Cpt2 (carnitine palmitoyltransferase 2) - Rat Genome Database

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Gene: Cpt2 (carnitine palmitoyltransferase 2) Rattus norvegicus
Symbol: Cpt2
Name: carnitine palmitoyltransferase 2
RGD ID: 2398
Description: Enables carnitine O-palmitoyltransferase activity. Involved in fatty acid beta-oxidation and response to fatty acid. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in brain disease; lipid metabolism disorder; and muscular disease. Orthologous to human CPT2 (carnitine palmitoyltransferase 2); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine palmitoyltransferase I deficiency pathway; carnitine-acylcarnitine translocase deficiency; INTERACTS WITH 17beta-estradiol; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: carnitine O-palmitoyltransferase; carnitine O-palmitoyltransferase 2, mitochondrial; carnitine palmitoyltransferase II; CPT II; CPTII
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cpt2m1Mcwi  
Genetic Models: SS-Cpt2m1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr85127,893,450 - 127,911,347 (-)NCBIGRCr8
mRatBN7.25122,664,677 - 122,682,126 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5122,664,677 - 122,682,095 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5125,284,849 - 125,302,210 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05127,007,897 - 127,025,259 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05127,059,205 - 127,076,568 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05127,505,646 - 127,523,016 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5127,505,614 - 127,523,089 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05131,353,542 - 131,370,821 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45129,007,685 - 129,025,501 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15129,012,910 - 129,030,727 (-)NCBI
Celera5121,406,314 - 121,423,718 (-)NCBICelera
Cytogenetic Map5q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(R)-carnitine  (ISO)
(S)-colchicine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
acetamide  (EXP)
adenine  (ISO)
Aescin  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
ciprofibrate  (EXP,ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (EXP)
copper(II) sulfate  (ISO)
corn oil  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP)
D-glucose  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Diosbulbin B  (ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (EXP,ISO)
fenthion  (ISO)
finasteride  (EXP)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gemfibrozil  (EXP)
gentamycin  (EXP)
Gingerenone A  (ISO)
glafenine  (EXP)
glucose  (EXP)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
hexadecanoic acid  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (EXP)
hydroxyurea  (ISO)
imidacloprid  (EXP)
indometacin  (EXP)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
lead(0)  (ISO)
leflunomide  (EXP,ISO)
lenvatinib  (EXP,ISO)
lithocholic acid  (ISO)
Mesaconitine  (EXP)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP,ISO)
nefazodone  (EXP)
nicotinic acid  (ISO)
nimesulide  (EXP)
nordihydroguaiaretic acid  (EXP)
obeticholic acid  (ISO)
olanzapine  (EXP)
oleic acid  (ISO)
orlistat  (ISO)
oxybenzone  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phlorizin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium chloride  (ISO)
pravastatin  (ISO)
prochloraz  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP,ISO)
tetrachloromethane  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
Tris(2,3-dibromopropyl) phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
Tris(2-ethylhexyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Functional characterization of mitochondrial carnitine palmitoyltransferases I and II expressed in the yeast Pichia pastoris. de Vries Y, etal., Biochemistry 1997 Apr 29;36(17):5285-92.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Crystal structure of rat carnitine palmitoyltransferase II (CPT-II). Hsiao YS, etal., Biochem Biophys Res Commun. 2006 Aug 4;346(3):974-80. Epub 2006 Jun 9.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Adipose fatty acid oxidation is required for thermogenesis and potentiates oxidative stress-induced inflammation. Lee J, etal., Cell Rep. 2015 Jan 13;10(2):266-79. doi: 10.1016/j.celrep.2014.12.023. Epub 2015 Jan 8.
7. 3-Thia fatty acid treatment, in contrast to eicosapentaenoic acid and starvation, induces gene expression of carnitine palmitoyltransferase-II in rat liver. Madsen L and Berge RK, Lipids. 1999 May;34(5):447-56. doi: 10.1007/s11745-999-0384-6.
8. Mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase and carnitine palmitoyltransferase II as potential control sites for ketogenesis during mitochondrion and peroxisome proliferation. Madsen L, etal., Biochem Pharmacol. 1999 May 1;57(9):1011-9.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Structural insight into function and regulation of carnitine palmitoyltransferase. Rufer AC, etal., Cell Mol Life Sci. 2009 Aug;66(15):2489-501. Epub 2009 May 9.
18. The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment. Rufer AC, etal., Structure. 2006 Apr;14(4):713-23.
19. Molecular characterization of inherited carnitine palmitoyltransferase II deficiency. Taroni F, etal., Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8429-33.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. A variable myopathy associated with heterozygosity for the R503C mutation in the carnitine palmitoyltransferase II gene. Vladutiu GD, etal., Mol Genet Metab 2000 Jun;70(2):134-41.
22. Cloning, sequencing, and expression of a cDNA encoding rat liver mitochondrial carnitine palmitoyltransferase II. Woeltje KF, etal., J Biol Chem 1990 Jun 25;265(18):10720-5.
23. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
24. Identification by mutagenesis of a conserved glutamate (Glu487) residue important for catalytic activity in rat liver carnitine palmitoyltransferase II. Zheng G, etal., J Biol Chem 2002 Nov 1;277(44):42219-23. Epub 2002 Aug 27.
Additional References at PubMed
PMID:1869564   PMID:7711730   PMID:14651853   PMID:17585909   PMID:18614015   PMID:24898781   PMID:26316108   PMID:26945066   PMID:27996060   PMID:28127199   PMID:34350838   PMID:38171776  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr85127,893,450 - 127,911,347 (-)NCBIGRCr8
mRatBN7.25122,664,677 - 122,682,126 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5122,664,677 - 122,682,095 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5125,284,849 - 125,302,210 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05127,007,897 - 127,025,259 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05127,059,205 - 127,076,568 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05127,505,646 - 127,523,016 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5127,505,614 - 127,523,089 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05131,353,542 - 131,370,821 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45129,007,685 - 129,025,501 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15129,012,910 - 129,030,727 (-)NCBI
Celera5121,406,314 - 121,423,718 (-)NCBICelera
Cytogenetic Map5q34NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38153,196,824 - 53,214,197 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl153,196,792 - 53,214,197 (+)EnsemblGRCh38hg38GRCh38
GRCh37153,662,496 - 53,679,869 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36153,434,689 - 53,452,455 (+)NCBINCBI36Build 36hg18NCBI36
Build 34153,374,121 - 53,391,888NCBI
Celera151,949,941 - 51,967,712 (+)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef151,777,752 - 51,795,523 (+)NCBIHuRef
CHM1_1153,779,095 - 53,796,864 (+)NCBICHM1_1
T2T-CHM13v2.0153,078,266 - 53,095,633 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394107,761,179 - 107,780,786 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4107,761,178 - 107,780,807 (-)EnsemblGRCm39 Ensembl
GRCm384107,903,982 - 107,923,589 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4107,903,981 - 107,923,610 (-)EnsemblGRCm38mm10GRCm38
MGSCv374107,576,587 - 107,596,194 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364107,401,914 - 107,421,466 (-)NCBIMGSCv36mm8
Celera4106,252,864 - 106,272,513 (-)NCBICelera
Cytogenetic Map4C7NCBI
cM Map450.18NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554645,942,986 - 5,970,345 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554645,942,986 - 5,970,325 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21173,623,572 - 173,641,027 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11172,764,332 - 172,781,782 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0152,469,416 - 52,487,166 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1154,069,334 - 54,086,994 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl154,069,334 - 54,086,994 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1555,718,209 - 55,786,175 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl555,718,510 - 55,744,809 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha555,784,409 - 55,811,033 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0555,907,324 - 55,933,944 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl555,906,033 - 55,933,959 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1555,899,940 - 55,926,541 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0555,791,152 - 55,817,745 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0556,180,213 - 56,206,825 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505867,540,611 - 67,558,122 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365227,856,087 - 7,875,685 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365227,858,172 - 7,875,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl6159,036,422 - 159,061,327 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16159,038,129 - 159,061,327 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26146,702,081 - 146,774,794 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12079,710,638 - 79,728,100 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2079,706,584 - 79,727,689 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603337,554,717 - 37,572,175 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046249341,250,956 - 1,271,983 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249341,239,849 - 1,271,993 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cpt2
60 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:33
Interacting mature miRNAs:34
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
7794739Bp372Blood pressure QTL 3720.0058arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5117913688125222967Rat
1582230Bw78Body weight QTL 783.20.0016epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)5119085612128034027Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25122,667,705 - 122,667,958 (+)MAPPERmRatBN7.2
Rnor_6.05127,508,672 - 127,508,924NCBIRnor6.0
Rnor_5.05131,356,568 - 131,356,820UniSTSRnor5.0
RGSC_v3.45129,010,711 - 129,010,963UniSTSRGSC3.4
Celera5121,409,340 - 121,409,592UniSTS
Cytogenetic Map5q35UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25122,664,974 - 122,665,056 (+)MAPPERmRatBN7.2
Rnor_6.05127,505,941 - 127,506,022NCBIRnor6.0
Rnor_5.05131,353,837 - 131,353,918UniSTSRnor5.0
RGSC_v3.45129,007,980 - 129,008,061UniSTSRGSC3.4
Celera5121,406,609 - 121,406,690UniSTS
Cytogenetic Map5q35UniSTS

Genetic Models
This gene Cpt2 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 56 41 12 41 8 11 35 35 41 11 8
Low 1 7 39
Below cutoff


RefSeq Acc Id: ENSRNOT00000016954   ⟹   ENSRNOP00000016954
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5122,664,677 - 122,682,058 (-)Ensembl
Rnor_6.0 Ensembl5127,505,614 - 127,523,089 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095862   ⟹   ENSRNOP00000083117
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5122,664,677 - 122,681,313 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104689   ⟹   ENSRNOP00000083946
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5122,664,937 - 122,682,095 (-)Ensembl
RefSeq Acc Id: NM_012930   ⟹   NP_037062
Rat AssemblyChrPosition (strand)Source
GRCr85127,893,453 - 127,910,818 (-)NCBI
mRatBN7.25122,664,680 - 122,682,046 (-)NCBI
Rnor_6.05127,505,646 - 127,523,016 (-)NCBI
Rnor_5.05131,353,542 - 131,370,821 (-)NCBI
RGSC_v3.45129,007,685 - 129,025,501 (-)RGD
Celera5121,406,314 - 121,423,718 (-)RGD
RefSeq Acc Id: XM_039109299   ⟹   XP_038965227
Rat AssemblyChrPosition (strand)Source
GRCr85127,893,450 - 127,911,347 (-)NCBI
mRatBN7.25122,664,677 - 122,682,126 (-)NCBI
RefSeq Acc Id: NP_037062   ⟸   NM_012930
- Peptide Label: precursor
- UniProtKB: P97781 (UniProtKB/Swiss-Prot),   P18886 (UniProtKB/Swiss-Prot),   A6JYT6 (UniProtKB/TrEMBL),   G3V7N5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016954   ⟸   ENSRNOT00000016954
RefSeq Acc Id: XP_038965227   ⟸   XM_039109299
- Peptide Label: isoform X1
- UniProtKB: A6JYT6 (UniProtKB/TrEMBL),   G3V7N5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083117   ⟸   ENSRNOT00000095862
RefSeq Acc Id: ENSRNOP00000083946   ⟸   ENSRNOT00000104689
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18886-F1-model_v2 AlphaFold P18886 1-658 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693896
Promoter ID:EPDNEW_R4421
Type:initiation region
Description:carnitine palmitoyltransferase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.05127,523,027 - 127,523,087EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2398 AgrOrtholog
BioCyc Gene G2FUF-40403 BioCyc
BioCyc Pathway PWY-6111 [mitochondrial L-carnitine shuttle] BioCyc
BioCyc Pathway Image PWY-6111 BioCyc
Ensembl Genes ENSRNOG00000012443 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055028336 UniProtKB/Swiss-Prot
  ENSRNOG00060018750 UniProtKB/Swiss-Prot
  ENSRNOG00065023289 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016954 ENTREZGENE
  ENSRNOT00000016954.4 UniProtKB/TrEMBL
  ENSRNOT00000095862.1 UniProtKB/TrEMBL
  ENSRNOT00000104689.1 UniProtKB/TrEMBL
  ENSRNOT00055049104 UniProtKB/Swiss-Prot
  ENSRNOT00060032363 UniProtKB/Swiss-Prot
  ENSRNOT00065039839 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.1280.180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.559.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.559.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Carn_acyl_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carn_acyl_trans_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAT-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cho/carn_acyl_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cho/carn_acyl_trans_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25413 UniProtKB/Swiss-Prot
  PTHR22589 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carn_acyltransf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cpt2 PhenoGen
  ACYLTRANSF_C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012443 RatGTEx
  ENSRNOG00055028336 RatGTEx
  ENSRNOG00060018750 RatGTEx
  ENSRNOG00065023289 RatGTEx
Superfamily-SCOP CoA-dependent acyltransferases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205395
UniProt A0A8I5ZV78_RAT UniProtKB/TrEMBL
  CPT2_RAT UniProtKB/Swiss-Prot
UniProt Secondary P97781 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cpt2  Carnitine palmitoyltransferase 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to mitochondria 1298788
gene_cellular_localization localized to inner mitochondrial membrane 1298785
gene_function exhibits mitochondrial carnitine palmitoyltransferase II activity 1298788
gene_function converts acylcarnitine back to acyl-CoA 1298785
gene_mutations_overexpression mutation of Glu(487) with alanine, aspartate, or lysine results in loss of enzyme activity; mutation of Glu(500) alters enzymatic Vmax 1298789
gene_protein 658 amino acid protein 1298788