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Gene: Abca1 (ATP binding cassette subfamily A member 1) Rattus norvegicus
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Symbol: Abca1
Name: ATP binding cassette subfamily A member 1
Description: Exhibits ATPase-coupled transmembrane transporter activity and high-density lipoprotein particle binding activity. Involved in several processes, including cellular response to cholesterol; lipid transport; and lipoprotein biosynthetic process. Localizes to the cell surface. Biomarker of familial hyperlipidemia; fatty liver disease; hepatocellular carcinoma; and membranous glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; familial hypercholesterolemia; hypolipoproteinemia (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human ABCA1 (ATP binding cassette subfamily A member 1); PARTICIPATES IN altered reverse cholesterol transport pathway; retinol metabolic pathway; reverse cholesterol transport pathway; INTERACTS WITH (25R)-cholest-5-ene-3beta,26-diol; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATP-binding cassette sub-family A member 1; ATP-binding cassette, sub-family A (ABC1), member 1; ATP-binding cassette, subfamily A (ABC1), member 1
Orthologs:
Homo sapiens (human) : ABCA1 (ATP binding cassette subfamily A member 1)  HGNC  Alliance
Mus musculus (house mouse) : Abca1 (ATP-binding cassette, sub-family A (ABC1), member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Abca1 (ATP binding cassette subfamily A member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ABCA1 (ATP binding cassette subfamily A member 1)
Canis lupus familiaris (dog) : ABCA1 (ATP binding cassette subfamily A member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Abca1 (ATP binding cassette subfamily A member 1)
Sus scrofa (pig) : ABCA1 (ATP binding cassette subfamily A member 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0569,857,717 - 69,983,042 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0574,023,652 - 74,112,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4570,493,357 - 70,583,729 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1570,498,469 - 70,588,842 (-)NCBI
Celera566,575,764 - 66,665,022 (-)NCBICelera
Cytogenetic Map5q23-q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Abca1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 631344
Created: 2003-08-13
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.