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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631344
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abca1
Name: ATP binding cassette subfamily A member 1
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:13323546480464CTDAspirin affects the expression of ABCA1 mRNA

PMID:21088444
decreases expressionISORGD:7361576480464CTDAspirin results in decreased expression of ABCA1 mRNA

PMID:15037193
increases expressionISORGD:7361576480464CTDAspirin results in increased expression of ABCA1 mRNA, Aspirin results in increased expression of ABCA1 protein

PMID:20137092
multiple interactionsISORGD:13323546480464CTDAspirin affects the expression of and affects the activity of ABCA1 protein, PPARA affects the reaction [Aspirin affects the expression of ABCA1 mRNA], PPARA affects the reaction [Aspirin affects the expression of ABCA1 protein]

PMID:21088444
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.