(+)-pilocarpine decreases expression EXP 6480464 Pilocarpine results in decreased expression of CDKN2A mRNA CTD PMID:17971868 (+)-pilocarpine increases expression EXP 6480464 Pilocarpine results in increased expression of CDKN2A mRNA CTD PMID:17971868 (-)-epigallocatechin 3-gallate decreases metabolic processing ISO CDKN2A (Homo sapiens) 6480464 epigallocatechin gallate results in decreased metabolism of CDKN2A promoter CTD PMID:16037419 (-)-epigallocatechin 3-gallate increases expression ISO CDKN2A (Homo sapiens) 6480464 epigallocatechin gallate results in increased expression of CDKN2A mRNA and epigallocatechin gallate results in increased expression of CDKN2A protein CTD PMID:14633667 and PMID:17683969 (-)-epigallocatechin 3-gallate decreases methylation ISO CDKN2A (Homo sapiens) 6480464 epigallocatechin gallate results in decreased methylation of CDKN2A gene and epigallocatechin gallate results in decreased methylation of CDKN2A promoter CTD PMID:14633667 and PMID:17683969 (S)-naringenin multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [naringenin co-treated with bisphenol A] results in increased expression of CDKN2A mRNA CTD PMID:36235125 (S)-nicotine multiple interactions ISO Cdkn2a (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA] more ... CTD PMID:32473187 (S)-nicotine increases expression ISO Cdkn2a (Mus musculus) 6480464 Nicotine results in increased expression of CDKN2A mRNA and Nicotine results in increased expression of CDKN2A protein CTD PMID:32473187 (Z)-3-butylidenephthalide increases expression ISO CDKN2A (Homo sapiens) 6480464 butylidenephthalide results in increased expression of CDKN2A protein CTD PMID:16987298 and PMID:23770345 1,2-dichloroethane decreases expression ISO Cdkn2a (Mus musculus) 6480464 ethylene dichloride results in decreased expression of CDKN2A mRNA CTD PMID:28960355 1,2-dimethylhydrazine multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [NFE2L2 protein affects the susceptibility to 1 more ... CTD PMID:26388957 1,2-dimethylhydrazine increases expression ISO Cdkn2a (Mus musculus) 6480464 1 more ... CTD PMID:26388957 17beta-estradiol decreases expression ISO CDKN2A (Homo sapiens) 6480464 Estradiol results in decreased expression of CDKN2A mRNA CTD PMID:19027819 and PMID:23094148 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expression ISO CDKN2A (Homo sapiens) 6480464 Metribolone results in increased expression of CDKN2A protein CTD PMID:23272087 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Cdkn2a (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of CDKN2A mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO CDKN2A (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of CDKN2A mRNA and Tetrachlorodibenzodioxin results in decreased expression of CDKN2A protein CTD PMID:17070097 and PMID:17257637 2,3,7,8-tetrachlorodibenzodioxine increases methylation EXP 6480464 Tetrachlorodibenzodioxin results in increased methylation of CDKN2A promoter alternative form CTD PMID:26431795 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of CDKN2A mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of CDKN2A mRNA and [Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of CDKN2A protein CTD PMID:21167638 2,4-dinitrotoluene affects expression EXP 6480464 2 and 4-dinitrotoluene affects the expression of CDKN2A mRNA CTD PMID:21346803 2-acetamidofluorene multiple interactions EXP 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDKN2A mRNA and [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDKN2A protein CTD PMID:16317707 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of CDKN2A mRNA CTD PMID:19167416 and PMID:22213190 2-acetamidofluorene increases methylation EXP 6480464 2-Acetylaminofluorene results in increased methylation of CDKN2A gene and 2-Acetylaminofluorene results in increased methylation of CDKN2A promoter CTD PMID:18204080 and PMID:20188851 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin analog results in increased expression of CDKN2A protein and alpha-Chlorohydrin results in increased expression of CDKN2A protein CTD PMID:26072098 4,4'-sulfonyldiphenol increases expression ISO Cdkn2a (Mus musculus) 6480464 bisphenol S results in increased expression of CDKN2A mRNA CTD PMID:30951980 4,4'-sulfonyldiphenol increases expression ISO CDKN2A (Homo sapiens) 6480464 bisphenol S results in increased expression of CDKN2A mRNA and bisphenol S results in increased expression of CDKN2A protein CTD PMID:36565802 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of CDKN2A mRNA and [Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of CDKN2A protein CTD PMID:21167638 4-hydroxyphenyl retinamide increases expression ISO CDKN2A (Homo sapiens) 6480464 Fenretinide results in increased expression of CDKN2A protein CTD PMID:16570282 4-phenylbutyric acid multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [4-phenylbutyric acid co-treated with decitabine] results in increased expression of CDKN2A mRNA CTD PMID:17210717 4-vinylcyclohexene dioxide increases expression ISO Cdkn2a (Mus musculus) 6480464 4-vinyl-1-cyclohexene dioxide results in increased expression of CDKN2A mRNA CTD PMID:20829426 5-aza-2'-deoxycytidine multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [4-phenylbutyric acid co-treated with Decitabine] results in increased expression of CDKN2A mRNA more ... CTD PMID:16613325 more ... 5-aza-2'-deoxycytidine decreases methylation ISO CDKN2A (Homo sapiens) 6480464 Decitabine results in decreased methylation of CDKN2A gene more ... CTD PMID:12859993 more ... 5-aza-2'-deoxycytidine increases phosphorylation ISO CDKN2A (Homo sapiens) 6480464 Decitabine results in increased phosphorylation of CDKN2A protein CTD PMID:19732952 5-aza-2'-deoxycytidine increases expression ISO Cdkn2a (Mus musculus) 6480464 Decitabine results in increased expression of CDKN2A mRNA CTD PMID:27915011 5-aza-2'-deoxycytidine decreases expression ISO CDKN2A (Homo sapiens) 6480464 Decitabine results in decreased expression of CDKN2A mRNA CTD PMID:19027819 5-aza-2'-deoxycytidine increases expression ISO CDKN2A (Homo sapiens) 6480464 Decitabine results in increased expression of CDKN2A mRNA more ... CTD PMID:12859993 more ... 5-aza-2'-deoxycytidine affects expression ISO CDKN2A (Homo sapiens) 6480464 Decitabine affects the expression of CDKN2A mRNA CTD PMID:17194187 5-aza-2'-deoxycytidine affects methylation ISO CDKN2A (Homo sapiens) 6480464 [Decitabine affects the methylation of H3-4 protein] which affects the methylation of CDKN2A gene and Decitabine affects the methylation of CDKN2A promoter CTD PMID:17571247 more ... 5-azacytidine multiple interactions EXP 6480464 [Azacitidine co-treated with entinostat] results in decreased methylation of CDKN2A gene and [Azacitidine co-treated with entinostat] results in increased expression of CDKN2A mRNA CTD PMID:21224363 5-azacytidine multiple interactions ISO Cdkn2a (Mus musculus) 6480464 Azacitidine inhibits the reaction [Particulate Matter results in increased methylation of CDKN2A promoter] CTD PMID:22355787 5-azacytidine multiple interactions ISO CDKN2A (Homo sapiens) 6480464 Hydroxyurea inhibits the reaction [Azacitidine results in decreased methylation of CDKN2A gene] CTD PMID:17686055 5-azacytidine decreases methylation ISO CDKN2A (Homo sapiens) 6480464 Azacitidine results in decreased methylation of CDKN2A gene CTD PMID:17686055 5-azacytidine affects methylation ISO CDKN2A (Homo sapiens) 6480464 Azacitidine affects the methylation of CDKN2A gene CTD PMID:18443271 5-azacytidine increases expression EXP 6480464 Azacitidine results in increased expression of CDKN2A mRNA CTD PMID:21224363 5-azacytidine decreases methylation EXP 6480464 Azacitidine results in decreased methylation of CDKN2A gene CTD PMID:21224363 5-fluorouracil decreases expression ISO CDKN2A (Homo sapiens) 6480464 Fluorouracil results in decreased expression of CDKN2A protein CTD PMID:17982676 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of CDKN2A mRNA CTD PMID:22504374 more ... 