GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abca1 | increases degradation | ISO | ABCA1 (Homo sapiens) | 18936994 | RGD | GW3965 increases degradation of cell surface resident ABCA1 protein in HepG2 cells | | Abca1 | increases expression | EXP | | 6480464 | CTD | GW 3965 results in increased expression of ABCA1 mRNA | PMID:28315714 | Abca1 | increases expression | ISO | Abca1 (Mus musculus) | 6480464 | CTD | GW 3965 results in increased expression of ABCA1 mRNA | PMID:15633131 PMID:27598782 | Abca1 | increases expression | ISO | ABCA1 (Homo sapiens) | 6480464 | CTD | GW 3965 results in increased expression of ABCA1 mRNA; GW 3965 results in increased expression of ABCA1 protein | PMID:16107141 PMID:17449538 PMID:18841091 PMID:19426978 PMID:23732298 PMID:27598782 | Abca1 | multiple interactions | ISO | Abca1 (Mus musculus) | 6480464 | CTD | NR1H2 protein affects the reaction [GW 3965 results in increased expression of ABCA1 mRNA]; NR1H3 protein affects the reaction [GW 3965 results in increased expression of ABCA1 mRNA] | PMID:27598782 | Abca1 | multiple interactions | ISO | ABCA1 (Homo sapiens) | 6480464 | CTD | GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]; NR1H3 mutant form inhibits the reaction [GW 3965 results in increased expression of ABCA1 mRNA] | PMID:23732298 PMID:30036686 | |
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