Gabbr2 (gamma-aminobutyric acid type B receptor subunit 2) - Rat Genome Database

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Gene: Gabbr2 (gamma-aminobutyric acid type B receptor subunit 2) Rattus norvegicus
Analyze
Symbol: Gabbr2
Name: gamma-aminobutyric acid type B receptor subunit 2
RGD ID: 619864
Description: Enables G protein-coupled GABA receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; gamma-aminobutyric acid signaling pathway; and neuron-glial cell signaling. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Human ortholog(s) of this gene implicated in alcohol use disorder; developmental and epileptic encephalopathy 59; and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2); INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G protein-coupled receptor 51; G-protein coupled receptor 51; GABA-B R2 receptor; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; gamma-aminobutyric acid (GABA) B receptor 2; gb2; Gpr51
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8565,743,073 - 66,083,695 (-)NCBIGRCr8
mRatBN7.2560,947,517 - 61,288,104 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl560,947,526 - 61,288,104 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx562,918,639 - 63,259,788 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0564,738,005 - 65,079,085 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0564,707,402 - 65,048,578 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0562,276,100 - 62,621,737 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl562,276,100 - 62,621,737 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0566,802,348 - 67,142,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4563,241,397 - 63,611,907 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1563,241,575 - 63,612,086 (-)NCBI
Celera559,508,888 - 59,731,378 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-(3-chlorophenyl)piperazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3-diphenyl-N-(1-phenylethyl)-1-propanamine  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
baclofen  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
butanal  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
D-glucose  (ISO)
DDT  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dichloroacetic acid  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
gabapentin  (ISO)
gamma-aminobutyric acid  (ISO)
gentamycin  (EXP)
glucose  (ISO)
graphite  (EXP)
hexachlorophene  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ketoconazole  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mercury dichloride  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
Methylone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
nitrofen  (EXP)
ochratoxin A  (EXP)
paracetamol  (EXP,ISO)
parathion  (EXP)
parathion-methyl  (EXP)
PCB138  (EXP)
pentanal  (ISO)
permethrin  (EXP)
picrotoxin  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
quercitrin  (ISO)
raloxifene  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
tipifarnib  (EXP)
trichloroethene  (EXP)
trifluoperazine  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Alcohol use disorder and GABAB receptor gene polymorphisms in an Italian sample: haplotype frequencies, linkage disequilibrium and association studies. Caputo F, etal., Ann Hum Biol. 2017 Jun;44(4):384-388. doi: 10.1080/03014460.2017.1287307. Epub 2017 Feb 14.
2. Constitutive expression of functional GABA(B) receptors in mIL-tsA58 cells requires both GABA(B(1)) and GABA(B(2)) genes. Chronwall BM, etal., J Neurochem 2001 Jun;77(5):1237-47.
3. Distribution of the GABA(B) receptor subunit gb2 in rat CNS. Clark JA, etal., Brain Res 2000 Mar 31;860(1-2):41-52.
4. The oligomeric state sets GABA(B) receptor signalling efficacy. Comps-Agrar L, etal., EMBO J. 2011 May 6;30(12):2336-49. doi: 10.1038/emboj.2011.143.
5. GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats. Enoch MA, etal., PLoS One. 2012;7(1):e29369. doi: 10.1371/journal.pone.0029369. Epub 2012 Jan 13.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Astrocyte-mediated potentiation of inhibitory synaptic transmission. Kang J, etal., Nat Neurosci. 1998 Dec;1(8):683-92. doi: 10.1038/3684.
9. GABA(B)-receptor subtypes assemble into functional heteromeric complexes. Kaupmann K, etal., Nature 1998 Dec 17;396(6712):683-7.
10. Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. Kitano J, etal., J Neurosci 2002 Feb 15;22(4):1280-9.
11. Subcellular localization of metabotropic GABA(B) receptor subunits GABA(B1a/b) and GABA(B2) in the rat hippocampus. Kulik A, etal., J Neurosci. 2003 Dec 3;23(35):11026-35.
12. Role of heteromer formation in GABAB receptor function. Kuner R, etal., Science 1999 Jan 1;283(5398):74-7.
13. Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African-American populations. Li MD, etal., PLoS One. 2009 Sep 18;4(9):e7055. doi: 10.1371/journal.pone.0007055.
14. GABAB receptors in Schwann cells influence proliferation and myelin protein expression. Magnaghi V, etal., Eur J Neurosci. 2004 May;19(10):2641-9.
15. Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1. Martin SC, etal., Mol Cell Neurosci 1999 Mar;13(3):180-91.