7,12-dimethyltetraphene increases response to substance ISO Cdkn2a (Mus musculus) 6480464 CDKN2A gene polymorphism results in increased susceptibility to 9 more ... CTD PMID:11544531 7,12-dimethyltetraphene decreases expression ISO Cdkn2a (Mus musculus) 6480464 9 more ... CTD PMID:24792773 7,12-dimethyltetraphene multiple interactions ISO Cdkn2a (Mus musculus) 6480464 Butyric Acid inhibits the reaction [9 more ... CTD PMID:24792773 7,12-dimethyltetraphene increases methylation ISO Cdkn2a (Mus musculus) 6480464 9 more ... CTD PMID:24792773 aflatoxin B1 decreases methylation ISO CDKN2A (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of CDKN2A gene CTD PMID:27153756 aflatoxin B1 increases expression ISO CDKN2A (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of CDKN2A mRNA CTD PMID:28965971 agomelatine multiple interactions EXP 6480464 agomelatine inhibits the reaction [Galactose results in increased expression of CDKN2A protein] CTD PMID:34673010 aldehydo-D-glucose multiple interactions ISO CDKN2A (Homo sapiens) 6480464 SIRT3 protein inhibits the reaction [Glucose results in increased expression of CDKN2A protein alternative form] CTD PMID:23494737 aldehydo-D-glucose increases expression ISO CDKN2A (Homo sapiens) 6480464 Glucose results in increased expression of CDKN2A protein alternative form CTD PMID:23494737 all-trans-retinoic acid decreases expression ISO CDKN2A (Homo sapiens) 6480464 Tretinoin results in decreased expression of CDKN2A mRNA CTD PMID:16494909 all-trans-retinoic acid increases expression ISO CDKN2A (Homo sapiens) 6480464 Tretinoin results in increased expression of CDKN2A mRNA CTD PMID:17138961 alpha-D-galactose multiple interactions ISO Cdkn2a (Mus musculus) 6480464 (1E more ... CTD PMID:36792013 alpha-D-galactose increases expression ISO Cdkn2a (Mus musculus) 6480464 Galactose results in increased expression of CDKN2A protein CTD PMID:36792013 alpha-D-galactose increases expression EXP 6480464 Galactose results in increased expression of CDKN2A protein CTD PMID:34673010 alpha-D-galactose multiple interactions EXP 6480464 agomelatine inhibits the reaction [Galactose results in increased expression of CDKN2A protein] and Melatonin inhibits the reaction [Galactose results in increased expression of CDKN2A protein] CTD PMID:34673010 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of CDKN2A protein CTD PMID:16483693 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CDKN2A mRNA CTD PMID:16483693 amosite asbestos decreases expression ISO Cdkn2a (Mus musculus) 6480464 Asbestos more ... CTD PMID:29112861 amosite asbestos increases methylation ISO Cdkn2a (Mus musculus) 6480464 Asbestos and Amosite results in increased methylation of CDKN2A exon CTD PMID:29112861 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO Cdkn2a (Mus musculus) 6480464 pyrazolanthrone inhibits the reaction [Particulate Matter results in increased methylation of CDKN2A promoter] CTD PMID:22355787 aristolochic acid A increases expression ISO CDKN2A (Homo sapiens) 6480464 aristolochic acid I results in increased expression of CDKN2A mRNA CTD PMID:33212167 arsane decreases expression ISO Cdkn2a (Mus musculus) 6480464 Arsenic results in decreased expression of CDKN2A mRNA and Arsenic results in decreased expression of CDKN2A protein CTD PMID:22843710 arsane increases expression ISO CDKN2A (Homo sapiens) 6480464 Arsenic results in increased expression of CDKN2A mRNA CTD PMID:12773770 arsane affects expression ISO CDKN2A (Homo sapiens) 6480464 Arsenic affects the expression of CDKN2A protein CTD PMID:17450239 arsane increases methylation ISO CDKN2A (Homo sapiens) 6480464 Arsenic results in increased methylation of CDKN2A gene more ... CTD PMID:16251483 more ... arsane decreases expression ISO CDKN2A (Homo sapiens) 6480464 Arsenic results in decreased expression of CDKN2A mRNA CTD PMID:23872714 arsane multiple interactions ISO Cdkn2a (Mus musculus) 6480464 BMI1 protein promotes the reaction [Arsenic results in decreased expression of CDKN2A mRNA] more ... CTD PMID:22843710 arsenic atom decreases expression ISO Cdkn2a (Mus musculus) 6480464 Arsenic results in decreased expression of CDKN2A mRNA and Arsenic results in decreased expression of CDKN2A protein CTD PMID:22843710 arsenic atom increases expression ISO CDKN2A (Homo sapiens) 6480464 Arsenic results in increased expression of CDKN2A mRNA CTD PMID:12773770 arsenic atom affects expression ISO CDKN2A (Homo sapiens) 6480464 Arsenic affects the expression of CDKN2A protein CTD PMID:17450239 arsenic atom increases methylation ISO CDKN2A (Homo sapiens) 6480464 Arsenic results in increased methylation of CDKN2A gene more ... CTD PMID:16251483 more ... arsenic atom decreases expression ISO CDKN2A (Homo sapiens) 6480464 Arsenic results in decreased expression of CDKN2A mRNA CTD PMID:23872714 arsenic atom multiple interactions ISO Cdkn2a (Mus musculus) 6480464 BMI1 protein promotes the reaction [Arsenic results in decreased expression of CDKN2A mRNA] more ... CTD PMID:22843710 arsenite(3-) increases expression ISO Cdkn2a (Mus musculus) 6480464 arsenite results in increased expression of CDKN2A mRNA CTD PMID:33010264 arsenite(3-) multiple interactions ISO CDKN2A (Homo sapiens) 6480464 arsenite promotes the reaction [G3BP1 protein binds to CDKN2A mRNA] more ... CTD PMID:21040761 and PMID:32406909 arsenite(3-) decreases methylation ISO CDKN2A (Homo sapiens) 6480464 arsenite results in decreased methylation of CDKN2A promoter CTD PMID:23974009 arsenite(3-) decreases expression ISO CDKN2A (Homo sapiens) 6480464 arsenite results in decreased expression of CDKN2A mRNA and arsenite results in decreased expression of CDKN2A protein CTD PMID:21040761 arsenite(3-) increases methylation ISO CDKN2A (Homo sapiens) 6480464 arsenite results in increased methylation of CDKN2A gene CTD PMID:21040761 arsenous acid multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [Arsenic Trioxide co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CDKN2A mRNA more ... CTD PMID:16613325 more ... arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of CDKN2A protein CTD PMID:31734849 arsenous acid increases expression ISO CDKN2A (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of CDKN2A gene more ... CTD PMID:12864950 more ... arsenous acid decreases methylation ISO CDKN2A (Homo sapiens) 6480464 Arsenic Trioxide results in decreased methylation of CDKN2A gene and Arsenic Trioxide results in decreased methylation of CDKN2A promoter CTD PMID:15191659 more ... asbestos decreases expression ISO CDKN2A (Homo sapiens) 6480464 Asbestos results in decreased expression of CDKN2A mRNA CTD PMID:22076105 asbestos increases mutagenesis ISO CDKN2A (Homo sapiens) 6480464 Asbestos results in increased mutagenesis of CDKN2A gene CTD PMID:19375815 asbestos increases methylation ISO CDKN2A (Homo sapiens) 6480464 Asbestos results in increased methylation of CDKN2A promoter CTD PMID:15911247 belinostat decreases expression ISO CDKN2A (Homo sapiens) 6480464 belinostat results in decreased expression of CDKN2A mRNA CTD PMID:19606018 benzene affects response to substance ISO CDKN2A (Homo sapiens) 6480464 CDKN2A gene polymorphism affects the susceptibility to Benzene CTD PMID:19596022 benzene decreases expression ISO CDKN2A (Homo sapiens) 6480464 Benzene results in decreased expression of CDKN2A mRNA CTD PMID:20044985 benzene multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [Benzene results in increased methylation of CDKN2A promoter] which results in decreased expression of CDKN2A mRNA and MDM2 gene polymorphism affects the reaction [CDKN2A gene polymorphism affects the susceptibility to Benzene] CTD PMID:19596022 and PMID:20044985 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of CDKN2A mRNA and Benzo(a)pyrene results in decreased expression of CDKN2A protein CTD PMID:19408242 more ... benzo[a]pyrene multiple interactions ISO CDKN2A (Homo sapiens) 6480464 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN2A mRNA] and AHR protein affects the reaction [Benzo(a)pyrene results in increased expression of CDKN2A mRNA] CTD PMID:35182551 benzo[a]pyrene increases expression ISO CDKN2A (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of CDKN2A mRNA CTD PMID:35182551 benzo[a]pyrene increases mutagenesis ISO CDKN2A (Homo sapiens) 6480464 Benzo(a)pyrene results in increased mutagenesis of CDKN2A gene CTD PMID:25435355 benzo[a]pyrene multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of CDKN2A mRNA and Benzo(a)pyrene affects the reaction [sodium bichromate results in decreased expression of CDKN2A mRNA] CTD PMID:22613061 and PMID:25820237 benzo[a]pyrene multiple interactions EXP 6480464 [Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of CDKN2A mRNA more ... CTD PMID:19408242 and PMID:20064080 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of CDKN2A protein CTD PMID:19408242 benzo[b]fluoranthene decreases expression ISO Cdkn2a (Mus musculus) 6480464 benzo(b)fluoranthene results in decreased expression of CDKN2A mRNA CTD PMID:26377693 beryllium atom multiple interactions EXP 6480464 [Beryllium results in increased methylation of CDKN2A promoter] which results in decreased expression of CDKN2A mRNA CTD PMID:11872642 beryllium dihydride multiple interactions EXP 6480464 [Beryllium results in increased methylation of CDKN2A promoter] which results in decreased expression of CDKN2A mRNA CTD PMID:11872642 beryllium sulfate increases expression ISO CDKN2A (Homo sapiens) 6480464 beryllium sulfate results in increased expression of CDKN2A mRNA and beryllium sulfate results in increased expression of CDKN2A protein CTD PMID:17395767 beryllium(0) multiple interactions EXP 6480464 [Beryllium results in increased methylation of CDKN2A promoter] which results in decreased expression of CDKN2A mRNA CTD PMID:11872642 bis(2-chloroethyl) sulfide increases expression ISO CDKN2A (Homo sapiens) 6480464 Mustard Gas results