PMID:24814386   PMID:25084135   PMID:25305669   PMID:25323823   PMID:26663205   PMID:26707062   PMID:26743528   PMID:28642575   PMID:28694219   PMID:28704619   PMID:29775222   PMID:31608710  
PMID:32505219   PMID:34943934   PMID:35085709  


Genomics

Comparative Map Data
Abca1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8572,473,676 - 72,596,563 (-)NCBIGRCr8
mRatBN7.2567,678,267 - 67,801,162 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl567,681,297 - 67,801,170 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx569,563,415 - 69,686,148 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0571,378,268 - 71,502,004 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0571,352,251 - 71,474,997 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0569,857,717 - 69,983,042 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl569,857,771 - 69,983,015 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0574,023,652 - 74,112,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4570,493,357 - 70,583,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1570,498,469 - 70,588,842 (-)NCBI
Celera566,575,764 - 66,665,022 (-)NCBICelera
Cytogenetic Map5q23-q24NCBI
ABCA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389104,781,006 - 104,928,155 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9104,781,006 - 104,928,155 (-)EnsemblGRCh38hg38GRCh38
GRCh379107,543,287 - 107,690,436 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369106,583,104 - 106,730,257 (-)NCBINCBI36Build 36hg18NCBI36
Build 349104,622,837 - 104,769,991NCBI
Celera978,048,593 - 78,195,737 (-)NCBICelera
Cytogenetic Map9q31.1NCBI
HuRef977,145,450 - 77,292,489 (-)NCBIHuRef
CHM1_19107,690,161 - 107,837,338 (-)NCBICHM1_1
T2T-CHM13v2.09116,955,789 - 117,102,979 (-)NCBIT2T-CHM13v2.0
Abca1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39453,030,789 - 53,159,988 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl453,030,787 - 53,159,895 (-)EnsemblGRCm39 Ensembl
GRCm38453,030,789 - 53,159,988 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl453,030,787 - 53,159,895 (-)EnsemblGRCm38mm10GRCm38
MGSCv37453,043,661 - 53,172,767 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36453,051,888 - 53,180,992 (-)NCBIMGSCv36mm8
Celera453,009,587 - 53,133,003 (-)NCBICelera
Cytogenetic Map4B2NCBI
cM Map428.57NCBI
Abca1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541921,553,835 - 21,681,619 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541921,553,863 - 21,681,626 (+)NCBIChiLan1.0ChiLan1.0
ABCA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21134,463,364 - 34,610,716 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1934,465,794 - 34,613,069 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0975,948,831 - 76,096,136 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19104,076,516 - 104,224,188 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9104,076,516 - 104,224,188 (-)Ensemblpanpan1.1panPan2
ABCA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11160,761,669 - 60,869,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1160,761,655 - 60,890,496 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1159,222,894 - 59,351,153 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01161,895,159 - 62,023,474 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1161,896,168 - 62,023,462 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11160,416,579 - 60,544,839 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01160,430,633 - 60,559,576 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01161,125,735 - 61,254,053 (-)NCBIUU_Cfam_GSD_1.0
Abca1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947175,953,909 - 176,088,687 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365597,177,904 - 7,312,741 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365597,177,887 - 7,312,660 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1246,144,277 - 246,278,492 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11246,144,277 - 246,278,492 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21275,475,434 - 275,507,918 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11234,587,123 - 34,734,936 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1234,587,118 - 34,731,642 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660357,887,897 - 8,035,290 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abca1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247586,449,629 - 6,588,664 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247586,449,583 - 6,590,244 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abca1
711 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:29
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000024564
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
1598814Mcs13Mammary carcinoma susceptibility QTL 130.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)56319089069927503Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat

Markers in Region
D5Got6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2567,768,132 - 67,768,317 (+)MAPPERmRatBN7.2
Rnor_6.0569,950,003 - 69,950,187NCBIRnor6.0
Rnor_5.0574,110,339 - 74,110,523UniSTSRnor5.0
RGSC_v3.4570,581,265 - 70,581,450RGDRGSC3.4
RGSC_v3.4570,581,266 - 70,581,450UniSTSRGSC3.4
RGSC_v3.1570,586,379 - 70,586,563RGD
Celera566,662,560 - 66,662,748UniSTS
RH 3.4 Map5459.5UniSTS
RH 3.4 Map5459.5RGD
RH 2.0 Map5382.7RGD
Cytogenetic Map5q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000024564   ⟹   ENSRNOP00000024564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl567,681,297 - 67,801,170 (-)Ensembl
Rnor_6.0 Ensembl569,857,771 - 69,983,015 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110113   ⟹   ENSRNOP00000078596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl567,681,297 - 67,801,086 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114269   ⟹   ENSRNOP00000095590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl567,681,297 - 67,801,170 (-)Ensembl
RefSeq Acc Id: NM_178095   ⟹   NP_835196
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8572,473,676 - 72,596,473 (-)NCBI
mRatBN7.2567,678,284 - 67,801,086 (-)NCBI
Rnor_6.0569,860,747 - 69,952,466 (-)NCBI
Rnor_5.0574,023,652 - 74,112,802 (-)NCBI
RGSC_v3.4570,493,357 - 70,583,729 (-)RGD
Celera566,575,764 - 66,665,022 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109846   ⟹   XP_038965774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8572,473,676 - 72,596,563 (-)NCBI
mRatBN7.2567,678,267 - 67,801,162 (-)NCBI
Protein Sequences
Protein RefSeqs NP_835196 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965774 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO53557 (Get FASTA)   NCBI Sequence Viewer  
  BAF81890 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024564.8
  ENSRNOP00000078596.1
  ENSRNOP00000095590.1
RefSeq Acc Id: NP_835196   ⟸   NM_178095
- UniProtKB: A6KDN7 (UniProtKB/TrEMBL),   F1LNL3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024564   ⟸   ENSRNOT00000024564
RefSeq Acc Id: XP_038965774   ⟸   XM_039109846
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZLK5 (UniProtKB/TrEMBL),   F1LNL3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095590   ⟸   ENSRNOT00000114269
Ensembl Acc Id: ENSRNOP00000078596   ⟸   ENSRNOT00000110113
Protein Domains
ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LNL3-F1-model_v2 AlphaFold F1LNL3 1-2261 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693741
Promoter ID:EPDNEW_R4266
Type:multiple initiation site
Name:Abca1_2
Description:ATP binding cassette subfamily A member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4267  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0569,966,836 - 69,966,896EPDNEW
RGD ID:13693742
Promoter ID:EPDNEW_R4267
Type:single initiation site
Name:Abca1_1
Description:ATP binding cassette subfamily A member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4266  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0569,982,955 - 69,983,015EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631344 AgrOrtholog
BioCyc Gene G2FUF-41282 BioCyc
Ensembl Genes ENSRNOG00000018126 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024564.8 UniProtKB/TrEMBL
  ENSRNOT00000110113.1 UniProtKB/TrEMBL
  ENSRNOT00000114269.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro ABC2_TM UniProtKB/TrEMBL
  ABC_A UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/TrEMBL
  ATPase_AAA+_core UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:313210 UniProtKB/TrEMBL
NCBI Gene 313210 ENTREZGENE
PANTHER PHOSPHOLIPID-TRANSPORTING ATPASE ABCA1 UniProtKB/TrEMBL
  PTHR19229 UniProtKB/TrEMBL
Pfam ABC2_membrane_3 UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PharmGKB ABCA1 RGD
PhenoGen Abca1 PhenoGen
PROSITE ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018126 RatGTEx
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I5ZLK5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATT1_RAT UniProtKB/TrEMBL
  A6KDN7 ENTREZGENE, UniProtKB/TrEMBL
  A8J6V3_RAT UniProtKB/TrEMBL
  F1LNL3 ENTREZGENE, UniProtKB/TrEMBL
  Q80ZB2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Abca1  ATP binding cassette subfamily A member 1  Abca1  ATP-binding cassette, subfamily A (ABC1), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abca1  ATP-binding cassette, subfamily A (ABC1), member 1  Abca1  ATP-binding cassette, sub-family A (ABC1), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Abca1  ATP-binding cassette, sub-family A (ABC1), member 1      Symbol and Name status set to approved 625702 APPROVED