Mir455 (microRNA 455) - Rat Genome Database

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Gene: Mir455 (microRNA 455) Rattus norvegicus
Analyze
Symbol: Mir455
Name: microRNA 455
RGD ID: 2325417
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in cellular response to cortisone stimulus and regulation of progesterone biosynthetic process. Predicted to be part of RISC complex. Orthologous to human MIR455 (microRNA 455); INTERACTS WITH aflatoxin B1; bisphenol A; bucladesine.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-mir-455
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2576,689,313 - 76,689,390 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl576,689,313 - 76,689,390 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx579,088,449 - 79,088,526 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,905,581 - 80,905,658 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,881,087 - 80,881,164 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0579,097,208 - 79,097,285 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl579,097,208 - 79,097,285 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0583,211,456 - 83,211,533 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera575,623,186 - 75,623,263 (+)NCBICelera
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MicroRNAs 125a and 455 repress lipoprotein-supported steroidogenesis by targeting scavenger receptor class B type I in steroidogenic cells. Hu Z, etal., Mol Cell Biol. 2012 Dec;32(24):5035-45. doi: 10.1128/MCB.01002-12. Epub 2012 Oct 8.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:20403161   PMID:20439489   PMID:20548288   PMID:23185045   PMID:23646144   PMID:23946534   PMID:30858037   PMID:32114773   PMID:32237270   PMID:32833902  
PMID:34823099   PMID:35577544   PMID:36648213  


Genomics

Comparative Map Data
Mir455
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2576,689,313 - 76,689,390 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl576,689,313 - 76,689,390 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx579,088,449 - 79,088,526 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,905,581 - 80,905,658 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,881,087 - 80,881,164 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0579,097,208 - 79,097,285 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl579,097,208 - 79,097,285 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0583,211,456 - 83,211,533 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera575,623,186 - 75,623,263 (+)NCBICelera
Cytogenetic Map5q24NCBI
MIR455
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389114,209,434 - 114,209,529 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9114,209,434 - 114,209,529 (+)EnsemblGRCh38hg38GRCh38
GRCh379116,971,714 - 116,971,809 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369116,011,534 - 116,011,629 (+)NCBINCBI36Build 36hg18NCBI36
Celera987,619,629 - 87,619,724 (+)NCBICelera
Cytogenetic Map9q32NCBI
HuRef986,578,236 - 86,578,331 (+)NCBIHuRef
CHM1_19117,118,235 - 117,118,330 (+)NCBICHM1_1
T2T-CHM13v2.09126,408,154 - 126,408,249 (+)NCBIT2T-CHM13v2.0
Mir455
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39463,175,088 - 63,175,169 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl463,175,088 - 63,175,169 (+)EnsemblGRCm39 Ensembl
GRCm38463,256,851 - 63,256,932 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl463,256,851 - 63,256,932 (+)EnsemblGRCm38mm10GRCm38
MGSCv37462,917,885 - 62,917,966 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera461,913,734 - 61,913,815 (+)NCBICelera
Cytogenetic Map4B3NCBI
cM Map433.96NCBI
MIR455
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11168,461,911 - 68,461,968 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1168,461,896 - 68,461,983 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1166,864,258 - 66,864,315 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01169,585,477 - 69,585,534 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11168,101,107 - 68,101,164 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01168,132,141 - 68,132,198 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01168,871,375 - 68,871,432 (+)NCBIUU_Cfam_GSD_1.0
MIR455
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1254,824,196 - 254,824,291 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11254,824,200 - 254,824,279 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21286,017,379 - 286,017,458 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Scarb1rno-miR-455-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23045399

Predicted Targets
Summary Value
Count of predictions:6739
Count of gene targets:4851
Count of transcripts:5198
Interacting mature miRNAs:rno-miR-455-3p, rno-miR-455-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1598845Mcs14Mammary carcinoma susceptibility QTL 140.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)57636977680813390Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system renal system reproductive system respiratory system appendage
High
Medium
Low 1 2 4 4 1 1 3 6 1 1
Below cutoff 1 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_032279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000054389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl576,689,313 - 76,689,390 (+)Ensembl
Rnor_6.0 Ensembl579,097,208 - 79,097,285 (+)Ensembl
RefSeq Acc Id: NR_032279
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,689,313 - 76,689,390 (+)NCBI
Rnor_6.0579,097,208 - 79,097,285 (+)NCBI
Rnor_5.0583,211,456 - 83,211,533 (+)NCBI
Celera575,623,186 - 75,623,263 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325417 AgrOrtholog
BioCyc Gene G2FUF-41071 BioCyc
Ensembl Genes ENSRNOG00000036266 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000054389 ENTREZGENE
miRBase MI0006148 ENTREZGENE
NCBI Gene 100314205 ENTREZGENE
PhenoGen Mir455 PhenoGen
RatGTEx ENSRNOG00000036266 RatGTEx
RNAcentral URS00000AD002 RNACentral
  URS000075B31F RNACentral
  URS000075D735 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir455  microRNA 455  Mir455  microRNA mir-455  Name updated 61478 APPROVED
2010-06-02 Mir455  microRNA mir-455      Symbol and Name status set to provisional 70820 PROVISIONAL