in increased expression of CDKN2A mRNA and Mustard Gas results in increased expression of CDKN2A protein CTD PMID:33491125 bis(2-ethylhexyl) phthalate multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in increased expression of CDKN2A mRNA CTD PMID:28013214 bis(2-ethylhexyl) phthalate affects expression ISO Cdkn2a (Mus musculus) 6480464 Diethylhexyl Phthalate affects the expression of CDKN2A mRNA CTD PMID:31211961 bis(2-ethylhexyl) phthalate increases expression ISO CDKN2A (Homo sapiens) 6480464 Diethylhexyl Phthalate results in increased expression of CDKN2A mRNA CTD PMID:31163220 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of CDKN2A mRNA CTD PMID:25181051 bisphenol A multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [bisphenol A co-treated with Quercetin metabolite] results in decreased expression of CDKN2A mRNA and [naringenin co-treated with bisphenol A] results in increased expression of CDKN2A mRNA CTD PMID:36235125 and PMID:36982678 bisphenol A decreases expression ISO CDKN2A (Homo sapiens) 6480464 bisphenol A results in decreased expression of CDKN2A mRNA CTD PMID:31610501 and PMID:36982678 bisphenol A increases expression ISO Cdkn2a (Mus musculus) 6480464 bisphenol A results in increased expression of CDKN2A mRNA CTD PMID:30951980 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of CDKN2A gene CTD PMID:28505145 bisphenol A increases methylation ISO CDKN2A (Homo sapiens) 6480464 bisphenol A results in increased methylation of CDKN2A gene and bisphenol A results in increased methylation of CDKN2A promoter CTD PMID:22258036 and PMID:31610501 bisphenol A increases expression ISO CDKN2A (Homo sapiens) 6480464 bisphenol A results in increased expression of CDKN2A protein CTD PMID:22258036 bisphenol F increases expression ISO Cdkn2a (Mus musculus) 6480464 bisphenol F results in increased expression of CDKN2A mRNA CTD PMID:30951980 BMS-754807 decreases response to substance ISO CDKN2A (Homo sapiens) 6480464 CDKN2A gene mutant form results in decreased susceptibility to BMS 754807 CTD PMID:24986516 busulfan increases expression ISO Cdkn2a (Mus musculus) 6480464 Busulfan results in increased expression of CDKN2A mRNA CTD PMID:14500376 Butylbenzyl phthalate multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in increased expression of CDKN2A mRNA CTD PMID:28013214 Butylbenzyl phthalate increases methylation ISO CDKN2A (Homo sapiens) 6480464 butylbenzyl phthalate results in increased methylation of CDKN2A promoter CTD PMID:35487445 Butylbenzyl phthalate decreases expression ISO CDKN2A (Homo sapiens) 6480464 butylbenzyl phthalate results in decreased expression of CDKN2A mRNA CTD PMID:35487445 butyric acid multiple interactions ISO Cdkn2a (Mus musculus) 6480464 Butyric Acid inhibits the reaction [9 more ... CTD PMID:24792773 C60 fullerene increases expression ISO CDKN2A (Homo sapiens) 6480464 fullerene C60 analog results in increased expression of CDKN2A protein CTD PMID:20045429 cadmium atom increases methylation ISO CDKN2A (Homo sapiens) 6480464 Cadmium results in increased methylation of CDKN2A promoter CTD PMID:17938735 cadmium dichloride increases methylation ISO CDKN2A (Homo sapiens) 6480464 Cadmium Chloride results in increased methylation of CDKN2A promoter alternative form CTD PMID:25448810 cadmium dichloride multiple interactions EXP 6480464 SIRT1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CDKN2A protein] CTD PMID:37451666 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of CDKN2A protein CTD PMID:37451666 cadmium dichloride decreases expression ISO CDKN2A (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of CDKN2A mRNA alternative form and Cadmium Chloride results in decreased expression of CDKN2A protein CTD PMID:17938735 more ... cadmium dichloride multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of CDKN2A mRNA more ... CTD PMID:12634122 more ... cadmium dichloride decreases response to substance ISO CDKN2A (Homo sapiens) 6480464 CDKN2A results in decreased susceptibility to Cadmium Chloride CTD PMID:25448810 calcium dichloride multiple interactions EXP 6480464 Calcium Chloride inhibits the reaction [Azoxymethane results in decreased expression of CDKN2A mRNA] and Calcium Chloride inhibits the reaction [Azoxymethane results in decreased expression of CDKN2A protein] CTD PMID:12189186 cannabidiol increases expression ISO Cdkn2a (Mus musculus) 6480464 Cannabidiol results in increased expression of CDKN2A mRNA CTD PMID:21542829 cannabidiol increases expression ISO CDKN2A (Homo sapiens) 6480464 Cannabidiol results in increased expression of CDKN2A mRNA and Cannabidiol results in increased expression of CDKN2A protein CTD PMID:36519830 cannabidiol multiple interactions ISO CDKN2A (Homo sapiens) 6480464 Cannabidiol promotes the reaction [[Oxygen co-treated with Ozone] results in increased expression of CDKN2A mRNA] CTD PMID:32992648 cannabidiol decreases expression EXP 6480464 Cannabidiol results in decreased expression of CDKN2A mRNA CTD PMID:32553926 capecitabine decreases expression ISO CDKN2A (Homo sapiens) 6480464 Capecitabine results in decreased expression of CDKN2A protein CTD PMID:17904787 capsaicin increases expression ISO CDKN2A (Homo sapiens) 6480464 Capsaicin results in increased expression of CDKN2A mRNA CTD PMID:18533110 carbon nanotube decreases expression ISO Cdkn2a (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 and PMID:29112861 carbon nanotube increases methylation ISO Cdkn2a (Mus musculus) 6480464 Nanotubes and Carbon results in increased methylation of CDKN2A exon CTD PMID:29112861 carbon nanotube increases mutagenesis ISO Cdkn2a (Mus musculus) 6480464 Nanotubes and Carbon results in increased mutagenesis of CDKN2A gene alternative form CTD PMID:29112861 carbon nanotube decreases expression ISO CDKN2A (Homo sapiens) 6480464 Nanotubes and Carbon results in decreased expression of CDKN2A mRNA CTD PMID:22076105 carbon nanotube increases expression ISO CDKN2A (Homo sapiens) 6480464 Nanotubes and Carbon results in increased expression of CDKN2A mRNA CTD PMID:15585362 and PMID:23634900 carmustine increases response to substance ISO CDKN2A (Homo sapiens) 6480464 CDKN2A protein results in increased susceptibility to Carmustine CTD PMID:16786135 carteolol increases expression ISO CDKN2A (Homo sapiens) 6480464 Carteolol results in increased expression of CDKN2A mRNA CTD PMID:37120125 casticin increases expression ISO CDKN2A (Homo sapiens) 6480464 casticin results in increased expression of CDKN2A protein CTD PMID:29098808 chloramphenicol increases expression ISO CDKN2A (Homo sapiens) 6480464 Chloramphenicol results in increased expression of CDKN2A protein CTD PMID:15905168 chloroethene affects response to substance ISO CDKN2A (Homo sapiens) 6480464 CDKN2A polymorphism affects the susceptibility to Vinyl Chloride CTD PMID:24464562 chloroquine multiple interactions ISO Cdkn2a (Mus musculus) 6480464 Chloroquine inhibits the reaction [(1E more ... CTD PMID:36792013 chromium atom affects methylation ISO CDKN2A (Homo sapiens) 6480464 Chromium affects the methylation of CDKN2A protein CTD PMID:16828922 chromium atom decreases expression ISO CDKN2A (Homo sapiens) 6480464 Chromium results in decreased expression of CDKN2A protein CTD PMID:16828922 chromium(6+) multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in increased expression of CDKN2A protein] CTD PMID:21621607 chromium(6+) increases expression ISO CDKN2A (Homo sapiens) 6480464 chromium hexavalent ion results in increased expression of CDKN2A mRNA CTD PMID:23940686 chromium(6+) multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of CDKN2A mRNA CTD PMID:25820237 chromium(6+) increases expression EXP 6480464 chromium hexavalent ion results in increased expression of CDKN2A protein CTD PMID:21621607 chymostatin multiple interactions ISO CDKN2A (Homo sapiens) 6480464 chymostatin inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 cisplatin increases expression ISO CDKN2A (Homo sapiens) 6480464 Cisplatin results in increased expression of CDKN2A mRNA and Cisplatin results in increased expression of CDKN2A protein CTD PMID:16797627 and PMID:20540955 cisplatin multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [Cisplatin co-treated with Quercetin] results in increased expression of CDKN2A mRNA and [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of CDKN2A mRNA CTD PMID:27514524 and PMID:30871063 cisplatin decreases expression ISO CDKN2A (Homo sapiens) 6480464 Cisplatin results in decreased expression of CDKN2A protein CTD PMID:16797627 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CDKN2A mRNA CTD PMID:17602206 copper atom decreases expression ISO CDKN2A (Homo sapiens) 6480464 Copper results in decreased expression of CDKN2A protein CTD PMID:16246896 copper atom multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in decreased expression of CDKN2A mRNA and [Copper results in increased activity of TP53 protein] which results in increased