Tusc1 (tumor suppressor candidate 1) - Rat Genome Database

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Gene: Tusc1 (tumor suppressor candidate 1) Rattus norvegicus
Analyze
Symbol: Tusc1
Name: tumor suppressor candidate 1
RGD ID: 41074883
Description: INTERACTS WITH bisphenol A; 1,2-dichloroethane (ortholog); 1,2-dimethylhydrazine (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: tumor suppressor candidate gene 1 protein
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85113,205,748 - 113,207,111 (-)NCBIGRCr8
mRatBN7.25108,089,952 - 108,091,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5108,090,613 - 108,091,224 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5110,603,769 - 110,605,134 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05112,329,524 - 112,330,889 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05112,391,791 - 112,393,156 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Cytogenetic Map5q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Tusc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85113,205,748 - 113,207,111 (-)NCBIGRCr8
mRatBN7.25108,089,952 - 108,091,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5108,090,613 - 108,091,224 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5110,603,769 - 110,605,134 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05112,329,524 - 112,330,889 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05112,391,791 - 112,393,156 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Cytogenetic Map5q32NCBI
TUSC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38925,676,969 - 25,678,444 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl925,676,969 - 25,678,444 (-)EnsemblGRCh38hg38GRCh38
GRCh37925,676,967 - 25,678,442 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36925,666,387 - 25,668,856 (-)NCBINCBI36Build 36hg18NCBI36
Celera925,603,429 - 25,605,898 (-)NCBICelera
Cytogenetic Map9p21.2NCBI
HuRef925,628,732 - 25,631,200 (-)NCBIHuRef
CHM1_1925,676,275 - 25,678,743 (-)NCBICHM1_1
T2T-CHM13v2.0925,687,486 - 25,688,961 (-)NCBIT2T-CHM13v2.0
Tusc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39493,222,385 - 93,223,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl493,222,375 - 93,223,748 (-)EnsemblGRCm39 Ensembl
GRCm38493,334,148 - 93,335,511 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl493,334,138 - 93,335,511 (-)EnsemblGRCm38mm10GRCm38
MGSCv37493,000,839 - 93,002,202 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36492,826,166 - 92,827,529 (-)NCBIMGSCv36mm8
Celera491,762,728 - 91,764,037 (-)NCBICelera
Cytogenetic Map4C5NCBI
cM Map443.25NCBI
TUSC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21198,859,180 - 98,865,060 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1998,865,128 - 98,871,004 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0925,526,822 - 25,529,415 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1926,139,915 - 26,149,810 (-)NCBIpanpan1.1PanPan1.1panPan2
TUSC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1142,799,680 - 42,800,342 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01145,068,249 - 45,068,911 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1145,068,249 - 45,068,920 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11143,728,402 - 43,729,064 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01143,620,995 - 43,621,732 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01144,368,166 - 44,368,828 (-)NCBIUU_Cfam_GSD_1.0
Tusc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947158,997,724 - 158,999,323 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366113,669,415 - 3,670,017 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366113,669,285 - 3,670,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TUSC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1197,309,229 - 197,309,864 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11197,240,649 - 197,312,349 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,726,003 - 219,727,399 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Tusc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473629,855,592 - 29,856,416 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)5104018576124314782Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001401265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000102835   ⟹   ENSRNOP00000083265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5108,090,613 - 108,091,224 (-)Ensembl
RefSeq Acc Id: NM_001401265   ⟹   NP_001388194
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85113,205,748 - 113,207,111 (-)NCBI
mRatBN7.25108,089,952 - 108,091,315 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001388194 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000083265.1
Ensembl Acc Id: ENSRNOP00000083265   ⟸   ENSRNOT00000102835
RefSeq Acc Id: NP_001388194   ⟸   NM_001401265
- UniProtKB: A0A8I5ZZN7 (UniProtKB/TrEMBL)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-40723 BioCyc
Ensembl Genes ENSRNOG00000066328 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000102835.1 UniProtKB/TrEMBL
InterPro CCDC89-like UniProtKB/TrEMBL
NCBI Gene Tusc1 ENTREZGENE
PANTHER PTHR34768 UniProtKB/TrEMBL
  TUMOR SUPPRESSOR CANDIDATE GENE 1 PROTEIN UniProtKB/TrEMBL
PhenoGen Tusc1 PhenoGen
RatGTEx ENSRNOG00000066328 RatGTEx
UniProt A0A8I5ZZN7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Tusc1  tumor suppressor candidate 1  Tusc1  tumor suppressor candidate 1  Data merged from RGD:149736393 737654 PROVISIONAL
2021-08-09 Tusc1  tumor suppressor candidate 1      Symbol and Name status set to provisional 45752 PROVISIONAL
2021-01-27 Tusc1  tumor suppressor candidate 1      Symbol and Name status set to provisional 70820 PROVISIONAL