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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631344
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abca1
Name: ATP binding cassette subfamily A member 1
Acc ID: CHEBI:17703
Term: 26-hydroxycholesterol
Definition: An oxysterol that is cholesterol substituted at position 26 by a hydroxy group.
Chemical ID: MESH:C076996
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abca1increases expressionEXP 6480464CTD27-hydroxycholesterol results in increased expression of ABCA1 mRNA; 27-hydroxycholesterol results in increased expression of ABCA1 proteinPMID:28167099
Abca1increases expressionISOAbca1 (Mus musculus)6480464CTD27-hydroxycholesterol results in increased expression of ABCA1 mRNAPMID:18356535
Abca1increases expressionISOABCA1 (Homo sapiens)6480464CTD27-hydroxycholesterol results in increased expression of ABCA1 mRNA; 27-hydroxycholesterol results in increased expression of ABCA1 proteinPMID:15148325 PMID:17088262 PMID:18841091
Abca1multiple interactionsISOAbca1 (Mus musculus)6480464CTDDocosahexaenoic Acids inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]; Linoleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]; Oleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]PMID:18356535
Abca1multiple interactionsISOABCA1 (Homo sapiens)6480464CTD[Fingolimod Hydrochloride results in increased abundance of 27-hydroxycholesterol] which results in increased expression of ABCA1 mRNAPMID:20056921
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