expression of CDKN2A mRNA CTD PMID:16391388 and PMID:30911355 copper(0) decreases expression ISO CDKN2A (Homo sapiens) 6480464 Copper results in decreased expression of CDKN2A protein CTD PMID:16246896 copper(0) multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in decreased expression of CDKN2A mRNA and [Copper results in increased activity of TP53 protein] which results in increased expression of CDKN2A mRNA CTD PMID:16391388 and PMID:30911355 copper(II) sulfate increases expression ISO CDKN2A (Homo sapiens) 6480464 Copper Sulfate results in increased expression of CDKN2A mRNA CTD PMID:19549813 cordycepin multiple interactions EXP 6480464 cordycepin inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA] CTD PMID:23690541 corticosterone decreases expression EXP 6480464 Corticosterone results in decreased expression of CDKN2A mRNA CTD PMID:15755911 crocidolite asbestos increases response to substance ISO Cdkn2a (Mus musculus) 6480464 CDKN2A gene mutant form results in increased susceptibility to Asbestos and Crocidolite CTD PMID:21526190 crocidolite asbestos decreases expression ISO CDKN2A (Homo sapiens) 6480464 Asbestos more ... CTD PMID:21570478 crocidolite asbestos multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [CDKN2A mRNA alternative form affects the susceptibility to Asbestos and Crocidolite] which affects the expression of FAF1 mRNA CTD PMID:19223589 crocidolite asbestos affects response to substance ISO Cdkn2a (Mus musculus) 6480464 CDKN2A mRNA alternative form affects the susceptibility to Asbestos and Crocidolite CTD PMID:19223589 crocidolite asbestos increases mutagenesis ISO Cdkn2a (Mus musculus) 6480464 Asbestos and Crocidolite results in increased mutagenesis of CDKN2A gene alternative form CTD PMID:19223589 crocidolite asbestos decreases expression ISO Cdkn2a (Mus musculus) 6480464 Asbestos more ... CTD PMID:19223589 curcumin decreases expression ISO CDKN2A (Homo sapiens) 6480464 Curcumin results in decreased expression of CDKN2A protein CTD PMID:17148446 curcumin increases expression ISO CDKN2A (Homo sapiens) 6480464 Curcumin results in increased expression of CDKN2A protein CTD PMID:18156803 cycloheximide increases expression ISO CDKN2A (Homo sapiens) 6480464 Cycloheximide results in increased expression of CDKN2A mRNA CTD PMID:17257637 cypermethrin increases expression ISO CDKN2A (Homo sapiens) 6480464 cypermethrin results in increased expression of CDKN2A mRNA CTD PMID:36063984 D-glucose multiple interactions ISO CDKN2A (Homo sapiens) 6480464 SIRT3 protein inhibits the reaction [Glucose results in increased expression of CDKN2A protein alternative form] CTD PMID:23494737 D-glucose increases expression ISO CDKN2A (Homo sapiens) 6480464 Glucose results in increased expression of CDKN2A protein alternative form CTD PMID:23494737 daunorubicin affects expression ISO CDKN2A (Homo sapiens) 6480464 Daunorubicin affects the expression of CDKN2A mRNA CTD PMID:12656675 DDT decreases expression EXP 6480464 DDT results in decreased expression of CDKN2A mRNA alternative form and DDT results in decreased expression of CDKN2A protein alternative form CTD PMID:25410620 DDT increases methylation EXP 6480464 DDT results in increased methylation of CDKN2A promoter alternative form CTD PMID:25410620 dehydroepiandrosterone increases expression EXP 6480464 Dehydroepiandrosterone results in increased expression of CDKN2A protein CTD PMID:16457693 Deoxycorticosterone acetate multiple interactions EXP 6480464 [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein] more ... CTD PMID:18504326 Deoxycorticosterone acetate affects localization EXP 6480464 Desoxycorticosterone Acetate affects the localization of CDKN2A protein CTD PMID:18504326 Deoxycorticosterone acetate increases expression EXP 6480464 Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA and Desoxycorticosterone Acetate results in increased expression of CDKN2A protein CTD PMID:18504326 Diacetoxyscirpenol decreases expression ISO Cdkn2a (Mus musculus) 6480464 diacetoxyscirpenol results in decreased expression of CDKN2A mRNA CTD PMID:31836554 diarsenic trioxide multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [Arsenic Trioxide co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CDKN2A mRNA more ... CTD PMID:16613325 more ... diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of CDKN2A protein CTD PMID:31734849 diarsenic trioxide decreases methylation ISO CDKN2A (Homo sapiens) 6480464 Arsenic Trioxide results in decreased methylation of CDKN2A gene and Arsenic Trioxide results in decreased methylation of CDKN2A promoter CTD PMID:15191659 more ... diarsenic trioxide increases expression ISO CDKN2A (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of CDKN2A gene more ... CTD PMID:12864950 more ... dibutyl phthalate multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in increased expression of CDKN2A mRNA CTD PMID:28013214 dibutyl phthalate increases methylation ISO CDKN2A (Homo sapiens) 6480464 Dibutyl Phthalate results in increased methylation of CDKN2A promoter CTD PMID:35487445 dibutyl phthalate decreases expression ISO CDKN2A (Homo sapiens) 6480464 Dibutyl Phthalate results in decreased expression of CDKN2A mRNA CTD PMID:35487445 dichloroacetic acid increases expression ISO Cdkn2a (Mus musculus) 6480464 Dichloroacetic Acid results in increased expression of CDKN2A mRNA CTD PMID:28962523 dichromic acid increases methylation ISO CDKN2A (Homo sapiens) 6480464 chromic acid results in increased methylation of CDKN2A gene CTD PMID:27005777 dichromic acid decreases expression ISO CDKN2A (Homo sapiens) 6480464 chromic acid results in decreased expression of CDKN2A mRNA CTD PMID:27005777 dichromium trioxide multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of CDKN2A mRNA CTD PMID:12634122 diethyl phthalate multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in increased expression of CDKN2A mRNA CTD PMID:28013214 diisobutyl phthalate multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in increased expression of CDKN2A mRNA CTD PMID:28013214 diisononyl phthalate multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in increased expression of CDKN2A mRNA CTD PMID:28013214 dimethylarsinic acid decreases expression EXP 6480464 Cacodylic Acid results in decreased expression of CDKN2A mRNA CTD PMID:16122865 dimethylarsinic acid decreases methylation ISO CDKN2A (Homo sapiens) 6480464 Cacodylic Acid results in decreased methylation of CDKN2A promoter alternative form CTD PMID:23073540 dioscin increases expression ISO CDKN2A (Homo sapiens) 6480464 dioscin results in increased expression of CDKN2A mRNA and dioscin results in increased expression of CDKN2A protein CTD PMID:33359023 dioxygen multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [Oxygen co-treated with Ozone] results in increased expression of CDKN2A mRNA and Cannabidiol promotes the reaction [[Oxygen co-treated with Ozone] results in increased expression of CDKN2A mRNA] CTD PMID:32992648 disodium selenite increases expression ISO CDKN2A (Homo sapiens) 6480464 Sodium Selenite results in increased expression of CDKN2A protein CTD PMID:25204997 diuron decreases expression ISO CDKN2A (Homo sapiens) 6480464 Diuron results in decreased expression of CDKN2A mRNA CTD PMID:35967413 dorsomorphin multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of CDKN2A mRNA more ... CTD PMID:24902966 more ... doxorubicin increases expression ISO Cdkn2a (Mus musculus) 6480464 Doxorubicin results in increased expression of CDKN2A mRNA CTD PMID:34713381 doxorubicin increases expression ISO CDKN2A (Homo sapiens) 6480464 Doxorubicin results in increased expression of CDKN2A mRNA CTD PMID:16705698 doxorubicin multiple interactions EXP 6480464 Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of CDKN2A protein] more ... CTD PMID:24902966 and PMID:33484087 entinostat multiple interactions EXP 6480464 [Azacitidine co-treated with entinostat] results in decreased methylation of CDKN2A gene and [Azacitidine co-treated with entinostat] results in increased expression of CDKN2A mRNA CTD PMID:21224363 ethanol multiple interactions ISO Cdkn2a (Mus musculus) 6480464 CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CDKN2A protein]] more ... CTD PMID:34192554 and PMID:34405320 ethanol increases expression ISO CDKN2A (Homo sapiens) 6480464 Ethanol results in increased expression of CDKN2A mRNA and Ethanol results in increased expression of CDKN2A protein CTD PMID:34192554 and PMID:34405320 ethanol multiple interactions ISO CDKN2A (Homo sapiens) 6480464 CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CDKN2A protein]] more ... CTD PMID:34192554 and PMID:34405320 ethanol increases expression ISO Cdkn2a (Mus musculus) 6480464 Ethanol results in increased expression of CDKN2A mRNA and Ethanol results in increased expression of CDKN2A protein CTD PMID:34192554 and PMID:34405320 ethylparaben increases expression ISO CDKN2A (Homo sapiens) 6480464 