16. Trans-activation between 7TM domains: implication in heterodimeric GABAB receptor activation. Monnier C, etal., EMBO J. 2011 Jan 5;30(1):32-42. doi: 10.1038/emboj.2010.270. Epub 2010 Nov 9.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Direct interaction and functional coupling between voltage-gated CaV1.3 Ca2+ channel and GABAB receptor subunit 2. Park HW, etal., FEBS Lett. 2010 Aug 4;584(15):3317-22. doi: 10.1016/j.febslet.2010.07.014. Epub 2010 Jul 11.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration. Rives ML, etal., EMBO J. 2009 Aug 5;28(15):2195-208. doi: 10.1038/emboj.2009.177. Epub 2009 Jul 9.
Additional References at PubMed
PMID:9872315   PMID:9872316   PMID:10924501   PMID:12948615   PMID:14503843   PMID:14967916   PMID:15013631   PMID:15304491   PMID:17044980   PMID:18338268   PMID:19328818   PMID:20016095  
PMID:20643948   PMID:21290407   PMID:21371537   PMID:21618582   PMID:21724853   PMID:22120979   PMID:22169202   PMID:22871113   PMID:23653212   PMID:23829864   PMID:24020808   PMID:24114844  
PMID:24425870   PMID:24482233   PMID:27515806   PMID:29476059   PMID:34680170  


Genomics

Comparative Map Data
Gabbr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8565,743,073 - 66,083,695 (-)NCBIGRCr8
mRatBN7.2560,947,517 - 61,288,104 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl560,947,526 - 61,288,104 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx562,918,639 - 63,259,788 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0564,738,005 - 65,079,085 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0564,707,402 - 65,048,578 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0562,276,100 - 62,621,737 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl562,276,100 - 62,621,737 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0566,802,348 - 67,142,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4563,241,397 - 63,611,907 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1563,241,575 - 63,612,086 (-)NCBI
Celera559,508,888 - 59,731,378 (-)NCBICelera
Cytogenetic Map5q22NCBI
GABBR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38998,288,109 - 98,708,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl998,288,109 - 98,708,935 (-)EnsemblGRCh38hg38GRCh38
GRCh379101,050,391 - 101,471,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369100,090,187 - 100,511,300 (-)NCBINCBI36Build 36hg18NCBI36
Build 34998,129,920 - 98,551,034NCBI
Celera971,564,671 - 71,985,374 (-)NCBICelera
Cytogenetic Map9q22.33NCBI
HuRef970,650,446 - 70,940,183 (-)NCBIHuRef
CHM1_19101,196,866 - 101,617,897 (-)NCBICHM1_1
T2T-CHM13v2.09110,460,053 - 110,880,595 (-)NCBIT2T-CHM13v2.0
Gabbr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39446,662,318 - 46,991,714 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl446,662,305 - 46,991,873 (-)EnsemblGRCm39 Ensembl
GRCm38446,662,318 - 46,991,714 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl446,662,305 - 46,991,873 (-)EnsemblGRCm38mm10GRCm38
MGSCv37446,676,770 - 47,004,586 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36446,684,998 - 47,012,814 (-)NCBIMGSCv36mm8
Celera446,675,526 - 47,003,236 (-)NCBICelera
Cytogenetic Map4B1NCBI
cM Map425.18NCBI
Gabbr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541926,872,728 - 27,239,464 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541926,872,734 - 27,241,917 (+)NCBIChiLan1.0ChiLan1.0
GABBR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21140,747,751 - 41,170,503 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1940,750,129 - 41,172,879 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0969,377,091 - 69,799,867 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1997,500,606 - 97,919,053 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl997,500,904 - 97,790,605 (-)Ensemblpanpan1.1panPan2
GABBR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11155,469,327 - 55,817,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1155,470,197 - 55,817,945 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1153,902,316 - 54,251,118 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01156,578,376 - 56,927,274 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1156,580,523 - 56,927,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11155,076,468 - 55,431,616 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01155,107,840 - 55,455,961 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01155,804,321 - 56,153,068 (-)NCBIUU_Cfam_GSD_1.0
Gabbr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947170,397,327 - 170,750,253 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365246,943,147 - 7,297,835 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365246,944,923 - 7,297,833 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABBR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,107,466 - 240,496,101 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,107,469 - 240,495,917 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21268,546,934 - 268,740,787 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GABBR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11240,719,126 - 41,135,602 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1240,719,577 - 41,135,770 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603837,753,365 - 38,173,474 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabbr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248252,233,759 - 2,610,255 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248252,233,759 - 2,608,159 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gabbr2
