Rgs3 (regulator of G-protein signaling 3) - Rat Genome Database

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Gene: Rgs3 (regulator of G-protein signaling 3) Rattus norvegicus
Analyze
Symbol: Rgs3
Name: regulator of G-protein signaling 3
RGD ID: 3566
Description: Involved in signal transduction. Predicted to be located in cytoplasm. Predicted to be active in nucleus and plasma membrane. Biomarker of bladder disease and lesion of sciatic nerve. Orthologous to human RGS3 (regulator of G protein signaling 3); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93233; regulator of G-protein signalling 3; SRB-RGS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2576,022,038 - 76,161,895 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl576,022,001 - 76,161,894 (+)Ensembl
Rnor_6.0578,429,017 - 78,567,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl578,428,669 - 78,567,288 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0582,550,757 - 82,690,343 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4579,624,388 - 79,709,035 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1579,629,500 - 79,714,147 (+)NCBI
Celera575,018,488 - 75,101,807 (+)NCBICelera
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(S)-timolol (anhydrous)  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl malate  (ISO)
dopamine  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
menadione  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
monosodium L-glutamate  (EXP)
N-nitrosodimethylamine  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylephrine  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
Tungsten carbide  (ISO)
valproic acid  (ISO)
valsartan  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nucleus  (IBA,ISO)
plasma membrane  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons. Costigan M, etal., Mol Cell Neurosci. 2003 Sep;24(1):106-16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Molecular cloning and characterization of a steroid receptor-binding regulator of G-protein signaling protein cDNA. Ikeda M, etal., Gene 2001 Aug 8;273(2):207-14.
5. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Koelle MR and Horvitz HR, Cell 1996 Jan 12;84(1):115-25.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells. Wang Q, etal., J Biol Chem 2002 Jul 12;277(28):24949-58.
12. Identification of potential therapeutic targets in hypertension-associated bladder dysfunction. Yono M, etal., BJU Int. 2010 Mar;105(6):877-83. doi: 10.1111/j.1464-410X.2009.08809.x. Epub 2009 Aug 18.
Additional References at PubMed
PMID:10702309   PMID:11034339   PMID:12062898   PMID:12477932   PMID:15458844   PMID:15489334   PMID:17541154   PMID:25931508  


Genomics

Comparative Map Data
Rgs3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2576,022,038 - 76,161,895 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl576,022,001 - 76,161,894 (+)Ensembl
Rnor_6.0578,429,017 - 78,567,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl578,428,669 - 78,567,288 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0582,550,757 - 82,690,343 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4579,624,388 - 79,709,035 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1579,629,500 - 79,714,147 (+)NCBI
Celera575,018,488 - 75,101,807 (+)NCBICelera
Cytogenetic Map5q24NCBI
RGS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389113,444,730 - 113,597,738 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9113,444,731 - 113,597,743 (+)EnsemblGRCh38hg38GRCh38
GRCh379116,207,010 - 116,360,018 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369115,246,832 - 115,399,839 (+)NCBINCBI36hg18NCBI36
Build 349113,435,753 - 113,439,571NCBI
Celera986,854,611 - 87,007,602 (+)NCBI
Cytogenetic Map9q32NCBI
HuRef985,813,933 - 85,966,662 (+)NCBIHuRef
CHM1_19116,353,638 - 116,506,463 (+)NCBICHM1_1
T2T-CHM13v2.09125,643,547 - 125,796,339 (+)NCBI
Rgs3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39462,478,079 - 62,621,256 (+)NCBIGRCm39mm39
GRCm39 Ensembl462,478,084 - 62,622,238 (+)Ensembl
GRCm38462,559,835 - 62,703,019 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl462,559,847 - 62,704,001 (+)EnsemblGRCm38mm10GRCm38
MGSCv37462,220,881 - 62,364,053 (+)NCBIGRCm37mm9NCBIm37
MGSCv36462,046,208 - 62,188,696 (+)NCBImm8
Celera461,227,755 - 61,366,061 (+)NCBICelera
Cytogenetic Map4B3NCBI
cM Map433.19NCBI
Rgs3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541913,919,051 - 14,056,521 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541913,918,274 - 14,042,090 (-)NCBIChiLan1.0ChiLan1.0
RGS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19112,929,604 - 113,065,746 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9112,927,407 - 113,065,746 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0984,561,302 - 84,696,534 (+)NCBIMhudiblu_PPA_v0panPan3
RGS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11167,781,832 - 67,878,153 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1167,781,962 - 67,920,075 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1166,186,531 - 66,324,166 (+)NCBI
ROS_Cfam_1.01168,906,019 - 69,044,294 (+)NCBI
ROS_Cfam_1.0 Ensembl1168,923,206 - 69,044,285 (+)Ensembl
UMICH_Zoey_3.11167,424,053 - 67,562,277 (+)NCBI
UNSW_CanFamBas_1.01167,455,234 - 67,593,195 (+)NCBI
UU_Cfam_GSD_1.01168,210,062 - 68,330,325 (+)NCBI