ethyl-p-hydroxybenzoate results in increased expression of CDKN2A mRNA CTD PMID:37690743 etoposide multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [CDKN2A gene mutant form results in increased expression of CDKN2A protein alternative form] inhibits the reaction [Etoposide results in increased expression of CDKN1A protein] and [CDKN2A gene mutant form results in increased expression of CDKN2A protein alternative form] inhibits the reaction [Etoposide results in increased expression of TRP53 protein] CTD PMID:21526190 etoposide increases expression EXP 6480464 Etoposide results in increased expression of CDKN2A mRNA CTD PMID:23690541 etoposide multiple interactions EXP 6480464 cordycepin inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA] more ... CTD PMID:23690541 farrerol increases expression ISO CDKN2A (Homo sapiens) 6480464 farrerol results in increased expression of CDKN2A mRNA and farrerol results in increased expression of CDKN2A protein CTD PMID:35833306 fenbendazole increases methylation EXP 6480464 Fenbendazole results in increased methylation of CDKN2A gene CTD PMID:22659510 fenbendazole increases expression EXP 6480464 Fenbendazole results in increased expression of CDKN2A protein CTD PMID:23411599 fenbendazole decreases expression EXP 6480464 Fenbendazole results in decreased expression of CDKN2A protein CTD PMID:22659510 ferric oxide decreases expression ISO Cdkn2a (Mus musculus) 6480464 ferric oxide analog results in decreased expression of CDKN2A mRNA CTD PMID:24525745 ferrostatin-1 multiple interactions EXP 6480464 ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CDKN2A protein] CTD PMID:33737050 fluoxetine increases expression ISO Cdkn2a (Mus musculus) 6480464 Fluoxetine results in increased expression of CDKN2A mRNA CTD PMID:21497159 folic acid affects methylation ISO Cdkn2a (Mus musculus) 6480464 Folic Acid affects the methylation of CDKN2A promoter CTD PMID:17585020 folic acid affects methylation ISO CDKN2A (Homo sapiens) 6480464 Folic Acid affects the methylation of CDKN2A promoter CTD PMID:16646054 folic acid multiple interactions ISO CDKN2A (Homo sapiens) 6480464 MTHFR gene polymorphism affects the reaction [Folic Acid affects the methylation of CDKN2A promoter] CTD PMID:16646054 folic acid affects expression ISO Cdkn2a (Mus musculus) 6480464 Folic Acid affects the expression of CDKN2A mRNA CTD PMID:17585020 fumonisin B1 increases expression ISO Cdkn2a (Mus musculus) 6480464 fumonisin B1 results in increased expression of CDKN2A mRNA CTD PMID:16221962 furan increases expression EXP 6480464 furan results in increased expression of CDKN2A mRNA CTD PMID:20562052 and PMID:22079235 galactose increases expression ISO Cdkn2a (Mus musculus) 6480464 Galactose results in increased expression of CDKN2A protein CTD PMID:36792013 galactose multiple interactions ISO Cdkn2a (Mus musculus) 6480464 (1E more ... CTD PMID:36792013 galactose multiple interactions EXP 6480464 agomelatine inhibits the reaction [Galactose results in increased expression of CDKN2A protein] and Melatonin inhibits the reaction [Galactose results in increased expression of CDKN2A protein] CTD PMID:34673010 galactose increases expression EXP 6480464 Galactose results in increased expression of CDKN2A protein CTD PMID:34673010 gamma-tocopherol decreases expression ISO CDKN2A (Homo sapiens) 6480464 gamma-Tocopherol results in decreased expression of CDKN2A protein CTD PMID:12368234 glucaric acid multiple interactions ISO Cdkn2a (Mus musculus) 6480464 Glucaric Acid inhibits the reaction [9 more ... CTD PMID:24792773 glucose multiple interactions ISO CDKN2A (Homo sapiens) 6480464 SIRT3 protein inhibits the reaction [Glucose results in increased expression of CDKN2A protein alternative form] CTD PMID:23494737 glucose increases expression ISO CDKN2A (Homo sapiens) 6480464 Glucose results in increased expression of CDKN2A protein alternative form CTD PMID:23494737 glycidol increases expression EXP 6480464 glycidol results in increased expression of CDKN2A mRNA CTD PMID:24915197 glycine betaine multiple interactions EXP 6480464 Betaine promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN2A mRNA] CTD PMID:19642983 glyphosate decreases expression ISO CDKN2A (Homo sapiens) 6480464 Glyphosate results in decreased expression of CDKN2A mRNA CTD PMID:31751608 GW 3965 increases expression ISO CDKN2A (Homo sapiens) 6480464 GW 3965 results in increased expression of CDKN2A mRNA CTD PMID:31437187 harmine decreases expression ISO CDKN2A (Homo sapiens) 6480464 Harmine results in decreased expression of CDKN2A mRNA and Harmine results in decreased expression of CDKN2A protein CTD PMID:25751815 hexachlorobenzene increases methylation EXP 6480464 Hexachlorobenzene results in increased methylation of CDKN2A promoter alternative form CTD PMID:26431795 hydralazine multiple interactions EXP 6480464 [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein] and [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] CTD PMID:18504326 hydralazine decreases methylation ISO CDKN2A (Homo sapiens) 6480464 Hydralazine results in decreased methylation of CDKN2A promoter CTD PMID:15862127 hydrochlorothiazide multiple interactions EXP 6480464 [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein] and [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] CTD PMID:18504326 hydrogen peroxide affects expression ISO CDKN2A (Homo sapiens) 6480464 Hydrogen Peroxide affects the expression of CDKN2A protein CTD PMID:21179406 hydrogen peroxide multiple interactions ISO CDKN2A (Homo sapiens) 6480464 Hydrogen Peroxide promotes the reaction [MAPT results in increased expression of CDKN2A protein] CTD PMID:28526263 hydroquinone multiple interactions ISO CDKN2A (Homo sapiens) 6480464 CDKN2A protein affects the reaction [hydroquinone results in decreased expression of BAX protein] more ... CTD PMID:33771647 and PMID:33932074 hydroquinone decreases expression ISO CDKN2A (Homo sapiens) 6480464 hydroquinone results in decreased expression of CDKN2A mRNA and hydroquinone results in decreased expression of CDKN2A protein CTD PMID:33771647 and PMID:33932074 hydroxyurea multiple interactions ISO CDKN2A (Homo sapiens) 6480464 Hydroxyurea inhibits the reaction [Azacitidine results in decreased methylation of CDKN2A gene] and Hydroxyurea inhibits the reaction [decitabine results in decreased methylation of CDKN2A gene] CTD PMID:17686055 hydroxyurea increases expression ISO CDKN2A (Homo sapiens) 6480464 Hydroxyurea results in increased expression of CDKN2A protein CTD PMID:10961388 imidacloprid affects methylation ISO Cdkn2a (Mus musculus) 6480464 imidacloprid affects the methylation of CDKN2A promoter CTD PMID:33865946 imidacloprid multiple interactions ISO Cdkn2a (Mus musculus) 6480464 LIF protein affects the reaction [imidacloprid affects the methylation of CDKN2A promoter] CTD PMID:33865946 irbesartan multiple interactions ISO Cdkn2a (Mus musculus) 6480464 Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 irinotecan affects expression ISO CDKN2A (Homo sapiens) 6480464 Irinotecan affects the expression of CDKN2A protein CTD PMID:22898888 irinotecan increases response to substance ISO CDKN2A (Homo sapiens) 6480464 CDKN2A results in increased susceptibility to Irinotecan CTD PMID:22898888 irinotecan decreases expression ISO CDKN2A (Homo sapiens) 6480464 Irinotecan results in decreased expression of CDKN2A mRNA CTD PMID:16432164 isocyanates increases expression ISO Cdkn2a (Mus musculus) 6480464 Isocyanates results in increased expression of CDKN2A protein CTD PMID:20685613 ivermectin decreases expression ISO CDKN2A (Homo sapiens) 6480464 Ivermectin results in decreased expression of CDKN2A protein CTD PMID:32959892 L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in increased expression of CDKN2A protein] CTD PMID:21621607 lead diacetate multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of CDKN2A mRNA CTD PMID:12634122 lidocaine affects expression ISO Cdkn2a (Mus musculus) 6480464 Lidocaine affects the expression of CDKN2A mRNA CTD PMID:18931217 linalool increases expression ISO CDKN2A (Homo sapiens) 6480464 linalool results in increased expression of CDKN2A mRNA CTD PMID:26703569 lithium chloride increases expression ISO CDKN2A (Homo sapiens) 6480464 Lithium Chloride results in increased expression of CDKN2A mRNA CTD PMID:23527032 losartan multiple interactions ISO CDKN2A (Homo sapiens) 6480464 Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 LY294002 multiple interactions ISO CDKN2A (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDKN2A mRNA] CTD PMID:12710931 maneb increases expression EXP 6480464 Maneb results in increased expression of CDKN2A mRNA CTD PMID:29859004 maneb multiple interactions EXP 6480464 [Maneb co-treated with Paraquat] results in increased expression of CDKN2A mRNA CTD PMID:29859004 masoprocol decreases methylation ISO CDKN2A (Homo sapiens) 6480464 Masoprocol results in decreased methylation of CDKN2A