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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631344
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abca1
Name: ATP binding cassette subfamily A member 1
Acc ID: CHEBI:79995
Term: GW 3965
Definition: A diarylmethane that has formula C33H31ClF3NO3.
Chemical ID: MESH:C473027
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abca1increases degradationISOABCA1 (Homo sapiens)18936994RGDGW3965 increases degradation of cell surface resident ABCA1 protein in HepG2 cells 
Abca1increases expressionEXP 6480464CTDGW 3965 results in increased expression of ABCA1 mRNAPMID:28315714
Abca1increases expressionISOAbca1 (Mus musculus)6480464CTDGW 3965 results in increased expression of ABCA1 mRNAPMID:15633131 PMID:27598782
Abca1increases expressionISOABCA1 (Homo sapiens)6480464CTDGW 3965 results in increased expression of ABCA1 mRNA; GW 3965 results in increased expression of ABCA1 proteinPMID:16107141 PMID:17449538 PMID:18841091 PMID:19426978 PMID:23732298 PMID:27598782
Abca1multiple interactionsISOAbca1 (Mus musculus)6480464CTDNR1H2 protein affects the reaction [GW 3965 results in increased expression of ABCA1 mRNA]; NR1H3 protein affects the reaction [GW 3965 results in increased expression of ABCA1 mRNA]PMID:27598782
Abca1multiple interactionsISOABCA1 (Homo sapiens)6480464CTDGW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]; NR1H3 mutant form inhibits the reaction [GW 3965 results in increased expression of ABCA1 mRNA]PMID:23732298 PMID:30036686
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