Rgs3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947183,085,781 - 183,161,654 (+)NCBI
SpeTri2.0NW_004936559112,375 - 180,737 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1254,067,492 - 254,211,805 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11254,078,618 - 254,211,805 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21284,875,313 - 284,953,037 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RGS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11225,985,782 - 26,118,393 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1225,985,723 - 26,117,343 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603516,686,032 - 16,825,304 (+)NCBIVero_WHO_p1.0
Rgs3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476021,514,359 - 21,636,684 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D3Rat120  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0582,611,942 - 82,612,198UniSTSRnor5.0
RGSC_v3.4579,629,452 - 79,629,709RGDRGSC3.4
RGSC_v3.4579,629,453 - 79,629,709UniSTSRGSC3.4
RGSC_v3.1579,634,565 - 79,634,822RGD
Celera575,023,580 - 75,023,822UniSTS
Cytogenetic Map5q24UniSTS
D5Uwm20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2576,146,283 - 76,146,472 (+)MAPPERmRatBN7.2
Rnor_6.0578,551,671 - 78,551,859NCBIRnor6.0
Rnor_5.0582,674,733 - 82,674,921UniSTSRnor5.0
RGSC_v3.4579,693,425 - 79,693,614RGDRGSC3.4
RGSC_v3.4579,693,426 - 79,693,614UniSTSRGSC3.4
RGSC_v3.1579,698,538 - 79,698,727RGD
Celera575,086,215 - 75,086,395UniSTS
Cytogenetic Map5q24UniSTS
RH141488  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2576,118,076 - 76,118,265 (+)MAPPERmRatBN7.2
Rnor_6.0578,523,465 - 78,523,653NCBIRnor6.0
Rnor_5.0582,646,665 - 82,646,853UniSTSRnor5.0
RGSC_v3.4579,663,973 - 79,664,161UniSTSRGSC3.4
Celera575,058,088 - 75,058,276UniSTS
RH 3.4 Map5559.0UniSTS
Cytogenetic Map5q24UniSTS
BE098515  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2576,159,438 - 76,159,588 (+)MAPPERmRatBN7.2
Rnor_6.0578,564,824 - 78,564,973NCBIRnor6.0
Rnor_5.0582,687,886 - 82,688,035UniSTSRnor5.0
RGSC_v3.4579,706,579 - 79,706,728UniSTSRGSC3.4
Celera575,099,351 - 75,099,500UniSTS
Cytogenetic Map5q24UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:356
Count of miRNA genes:200
Interacting mature miRNAs:244
Transcripts:ENSRNOT00000059183
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 10 5 14 5 68 22 39 11
Low 9 47 36 5 36 8 11 6 13 2 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005504532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB055153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC099453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U32434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000059181   ⟹   ENSRNOP00000055954
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl576,022,001 - 76,116,179 (+)Ensembl
Rnor_6.0 Ensembl578,483,904 - 78,521,567 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000059183   ⟹   ENSRNOP00000055956
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl576,078,492 - 76,161,894 (+)Ensembl
Rnor_6.0 Ensembl578,483,893 - 78,567,279 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080744   ⟹   ENSRNOP00000071774
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl576,022,001 - 76,161,894 (+)Ensembl
Rnor_6.0 Ensembl578,428,669 - 78,567,288 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099793   ⟹   ENSRNOP00000093735
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl576,158,469 - 76,161,888 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107343   ⟹   ENSRNOP00000081496
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl576,041,973 - 76,161,894 (+)Ensembl
RefSeq Acc Id: NM_019340   ⟹   NP_062213
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,078,492 - 76,161,895 (+)NCBI
Rnor_6.0578,483,893 - 78,567,280 (+)NCBI
Rnor_5.0582,550,757 - 82,690,343 (+)NCBI
RGSC_v3.4579,624,388 - 79,709,035 (+)RGD
Celera575,018,488 - 75,101,807 (+)RGD
Sequence:
RefSeq Acc Id: XM_006238260   ⟹   XP_006238322
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,042,138 - 76,161,895 (+)NCBI
Rnor_6.0578,447,541 - 78,567,281 (+)NCBI
Rnor_5.0582,550,757 - 82,690,343 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006238263   ⟹   XP_006238325
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,022,167 - 76,123,754 (+)NCBI
Rnor_6.0578,429,017 - 78,523,819 (+)NCBI
Rnor_5.0582,550,757 - 82,690,343 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006238264   ⟹   XP_006238326
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,042,119 - 76,123,754 (+)NCBI
Rnor_6.0578,447,527 - 78,523,819 (+)NCBI
Rnor_5.0582,550,757 - 82,690,343 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006238265   ⟹   XP_006238327
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,077,759 - 76,123,754 (+)NCBI
Rnor_6.0578,481,697 - 78,523,819 (+)NCBI
Rnor_5.0582,550,757 - 82,690,343 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763801   ⟹   XP_008762023
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,133,480 - 76,161,895 (+)NCBI
Rnor_6.0578,538,902 - 78,567,281 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763802   ⟹   XP_008762024
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,132,987 - 76,161,895 (+)NCBI
Rnor_6.0578,537,274 - 78,567,281 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593595   ⟹   XP_017449084
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,022,167 - 76,161,895 (+)NCBI
Rnor_6.0578,429,042 - 78,567,281 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593596   ⟹   XP_017449085
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,022,167 - 76,161,895 (+)NCBI
Rnor_6.0578,429,042 - 78,567,281 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593597   ⟹   XP_017449086
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,042,138 - 76,161,895 (+)NCBI
Rnor_6.0578,447,541 - 78,567,281 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110674   ⟹   XP_038966602
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,022,038 - 76,161,895 (+)NCBI
RefSeq Acc Id: XM_039110675   ⟹   XP_038966603
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,022,167 - 76,161,895 (+)NCBI
RefSeq Acc Id: XM_039110676   ⟹   XP_038966604
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,066,756 - 76,161,895 (+)NCBI
RefSeq Acc Id: XM_039110678   ⟹   XP_038966606
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,133,745 - 76,161,895 (+)NCBI
RefSeq Acc Id: XR_005504532
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,022,167 - 76,115,682 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_062213   ⟸   NM_019340
- UniProtKB: Q920Q9 (UniProtKB/Swiss-Prot),   P49797 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006238325   ⟸   XM_006238263
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006238326   ⟸   XM_006238264
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_006238322   ⟸   XM_006238260
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006238327   ⟸   XM_006238265
- Peptide Label: isoform X10
- UniProtKB: P49797 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008762024   ⟸   XM_008763802
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_008762023   ⟸   XM_008763801
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_017449084   ⟸   XM_017593595
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K1B5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449085   ⟸   XM_017593596
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017449086   ⟸   XM_017593597
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000071774   ⟸   ENSRNOT00000080744
RefSeq Acc Id: ENSRNOP00000055954   ⟸   ENSRNOT00000059181
RefSeq Acc Id: ENSRNOP00000055956   ⟸   ENSRNOT00000059183
RefSeq Acc Id: XP_038966602   ⟸   XM_039110674
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038966603   ⟸   XM_039110675
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038966604   ⟸   XM_039110676
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038966606   ⟸   XM_039110678
- Peptide Label: isoform X9
RefSeq Acc Id: ENSRNOP00000093735   ⟸   ENSRNOT00000099793
RefSeq Acc Id: ENSRNOP00000081496   ⟸   ENSRNOT00000107343
Protein Domains
C2   PDZ   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49797-F1-model_v2 AlphaFold P49797 1-967 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693797
Promoter ID:EPDNEW_R4321
Type:single initiation site
Name:Rgs3_1
Description:regulator of G-protein signaling 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0578,483,872 - 78,483,932EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3566 AgrOrtholog
BioCyc Gene G2FUF-41084 BioCyc
Ensembl Genes ENSRNOG00000024501 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000055954 ENTREZGENE
  ENSRNOP00000055954.4 UniProtKB/TrEMBL
  ENSRNOP00000055956 ENTREZGENE
  ENSRNOP00000055956.4 UniProtKB/TrEMBL
  ENSRNOP00000071774 ENTREZGENE
  ENSRNOP00000071774.1 UniProtKB/TrEMBL
  ENSRNOP00000081496 ENTREZGENE
  ENSRNOP00000081496.1 UniProtKB/TrEMBL
  ENSRNOP00000093735.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059181 ENTREZGENE
  ENSRNOT00000059181.5 UniProtKB/TrEMBL
  ENSRNOT00000059183 ENTREZGENE
  ENSRNOT00000059183.4 UniProtKB/TrEMBL
  ENSRNOT00000080744 ENTREZGENE
  ENSRNOT00000080744.2 UniProtKB/TrEMBL
  ENSRNOT00000099793.1 UniProtKB/TrEMBL
  ENSRNOT00000107343 ENTREZGENE
  ENSRNOT00000107343.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.196.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_RGS3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdom1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54293 UniProtKB/Swiss-Prot
NCBI Gene 54293 ENTREZGENE
Pfam PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rgs3 PhenoGen
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K1B5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZT37_RAT UniProtKB/TrEMBL
  A0A8I6AJG0_RAT UniProtKB/TrEMBL
  A0A8L2QRC0_RAT UniProtKB/TrEMBL
  G3V9Q2_RAT UniProtKB/TrEMBL
  P49797 ENTREZGENE
  Q920Q9 ENTREZGENE
  RGS3_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q5RKK6 UniProtKB/Swiss-Prot
  Q920Q9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Rgs3  regulator of G-protein signaling 3  Rgs3  regulator of G-protein signalling 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Rgs3  regulator of G-protein signalling 3    regulator of G-protein signaling 3  Name updated 1299863 APPROVED
2002-06-10 Rgs3  regulator of G-protein signaling 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds directly to the activated Ga subunits and pormotes GTP hydrolysis 625585
gene_process serves as a GTPase-activating protein (GAP) and inhibits G protein signaling; inhibits muscarinic m3 receptor signaling through MAP kinase (ERK) 625585