promoter CTD PMID:18164318 masoprocol increases expression ISO CDKN2A (Homo sapiens) 6480464 Masoprocol results in increased expression of CDKN2A mRNA and Masoprocol results in increased expression of CDKN2A protein CTD PMID:18164318 Mecamylamine multiple interactions ISO Cdkn2a (Mus musculus) 6480464 Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA] and Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN2A protein] CTD PMID:32473187 melatonin multiple interactions EXP 6480464 Melatonin inhibits the reaction [Galactose results in increased expression of CDKN2A protein] CTD PMID:34673010 menadione increases expression ISO CDKN2A (Homo sapiens) 6480464 Vitamin K 3 results in increased expression of CDKN2A mRNA CTD PMID:16010434 menaquinone increases expression ISO CDKN2A (Homo sapiens) 6480464 Vitamin K 2 results in increased expression of CDKN2A mRNA CTD PMID:16010434 mercury dibromide increases expression ISO CDKN2A (Homo sapiens) 6480464 mercuric bromide results in increased expression of CDKN2A mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDKN2A mRNA CTD PMID:27188386 methamphetamine increases expression ISO Cdkn2a (Mus musculus) 6480464 Methamphetamine results in increased expression of CDKN2A protein CTD PMID:36914120 methamphetamine multiple interactions EXP 6480464 GATA4 protein affects the reaction [Methamphetamine results in increased expression of CDKN2A protein] CTD PMID:36914120 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of CDKN2A protein CTD PMID:36914120 methimazole increases expression EXP 6480464 Methimazole results in increased expression of CDKN2A mRNA CTD PMID:22504374 and PMID:30047161 methoxyacetic acid increases expression ISO CDKN2A (Homo sapiens) 6480464 methoxyacetic acid results in increased expression of CDKN2A protein CTD PMID:21573189 methoxyacetic acid multiple interactions ISO CDKN2A (Homo sapiens) 6480464 withanone inhibits the reaction [methoxyacetic acid results in increased expression of CDKN2A protein] CTD PMID:21573189 methoxychlor increases expression ISO Cdkn2a (Mus musculus) 6480464 Methoxychlor results in increased expression of CDKN2A mRNA CTD PMID:20829426 methylmercury chloride decreases expression ISO Cdkn2a (Mus musculus) 6480464 methylmercuric chloride results in decreased expression of CDKN2A mRNA CTD PMID:20061341 methylmercury chloride decreases methylation EXP 6480464 methylmercuric chloride results in decreased methylation of CDKN2A promoter CTD PMID:19636072 methylseleninic acid multiple interactions ISO CDKN2A (Homo sapiens) 6480464 methylselenic acid promotes the reaction [CDKN2A protein binds to CDK4 protein binds to CCND1 protein] more ... CTD PMID:17847021 methylseleninic acid increases expression ISO CDKN2A (Homo sapiens) 6480464 methylselenic acid results in increased expression of CDKN2A protein CTD PMID:17847021 microcystin RR decreases expression ISO CDKN2A (Homo sapiens) 6480464 microcystin RR results in decreased expression of CDKN2A protein CTD PMID:19111056 microcystin-LR decreases expression ISO CDKN2A (Homo sapiens) 6480464 cyanoginosin LR results in decreased expression of CDKN2A protein CTD PMID:33474710 mono(2-ethylhexyl) phthalate multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CDKN2A mRNA CTD PMID:31884101 mono(2-ethylhexyl) phthalate multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with monobutyl phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDKN2A mRNA CTD PMID:35861251 monobenzyl phthalate multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CDKN2A mRNA CTD PMID:31884101 monobenzyl phthalate increases methylation ISO CDKN2A (Homo sapiens) 6480464 mono-benzyl phthalate results in increased methylation of CDKN2A promoter CTD PMID:35487445 monobenzyl phthalate decreases expression ISO CDKN2A (Homo sapiens) 6480464 mono-benzyl phthalate results in decreased expression of CDKN2A mRNA CTD PMID:35487445 monobenzyl phthalate multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with monobutyl phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDKN2A mRNA CTD PMID:35861251 Monobutylphthalate multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with monobutyl phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDKN2A mRNA CTD PMID:35861251 Monobutylphthalate decreases expression ISO CDKN2A (Homo sapiens) 6480464 monobutyl phthalate results in decreased expression of CDKN2A mRNA CTD PMID:35487445 Monobutylphthalate increases methylation ISO CDKN2A (Homo sapiens) 6480464 monobutyl phthalate results in increased methylation of CDKN2A promoter CTD PMID:35487445 monoethyl phthalate multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CDKN2A mRNA CTD PMID:31884101 monoethyl phthalate multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with monobutyl phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDKN2A mRNA CTD PMID:35861251 monosodium L-glutamate decreases expression EXP 6480464 Sodium Glutamate results in decreased expression of CDKN2A mRNA and Sodium Glutamate results in decreased expression of CDKN2A protein CTD PMID:28954212 monosodium L-glutamate increases expression ISO Cdkn2a (Mus musculus) 6480464 Sodium Glutamate results in increased expression of CDKN2A mRNA CTD PMID:22078008 myo-inositol hexakisphosphate multiple interactions ISO Cdkn2a (Mus musculus) 6480464 Phytic Acid inhibits the reaction [Ethylnitrosourea results in decreased expression of CDKN2A] CTD PMID:21154115 myo-inositol hexakisphosphate affects methylation ISO Cdkn2a (Mus musculus) 6480464 Phytic Acid affects the methylation of CDKN2A promoter CTD PMID:21154115 N-acetyl-L-cysteine multiple interactions ISO Cdkn2a (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CDKN2A protein] more ... CTD PMID:31551408 and PMID:32473187 N-acetyl-L-cysteine multiple interactions ISO CDKN2A (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] inhibits the reaction [DNMT1 protein binds to CDKN2A promoter]] more ... CTD PMID:31551408 and PMID:35303175 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal decreases expression ISO Cdkn2a (Mus musculus) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CDKN2A mRNA CTD PMID:20061341 N-ethyl-N-nitrosourea increases response to substance ISO Cdkn2a (Mus musculus) 6480464 CDKN2A gene mutant form results in increased susceptibility to Ethylnitrosourea CTD PMID:17943659 N-ethyl-N-nitrosourea multiple interactions ISO Cdkn2a (Mus musculus) 6480464 Phytic Acid inhibits the reaction [Ethylnitrosourea results in decreased expression of CDKN2A] CTD PMID:21154115 N-ethyl-N-nitrosourea decreases expression ISO Cdkn2a (Mus musculus) 6480464 Ethylnitrosourea results in decreased expression of CDKN2A CTD PMID:21154115 N-methyl-4-phenylpyridinium multiple interactions ISO CDKN2A (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDKN2A mRNA] CTD PMID:12710931 N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of CDKN2A protein CTD PMID:33737050 N-methyl-4-phenylpyridinium multiple interactions EXP 6480464 ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CDKN2A protein] CTD PMID:33737050 N-nitrosodiethylamine multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of CDKN2A mRNA more ... CTD PMID:15082532 more ... N-nitrosodiethylamine decreases expression EXP 6480464 Diethylnitrosamine results in decreased expression of CDKN2A mRNA CTD PMID:19642983 and PMID:20360939 N-nitrosodiethylamine increases methylation EXP 6480464 Diethylnitrosamine results in increased methylation of CDKN2A promoter CTD PMID:19642983 N-nitrosodiethylamine increases expression ISO Cdkn2a (Mus musculus) 6480464 Diethylnitrosamine results in increased expression of CDKN2A mRNA and Diethylnitrosamine results in increased expression of CDKN2A protein CTD PMID:19919837 and PMID:24535843 N-nitrosodiethylamine multiple interactions EXP 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDKN2A mRNA more ... CTD PMID:16317707 more ... N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of CDKN2A mRNA CTD PMID:15138612 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of CDKN2A mRNA CTD PMID:22546817 nickel subsulfide decreases expression EXP 6480464 nickel subsulfide results in decreased expression of CDKN2A mRNA CTD PMID:21565688 nickel subsulfide increases methylation EXP 6480464 nickel subsulfide results in increased methylation of CDKN2A gene CTD PMID:21565688 nicotinamide multiple interactions ISO Cdkn2a (Mus musculus) 6480464 Niacinamide inhibits the reaction [9 more ... CTD PMID:24792773 nicotine increases expression ISO Cdkn2a (Mus musculus) 6480464 Nicotine results in increased expression of CDKN2A mRNA and Nicotine results in increased expression of CDKN2A protein CTD PMID:32473187 nicotine multiple interactions ISO Cdkn2a (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA] more ... CTD PMID:32473187 nitrogen dioxide multiple interactions EXP 6480464 [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased methylation of CDKN2A gene CTD PMID:26778509 O-methyleugenol increases expression EXP 6480464 methyleugenol results in increased expression of CDKN2A protein CTD PMID:23411599 O-methyleugenol decreases expression EXP 6480464 methyleugenol results in decreased expression of CDKN2A mRNA CTD PMID:26011634 ochratoxin A increases expression ISO CDKN2A (Homo sapiens) 6480464 ochratoxin A results in increased expression of CDKN2A protein CTD PMID:28286205 oxaliplatin increases expression ISO Cdkn2a (Mus musculus) 6480464 Oxaliplatin results in increased expression of CDKN2A protein CTD PMID:30031110 ozone multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [Oxygen co-treated with Ozone] results in increased expression of CDKN2A mRNA and Cannabidiol promotes the reaction [[Oxygen co-treated with Ozone] results in increased expression of CDKN2A mRNA] CTD PMID:32992648 p-menthan-3-ol increases expression ISO CDKN2A (Homo sapiens) 6480464 Menthol results in increased expression of CDKN2A mRNA CTD PMID:26760959 palbociclib affects response to substance ISO CDKN2A (Homo sapiens) 6480464 CDKN2A gene modified form affects the susceptibility to palbociclib more ... CTD PMID:24495407 palbociclib decreases response to substance ISO CDKN2A (Homo sapiens) 6480464 CDKN2A protein results in decreased susceptibility to palbociclib CTD PMID:21278246 and PMID:22711607 palbociclib increases response to substance ISO Cdkn2a (Mus musculus) 6480464 CDKN2A gene mutant form results in increased susceptibility to palbociclib CTD PMID:24098593 palbociclib multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [CDKN2A gene mutant form results in increased expression of CCND1 protein] which results in increased susceptibility to palbociclib more ... CTD PMID:24098593 palbociclib multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [CDKN2A protein co-treated with CDKN2C protein] affects the susceptibility to palbociclib CTD PMID:20534551 palbociclib increases response to substance ISO CDKN2A (Homo sapiens) 6480464 CDKN2A gene mutant form results in increased susceptibility to palbociclib CTD PMID:21278246 paracetamol decreases expression ISO CDKN2A (Homo sapiens) 6480464 Acetaminophen results in decreased expression of CDKN2A mRNA CTD PMID:26690555 paraquat multiple interactions EXP 6480464 [Maneb co-treated with Paraquat] results in increased expression of CDKN2A mRNA CTD PMID:29859004 paraquat increases expression EXP 6480464 Paraquat results in increased expression of CDKN2A mRNA CTD PMID:29859004 parathion increases expression ISO CDKN2A (Homo sapiens) 6480464 Parathion results in increased expression of CDKN2A mRNA CTD PMID:17390078 perfluorohexanesulfonic acid increases expression ISO Cdkn2a (Mus musculus) 6480464 perfluorohexanesulfonic acid results in increased expression of CDKN2A mRNA CTD PMID:37995155 perfluorooctanoic acid increases expression ISO CDKN2A (Homo sapiens) 6480464 perfluorooctanoic acid results in increased expression of CDKN2A mRNA CTD PMID:22425687 and PMID:25868421 phenethyl caffeate increases expression EXP 6480464 caffeic acid phenethyl ester results in increased expression of CDKN2A protein CTD PMID:15885897 phenethyl caffeate multiple interactions EXP 6480464 caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN2A mRNA] CTD PMID:20360939 phenobarbital multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDKN2A protein CTD PMID:15082532 phenylmercury acetate multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDKN2A mRNA CTD PMID:27188386 phenylmercury acetate increases expression ISO CDKN2A (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of CDKN2A mRNA CTD PMID:26272509 PhIP decreases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4 more ... CTD PMID:23313794 phorbol 13-acetate 12-myristate multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CDKN2A mRNA CTD PMID:16368122 phorbol 13-acetate 12-myristate multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [arsenic trioxide co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CDKN2A mRNA CTD PMID:18922899 pirinixic acid increases expression ISO Cdkn2a (Mus musculus) 6480464 pirinixic acid results in increased expression of CDKN2A mRNA CTD PMID:16221962 pirinixic acid multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CDKN2A mRNA CTD PMID:19710929 pirinixic acid multiple interactions ISO Cdkn2a (Mus musculus) 6480464 PPARA protein affects the reaction [pirinixic acid results in increased expression of CDKN2A mRNA] CTD PMID:16221962 piroxicam multiple interactions EXP 6480464 Piroxicam inhibits the reaction [Azoxymethane results in decreased expression of CDKN2A mRNA] and Piroxicam inhibits the reaction [Azoxymethane results in decreased expression of CDKN2A protein] CTD PMID:12189186 potassium dichromate increases expression ISO CDKN2A (Homo sapiens) 6480464 Potassium Dichromate results in increased expression of CDKN2A mRNA and Potassium Dichromate results in increased expression of CDKN2A protein CTD PMID:23718831 and PMID:23940686 prednisone increases expression ISO CDKN2A (Homo sapiens) 6480464 Prednisone results in increased expression of CDKN2A protein CTD PMID:15034294 proanthocyanidin multiple interactions EXP 6480464 Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of CDKN2A protein] CTD PMID:33484087 procainamide increases expression ISO CDKN2A (Homo sapiens) 6480464 Procainamide results in increased expression of CDKN2A protein CTD PMID:17938735 promethazine decreases expression EXP 6480464 Promethazine results in decreased expression of CDKN2A mRNA CTD PMID:26011634 pterostilbene multiple interactions ISO Cdkn2a (Mus musculus) 6480464 CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CDKN2A protein]] more ... CTD PMID:34405320 pterostilbene multiple interactions ISO CDKN2A (Homo sapiens) 6480464 CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CDKN2A protein]] more ... CTD PMID:34405320 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Doxorubicin results in increased expression of CDKN2A protein alternative form] and Quercetin inhibits the reaction [Doxorubicin results in increased expression of CDKN2A protein] CTD PMID:24902966 quercetin increases expression ISO CDKN2A (Homo sapiens) 6480464 Quercetin results in increased expression of CDKN2A mRNA and Quercetin results in increased expression of CDKN2A protein CTD PMID:28251795 and PMID:36982678 quercetin decreases expression ISO CDKN2A (Homo sapiens) 6480464 Quercetin results in decreased expression of CDKN2A mRNA CTD PMID:23727915 quercetin multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [bisphenol A co-treated with Quercetin metabolite] results in decreased expression of CDKN2A mRNA and [Cisplatin co-treated with Quercetin] results in increased expression of CDKN2A mRNA CTD PMID:27514524 and PMID:36982678 quercetin decreases methylation ISO CDKN2A (Homo sapiens) 6480464 Quercetin results in decreased methylation of CDKN2A promoter CTD PMID:18974642 quinoline increases expression ISO CDKN2A (Homo sapiens) 6480464 quinoline analog results in increased expression of CDKN2A mRNA and quinoline analog results in increased expression of CDKN2A protein CTD PMID:19417133 quinoline decreases methylation ISO CDKN2A (Homo sapiens) 6480464 quinoline analog results in decreased methylation of CDKN2A promoter CTD PMID:19417133 radon atom increases methylation ISO CDKN2A (Homo sapiens) 6480464 Radon results in increased methylation of CDKN2A promoter CTD PMID:16902270 radon(0) increases methylation ISO CDKN2A (Homo sapiens) 6480464 Radon results in increased methylation of CDKN2A promoter CTD PMID:16902270 reserpine multiple interactions EXP 6480464 [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein] and [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] CTD PMID:18504326 resveratrol decreases expression ISO CDKN2A (Homo sapiens) 6480464 resveratrol results in decreased expression of CDKN2A mRNA CTD PMID:17804521 resveratrol multiple interactions ISO CDKN2A (Homo sapiens) 6480464 CBX7 protein inhibits the reaction [Resveratrol results in increased expression of CDKN2A protein] and PARP1 protein affects the reaction [Resveratrol results in increased expression of CDKN2A protein] CTD PMID:25533949 and PMID:32621571 resveratrol increases expression ISO CDKN2A (Homo sapiens) 6480464 Resveratrol results in increased expression of CDKN2A protein CTD PMID:25533949 and PMID:32621571 S-(1,2-dichlorovinyl)-L-cysteine decreases expression ISO Cdkn2a (Mus musculus) 6480464 S-(1 and 2-dichlorovinyl)cysteine results in decreased expression of CDKN2A protein CTD PMID:16495211 salubrinal multiple interactions EXP 6480464 salubrinal inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA] CTD PMID:23690541 SB 203580 multiple interactions ISO CDKN2A (Homo sapiens) 6480464 SB 203580 inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN2A protein] CTD PMID:31734849 SB 431542 multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 serpentine asbestos decreases expression EXP 6480464 Asbestos more ... CTD PMID:32755622 silver(1+) nitrate increases expression ISO CDKN2A (Homo sapiens) 6480464 Silver Nitrate results in increased expression of CDKN2A mRNA CTD PMID:22831968 simvastatin increases expression EXP 6480464 Simvastatin results in increased expression of CDKN2A protein CTD PMID:18804536 sodium arsenate decreases expression ISO CDKN2A (Homo sapiens) 6480464 sodium arsenate results in decreased expression of CDKN2A mRNA CTD PMID:11825526 sodium arsenate increases methylation ISO CDKN2A (Homo sapiens) 6480464 sodium arsenate results in increased methylation of CDKN2A gene CTD PMID:11825526 sodium arsenite multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CDKN2A mRNA more ... CTD PMID:16368122 more ... sodium arsenite multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of CDKN2A mRNA CTD PMID:12634122 sodium arsenite decreases expression ISO CDKN2A (Homo sapiens) 6480464 sodium arsenite results in decreased expression of CDKN2A mRNA more ... CTD PMID:11825526 more ... sodium arsenite increases expression ISO CDKN2A (Homo sapiens) 6480464 sodium arsenite results in increased expression of CDKN2A mRNA CTD PMID:12016162 and PMID:12634122 sodium arsenite increases methylation ISO CDKN2A (Homo sapiens) 6480464 sodium arsenite results in increased methylation of CDKN2A gene CTD PMID:11825526 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of CDKN2A mRNA and sodium arsenite results in decreased expression of CDKN2A protein CTD PMID:16876216 sodium arsenite increases expression ISO Cdkn2a (Mus musculus) 6480464 sodium arsenite results in increased expression of CDKN2A mRNA more ... CTD PMID:23890198 and PMID:25787150 sodium arsenite decreases expression ISO Cdkn2a (Mus musculus) 6480464 sodium arsenite results in decreased expression of CDKN2A mRNA CTD PMID:22733434 sodium arsenite affects expression ISO Cdkn2a (Mus musculus) 6480464 sodium arsenite affects the expression of CDKN2A mRNA CTD PMID:16507464 sodium dichromate decreases expression ISO Cdkn2a (Mus musculus) 6480464 sodium bichromate results in decreased expression of CDKN2A mRNA CTD PMID:22613061 sodium dichromate multiple interactions ISO Cdkn2a (Mus musculus) 6480464 Benzo(a)pyrene affects the reaction [sodium bichromate results in decreased expression of CDKN2A mRNA] CTD PMID:22613061 sodium fluoride decreases expression ISO Cdkn2a (Mus musculus) 6480464 Sodium Fluoride results in decreased expression of CDKN2A mRNA CTD PMID:27862939 sodium fluoride increases methylation ISO CDKN2A (Homo sapiens) 6480464 Sodium Fluoride results in increased methylation of CDKN2A promoter CTD PMID:30259626 sodium fluoride decreases expression ISO CDKN2A (Homo sapiens) 6480464 Sodium Fluoride results in decreased expression of CDKN2A mRNA and Sodium Fluoride results in decreased expression of CDKN2A protein CTD PMID:30259626 sodium fluoride multiple interactions ISO CDKN2A (Homo sapiens) 6480464 Decitabine inhibits the reaction [Sodium Fluoride results in decreased expression of CDKN2A mRNA] more ... CTD PMID:30259626 spironolactone multiple interactions EXP 6480464 Spironolactone inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein] and Spironolactone inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] CTD PMID:18504326 stavudine affects expression ISO Cdkn2a (Mus musculus) 6480464 Stavudine affects the expression of CDKN2A protein CTD PMID:18389896 streptozocin multiple interactions ISO Cdkn2a (Mus musculus) 6480464 2-amino-6-boronohexanoic acid inhibits the reaction [Streptozocin results in increased expression of CDKN2A mRNA] more ... CTD PMID:29059224 and PMID:29673160 streptozocin increases expression ISO Cdkn2a (Mus musculus) 6480464 Streptozocin results in increased expression of CDKN2A mRNA and Streptozocin results in increased expression of CDKN2A protein CTD PMID:29059224 and PMID:29673160 sulforaphane multiple interactions ISO Cdkn2a (Mus musculus) 6480464 sulforaphane inhibits the reaction [[NFE2L2 protein affects the susceptibility to 1 more ... CTD PMID:26388957 sulforaphane decreases expression ISO Cdkn2a (Mus musculus) 6480464 sulforaphane results in decreased expression of CDKN2A mRNA CTD PMID:30529165 sulfur dioxide multiple interactions EXP 6480464 [Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of CDKN2A mRNA more ... CTD PMID:19408242 and PMID:20064080 sulfur dioxide decreases expression EXP 6480464 Sulfur Dioxide results in decreased expression of CDKN2A mRNA and Sulfur Dioxide results in decreased expression of CDKN2A protein CTD PMID:19408242 more ... sulfur dioxide increases expression EXP 6480464 Sulfur Dioxide results in increased expression of CDKN2A protein CTD PMID:19408242 sulindac multiple interactions EXP 6480464 Sulindac inhibits the reaction [Azoxymethane results in decreased expression of CDKN2A mRNA] CTD PMID:12189186 T-2 toxin increases expression EXP 6480464 T-2 Toxin results in increased expression of CDKN2A mRNA and T-2 Toxin results in increased expression of CDKN2A protein CTD PMID:29567467 terephthalic acid decreases expression EXP 6480464 terephthalic acid results in decreased expression of CDKN2A protein CTD PMID:16896691 tetrachloromethane multiple interactions ISO Cdkn2a (Mus musculus) 6480464 [Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of CDKN2A mRNA CTD PMID:23288052 tetrachloromethane increases expression ISO Cdkn2a (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of CDKN2A mRNA CTD PMID:23288052 thioacetamide affects localization EXP 6480464 Thioacetamide affects the localization of CDKN2A protein CTD PMID:22659510 thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of CDKN2A mRNA CTD PMID:26011634 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of CDKN2A protein CTD PMID:22659510 and PMID:23411599 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of CDKN2A mRNA CTD PMID:22659510 thioridazine increases expression ISO CDKN2A (Homo sapiens) 6480464 Thioridazine results in increased expression of CDKN2A protein CTD PMID:21035837 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of CDKN2A mRNA CTD PMID:30012374 trichostatin A multiple interactions ISO CDKN2A (Homo sapiens) 6480464 [[decitabine co-treated with trichostatin A] affects the methylation of CDKN2A promoter] which affects the expression of CDKN2A mRNA more ... CTD PMID:17019711 more ... trichostatin A increases expression ISO CDKN2A (Homo sapiens) 6480464 trichostatin A results in increased expression of CDKN2A mRNA and trichostatin A results in increased expression of CDKN2A protein CTD PMID:23770000 trichostatin A decreases expression ISO CDKN2A (Homo sapiens) 6480464 trichostatin A results in decreased expression of CDKN2A mRNA CTD PMID:19606018 triclosan increases methylation ISO CDKN2A (Homo sapiens) 6480464 Triclosan results in increased methylation of CDKN2A gene CTD PMID:26970259 triclosan decreases expression ISO CDKN2A (Homo sapiens) 6480464 Triclosan results in decreased expression of CDKN2A mRNA alternative form CTD PMID:26970259 urethane decreases expression ISO Cdkn2a (Mus musculus) 6480464 Urethane results in decreased expression of CDKN2A mRNA and Urethane results in decreased expression of CDKN2A protein CTD PMID:12117781 and PMID:25168426 urethane increases response to substance ISO Cdkn2a (Mus musculus) 6480464 CDKN2A gene polymorphism results in increased susceptibility to Urethane CTD PMID:11544531 valproic acid increases methylation ISO CDKN2A (Homo sapiens) 6480464 Valproic Acid results in increased methylation of CDKN2A gene CTD PMID:29154799 valproic acid increases expression ISO CDKN2A (Homo sapiens) 6480464 Valproic Acid results in increased expression of CDKN2A mRNA CTD PMID:19101580 more ... valproic acid affects expression ISO CDKN2A (Homo sapiens) 6480464 Valproic Acid affects the expression of CDKN2A mRNA CTD PMID:25979313 vincristine increases response to substance ISO CDKN2A (Homo sapiens) 6480464 CDKN2A protein results in increased susceptibility to Vincristine CTD PMID:16786135 vinorelbine decreases expression ISO CDKN2A (Homo sapiens) 6480464 vinorelbine results in decreased expression of CDKN2A protein CTD PMID:17904787 wogonin increases expression ISO CDKN2A (Homo sapiens) 6480464 wogonin results in increased expression of CDKN2A mRNA and wogonin results in increased expression of CDKN2A protein CTD PMID:32671444 zearalenone decreases expression ISO CDKN2A (Homo sapiens) 6480464 Zearalenone results in decreased expression of CDKN2A mRNA CTD PMID:28965971 zidovudine affects expression ISO Cdkn2a (Mus musculus) 6480464 Zidovudine affects the expression of CDKN2A protein CTD PMID:18389896 zidovudine increases expression ISO CDKN2A (Homo sapiens) 6480464 Zidovudine results in increased expression of CDKN2A mRNA and Zidovudine results in increased expression of CDKN2A protein CTD PMID:16797627 zinc pyrithione affects expression ISO CDKN2A (Homo sapiens) 6480464 pyrithione zinc affects the expression of CDKN2A protein CTD PMID:21557991