2209 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:961
Count of miRNA genes:328
Interacting mature miRNAs:440
Transcripts:ENSRNOT00000011573
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat

Markers in Region
D5Wox44  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2560,947,619 - 60,947,736 (+)MAPPERmRatBN7.2
Rnor_6.0562,276,194 - 62,276,310NCBIRnor6.0
Rnor_5.0566,802,442 - 66,802,558UniSTSRnor5.0
RGSC_v3.4563,241,491 - 63,241,607UniSTSRGSC3.4
Celera559,508,982 - 59,509,098UniSTS
Cytogenetic Map5q22UniSTS
BF399143  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2561,096,762 - 61,096,975 (+)MAPPERmRatBN7.2
Rnor_6.0562,426,225 - 62,426,437NCBIRnor6.0
Rnor_5.0566,951,015 - 66,951,227UniSTSRnor5.0
RGSC_v3.4563,417,805 - 63,418,017UniSTSRGSC3.4
Celera559,654,909 - 59,655,121UniSTS
RH 3.4 Map5374.5UniSTS
Cytogenetic Map5q22UniSTS
RH142538  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2561,063,413 - 61,063,515 (+)MAPPERmRatBN7.2
Rnor_6.0562,392,207 - 62,392,308NCBIRnor6.0
Rnor_5.0566,917,473 - 66,917,574UniSTSRnor5.0
RGSC_v3.4563,368,880 - 63,368,981UniSTSRGSC3.4
RH 3.4 Map5376.5UniSTS
Cytogenetic Map5q22UniSTS
AU049025  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2561,271,032 - 61,271,303 (+)MAPPERmRatBN7.2
Rnor_6.0562,604,668 - 62,604,938NCBIRnor6.0
Rnor_5.0567,125,134 - 67,125,404UniSTSRnor5.0
RGSC_v3.4563,594,838 - 63,595,108UniSTSRGSC3.4
Celera559,828,917 - 59,829,181UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 10 49 113 73 72 41 25 41 6 198 96 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000011573   ⟹   ENSRNOP00000011573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl560,947,526 - 61,288,104 (-)Ensembl
Rnor_6.0 Ensembl562,276,100 - 62,621,737 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103037   ⟹   ENSRNOP00000086284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl560,947,526 - 61,288,104 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105909   ⟹   ENSRNOP00000085600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl560,952,001 - 61,288,104 (-)Ensembl
RefSeq Acc Id: NM_031802   ⟹   NP_113990
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8565,743,073 - 66,083,695 (-)NCBI
mRatBN7.2560,947,526 - 61,288,104 (-)NCBI
Rnor_6.0562,276,100 - 62,621,737 (-)NCBI
Rnor_5.0566,802,348 - 67,142,203 (-)NCBI
RGSC_v3.4563,241,397 - 63,611,907 (-)RGD
Celera559,508,888 - 59,731,378 (-)NCBI
Sequence:
RefSeq Acc Id: NP_113990   ⟸   NM_031802
- Peptide Label: precursor
- UniProtKB: Q9QWU2 (UniProtKB/Swiss-Prot),   Q9JK36 (UniProtKB/Swiss-Prot),   O88871 (UniProtKB/Swiss-Prot),   A0A0A0MXV8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011573   ⟸   ENSRNOT00000011573
Ensembl Acc Id: ENSRNOP00000085600   ⟸   ENSRNOT00000105909
Ensembl Acc Id: ENSRNOP00000086284   ⟸   ENSRNOT00000103037
Protein Domains
G-protein coupled receptors family 3 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88871-F1-model_v2 AlphaFold O88871 1-940 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619864 AgrOrtholog
BIND 144399
BioCyc Gene G2FUF-41393 BioCyc
Ensembl Genes ENSRNOG00000008431 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011573.5 UniProtKB/TrEMBL
  ENSRNOT00000103037.1 UniProtKB/TrEMBL
  ENSRNOT00000105909.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GBR2_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR3_GABA-B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_GABA_rcpt_B2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83633 UniProtKB/Swiss-Prot
NCBI Gene 83633 ENTREZGENE
PANTHER GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10519 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GBR2_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gabbr2 PhenoGen
PRINTS GABAB2RECPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABABRECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRMGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008431 RatGTEx
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MXV8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZK6_RAT UniProtKB/TrEMBL
  A0A8I6A7H8_RAT UniProtKB/TrEMBL
  A6IJD0_RAT UniProtKB/TrEMBL
  GABR2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9JK36 ENTREZGENE
  Q9QWU2 ENTREZGENE
UniProt Secondary Q9JK36 UniProtKB/Swiss-Prot
  Q9QWU2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Gabbr2  gamma-aminobutyric acid type B receptor subunit 2  Gabbr2  gamma-aminobutyric acid (GABA) B receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gabbr2  gamma-aminobutyric acid (GABA) B receptor 2  Gpr51  G protein-coupled receptor 51  Symbol and Name updated 1299863 APPROVED
2005-01-20 Gpr51  G protein-coupled receptor 51      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Gpr51  G protein-coupled receptor 51      Symbol and Name status set to provisional 70820 PROVISIONAL