Frem1 (Fras1 related extracellular matrix 1) - Rat Genome Database

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Gene: Frem1 (Fras1 related extracellular matrix 1) Rattus norvegicus
Analyze
Symbol: Frem1
Name: Fras1 related extracellular matrix 1
RGD ID: 1306981
Description: Predicted to be involved in craniofacial suture morphogenesis. Predicted to act upstream of or within cell-matrix adhesion. Predicted to be located in basement membrane. Predicted to be active in collagen-containing extracellular matrix. Biomarker of congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human FREM1 (FRAS1 related extracellular matrix 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: FRAS1-related extracellular matrix protein 1; LOC298185; RGD1306981; similar to bM410K19.2.2 (novel protein similar to extra-cellular matrix proteins and chondroitin sulfate proteoglycans, variant 2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2597,321,275 - 97,469,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl597,322,538 - 97,469,543 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx599,702,040 - 99,826,307 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05101,500,424 - 101,619,223 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05101,512,896 - 101,637,169 (-)NCBIRnor_WKY
Rnor_6.05101,018,009 - 101,166,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5101,020,448 - 101,166,651 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05105,039,872 - 105,188,547 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45101,773,603 - 101,891,178 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15101,778,828 - 102,082,081 (-)NCBI
Celera595,876,081 - 95,993,467 (-)NCBICelera
Cytogenetic Map5q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice. Beck TF, etal., Hum Mol Genet. 2013 Mar 1;22(5):1026-38. doi: 10.1093/hmg/dds507. Epub 2012 Dec 5.
2. Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3. Beck TF, etal., PLoS One. 2013;8(3):e58830. doi: 10.1371/journal.pone.0058830. Epub 2013 Mar 11.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Manitoba-oculo-tricho-anal (MOTA) syndrome is caused by mutations in FREM1. Slavotinek AM, etal., J Med Genet. 2011 Jun;48(6):375-82. doi: 10.1136/jmg.2011.089631. Epub 2011 Apr 20.
10. Gene Expression of FRAS1-Related Extracellular Matrix 1 Is Decreased in Nitrofen-Induced Congenital Diaphragmatic Hernia. Takahashi T, etal., Eur J Pediatr Surg. 2016 Feb;26(1):81-5. doi: 10.1055/s-0035-1559884. Epub 2015 Sep 18.
11. Heterozygous mutations of FREM1 are associated with an increased risk of isolated metopic craniosynostosis in humans and mice. Vissers LE, etal., PLoS Genet. 2011 Sep;7(9):e1002278. doi: 10.1371/journal.pgen.1002278. Epub 2011 Sep 8.
Additional References at PubMed
PMID:15345741   PMID:16880404   PMID:17251066   PMID:17596926   PMID:18757743  


Genomics

Comparative Map Data
Frem1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2597,321,275 - 97,469,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl597,322,538 - 97,469,543 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx599,702,040 - 99,826,307 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05101,500,424 - 101,619,223 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05101,512,896 - 101,637,169 (-)NCBIRnor_WKY
Rnor_6.05101,018,009 - 101,166,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5101,020,448 - 101,166,651 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05105,039,872 - 105,188,547 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45101,773,603 - 101,891,178 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15101,778,828 - 102,082,081 (-)NCBI
Celera595,876,081 - 95,993,467 (-)NCBICelera
Cytogenetic Map5q31NCBI
FREM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38914,737,152 - 14,910,995 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl914,737,152 - 14,910,995 (-)EnsemblGRCh38hg38GRCh38
GRCh37914,737,150 - 14,910,993 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36914,727,150 - 14,900,234 (-)NCBINCBI36Build 36hg18NCBI36
Build 34914,727,154 - 14,900,993NCBI
Celera914,668,102 - 14,844,502 (-)NCBICelera
Cytogenetic Map9p22.3NCBI
HuRef914,697,961 - 14,874,294 (-)NCBIHuRef
CHM1_1914,734,708 - 14,910,773 (-)NCBICHM1_1
T2T-CHM13v2.0914,746,865 - 14,920,791 (-)NCBIT2T-CHM13v2.0
Frem1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39482,816,157 - 82,970,743 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl482,816,157 - 82,970,576 (-)EnsemblGRCm39 Ensembl
GRCm38482,897,920 - 83,052,506 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl482,897,920 - 83,052,339 (-)EnsemblGRCm38mm10GRCm38
MGSCv37482,543,831 - 82,667,006 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36482,369,158 - 82,492,333 (-)NCBIMGSCv36mm8
Celera481,433,285 - 81,556,740 (-)NCBICelera
Cytogenetic Map4C3NCBI
Frem1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543417,753,925 - 17,901,407 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543417,754,002 - 17,901,416 (-)NCBIChiLan1.0ChiLan1.0
FREM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1915,081,208 - 15,254,581 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl915,081,208 - 15,253,399 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0914,567,781 - 14,748,474 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FREM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11135,174,390 - 35,338,983 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1135,176,934 - 35,310,335 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1133,817,394 - 33,982,281 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01136,078,485 - 36,243,845 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1136,079,144 - 36,351,936 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11134,782,597 - 34,947,751 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01134,574,867 - 34,739,782 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01135,231,916 - 35,396,660 (-)NCBIUU_Cfam_GSD_1.0
Frem1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947149,898,217 - 150,055,395 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365398,351,159 - 8,508,069 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365398,338,624 - 8,508,031 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FREM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1207,641,011 - 207,801,952 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11207,535,811 - 207,804,525 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21231,366,665 - 231,496,855 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FREM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11264,681,181 - 64,849,266 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603852,885,675 - 53,067,141 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Frem1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473618,989,320 - 19,132,416 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473618,975,104 - 19,346,159 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Frem1
777 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:146
Count of miRNA genes:119
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000058615
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat

Markers in Region
D5Got291  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2597,331,351 - 97,331,445 (+)MAPPERmRatBN7.2
Rnor_6.05101,028,082 - 101,028,175NCBIRnor6.0
Rnor_5.05105,049,945 - 105,050,038UniSTSRnor5.0
RGSC_v3.45101,781,241 - 101,781,334UniSTSRGSC3.4
Celera595,883,719 - 95,883,812UniSTS
Cytogenetic Map5q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 22 7 7 7 4 28 24 8
Low 20 43 27 18 27 8 9 70 7 14 3 8
Below cutoff 3 1 7 7 1 7 2 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000058615   ⟹   ENSRNOP00000055412
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5101,020,448 - 101,138,427 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078862   ⟹   ENSRNOP00000075592
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl597,322,538 - 97,469,543 (-)Ensembl
Rnor_6.0 Ensembl5101,023,247 - 101,166,651 (-)Ensembl
RefSeq Acc Id: NM_001191757   ⟹   NP_001178686
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2597,323,714 - 97,441,295 (-)NCBI
Rnor_6.05101,020,448 - 101,138,427 (-)NCBI
Rnor_5.05105,039,872 - 105,188,547 (-)NCBI
Celera595,876,081 - 95,993,467 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238349   ⟹   XP_006238411
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2597,321,275 - 97,469,523 (-)NCBI
Rnor_6.05101,018,009 - 101,166,793 (-)NCBI
Rnor_5.05105,039,872 - 105,188,547 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109508   ⟹   XP_038965436
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2597,378,319 - 97,469,523 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001178686 (Get FASTA)   NCBI Sequence Viewer  
  NP_001398464 (Get FASTA)   NCBI Sequence Viewer  
  XP_006238411 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965436 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001178686   ⟸   NM_001191757
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_006238411   ⟸   XM_006238349
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000055412   ⟸   ENSRNOT00000058615
RefSeq Acc Id: ENSRNOP00000075592   ⟸   ENSRNOT00000078862
RefSeq Acc Id: XP_038965436   ⟸   XM_039109508
- Peptide Label: isoform X2
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZC92-F1-model_v2 AlphaFold D3ZC92 1-2209 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306981 AgrOrtholog
BioCyc Gene G2FUF-40888 BioCyc
Ensembl Genes ENSRNOG00000022309 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000075592.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078862.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2030 UniProtKB/TrEMBL
  3.10.100.10 UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin_fold UniProtKB/TrEMBL
  CalX-like_sf UniProtKB/TrEMBL
  Calx_beta UniProtKB/TrEMBL
  CSPG_rpt UniProtKB/TrEMBL
  FRAS1-rel_N UniProtKB/TrEMBL
NCBI Gene 298185 ENTREZGENE
PANTHER MATRIX PROTEIN, PUTATIVE-RELATED UniProtKB/TrEMBL
  PTHR45739:SF7 UniProtKB/TrEMBL
Pfam Cadherin_3 UniProtKB/TrEMBL
  Calx-beta UniProtKB/TrEMBL
  Frem_N UniProtKB/TrEMBL
  Lectin_C UniProtKB/TrEMBL
PhenoGen Frem1 PhenoGen
PROSITE C_TYPE_LECTIN_2 UniProtKB/TrEMBL
  CSPG UniProtKB/TrEMBL
SMART CLECT UniProtKB/TrEMBL
Superfamily-SCOP C-type_lectin_fold UniProtKB/TrEMBL
  SSF141072 UniProtKB/TrEMBL
UniProt A0A0G2KB00_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Frem1  Fras1 related extracellular matrix 1  RGD1306981_predicted  similar to bM410K19.2.2 (novel protein similar to extra-cellular matrix proteins and chondroitin sulfate proteoglycans, variant 2) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1306981_predicted  similar to bM410K19.2.2 (novel protein similar to extra-cellular matrix proteins and chondroitin sulfate proteoglycans, variant 2) (predicted)  LOC298185_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC298185_predicted  similar to bM410K19.2.2 (novel protein similar to extra-cellular matrix proteins and chondroitin sulfate proteoglycans, variant 2) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL