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Gene: Cdkn2a (cyclin-dependent kinase inhibitor 2A) Rattus norvegicus
Symbol: Cdkn2a
Name: cyclin-dependent kinase inhibitor 2A
Description: Predicted to have several functions, including DNA-binding transcription factor activity; MDM2/MDM4 family protein binding activity; and enzyme regulator activity. Involved in several processes, including aging; negative regulation of hepatocyte proliferation; and nervous system development. Localizes to the cytoplasm and nucleus. Predicted to colocalize with the nuclear body. Used to study carcinoma (multiple); endometrial cancer; pre-malignant neoplasm; rhabdomyosarcoma; and sarcomatoid mesothelioma. Biomarker of hepatocellular carcinoma; hypertension; obesity; and osteoarthritis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); hematologic cancer (multiple); malignant glioma (multiple); melanoma (multiple); and pancreatic cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A); PARTICIPATES IN altered G1/S transition pathway; G1/S transition pathway; pancreatic cancer pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
Also known as: alternative reading frame; Arf; CDK4I; cell cycle inhibitor; cell cycle regulator; Cyclin dependent kinase inhibitor 2A (p16 inhibits CDK4); Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2a p16Ink4a; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 1; cyclin-dependent kinase inhibitor 2A, isoform 2; INK4A; MTS1; p16; p16-INK4; p16-INK4a; p16Cdkn2a; p19ARF
Homo sapiens (human) : CDKN2A (cyclin dependent kinase inhibitor 2A)  HGNC  Alliance
Mus musculus (house mouse) : Cdkn2a (cyclin dependent kinase inhibitor 2A)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CDKN2A (cyclin dependent kinase inhibitor 2A)
Canis lupus familiaris (dog) : CDKN2A (cyclin dependent kinase inhibitor 2A)
Sus scrofa (pig) : P14ARF (p14ARF protein)
more info ...
Allele / Splice: Cdkn2a_v1   Cdkn2a_v2  
Is Marker For: Strains:   F344/NRrrc  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05107,823,323 - 107,832,405 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05111,793,603 - 111,801,220 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05111,556,970 - 111,557,193 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45108,908,749 - 108,916,380 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15108,913,974 - 108,921,606 (-)NCBI
Celera5102,700,552 - 102,707,724 (-)NCBICelera
Cytogenetic Map5q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)